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Orthopaedic Proceedings
Vol. 105-B, Issue SUPP_11 | Pages 4 - 4
7 Jun 2023
Verhaegen J Milligan K Zaltz I Stover M Sink E Belzile E Clohisy J Poitras S Beaule P
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The gold standard treatment of hip dysplasia is a peri-acetabular osteotomy (PAO). Labral tears are seen in the majority of patients presenting with hip dysplasia and diagnosed using Magnetic Resonance Imaging (MRI). The goal was to (1) evaluate utility/value of MRI in patients undergoing hip arthroscopy at time of PAO, and (2) determine whether MRI findings of labral pathology can predict outcome.

A prospective randomized controlled trial was conducted at tertiary institutions, comparing patients with hip dysplasia treated with isolated PAO versus PAO with adjunct hip arthroscopy. This study was a subgroup analysis on 74 patients allocated to PAO and adjunct hip arthroscopy (age 26±8 years; 89.2% females). All patients underwent radiographic and MRI assessment using a 1.5-Tesla with or 3-Tesla MRI without arthrography to detect labral or cartilage pathology. Clinical outcome was assessed using international Hip Outcome Tool-33 (iHOT).

74% of patients (55/74) were pre-operatively diagnosed with a labral tear on MRI. Among these, 41 underwent labral treatment (74%); whilst among those without a labral tear on MRI, 42% underwent labral treatment (8/19). MRI had a high sensitivity (84%), but a low specificity (56%) for labral pathology (p=0.053). There was no difference in pre-operative (31.3±16.0 vs. 37.3±14.9; p=0.123) and post-operative iHOT (77.7±22.2 vs. 75.2±23.5; p=0.676) between patients with and without labral pathology on MRI.

Value of MRI in the diagnostic work-up of a patient with hip dysplasia is limited. MRI had a high sensitivity (84%), but low specificity (44%) to identify labral pathology in patients with hip dysplasia. Consequently, standard clinical MRI had little value as a predictor of outcome with no differences in PROM scores between patients with and without a labral tear on MRI. Treatment of labral pathology in patients with hip dysplasia remains controversial. The results of this subgroup analysis of a prospective, multi-centre RCT do not show improved outcome among patients with dysplasia treated with labral repair.


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_13 | Pages 62 - 62
1 Dec 2022
Milligan K Rakhra K Kreviazuk C Poitras S Wilkin G Zaltz I Belzile E Stover M Smit K Sink E Clohisy J Beaulé P
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It has been reported that 60-85% of patients who undergo PAO have concomitant intraarticular pathology that cannot be addressed with PAO alone. Currently, there are limited diagnostic tools to determine which patients would benefit from hip arthroscopy at the time of PAO to address intra-articular pathology. This study aims to see if preoperative PROMs scores measured by IHOT-33 scores have predictive value in whether intra-articular pathology is addressed during PAO + scope. The secondary aim is to see how often surgeons at high-volume hip preservation centers address intra-articular pathology if a scope is performed during the same anesthesia event.

A randomized, prospective Multicenter trial was performed on patients who underwent PAO and hip arthroscopy to treat hip dysplasia from 2019 to 2020. Preoperative PROMs and intraoperative findings and procedures were recorded and analyzed. A total of 75 patients, 84% Female, and 16% male, with an average age of 27 years old, were included in the study. Patients were randomized to have PAO alone 34 patients vs. PAO + arthroscopy 41 patients during the same anesthesia event. The procedures performed, including types of labral procedures and chondroplasty procedures, were recorded. Additionally, a two-sided student T-test was used to evaluate the difference in means of preoperative IHOT score among patients for whom a labral procedure was performed versus no labral procedure.

