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Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_11 | Pages 28 - 28
1 Jun 2016
Gill S McLuckie S Reidy M Cochrane L Johnston L
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Functional scores are used to clinically assess total hip arthroplasty (THA) and for comparative purposes in orthopaedic literature. Previous pilot work has highlighted patient comorbidity as a potential source of bias in addition to the often-examined factors of age, gender and underlying diagnosis.

We analysed prospectively collected data relating to 217 primary THAs (Tayside Arthroplasty Audit Group database). Sample size was calculated from previous pilot data (significance level 5%, power 80%, effect size 0.25). Proportional stratified sampling was performed including all patient age groups (≤40, 41–55, 56–65, >65) and four fixation classes (cemented, hybrid, uncemented and Birmingham resurfacing). Five year Harris Hip Function Score (HHFS) was the dependent variable; age, sex, underlying diagnosis, BMI, pre-operative HHFS and comorbidity (Functional Comorbidity Index; range 0–8) were co-variates/co-factors.

In univariate analysis, FCI accounted for 11% of the variation in HHFS at 5 years. Regarding patients with FCI 0–1 as a reference group, patients with greater comorbidity had lower HHFS at 5 years (FCI 2–3: −3.95; FCI 4–5: −7.21, FCI ≥6: −6.92). In a multivariable model of HHFS at 5 years, FCI group, diagnosis, pre-operative HHFS, patient age and BMI were significant. HHFS at 5 years was significantly higher in FCI group 0–1 than any other category (2–3 P=0.006, 4–5 P<0.001, ≥6 P=0.002). In total, the model accounted for 29% of variability in HHFS at 5 years.

This is the first statistically robust study to examine the effect of comorbidity on THA function. These results strongly suggest that increasing patient comorbidity is associated with poorer THA function when measured using HHS.

Two significant conclusions can be drawn:

Patient comorbidity should be taken into account pre-operatively when considering potential future THA function.

When comparing across implants, failure to give specific consideration to comorbidity of patient groups will limit relevance and weight of findings.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_33 | Pages 2 - 2
1 Sep 2013
Gill SL Karabayas M Al-Khabori S Scicluna G Cochrane L Thomas S
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Involvement in research forms a mandatory part of Trauma & Orthopaedic specialty training. Evidence of publication is a compulsory criterion for attaining Certificate of Completion of Training (CCT). The publishing behaviour of orthopaedic trainees from all four deaneries in Scotland was examined (East, North, South East and West of Scotland).

A literature search was performed for Scottish orthopaedic trainees achieving CCT between July 2005–July 2010 using Knowledge Network and PubMed databases. Data collected included date of publication, article type, journal, publishing institute, number of authors and position of trainee within authors.

There was no significant difference in mean number of publications/trainee prior to specialty training across the four deaneries (EOS 0.18; NOS 0.18; SES 0.25; WOS 0.73). The number of publications/trainee during training was statistically significantly higher in SES (mean 6.31; mode 9; median 4) compared to WOS (2.23;0;1), NOS (2.18;1;2) and EOS (1.72;1;1). However, there was no correlation between a trainee's number of publications during training and post–CCT. There was no significant difference for mean number of authors/trainee publication during training across the four deaneries (range 3.38–3.63), nor mean position of trainee in list of authors (range 1.37–1.67).

This study highlights important differences and notable similarities in publishing behaviour during orthopaedic training across the Scottish deaneries. It suggests that rates of publication relate to factors during training and that publishing during training is not predictive of future behaviour. This research may be of interest to trainees, training committees and orthopaedic departments in future appointments.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_25 | Pages 5 - 5
1 May 2013
Dalgleish S Finlayson D Cochrane L Hince A
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Radiation exposure is a hazard to orthopaedic surgeons, theatre staff and patients intra-operatively. Obesity is becoming a more prevalent problem worldwide and there is little evidence how a patient's body habitus correlates with the radiation doses required to penetrate the soft tissues for adequate imaging.

We aimed to identify if there was a correlation between Body Mass Index (BMI) and radiation exposure intra-operatively.

We performed a retrospective review of 75 patients who underwent sliding hip screw fixation for femoral neck fractures in one year. We recorded Body Mass Index (BMI), screening time, dose area product (DAP), American Society of Anesthesiologists (ASA) grade, seniority of surgeon and complexity of the fracture configuration. We analysed the data using statistical tests.

