Various studies have demonstrated that menisci heal in the vascular region but do not heal in the avascular area. Experimental studies of the promotion of meniscal healing in the avascular area have involved the application of fibrin clot, fibrin glue to the injured area, as well as the construction of an access chanel to the vascular regiòn, all of them with poor results. The multilineage potential of adult stem cells has been characterized extensively. The adipose tissue has been described as a useful source of adult stem cells. We try to show that the use of stem cells from the adipose tissue may promete meniscal healing in the avascular area.

Twelve New Zealand white rabbits with a mean weight of 3 kg were used. The medial meniscus of both knees was aproached, and was performed a longitudinal tear in the avascular area in the anterior horn with a mean length of 0.5 cm. All the tears were sutured with one vertical stitch of nonabsorbable suture. In each rabbit a solution with 1 00 000–1 000 000 stem cells from the fat was introduced in one of the knees, and the other one was used as a control. The rabbits were killed at 12 weeks, and a macro-microscopic study of the meniscus was done, and also a inmunohistochemistry study for the stem cells.

The incidence of healing was better in those menisci with the stem cells solution. Three total and three partial healing was obtained in the stem cells group and none in the control group. The inmunohistochemistry showed that the stem cells were in the repair zone.

We think that stem cells will be very useful in the treatment of the lesion in the avascular area of the meniscus.

Introduction: Our aim is to study the morphological changes (and related factors) that occur in the proximal femur in patients with THR with a minimum 10 year follow-up.

Materials and methods: We have included 50 THRs carried out between October 1992 and June 1995 with porous stems with metaphyseal support proximally coated with hydroxyapatite. Changes in the morphology and density of the proximal femur and its relationship with several factors, especially polyethylene wear, were carried out by means of a series of x-rays taken during the whole period of evolution and a spiral CT taken during the last review.

Results: There was no subsidence, stem migrations or femoral revision surgery. After one year, all patients show an sclerotic region in the area of metaphyseal support that remains stable throughout the study period. During this period, only two other types of changes were seen in the proximal area.

lytic areas surrounded by a halo of sclerosis in the greater trochanter (in 18 cases they were very small and in 14 cases of a greater size). These areas were statistically significantly related to a greater rate of wear;

Conclusions: The metaphyseal area of the stem continued to comply with its support function during the period studied. In more than half of the cases there was some sort of bone loss in the proximal area. There is a relationship between polyethylene wear and the appearance of areas of lysis in the trochanter.