A total of 82% of patients had an intra-articular procedure performed at the time of hip arthroscopy. 68% of patients who had PAO + arthroscopy had a labral procedure performed. The most common labral procedure was a labral refixation which was performed in 78% of patients who had a labral procedure performed. Femoral head-neck junction chondroplasty was performed in 51% of patients who had an intra-articular procedure performed. The mean IHOT score was 29.3 in patients who had a labral procedure performed and 33.63 in those who did not have a labral procedure performed P- value=0.24.

Our findings demonstrate preoperative IHOT-33 scores were not predictive in determining whether intra-articular labral pathology was addressed at the time of surgery. Additionally, we found that if labral pathology was addressed, labral refixation was the most common repair performed. This study also provides valuable information on what procedures high-volume hip preservation centers are performing when performing PAO + arthroscopy.


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_3 | Pages 59 - 59
1 Mar 2021
Beauchamp-Chalifour P Pelet S Belhumeur V Angers-Goulet M Belzile E
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Worldwide, it is expected that 6.3 million patients will sustain a hip fracture in 2050. Hemiarthroplasty is commonly practiced for displaced femoral neck fractures. The choice between unipolar (UH) or bipolar (BH) hemiarthroplasty is still controversial. The objective of this study was to assess the effect on hip function of BH compared to UH for a displaced femoral neck fracture in elderly patients.

We conducted a systematic review and meta-analysis of randomized controlled trials comparing BH to UH. Data sources were Medline, Embase, Cochrane Library and Web of Science. All data was pooled in Review Manager (RevMan) version 5.3 software. Selection of the studies included, data abstraction, data synthesis, risk of biais and quality of evidence evaluation was done independently by two authors. Our primary outcome was postoperative hip function. Secondary outcomes were health-related quality of life (HRQoL), acetabular erosion and postoperative complications.

13 randomized controlled trials (n=2256) were eligible for the meta-analysis. There was no difference in hip function scores (standardized mean difference of 0.33 [−0.09–0.75, n=864, I2= 87%,]). Patients with bipolar heads had higher Health-Related Quality of Life scores than patients with unipolar heads (mean difference in EQ-5D scores of 0.12 [0.04–0.19, n=550, I2= 44%]). The use of BH decreased the incidence of acetabular erosion (relative risk of 0.37 [0.17–0.83, n=525, I2= 0%]). There was no relative risk difference for mortality, dislocation, revision and infection.

Due to the high heterogeneity between the studies included, it is still unclear whether patients undergoing BH have better hip function than patients undergoing UH. Although, health-related quality of life (HRQoL) may be improved. Future research could be conducted to determine whether a BH offers a better quality of life than UH to geriatric patients undergoing surgery. More precise assessment scores could be developed to better evaluate postoperative outcomes.


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_3 | Pages 54 - 54
1 Mar 2021
Beauchamp-Chalifour P Belzile E Langevin V Michael R Gaudreau N Lapierre-Fortin M Landry L Normandeau N Veillette J Bouchard M Picard R Lebel-Bernier D Pelet S
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Elderly patients undergoing surgery for a hip fracture are at risk of thromboembolic events (TEV). The risk of TEV is now rare due to thromboprophylaxis. However, hip fracture treatment has evolved over the last decade. The risk of TEV may have been modified. The objective of this study was to determine the risk of symptomatic TEV following surgery for a hip fracture, in an elderly population.

Retrospective cohort study of all patients > 65 years old undergoing surgery for a femoral neck or intertrochanteric hip fracture in two academic centers, between January 1st 2008 and January 1st 2019. The follow-up was fixed at 3 months. The cumulated risk of thromboembolic events was calculated using the Kaplan-Meier estimator and a predictive logistic regression model was used to determine risk factors.

