Analysis of correlation of proliferation index Ki67 with grade and recurrence type of soft tissue sarcomas.

We reviewed 34 patients treated in RCRC RAMS. 53% patients were female, 47% – male. Adult patients – 97%, children – 3%. Soft tissue tumors localized on lower extremities in 47% cases (hip, shank), on upper extremities in 20% cases (shoulder, forearm, hand), on trunk in 24% cases, on head and neck in 9% patients. Histological subtypes were monophase synovial sarcoma – 32%, malignant fibrous histiocytoma – 23%, liposarcoma – 18%, malignant shwannoma – 6%, and other types in isolated instances. Synovial sarcoma more often observed in young and middle age women, malignant fibrous histiocytoma – in old men, liposarcoma – equally often in middle and old men and women. We observed soft tissue sarcoma grade 2 (FNCLCC) more frequently. Local recurrence development in 35% cases, number of recurrences was from 1 to 6. Distant metastases were in 8 patients (in lungs, lymph nodes, bones). We used monoclonal antibody Ki67 (clone MIB-1). Proliferation index Ki67 evaluated in the following way: low level – < 25% of tumor cells, middle level – 25–50%, and high level – > 50% of tumor cells.

Proliferation activity Ki67 increase in cases with high grade soft tissue sarcoma (in grade 1 tumors – low and middle proliferation activity, in grade 2 tumors – middle and high proliferation activity, in grade 3 tumors – only high proliferation activity).