We found that there was a statistically significant correlation between dose area product and patient's BMI. There was no statistically significant relationship between screening time and BMI. There was no statistical difference between ASA grade, seniority of surgeon, or complexity of fracture configuration and dose area product.

Obese patients are exposed to increased doses of radiation regardless of length of screening time. Surgeons and theatre staff should be aware of the increased radiation exposure during fixation of fractures in obese patients and, along with radiographers, ensure steps are taken to minimise these risks.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_10 | Pages 14 - 14
1 Feb 2013
Tinning C Cochrane L Putti A Singer B
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The prevalence of Parkinson's disease (PD) is expected to rise however reports of the outcomes of total knee arthroplasty (TKA) in patients with PD in the literature are sparse. We present the first study to compare short to medium term outcomes of TKA in patients with and without PD.

We performed a retrospective analysis of data from our regional arthroplasty database. In our PD group 32 TKAs were implanted. In our age-matched control group 33 TKAs were implanted. Mean age at operation was 73 years and the primary indication was osteoarthritis in both groups.

Data was collected pre-operatively and at routine 1, 3 and 5 year follow-up attendances. Median in-patient stay was comparable in both groups (P=0.714). Pre-operatively, there were no between-group differences in range of movement, Knee Society Function Score (KSFS), Knee Society Score (KSS) or Pain score taken as an independent variable (P=0.108, 0.079, 0.478 and 0.496). KSS improved in both groups post-operatively with no significant between-group differences (P=0.707). Improvement was maintained to Year 5 (median 30 points pre-operatively and 91 points at Year 5 in PD group). Pain score also improved in both groups. There was no functional improvement following TKA in the PD group. In the controls, an increase in KSFS at Year 1 was followed by a return to pre-operative values at Year 5. Complications in the PD group included 1 case of bilateral quadriceps tendon avulsion and 1 dislocation requiring revision.

Patients with PD benefit from excellent pain relief following TKA for at least 5 years after surgery.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXIX | Pages 175 - 175
1 Sep 2012
Kennedy J Johnston L Cochrane L Boscainos P
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Although total hip arthroplasty (THA) has been shown to be a cost-effective means of treating hip arthritis, there is some ambiguity within the literature as to its success in those over 80 years of age. With the rapid expansion of this population group and an estimated 40% rise in THA figures expected by 2026, this study aims to review the results of primary THA in the octogenarian population. A series of 510 consecutive cases was obtained from the local arthroplasty database, consisting of all patients aged 80 years and over who underwent primary THA between 1994 and 2004. A control group of 3404 individuals under 80 years was also established using the same database and inclusion criteria. Mean follow-up for the octogenarian group was 5.9 years. Pain scores were comparable five years post-operatively in both groups (P=0.479); in particular 81.5% of octogenarians and 80.2% of the control noted no pain. Pre-operatively, the mean Harris Hip Function and Harris Hip Score were significantly lower in the octogenarian group by 4.3 and 4.2 points (P< 0.001), respectively, and at five years follow-up were also lower by 8.4 and 8.0 points, respectively (P< 0.001). Median hospital stay was three days longer in the elderly population (12 cf 9, P< 0.001). More complications occurred in the octogenarian group (38.1% cf 28.7% of controls, P< 0.001) however fewer cases of revision were noted (1.4% cf 3.8%, P=0.005). Kaplan-Meier analysis found implant survival time to revision to be comparable in both groups (mean 16.4 years in control cf 14.3 years in octogenarian, P=0.17). Patient satisfaction was also similar (97.8% in octogenarians and 98.1% in controls, P=0.741). This study suggests that individuals over 80 years of age have comparable pain improvement and overall satisfaction, low revision rates, reduced functional improvement and are more prone to complications compared to younger patients.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVII | Pages 208 - 208
1 Sep 2012
Dalgleish S Reidy M Singer B Cochrane L
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Introduction

New methods to reduce inpatient stay, post-operative complications and recovery time are continually being sought in surgery. Many factors affect length of hospital stay, such as, analgesia, patient and surgeon expectations, as well as provision of nursing care and physiotherapy. Development of the use of postoperative local anaesthetic infiltration delivered intra-articularly by a catheter appears to be an effective analgesic method which reduces patient's opioid requirements and allows early physiotherapy without motor blockade of muscles. Our study aimed to explore if the use of local anaesthetic infiltration intra-articularly following joint athroplasty affected the patient's duration of hospitalisation.

