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Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 253 - 253
1 Sep 2005
Costigliola P Andollina A Maso A Bertoni G Borrelli A Tigani D Chiodo F
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Introduction: The aim of study was to evaluate the prevalence of microbiological isolates obtained from patients admitted to a 308-bed university-affiliated adult and children orthopaedic hospital of northern Italy (with more than 16.000 admissions per year), during a three year period (2000–2002), and, to analyze modifications during this period with regard to the prevalence of methicillin-resistant staphylococci strains.

Material and Methods: A retrospective study was conducted using laboratory records from 2000 to 2002 (2003 in progress) concerning bacterial and yeast isolates from all specimens sent to microbiological laboratory for culture. The specimens came from 8 surgical, 1 intensive care, 1 oncologie and 1 physiotherapy wards and included samples taken at surgical intervention, as like as at patient bed. Antimicrobial susceptibility testing results were also collected. All data were stored in an electronic database for statistical analysis.

Results: Between 2000 and 2002 a total of 8302 clinical specimens have been cultured and they yielded to 2978 isolates from 2653 positive samples. The prevalence of positive cultures form 24.8% in 2000 to 36.7% in 2002 and the isolated organisms are shown in table 1. Gram positive bacteria represent more than 70% of isolates and staphylococci are the most common organism (almost 50%). Staphylococcus epidermidis and other coagulase-negative staphylococci prevalence raised during the period 2000–2002 (respectively 25.4% to 33.4%, and 3.3% to 6.5%). Methicillin resistance rate resulted, 27.1% to 34.9% for Staphylococcus aureus, 37.6% to 28% for Staphylococcus epidermidis, and 33.3% to 42.1% for other coagulase-negative staphylococci. No difference in methicillin sensitivity was found between staphylococci isolated from surgical sites and other samples (urine, blood, sputum, throat swab).

Conclusions: Knowledge of the local epidemiology of pathogens in a surgical/orthopaedic hospital is critical in formulating policies on infection control. Amongst these rules the choice of antibiotic prophylaxis should be taken after analysis of bacteria prevalence and their antibiotic sensitivity.