3265 patients were eligible for analysis. The mean age was 83.3 ±8.1 years old and 75.6% of patients were female. The mortality was 7.55% (N=112) at 3 months. 98.53% of this cohort received thromboprophylaxis. The cumulated risk for a thromboembolic event was 3.55% at 1 month and 6.41% at 3 months (N=99). There were 9 fatal pulmonary embolisms. 89.19% thromboembolic events occurred within 20 days following surgery. Chronic obstructive pulmonary disease (odds ratio 1.909 [1.179–3.089]), renal failure (odds ratio 1.896 [1.172–3.066]) and the use of a bridge between different types of anticoagulant (odds ratio 2.793 [1.057–7.384]) were associated with TEV. The risk of bleeding was 5.67% at 1 month and 9.38% at 3 months (N=142). 77% of bleeding events were hematomas.

The risk of thromboembolic events is higher than expected in a population treated for this condition. Most thromboembolic events occur shortly following surgery. The risk of bleeding is high and most of them are hematomas. Future research could focus on the management of thromboprophylaxis in elderly patients undergoing surgery for a hip fracture.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_8 | Pages 61 - 61
1 Aug 2020
Jean P Belzile E Pelet S Caron J
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Over the last decade, the number of total knee arthroplasty (TKA) has risen over 125%. Numerous studies have established a relationship between obesity and complications in primary TKA. Interestingly, few studies have investigated medical and orthopaedic complications in obese patients undergoing revision TKA (RTKA). With the increasing number of RTKA and with the prevalence of obesity still on the rise, the study of obesity on complications following RTKA is indicated.

We retrospectively reviewed 180 RTKA performed by a single surgeon done between August 2008 and June 2017. All patients who underwent RTKA were included, but revisions done with simultaneous extensor mechanism reconstruction and/or distal femur replacement were excluded since these procedures are technically more demanding. 154 revisions met our inclusion/exclusion criteriaes and were included in the final analysis. 81 patients were included in the non-obese group (BMI .

The total number of orthopaedic complications in the obese group (46.6%) was significantly higher than in the non-obese group (27.2%) (OR=1.71) (p = 0.01). The number of infection was higher in the obese group (11%) than in the non-obese (6.2%) but this was not statistically significant (OR=1.77) (p = 0.28). Reoperation rate was also higher in the obese group (23.3%) than in the non-obese group (16%) but this did not reach statistical significance (OR=1.46) (p = 0.26) (Table 3). Medical complications were higher in the obese group (31.5% vs 19.8%) (OR=1.59) (p=0.09). According to the Dindo-Clavien classification, the obese group demonstrated a significantly higher rate of grade 3 or higher complications (p = 0.01).

Obesity significantly increases the occurrence of orthopaedic complications following RTKA. Obesity also seems to increase the number of medical complications following RTKA. The obese patient should be informed prior to revision TKA that there is an increased risk of complications when compared with the non-obese patient. Further research with higher power would seem advisable to confirm this trend.

For any figures or tables, please contact the authors directly.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_7 | Pages 68 - 68
1 Jul 2020
Pelet S Lechasseur B Belzile E Rivard-Cloutier M
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Radial head fractures are common and mainly require a functional conservative treatment. About 20% of patients will present an unsatisfactory final functional result. There is, however, little data allowing us to predict which patients are at risk of bad evolve. This makes it difficult to optimize our therapeutic strategies in these patients. The aim of this study is to determine the personal and environmental factors that influence the functional prognosis of patients with a radial head fracture.

We realized over a 1-year period a prospective observational longitudinal cohort study including 125 consecutive patients referred for a fracture of the radial head in a tertiary trauma center. We originally collected the factors believed to be prognostic indicators: age, sex, socioeconomic status, factors related to trauma or fracture, alcohol, tobacco, detection of depression scale, and financial compensation. A clinical and radiological follow-up took place at 6 weeks, 3 months, 6 months, and 1 year. The main functional measurement tool is the Mayo Elbow Performance Score (MEPS) and the Disabilities of the Arm, Shoulder and Hand (DASH).