Methods

Looking retrospectively at arthroplasty audit data, we compared two groups of age and sex-matched patients who underwent primary hip arthroplasty (replacement and resurfacing) and knee arthroplasty performed by a single surgeon using the same surgical techniques. The surgeon began to utilize local anesthetic infiltration intra-articularly in 2009. The first group included patients operated on the year prior to the change and the second group were those operated on within a year of the change of practice. There were 103 patients (27 resurfacings, 28 knees, 48 hips) in the local anaesthetic group and 141 patients (48 resurfacings, 36 knees, 64 hips) in the non-local anaesthetic group. The length of stay was investigated for plausible Normality using the Shapiro Wilks statistic. Between-treatment group differences were examined using one-way analysis of variance (ANOVA). Factors observed were, use of local anaesthetic (yes/no), joint (hip/knee) and day of surgery (weekend/not weekend). Between treatment group differences in gender and complications were investigated using Chi-squared methods.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_II | Pages 367 - 367
1 May 2009
Ramanathan AK John MC Arnold GP Cochrane L Abboud RJ
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Introduction: Off-the-shelf heel inserts are used widely without adequate scientific information regarding their effects under the forefoot and this study was aimed to fill this paucity.

Materials and Methods: Thirty-five asymptomatic volunteers consented to participate. Six brands of off-the-shelf heel inserts were tested. Subjects walked along a ten metre walkway with no inserts and then with each pair of inserts, in a randomised order. The Pedar® in-shoe pressure system was used to record data. The five areas of interest were the heel, lateral three and medial two metatarsals, lateral three and medial two toes.

Results: The mean peak pressure (PP) under the heel was significantly reduced with inserts whereas PP recorded under the medial and lateral metatarsal heads was higher. With inserts, the contact time (CT) and pressure time integral (PTI) had increased under the medial toes, lateral and medial metatarsal heads; while under the heel, the CT had increased and PTI had decreased. The percentage roll over process of beginning of contact (BoC) showed a generalized decrease in the values under the metatarsal heads and medial toes with inserts. Although the general trend was a decrease in contact area (CA) with inserts, little difference was seen in the areas of interest among both feet.

Discussion: A comparable CA and increased PP, CT and PTI under the metatarsal heads and a decreased PP under the toes suggest that the metatarsal heads are prone to increased risk of injury while using inserts. This is complimented by the hastened BoC of the forefoot. The decreased PTI and PP under the heels can be attributed directly to the use of inserts.

Conclusion: The heel inserts should be used with caution inspite of their beneficial effects under the heel. The classification of these inserts as an “over-the-counter” product may need to be reviewed.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 72 - 73
1 Mar 2009
Hussain S Savin J Cochrane L Singer B
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The merit of staging bilateral total knee arthroplasties (separate procedures) versus replacing both joints at the same anaesthetic (sequential) is a topic debated in literature. The aim of this study was to evaluate & compare the clinical outcome in patients who had undergone either bilateral staged or sequential total knee arthroplasties (TKAs).

METHODS: Computerized database and medical records of patients who had had bilateral TKAs in the Tayside region between 1984 and 2003 were retrospectively evaluated. Outcome was assessed using Knee Society Score, Pain Score, Function Score and Range of Movement.

RESULTS: 438 sequential and 526 staged procedures were evaluated. The sequential group had better function score at 1 and 3 years (P< 0.001). There was no other statistically significant difference in the outcome measures.

The mean ages of the sequential and staged study groups were 70.67 and 69.19 years, respectively (P=0.011).

CONCLUSION: Sequential TKA appears to confer a functional advantage over staged procedures in the short and medium term.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 235 - 235
1 May 2006
Campbell D Cochrane L Rowley D
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As part of a user group of a collarless polished tapered stem a database was established in 1993 recording all significant data pre-operatively, intra-operatively and at 1,3,5 and 7 years.

All were primary hip replacements and the study included 38 different surgeons who were free to use the head size, approach and cup of their choosing. All hips had a collarless polished tapered prosthesis (Zimmer inc.).

