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The Bone & Joint Journal
Vol. 95-B, Issue 2 | Pages 177 - 180
1 Feb 2013
Arthur CHC Wood AM Keenan ACM Clayton RAE Walmsley P Brenkel I

We report ten-year clinical and radiological follow-up data for the Sigma Press Fit Condylar total knee replacement system (Sigma PFC TKR). Between October 1998 and October 1999 a total of 235 consecutive PFC Sigma TKRs were carried out in 203 patients. Patients were seen at a specialist nurse-led clinic seven to ten days before admission and at six and 18 months, three, five and eight to ten years after surgery. Data were recorded prospectively at each clinic visit. Radiographs were obtained at the five- and eight- to ten-year follow-up appointments. Of the 203 patients, 147 (171 knees) were alive at ten years and 12 were lost to follow-up. A total of eight knees (3.4%) were revised, five for infection and three to change the polyethylene insert. The survival at ten years with an endpoint of revision for any reason was 95.9%, and with an endpoint of revision for aseptic failure was 98.7%. The mean American Knee Society Score (AKSS) was 79 (10 to 99) at eight to ten years, compared with 31 (2 to 62) pre-operatively. Of 109 knee with radiographs reviewed, 47 knees had radiolucent lines but none showed evidence of loosening.

Cite this article: Bone Joint J 2013;95-B:177–80.


The Journal of Bone & Joint Surgery British Volume
Vol. 94-B, Issue 10 | Pages 1351 - 1355
1 Oct 2012
Collins RA Walmsley PJ Amin AK Brenkel IJ Clayton RAE

A total of 445 consecutive primary total knee replacements (TKRs) were followed up prospectively at six and 18 months and three, six and nine years. Patients were divided into two groups: non-obese (body mass index (BMI) < 30 kg/m2) and obese (BMI ≥ 30 kg/m2). The obese group was subdivided into mildly obese (BMI 30 to 35 kg/m2) and highly obese (BMI ≥ 35 kg/m2) in order to determine the effects of increasing obesity on outcome. The clinical data analysed included the Knee Society score, peri-operative complications and implant survival. There was no difference in the overall complication rates or implant survival between the two groups.

Obesity appears to have a small but significant adverse effect on clinical outcome, with highly obese patients showing lower function scores than non-obese patients. However, significant improvements in outcome are sustained in all groups nine years after TKR. Given the substantial, sustainable relief of symptoms after TKR and the low peri-operative complication and revision rates in these two groups, we have found no reason to limit access to TKR in obese patients.


The Journal of Bone & Joint Surgery British Volume
Vol. 92-B, Issue 3 | Pages 468 - 468
1 Mar 2010
CLAYTON RAE GASTON P HOWIE CR

We welcome letters to the Editor concerning articles which have recently been published. Such letters will be subject to the usual stages of selection and editing; where appropriate the authors of the original article will be offered the opportunity to reply.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 326 - 326
1 Jul 2008
Clayton RAE Howie CR Gaston P Watts AC
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Aim: To investigate the incidence and type of venous thromboembolic event (VTE) diagnosed in patients undergoing total knee arthroplasty (TKA) and the trends over time following the introduction of a rigorously enforced thromboprophylaxis protocol.

Methods: Data from all 3260 TKAs performed in our unit between April 1996 and March 2003 were prospectively collected by the Scottish Arthroplasty Project (SAP). The SAP data identified 84 of these patients as having being admitted with or died from a VTE episode. A unified thromboprophylaxis protocol was introduced in 1999, from 2001 it was included as part of the integrated care pathway. We retrospectively reviewed all available casenotes of these patients to identify the assessment and thromboprophylaxis given, the precise diagnosis of VTE, the treatment and adverse outcomes.

Results: Of the 84 VTEs identified, 29 had pulmonary emboli (PE), 12 had above knee deep vein thrombosis (DVT), 24 had calf DVT and 10 had no evidence of VTE though were coded as such (but not treated) by physicians elsewhere. Data were unavailable for the remaining 9 but these were assumed to have had VTE for the purposes of this study. Of the 24 patients with calf only DVT, 16 were given therapeutic anticoagulation of whom five developed haemorrhagic complications. From 2001 the thromboprophylaxis protocol was followed in 100% of patients. The rate of VTE in our unit has fallen steadily from 2.26% in 1996–7 to 1.05% in 2002–3.

Conclusions: There has been a steady decline in the rate of venous thromboembolism in our unit over the seven years of the study. A thromboprophylaxis protocol has been successfully introduced in our unit and consistently applied since 2001. There is considerable overdiagnosis and treatment of calf DVT with significant resultant morbidity.


The Journal of Bone & Joint Surgery British Volume
Vol. 88-B, Issue 10 | Pages 1321 - 1326
1 Oct 2006
Amin AK Clayton RAE Patton JT Gaston M Cook RE Brenkel IJ

The results of 41 consecutive total knee replacements performed on morbidly obese patients with a body mass index > 40 kg/m2, were compared with a matched group of 41 similar procedures carried out in non-obese patients (body mass index < 30 kg/m2). The groups were matched for age, gender, diagnosis, type of prosthesis, laterality and pre-operative Knee Society Score. We prospectively followed up the patients for a mean of 38.5 months (6 to 66). No patients were lost to follow-up. At less than four years after operation, the results were worse in the morbidly obese group compared with the non-obese, as demonstrated by inferior Knee Society Scores (mean knee score 85.7 and 90.5 respectively, p = 0.08; mean function score 75.6 and 83.4, p = 0.01), a higher incidence of radiolucent lines on post-operative radiographs (29% and 7%, respectively, p = 0.02), a higher rate of complications (32% and 0%, respectively, p = 0.001) and inferior survivorship using revision and pain as end-points (72.3% and 97.6%, respectively, p = 0.02).

Patients with a body mass index > 40 kg/m2 should be advised to lose weight prior to total knee replacement and to maintain weight reduction. They should also be counselled regarding the inferior results which may occur if they do not lose weight before surgery.