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The Bone & Joint Journal
Vol. 102-B, Issue 2 | Pages 170 - 176
1 Feb 2020
Bernthal NM Burke ZDC Hegde V Upfill-Brown A Chen CJ Hwang R Eckardt JJ

Aims

We aimed to examine the long-term mechanical survivorship, describe the modes of all-cause failure, and identify risk factors for mechanical failure of all-polyethylene tibial components in endoprosthetic reconstruction.

Methods

This is a retrospective database review of consecutive endoprosthetic reconstructions performed for oncological indications between 1980 and 2019. Patients with all-polyethylene tibial components were isolated and analyzed for revision for mechanical failure. Outcomes included survival of the all-polyethylene tibial component, revision surgery categorized according to the Henderson Failure Mode Classification, and complications and functional outcome, as assessed by the Musculoskeletal Tumor Society (MSTS) score at the final follow-up.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_VIII | Pages 37 - 37
1 Mar 2012
Huang WT Chen CJ Chang HJ Chung FY Lin SR Chen YF Wang GJ
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Introduction

Osteonecrosis (ON) is a disease that ultimately results in bone collapse. We investigated the correlation between SNPs and osteonecrosis.

Methods

In this study, 109 patients with systematic lupus erythematosus (SLE) (21 with and 88 without osteonecrosis) were collected for genotype analysis of 7 genes including VEGF, MTHFR, eNOS, and PAI-1 related to the blood system and BMP2 and PPARĪ³-2, genes that regulate the differentiation of bone marrow stromal cells.