We undertook a retrospective review of 33 patients who underwent total femoral endoprosthetic replacement as limb salvage following excision of a malignant bone tumour. In 22 patients this was performed as a primary procedure following total femoral resection for malignant disease. Revision to a total femoral replacement was required in 11 patients following failed segmental endoprosthetic or allograft reconstruction. There were 33 patients with primary malignant tumours, and three had metastatic lesions. The mean age of the patients was 31 years (5 to 68). The mean follow-up was 4.2 years (9 months to 16.4 years). At five years the survival of the implants was 100%, with removal as the endpoint and 56% where the endpoint was another surgical intervention. At five years the patient survival was 32%. Complications included dislocation of the hip in six patients (18%), local recurrence in three (9%), peri-prosthetic fracture in two and infection in one. One patient subsequently developed pulmonary metastases. There were no cases of aseptic loosening or amputation. Four patients required a change of bushings. The mean Musculoskeletal Tumour Society functional outcome score was 67%, the mean Harris Hip Score was 70, and the mean Oxford Knee Score was 34.

Total femoral endoprosthetic replacement can provide good functional outcome without compromising patient survival, and in selected cases provides an effective alternative to amputation.

We have managed 27 patients (16 women and 11 men) with a mean age of 68.4 years (50 to 84), with failed total hip replacement and severe proximal femoral bone loss by revision using a distal fix/proximal wrap prosthesis. The mean follow-up was for 55.3 months (25 to 126). The mean number of previous operations was 2.2 (1 to 4). The mean Oxford hip score decreased from 46.2 (38 to 60) to 28.5 (17 to 42) (paired t-test, p < 0.001) and the mean Harris Hip score increased from 30.4 (3 to 57.7) to 71.7 (44 to 99.7) (paired t-test, p < 0.001). There were two dislocations, and in three patients we failed to eradicate previous infection. None required revision of the femoral stem.

This technique allows instant distal fixation while promoting biological integration and restoration of bone stock. In the short term, the functional outcome is encouraging and the complication rates acceptable in this difficult group of patients.

Between 1988 and 2006, 18 patients had a custom-made endoprosthetic replacement of the distal humerus for bone tumours at our institution. There were 11 primary malignant neoplasms, six secondary deposits, and one benign aggressive tumour. The mean follow-up was for 4.4 years (1 to 18.2). Complications occurred in nine patients and included aseptic loosening in three (16.6%), local recurrence in two (11%), infection in two (11%), neuropraxia of the radial nerve in one (5.5%) and a peri-prosthetic fracture in one (5.5%). Excision was inadequate in four patients (22%), all of which developed local recurrence and/or metastases. There were seven deaths from the primary disease after a mean of 2.3 years (1 to 5), one of whom had an above-elbow amputation for local recurrence seven months before death. The remaining six had satisfactory elbow function at their last follow-up. The 11 living patients were evaluated using the Musculoskeletal Tumour Society and Toronto Extremity Salvage scoring systems. The mean scores achieved were 76% (67% to 87%) and 73% (59% to 79%), respectively. Overall, 17 of 18 patients had significant improvement in the degree of their pain following operation.

Custom-made endoprosthetic reconstruction of the elbow for bone tumours is a viable treatment in carefully selected patients. It maintains satisfactory function and provides good pain relief.

We have performed a prospective, single-surgeon study analysing the histological results of autologous chondrocyte implantation.

Fourteen patients underwent autologous chondrocyte implantation of the knee and were evaluated at one year by clinical assessment and arthroscopy. Standard staining was used to examine the sections. In addition, in situ hybridisation was used to establish type-IIa and type-IIb collagen mRNA expression and immunolocalisation techniques demonstrated the positions of type-II and type-X collagen.

Eight patients regenerated hyaline cartilage and also contained type-X collagen in the deepest layers and type-II collagen in the deep layers. Three demonstrated fibrocartilage and had type-II collagen in the deep layers. In situ hybridisation revealed that all 14 samples had the potential to express both type-IIa and type-IIb collagen.

We have shown that one year after the initial implantation chondrocytes are capable of producing type-II collagen and that they continue to proliferate and mature.

We present the management and outcome of patients who presented following internal fixation of primary malignant tumours of the femur.

This is a retrospective study of eleven patients. All underwent internal fixation of pathological or impending fractures of the femur in the assumption of metastatic disease, or prior to diagnosis of primary malignancy. Data was collected from database records and case notes.

