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Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_14 | Pages 21 - 21
1 Nov 2018
Gbejuade H Elsakka M
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Surgical training in the UK is under increasing pressure with a high demand for service provision. This raises concerns about the resultant negative impact this is having on training opportunities for surgical trainees in theatre due to a high demand for surgical procedures to be performed expediently by consultants. This is due to the assumption that trainee take significantly longer time to operate in theatre and thus result in a slow progress of theatre lists. Our study evaluated the differences in operative time between orthopaedic trainees and orthopaedic consultants, as well as provide realistic timings for each stage encompassed within the entire duration a patient is in theatre. From our trauma unit electronic theatre database, we retrospectively collected data for six Joint Committee of Surgical Training (JCST) mandatory procedures. Information collected included patients' ASA grading, total surgical time and grade of surgeons. A total of 956 procedures were reviewed: 71.8% hip procedures, 14.2% intramedullary nail fixations and 14.2% ankle fixations. 46.2% and 53.8% of the procedures were performed by consultants and trainees as first surgeon, respectively. On average, consultants were found to be 13 minutes quicker in performing the hip procedures and this difference was found to be statically significant (p < 0.05). However, trainees were found to be quicker in performing intramedullary femoral nailings and simple ankle fixations, but consultant were faster at performing intramedullary tibial nailings and complex ankle fixations. However, the differences were not found to be statistically significant (p > 0.05).


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_23 | Pages 34 - 34
1 Dec 2016
Gbejuade H Hidalgo-Arroy A Sayers A Leeming J Lovering A Blom A Webb J
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Aim

To evaluate the ability of different combinations of antibiotic loaded cement to inhibit bacteria growth and biofilm formation.

Method

Cement beads were aseptically prepared using Palacos R (plain 40g PMMA cement) or Palacos R+G (40g PMMA cement containing industrially added 0.5g of gentamicin), with or without supplementary antibiotics as follows: Palacos R; Palacos R+G; Palacos R plus 1g / 2g daptomycin; Palacos R+G plus 1g / 2g of daptomycin; Palacos R plus 1g / 2g vancomcyin; and Palacos R+G plus 1g / 2g vancomycin. After production, each antibiotic loaded acrylic cement (ALAC) combination was allocated into two groups (group 1 and 2).

The group 2 cement beads were initially eluted in broth at 37o C for 72hours then transferred to fresh broth containing a known concentration of bacteria. The group 1 samples were not eluted but directly immerse in culture broth containing bacteria. All samples were thereafter incubated at 37oC for 24 hours. After incubation, group 1 samples were visually assessed for bacterial growth, while for the group 2 samples, biofilm formation were quantified using ultrasonication and viable bacteria counting technique. Three proficient biofilm forming Staphylococcus epidermidis bacterial strains (1457, 1585-RA and 5179-R1) were used for all experiments and the bacteria counts were expressed as colony forming units / ml (CFU/ml).


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 35 - 35
1 Jul 2014
Gbejuade H Lovering A Hidalgo-Arroyo A Leeming J Webb J
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Summary Statement

Conventional culture techniques have poor sensitivity for detecting bacteria growing in biofilms, which can result in under-diagnosis of infections. Sonication of biofilm colonised orthopaedic biomaterials can render bacteria in biofilm more culturable, thereby improving diagnosis of orthopaedic implant infections.

Introduction

Prosthetic joint infection (PJI) is a potentially devastating complication in arthroplasty. Biofilm formation is central to PJI offering protection to the contained bacteria against host defence system and antimicrobials. Orthopaedic biomaterials generally have a proclivity to biofilm colonisation. Conventional culture technique has a low sensitivity for detecting bacteria in biofilm. Sonication can disrupt bacteria biofilms aggregations and dislodge them from colonised surfaces, rendering them culturable and consequently improve the diagnosis of otherwise culture-negative PJI. We investigated the effect of ultrasonication on biofilms adherent to poylmethylmethacrylate PMMA cement.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_18 | Pages 12 - 12
1 Apr 2013
Gbejuade H Lovering A Blom A Webb J
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Prosthetic joint infection(PJI) still remains a concern in orthopaedic practice. Antibiotic-loaded acrylic-cement(ALAC) is a proven means of lowering the incidence of PJI. However, increasing antimicrobial resistance has complicated both prophylaxis and treatment, prompting the use of combination antimicrobial therapy, with the addition of vancomycin to gentamicin-containing ALAC commonly used. The new antimicrobial, daptomycin, has better activity than vancomycin and we studied its elution from ALAC in comparison with vancomycin, along with its impact on the co-elution of gentamicin.

Cement beads were prepared from PalacosRG containing, 1g/2g daptomycin, 1g/2g vancomycin and without additional antibiotics. Six replicates of each combination were eluted in PBS at 37oC, at timed intervals, for up to 90days, the antibiotic loss was assessed using validated assays.

