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The Journal of Bone & Joint Surgery British Volume
Vol. 92-B, Issue 8 | Pages 1152 - 1159
1 Aug 2010
Hayek S Gershon A Wientroub S Yizhar Z

Our aim was to evaluate the effect of adding inhibitory casting to the treatment of young children with cerebral palsy who received injections of botulinum neurotoxin A (BoNT-A) to gastrocnemius for equinus gait. Of the 20 patients in the series, 11 in group A had inhibitory casts applied on the day of the first set of BoNT-A injections and nine in group B did not have casting. Both groups received another BoNT-A injection four months later. The patients were followed for eight months and examined at five intervals.

Both groups showed significant improvement in gait parameters and function (p < 0.0001) and selective motor control (p = 0.041, − 0.036) throughout the study. Group A had significantly better passive dorsiflexion of the ankle (p = 0.029), observational gait score (p = 0.006) and selective motor control (p = 0.036). We conclude that the addition of inhibitory casting enhances and prolongs the results of treatment and mainly influences the passive range of movement, while BoNT-A mostly influences the dynamic motion. The second injection further improved the results of most parameters. The gross motor function measure, the selective motor control test and the modified Tardieu scale correlated well with the results of treatment.

We recommend the use of inhibitory casting whenever augmentation of the effect of treatment with BoNT-A is needed.


The Journal of Bone & Joint Surgery British Volume
Vol. 90-B, Issue 11 | Pages 1507 - 1511
1 Nov 2008
Kenet G Ezra E Wientroub S Steinberg DM Rosenberg N Waldman D Hayek S

The role of heritable thrombophilic risk factors in the pathogenesis of the Perthes’ disease is controversial. The clinical and radiological findings of Perthes’ disease may be indistinguishable from those of Gaucher’s disease, and the most common Jewish N370S Gaucher mutation is threefold greater in patients with Perthes’ disease. Familial osteonecrosis of the femoral head is associated with variant mutations of collagen type II (COL2A1 mutations). We therefore studied the potential role of genetic thrombophilia and the Gaucher and COL2A1 mutations in children with Perthes’ disease.

Genomic DNA of 119 children with radiologically-confirmed Perthes’ disease diagnosed between 1986 and 2005 was analysed for the thrombophilic polymorphisms Factor V Leiden, 677T-MTHFR and FIIG20210A. The results were compared with those of a group of 276 children without Perthes’ disease. DNA was also analysed for the Gaucher mutations N370S, G insertion (84GG), L444P, Intron 2 (IVS2+1G> A) and R496H. Enzymic assays confirmed the Gaucher disease status. Collagen (COL2A1) mutations of the 12q13 gene were also analysed. The prevalence of thrombophilic markers was similar among the 119 patients with Perthes’ disease and the 276 control subjects. The prevalence of the Gaucher mutation was consistent with Israeli population carriership data and did not confirm an earlier-claimed association with Perthes’ disease. All 199 patients were negative for the studied COL2A1 mutations.

We found no genetic association between Perthes’ disease and either Gaucher’s disease or COL2A1 mutations or increased genetic thrombophilia among our patients compared with the control group. A systematic review of case-control studies suggested that there was a positive association between Perthes’ disease and Factor V Leiden. The impact of this association upon the disease, although not consistent across the studies, remains unclear.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 386 - 386
1 Sep 2005
Hayek S Kfir M Khamis S Batt R Wientroub S Yizher Z
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Background: Ankle-foot orthoses (AFO) are frequently recommended to children with CP to improve their functional ambulatory ability, namely to increase walking velocity and stride length, and decrease cadence. Several studies examined the effectiveness of different types of AFOs based on gait analysis. AFOs however, are usually prescribed upon clinical examination alone. Based on our first year experience at the Dana Gait Lab not all AFOs improved function significantly.

Objective: To investigate the effect of prescribed AFOs on gait performance of children with cerebral palsy.

Methods: Twenty-two children with cerebral palsy (aage 5–17 y; gender: 11 males, 11 females, of them: 8 hemiplegic, 11 diplegic, 3 quadriplegic) were referred for full 3D instrumented gait analysis for different purposes. Using the Vicon 612 system they were studied walking both barefoot and with their prescribed AFOs. The two modes were compared in terms of spatio-temporal parameters and ankle-knee kinematics. Statistical analysis included paired t-test, and Pearson correlation coefficient; level of significance was set to .05.

Results: Using the prescribed AFOs, stride length was significantly increased (on average, 9.95±0.11 cm, p=0.000) while no significant changes were found in walking velocity and cadence (p= .111, p= .420, respectively). Split-by diaganosis revealed significant reduction in cadence (12.7 step/min, p=0.034) in the hemiplegic children. There was no significant improvement in the symmetry index of the stride length and step time due to the use of AFOs. Ankle and knee kinematics at initial contact and at loading response revealed non-significant changes. In the hemiplegic group knee flexion increased significantly (p=0.002) while ankle dorsiflexion at initial contact was almost significant (p=0.3).