The mean age was 47 years (range 13 – 73). Six patients were male and five female. Tumour type was osteosarcoma (3), MFH (3), chondrosarcoma (2), Ewing’s sarcoma (1), fibrosarcoma (1) and liposarcoma (1). The site of the lesion was proximal in six cases and distal in five. Nine patients presented initially with pathological fractures and two with lytic lesions. The mode of fixation was DHS (3), AO screws (1), antegrade IM nailing (2), retrograde IM nailing (3), Blade plate (1) and DCS fixation (1). No patients underwent biopsy prior to fixation. Surgical treatment at the Bone Tumour Unit was excision and segmental endoprosthetic replacement (5), total femoral replacement (2), hip disarticulation (2), above knee amputation (1) with one patient dying prior to surgery. Eight patients also received chemotherapy and three radiotherapy. Four patients had local recurrences, three presented with metastatic disease and five more went on to develop metastases. Two patients died within one year of initial surgery, three more within two years and none have so far survived five years. Three patients are still alive.

We believe that internal fixation of primary malignant tumours has a detrimental effect on limb salvage and survival, emphasising the absolute necessity of pre-operative investigation of solitary bone lesions.

Background: The purpose of this prospective study is to analyse the histological results of the treatment of deep chondral defects with autologous chondrocyte transplantation in patients with articular cartilage defects of the knee joint.

Methods: Patients with articular cartilage defects of the knee joint were recruited prospectively and underwent autologous chondrocyte transplantation. Chondrocytes from a non-weight bearing area of the knee were harvested, isolated and cultured in vitro. Subsequent reimplantation involved injection of the chondrocytes into the defect which was then sealed with a porcine IIIII collagen membrane. Postoperatively, patients were evaluated at one year by clinical assessment, arthroscopy and histological examination. The presence of hyaline cartilage in the transplanted region was determined by staining with Erlich’s H & E, Safranin 0 and polarised light microscopy and by imimmohistochemical analysis with S100. Confirmation of the presence of hyaline cartilage was further assessed by examination of Type 11 collagen messenger RNA expression using PCR.

Results: Thirty four patients were recruited between July 1998 and November 2001, with a median age of 31 years (range 15–51 years). Of the 34 patients treated, 17 had right-sided lesions, 15 had left-sided lesions and two patients had bilateral lesions. Solitary lesions were treated in 36 knees with two defects being treated in one knee (37 defects in total). The defects were located on the medial femoral condyle in 22 cases, the lateral femoral condyle in eight, the trochlea in two and the patella in five cases. The defect size ranged from 1–7 cm2 (mean area 2.88cm2). The follow-up of the patients ranged from 1–39 months (mean 19 months). Twenty five patients had at least one-year follow-up. Of these patients, using the BritIberg Rating, six patients had excellent results, with 11 good, six fair and two poor. The mean Lysholin and GilIquist scores improved from 44.7 pre-op to 76.2 one-year post-op and the mean Verbal Numerical Pain Scores improved from 7.1 to 1.1. Arthroscopy revealed that the transplants were level with the surrounding surface in most cases. Biopsy at one year confirmed the presence of hyaline cartilage in 13 out of 19 cases (70%).

Conclusion: Although long-term follow-up is currently unavailable, autologous chondrocyte transplantation can provide, with careful patient selection and meticulous surgical technique, an effective treatment for cartilage defects of the knee. The histological results are extremely encouraging and chondrocyte transplantation may be the only procedure to allow regeneration of hyaline cartilage.

Introduction: Articular cartilage defects within the knee joint have poor capacity for repair. The purpose of this study is to analyse the short-term clinical and histological results of the treatment of deep chondral defects with autologous chondrocyte transplantation.

Methods: This is a prospective study involving twenty-two consecutive patients receiving autologous chondrocyte transplantation. Chondrocytes from a non weight bearing area of the knee are harvested, then isolated and cultured in vitro. Re-implantation involves injection of the chondrocytes into the defect which is then sealed with a porcine I/III collagen membrane. Evaluation consists of clinical assessment, arthroscopy and histological examination. Histological evaluation consists of examination of a biopsy of the transplanted area one-year post-op. Staining techniques include the use of Erlich’s H & E, Safranin O and S100. Using polarised light, the absence of the fibrillar nature of fibrocartilage confirms the presence of hyaline cartilage. Further confirmation can be gained by the examination of messenger RNA content, confirming the presence of type II collagen.

