We assessed the rates of fracture healing in a number of patients in Southern Africa where the Human Immunodeficiency Virus (HIV) is highly prevalent.

Our aim was to deduce whether rates of union were affected by HIV and its subsequent clinical stages, including the Acquired Immune Deficiency Syndrome (AIDS). We evaluated 2376 patients with Weber B ankle fractures without talar shift. All the patients included in the study were tested for HIV using the Western Blot system and classified according to the WHO classification (Stages I–IV). From the sample group, 829 patients were HIV negative. 729 were HIV positive belonging to Stages I–III, whilst 755 were HIV positive in stage IV of the disease. Patients were all treated conservatively in below knee casts for a minimum of six weeks. All the patients were aged between 20 and 30. All patients were all part of similar socioeconomic circumstances and were non-smokers who used no dietary supplements.

From the sample of patients we reviewed, the results were as follows. In the HIV negative category, 56% of patients had fracture union at 4 weeks, 32% had fracture union at 6 weeks, 10.5% had fracture union at eight weeks and 1.5% of patients suffered non-union of the fractures. In the HIV positive group (WHO Stages I–III), 54.7% of patients had fracture union at 4 weeks, 33.7% had fracture union at 6 weeks, 10.2% had fracture union at 8 weeks and 1.26% of patients suffered non-union. From the HIV positive category (WHO Stage IV), 18.28% of patients had fracture union at four weeks, 32.72% had fracture union at 6 weeks, 36.56% had fracture union at 8 weeks and 12.45% of patients suffered non-union of the fractures. Healing and union were described as sufficient callous formation, no further displacement, and no malleolar tenderness at the time of cast removal. In addition to this, the patients must have been able to fully weight bear. There was no significant statistical difference in fracture union between patients who were HIV negative and the patients with HIV stages one to three. There were significant differences between the above mentioned groups and patients with Stage IV HIV/AIDS. In essence, the more progressive the disease, the higher the rates of non-union.