The consistency of the results within subject and between modes was highly correlated (r=0.858–0.928) and statistically very significant (p< 0.000).

Discussion: In the current study, the only benefits of AFOs were increasing stride length and some improvement in ankle and knee kinematics. Our findings show that the use of an AFO, by itself, does not change dramatically other walking parameters. The high correlation between barefoot and AFO modes suggests that the child’s basic capability is the main factor that affects the gait pattern. Inappropriate AFO may partly be the reason for the non-significant results in this study.

We conclude that AFO’s should be given only after optimization of the child’s physical capabilities. Prescription should be made after careful evaluation using gait analysis whenever possible.


The Journal of Bone & Joint Surgery British Volume
Vol. 84-B, Issue 7 | Pages 1015 - 1019
1 Sep 2002
Keret D Ezra E Lokiec F Hayek S Segev E Wientroub S

Club foot can be diagnosed by ultrasound of the fetus in more than 60% of cases. We have correlated the accuracy of the prenatal findings in 281 ultrasound surveys with the physical findings after birth and the subsequent treatment in 147 children who were born with club foot.

The earliest week of gestation in which the condition was diagnosed with a high degree of confidence was the 12th and the latest was the 32nd. Not all patients were diagnosed at an early stage. In 29% of fetuses the first ultrasound examination failed to detect the deformity which subsequently became obvious at a later examination. Club foot was diagnosed between 12 and 23 weeks of gestation in 86% of children and between 24 and 32 weeks of gestation in the remaining 14%. Therefore it can be considered to be an early event in gestation (45% identified by the 17th week), a late event (45% detected between 18th and 24th weeks) or a very late event (10% recognised between 25th and 32nd weeks). We cannot exclude, however, the possibility that the late-onset groups may have been diagnosed late because earlier scans were false-negative results. The prenatal ultrasonographic findings were correlated with the physical findings after birth and showed that bilateral involvement was more common than unilateral. There was no significant relationship between the prenatal diagnosis and the postnatal therapeutic approach (i.e., conservative or surgical), or the degree of rigidity of the affected foot.


The Journal of Bone & Joint Surgery British Volume
Vol. 82-B, Issue 7 | Pages 1026 - 1029
1 Sep 2000
Hayek S Segev E Ezra E Lokiec F Wientroub S

The conventional osteotomies used to treat infantile tibia vara (Blount’s disease) may require internal fixation and its subsequent removal. These techniques, which carry the risk of traction injury, and potential problems of stability and consolidation, do not always succeed in correcting the rotational deformity which accompanies the angular deformity.

We have used a new surgical approach, the serrated W/M osteotomy of the proximal tibia, to correct infantile tibia vara in 15 knees of 11 patients. We present the results in 13 knees of nine patients who have been followed up for a mean of eight years. The mean angular correction achieved after operation was 18 ± 5.8°. The mean femorotibial shaft angle was corrected from 14.2 ± 3.7° of varus to 4.6 ± 4.4° of valgus. At the last follow-up, the mean angular correction had reduced to 1.3 ± 4.9° of valgus without compromising the rotational correction and the overall good clinical results. All the patients and parents were satisfied, rating the result as excellent or good. There were no major postoperative complications and no reoperations. Eight patients were free from pain and able to perform physical activities suitable for their age. One complained of occasional pain. This procedure has the advantage of allowing both angular and rotational correction with a high degree of success without the need for internal fixation.


The Journal of Bone & Joint Surgery British Volume
Vol. 81-B, Issue 4 | Pages 686 - 690
1 Jul 1999
Hayek S Kenet G Lubetsky A Rosenberg N Gitel S Wientroub S

Heritable thrombophilic disorders have been proposed as one of the causes for Legg-Calvé-Perthes disease. A total of 62 patients diagnosed with this disease between 1988 and 1997 and 50 controls were screened for thrombophilia. The incidence and relationship of thrombophilia to the severity of the disease were evaluated.

One patient and none of the controls had protein S deficiency. One of the control group and one of the patients had protein C deficiency with the latter child also having a combined deficiency with a mutant factor V gene.

The number of children with a mutant factor V gene, protein C deficiency, who were homozygous for the C 677T polymorphism of methylenetetra-hydrofolate reductase or were heterozygous for mutant G20210A prothrombin did not differ statistically in the study and the control groups. No patient had antithrombin deficiency or positive lupus anticoagulant.

We found no correlation between thrombophilia and the extent of the disease. The most common risk factors for arteriovenous thromboembolism showed no statistical significance in our patients compared with the control group or with the general population. These data do not confirm an aetiological role for thrombophilia in Perthes’ disease.