In Italy the osteoporosis cause approximately 250000 fracture/year. A useful aid in the treatment of this pathology comes from the Teriparatide, a synthetic form of the natural human parathyroid hormone, that stimulates the formation of new bone by increasing the number and action of bone-forming cells, unlike estrogen and bisphosphonate which are only able in slowing or stopping bone loss by blocking the action of osteoclasts. The Authors presents theirs first results after treatment with 20 mcg per day of Forsteo (Ely Lilly), trade name of the teriparatide, along with calcium (1000mg) and vitamin D (400UI) supplementation, for the previewed maximum period of 18 months, in women older than 65 years with unsatisfactory bisphosphonate treatment, T-score equal or inferior to −4, multiple vertebral osteoporotic fractures and one or more age-independent factors risk like: BMI< 19 kg/m2, maternal familiarity with neck-femoral fractures before 65 years old, premature menopause, conditions associated with the extended immobility. The treatment induced in all patients an increase of Ca plasmatic concentrations for 16–24 hours with a maximum peak in 4–6 hours. Condition like hypercalcemia, severe renal insufficiency, renal calculosis, hyperpara-thyroidism, Paget, alkaline hyperphosphatasaemia and previous therapy radiating are the main parameter of exclusion from the treatment.

It is well known that wide resection and reconstruction with modular or composite prostheses is the treatment of choice in high chondrosarcoma of metasepiphyseal bone. Nevertheless there is a debate concerning the treatment of low grade chondrosarcoma, a locally aggressive tumour, similar also histologically to benign lesion. Two different therapeutic options are reported in these lesions: wide resection and intralesion curettage. Between 1995 and 2003 the Authors analysed a series of 37 cases of low grade chondrosarcoma of long bone treated with curettage and local adjuvant, like liquid nitrogen and acrylic cement, if necessary associated with synthesis. The least follow-up was two years. The authors observed 3 local recurrences within the first 12 months from the surgical treatment; and, in every case, an increased grade of malignity was observed at histology. The Authors confirmed that the aggressive intralesional treatment with the use of the local adjuvant like liquid nitrogen and cement, is a valid therapeutic possibility in these lesions, but they confirm that it’s necessary an accurate preoperative diagnosis with also open biopsy for an efficacy treatment.