Results: The patients were treated between July 1998 and December 2000. The age range of the patients was 15–51 years (mean age 31 years). Of the 22 patients treated, 13 had right-sided lesions, 11 had left-sided lesions with two patients receiving bilateral procedures. Solitary lesions were treated in 23 knees with two defects being treated in one knee (25 defects in total). The defects were located on the medial femoral condyle in 17 cases, the lateral femoral condyle in five, the trochlea in two and the patella in one case. The defect size ranged from 1–5.4cm2 (mean area 2.65cm2). The follow-up of the patients ranges from 3-30 months (mean 16 months). Thirteen patients have at least one-year follow-up. Of these patients, using the Brittberg Rating, two patients have excellent results, with six good, four fair and one poor. The mean Lysholm and Gillquist scores improved from 50 pre-op to 72 one-year post-op and the mean Verbal Numerical Pain Scores improved from 7.2 to 2.6. Arthroscopy revealed that the transplants were level with the surrounding surface in most cases. Biopsy at one year confirmed the presence of hyaline cartilage in 10 out of 13 cases.

Conclusion: Although the results are short-term, autologous chondrocyte transplantation can provide, with careful patient selection and meticulous surgical technique, an effective treatment for cartilage defects of the knee. The histological results are extremely encouraging and chondrocyte transplantation may be the only procedure to allow regeneration of hyaline cartilage.

Introduction: We discuss the use of the SMILES (Stanmore Modular Individualised Lower Extremity System) in revision knee arthroplasty and review the outcome of 32 cases.

Methods: The SMILES prosthesis incorporates a rotating hinge knee joint. It can overcome the major problems of bone loss and ligamentous laxity. 32 prostheses were used in 30 patients as salvage revision procedures between Sept. 1991 and Sept. 1998. Patients receiving surgery for tumours were excluded. The minimum follow-up was two years with a mean follow-up of 4 years and six months. The age of the patients ranged from 36–85 years (mean 68years and 6months). 18 of the patients were male. The original pathology was OA in 23 patients and RA in 7 patients. The number of previous arthroplasties ranged from 1–4. The main indications for a SMILES prosthesis were aseptic loosening, periprosthetic fracture and infection, in the presence of bone loss and ligamentous laxity.

Results: The patients were assessed using the Knee Society Rating Score. The mean knee score improved from 26 pre-op to 68 post-op while the mean fiction score improved from 27 to 75. Overall Knee Society scores improved from a mean of 26 to 72. The average range of motion was 60 degrees pre-op and 90 degrees post-op. Complications included: failure to eradicate infection in two patients, with one patient needing amputation; infection of the prosthesis leading to revision in one, and failure of the tibial component needing revision.

Conclusion: The Smiles has produced satisfactory results in the short to medium term, offering an alternative to amputation in some cases. The cost compares favourably with other designs and the use is increasing in frequency.

Introduction: Articular cartilage defects in the knee joint have poor capacity for repair. The purpose of this study is to analyse the short-term results of the treatment of deep chondral defects with autologous chondrocyte transplantation with the use of a collagen membrane.

Methods: This is a prospective study involving twentytwo consecutive patients receiving autologous chondrocyte transplantation. Chondrocytes from a non weight bearing area of the knee are harvested, then isolated and cultured in vitro. Re-implantation involves injection of the chondrocytes into the defect which is then sealed with a porcine I/III (Chondro-gide) membrane. Evaluation consists of clinical assessment, arthroscopy and histological examination.

Results: The patients were treated between July 1998 and December 2000. The age range of the patients was 15–51 years (mean age 31 years). Of the 22 patients treated, 13 had right-sided lesions, 11 had left-sided lesions with two patients receiving bilateral procedures. Solitary lesions were treated in 23 knees with two defects being treated in one knee (25 defects in total). The defects were located on the medial femoral condyle in 17 cases, the lateral femoral condyle in five, the trochlea in two and the patella in one case. The defect size ranged from 1–5.4cm² (mean area 2.65cm²). The follow-up of the patients ranges from 1–28 months (mean 14 months). Thirteen patients have at least one-year follow-up. Of these patients, using the Brittberg Rating, two patients have excellent results at one year, with six good, four fair and one poor. The mean Lysholm and GilIquist scores improved from 50 pre-op to 72 one-year post-op and the mean Verbal Numerical Pain Scores improved from 7.2 to 2.6. Arthroscopy revealed that the transplants were level with the surrounding surface in most cases. Biopsy at one year confirmed the presence of hyaline cartilage in 10 out of 13 cases.

Conclusion: Although the results are short-term, autologous chondrocyte transplantation using the Chondro-gide membrane can provide, with careful patient selection, an effective treatment for cartilage defects of the knee. Chondrocyte transplantation may be the only procedure to allow regeneration of hyaline articular cartilage.