Data on 2,250 hips were available for analysis and stratification of risk factors for dislocation. Correlation of head size and surgical approach was performed and tested for significance. The patient demographics were standard for a typical arthroplasty study group. Of the surgical approaches used, 13.1% were anterolateral, 27.55% lateral, 23.88% posterior and 35.47% Hardinge. There were no trochanter osteotomies or anterior approaches.

94 (100%) of the hips had a first dislocation occurring in the first two years: 38 during acute stay (40.43%), 45 from acute stay to the first year (47.88%) and 11 during the second year (11.7%). The 22mm head was associated with the greatest risk of dislocation (5.93%, P < 0.001). The risks with the 28mm head (3.05%) and the 26mm head (2.5%) were not significantly different. The lowest risk of dislocation occurred with the lateral approach (2.11%) and the highest with the posterior approach (5.99%). Dislocation rates for the anterolateral and Hardinge approaches (4.1% and 3.28% respectively) were not significantly different. Unfortunately data pertaining to frequency of capsular repair combined with the posterior approach was not available.

The combination of lateral approach and 28mm head was associated with the lowest dislocation risk of 1.56%, while the risk with the posterior approach and 22mm head was the highest at 10.09%.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 232 - 232
1 Sep 2005
Ahmed I Cochrane L Wigderowitz C
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Introduction: Substantial evidence is now available that complex multi-variate models such as Artificial Neural Networks and Finite Element Analysis can predict bone strength better than DXA. In order to build such models effectively, it is essential to determine which basic individual parameters will be used. The current study attempts to improve a number of existing parameters that reflect bone structure, originating from spectral analysis of cancellous bone in radiographic images, to assess whether their correlation with mechanical strength of bone can be improved.

M& M: Sixty standard AP x-rays of cadaveric human radii, for which mechanical data was available, have been examined. The bones had been mechanically tested to destruction and the details of the test have been published previously. The x-rays were digitized at 160 mm/ pixel, using a dedicated scanner. ROI of 64x64 pixels corresponding to 1x1 cm in the original x-rays were used for the analysis. Low pass and High pass filters were moved stepwise to determine the most effective bandwidth for the identification and measurements of the magnitude peaks in the fast Fourier transform (FFT).

Results: The spectral trabecular index had a correlation with load at fracture (LF) of −0.002 and with the work at fracture (WF) of −0.07. The filtered parameter, termed spectral index of bone structure (SIBS), increased these correlations to 0.41 and 0.46 respectively. The Longitudinal trabecular index had a correlation of 0.09 with LF and 0.04 with WF. The corresponding filtered parameter, termed longitudinal trabecular index of bone structure (LIBS), increased these correlation coefficients to 0.39 with LF and 0.41 with WF. Finally the Transverse trabecular index had a correlation of −0.19 with LF and −0.04 with WF. The Transverse index of bone structure (TIBS) altered the correlations to 0.17 with LF and 0.36 with WF. For this sample size, the 5% significance threshold for correlations is 0.25 and for the 1% level is 0.325.

Discussion: This refinement of the individual spectral parameters is an essential step towards the improvement of multivariate models, leading to a potentially improved assessment of fracture risk. The general assessment of trabeculae and particularly the longitudinal ones was substantially improved by the new method of measurement. These parameters can now be incorporated into more complex models that take into account other characteristics such as age of the patients, cortical thickness and size of the bones and which are knowingly related to bone fragility.


The Journal of Bone & Joint Surgery British Volume
Vol. 87-B, Issue 7 | Pages 997 - 999
1 Jul 2005
Reilly J Noone A Clift A Cochrane L Johnston L Rowley DI Phillips G Sullivan F

Post-discharge surveillance of surgical site infection is necessary if accurate rates of infection following surgery are to be available. We undertook a prospective study of 376 knee and hip replacements in 366 patients in order to estimate the rate of orthopaedic surgical site infection in the community. The inpatient infection was 3.1% and the post-discharge infection rate was 2.1%. We concluded that the use of telephone interviews of patients to identify the group at highest risk of having a surgical site infection (those who think they have an infection) with rapid follow-up by a professional trained to diagnose infection according to agreed criteria is an effective method of identifying infection after discharge from hospital.