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Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_1 | Pages 114 - 114
1 Jan 2013
Rankin K Nisar S Morfitt H Biswas S Lunec J Birch M Gerrand C
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Background

Membrane type 1 matrix metalloproteinase (MT1-MMP) plays a role in the progression of several common solid cancers. Given that osteosarcoma features extensive local invasion and haematogenous metastases, we hypothesised that osteosarcoma cells utilise MT1-MMP to drive these processes. Moreover, since hypoxia regulates MT1-MMP expression in breast cancer we investigated the effects of hypoxia on MT1-MMP expression in osteosarcoma cells.

Aims

Examination of MT1-MMP expression in osteosarcoma biopsy tissue in relation to clinical outcome

Assessment of MT1-MMP, together with hypoxia inducible factors HIF-1α and HIF-2α expression in a panel of osteosarcoma cell lines under normoxia and hypoxia


The Journal of Bone & Joint Surgery British Volume
Vol. 74-B, Issue 2 | Pages 313 - 314
1 Mar 1992
Biswas S Kurer M Mackenney R


The Journal of Bone & Joint Surgery British Volume
Vol. 72-B, Issue 5 | Pages 775 - 778
1 Sep 1990
Barrett D Biswas S MacKenney R

We present a study of 67 Oxford bicompartmental total knee replacements performed at a district general hospital. In this general orthopaedic unit, 57 of the knees (85%) had significant relief of pain with a mean flexion range of 95 degrees and a mean flexion deformity of only 9 degrees. There was a noticeable difference between osteoarthritic and rheumatoid knees. Poor results could be directly related to an avoidable postoperative complication. The results of this independent assessment may be compared favourably with the previously published series from the specialist centre at which the prosthesis was designed.