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Orthopaedic Proceedings
Vol. 106-B, Issue SUPP_19 | Pages 15 - 15
22 Nov 2024
GENOMIC CHARACTERIZATION AND CLINICAL EVALUATION OF PERIPROSTHETIC JOINT INFECTIONS CAUSED BY CUTIBACTERIUM ACNES
Liew-Littorin C Davidsson S Nilsdotter-Augustinsson Å Brueggemann H Söderquist B
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Aim

Cutibacterium acnes is a major skin commensal that may also act as an opportunistic pathogen. Findings of C. acnes in tissue cultures obtained during arthroplasty revision surgery are difficult to interpret, since they may represent true infection or contamination. This study investigated whether C. acnes isolates obtained from prosthetic joint infections (PJIs) were related and shared common genomic traits that might correlate with clinical courses and patient outcomes.

Method

C. acnes isolates from revision surgery of patients with PJIs of the hip, shoulder, and knee were characterized using molecular methods to determine sequence type (ST) and the presence of virulence determinants (CAMP factors, dermatan sulfate-binding adhesion 1, hyaluronidase lyase, and linear plasmid). A standardized review of the patients’ medical charts was performed.

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