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The Journal of Bone & Joint Surgery British Volume
Vol. 84-B, Issue 6 | Pages 920 - 930
1 Aug 2002
Liagre B Moalic S Vergne P Charissoux JL Bernache-Assollant D Beneytout JL

We describe a model which can be used for in vitro biocompatibility assays of biomaterials.

We studied the in vitro response of human osteoarthritis or rheumatoid arthritis fibroblast-like synoviocytes to Al2O3 or ZrO2 particles by analyzing the production of interleukin-1 (IL-1) and interleukin-6 (IL-6) and the metabolism of arachidonic acid via lipoxygenase and cyclo-oxygenase pathways.

Our results show that, in these cells and under our experimental conditions, Al2O3 and ZrO2 did not significantly modify the synthesis of IL-1 and IL-6 or the metabolism of arachidonic acid.