The mean recovery of gentamicin after 90days was 1.1mg with half eluted within the first 6 hours. Recovery was significantly increased by 60% and 40% with addition of 1g&2g of daptomycin(two-tail t-test: p=0.004 and p=0.02), respectively. Although there was a slight increase in gentamicin recovery in vancomycin loaded samples, this was not statistically significant(p>0.05).

The significant increases in gentamicin elution from Palacos RG when supplemented with daptomycin, along with a superior activity, may provide a better synergistic effect than PalacosRG supplemented with vancomycin in the management of PJI.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_9 | Pages 3 - 3
1 Feb 2013
Gbejuade H Hassaballa M Robinson J Porteous A Murray J
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The gold standard for measuring knee alignment is the lower limb mechanical axis. This is traditionally assessed by weight-bearing full length lower limb X-rays (LLX). CT scanograms (CTS) are however, becoming increasingly popular in view of lower radiation exposure, speed and supine positioning. We assessed the correlation and reproducibility of knee joint coronal alignment using these two imaging modalities.

LLX and CTS images were obtained in 24 knees with degenerate joint disease or failed TKR. Hip to ankle mechanical alignment were measured using the PACS software. Coronal knee alignment was assessed from the centre of the knee, measuring the valgus/varus angle relative to the mechanical axis. Measurements were made by two orthopaedic surgeons (Research Fellow and Consultant) on two separate occasions.

The mean alignment angles measured by observers 1 and 2 on CTS were 180.29° (SD 6.04) and 180.71° (SD 6.13) respectively, while on LLX were 181.04° (SD7.58) and 181.04° (SD 7.72). The measurements between the two observers were highly correlated for both the CTS (r = 0.97, p < 0.001) and the LLX (r = 0.99, p < 0.001). The angles measured on CTS and LLX were highly correlated (r = 0.826, p < 0.001) with high degree of internal consistency (ICC = 0.804). Malalignment of greater than 5° was seen in 19% of the CTS and 35% of the LLX.

There was good correlation between CT scanogram and weight-bearing X-ray measurements in normally-aligned knees. However, as expected, in the malaligned lower limb, the influence of weight-bearing is critical which demonstrates the significance of weight-bearing X-rays.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_9 | Pages 9 - 9
1 Feb 2013
Gbejuade H Bakare S Mackinnon H Verborg S
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With modern day easy access to information, many health staff may be presumptuous of patients' level of understanding of medical terms and abbreviations. A recent audit of consent forms in Orthopaedic trauma in our department showed that doctors used abbreviations in 21% of consent forms; this was seen to increase to 48% during the re-audit. The findings motivated us to conduct this study to evaluate the level of patients' understanding of commonly used abbreviations/terminologies.

This questionnaire-based study recruited patients from both our elective and Trauma Orthopaedic units. Patient age, gender, medical and educational backgrounds were all randomised. Patients' understanding of 24 abbreviations/terminologies, selected from consent forms, patients' discharge letters and verbal communication with patients, were quantitatively and qualitatively assessed. Patients' perspectives were also sought.

All 182 patients who participated were proficient in English language. Most patients(80.2%) understood the term “physio,” however only 3.8% could correctly interpret “DHS”. 10% of patients understood “TKR,” 8.2% understood “THR” and 3.8% understood “NOF”. Interestingly, although 61.5% understood “DVT,” only 8.2% understood “PE” with most interpreting it as physical education/exercise. Only 8.2% related “MI” to any form of cardiac pathology. Almost all patients confirmed the use of unfamiliar abbreviations by health staff during communication.

Our study revealed that patients were not conversant with many abbreviations used in Orthopaedics. There is a need for greater awareness amongst doctors and other health staff about the indiscriminate use of abbreviations. From patients' perspective, interpretation should be given when using abbreviations or avoid their use altogether.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXIX | Pages 69 - 69
1 Sep 2012
Gbejuade H Hassaballa M Robinson J Murray J Porteous A
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Introduction

Patients with severe knee instability and extensive bone loss remain a surgical challenge. In such cases, regular knee implants and constrained condylar implants may not be suitable or have been attempted and failed.

Hinged knee replacements have developed an important role in the management of such complex knee cases. They also have an increasingly important role in cases such as rheumatoid arthritis and other cases of severe joint destruction.

We present a review of 138 consecutive hinge knee arthroplasties of 8 different Hinge models performed in our unit between 2004 and 2010.

Method

Combined prospective and retrospective study of 138 (42 primary and 96 revisions) consecutive cases of Hinge knee replacements at a mean follow up of 4.2 years. Outcomes were recorded and scored using the American knee score preoperatively, 1, 2 and 5 years. Complications, re-revisions, implant failures and survivorship were also assessed.