123 patients were included in the study. 114 patients required nonsurgical management. 102 patients completed the 1-year follow-up for the main outcome (89 for the DASH score). Two patients required an unplanned surgery and were excluded from analyses. At 1 year, the average MEPS was 96.5 (range, 65–100) and 81% of subjects had an excellent result (MEPS ≥90). The most constant factor to predict an unsatisfactory functional outcome (MEPS <90 or DASH >17) is the presence of depressive symptoms at the initial time of the study (P = 0.03 and P = 0.0009, respectively). This factor is present throughout the follow-up. Other observed factors include a higher socioeconomic status (P = 0.009), the presence of financial compensation (P = 0.027), and a high-velocity trauma (P = 0.04). The severity of the fracture, advanced age, female sex, and the nature of the treatment does not influence the result at 1 year. No factor has been associated with a reduction in range of motion.

Most of the radial head fractures heal successfully. We identified for the first time, with a valid tool, the presence of depressive symptoms at the time of the fracture as a significant factor for an unsatisfactory functional result. Early detection is simple and fast and would allow patients at risk to adopt complementary strategies to optimize the result.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_7 | Pages 69 - 69
1 Jul 2020
Pelet S Belzile E Racine L Beauchamp-Chalifour P Nolet M Messier H Plante D
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Malnutrition is often associated with the advanced age and can be influenced by physical, mental, social and environmental changes. Hip fracture is a major issue and a prior poor nutritional status is associated with higher rates of perioperative complications and prolonged hospital length of stay.

Prospective observational cohort study performed in a Level one trauma center including 189 consecutive patients admitted for hip fracture. The main outcome measure was the Mini Nutritional Assessment (MNA), a specific tool validated for geriatric population. This questionnaire was performed at admission by an independent assessor, at the same time as a large set of demographic and functional data. Blood samples were tested for blood count and albuminemia. Two groups were constituted and analysed according to a MNA score ≥ 24 (lower limit for normal nutritional status). Factors explored included physical and mental items. Impact of malnutrition was determined on hospital length of stay (HLS), discharge in an adverse location than prior to admission (DAL), complications and mortality rate.

The rate of patients with malnutrition (or at risk) in this study is 47% (88 patients). Patients with a MNA < 24 are older (84.81 yrs ± 7.75 vs 80.41 ± 8.11, p<0,01), have more comorbidities (Charlson 2.8 ± 2.21 vs 1.67 ± 3.10, p<0,01), a more impaired mental (MMSE 19.39±8.55 vs 25.6±3.6, p<0,01) or physical status (MIF 105.3 ± 26.6 vs 121.8 ± 6.4, p< 0,01). Blood samples are not selective to detect malnutrition (p=0,64). Malnutrition is associated with a longer HLS (26.04±23.39 days vs 13.95±11.34 days, p<0,01), a greater DAL (58.9% vs 38.2%, p=0,02) and a higher one year mortality rate (23.9% vs 8.9 %, p<0,01).

The prevalence of malnutrition in a geriatric population admitted for hip fracture is high. Blood samples at admission have clearly a poor value and a systematic screening with the MNA is mandatory. An early diagnosis will target specific interventions to reduce the physical and socio-economic impact of the malnutrition. Future studies should focus on actions in the perioperative stage (fast-track surgery, nutritional protocols, analgesia) and their impact on the socio-economic burden.


Bone & Joint Research
Vol. 9, Issue 5 | Pages 242 - 249
1 May 2020
Bali K Smit K Ibrahim M Poitras S Wilkin G Galmiche R Belzile E Beaulé PE

Aims

The aim of the current study was to assess the reliability of the Ottawa classification for symptomatic acetabular dysplasia.

Methods

In all, 134 consecutive hips that underwent periacetabular osteotomy were categorized using a validated software (Hip2Norm) into four categories of normal, lateral/global, anterior, or posterior. A total of 74 cases were selected for reliability analysis, and these included 44 dysplastic and 30 normal hips. A group of six blinded fellowship-trained raters, provided with the classification system, looked at these radiographs at two separate timepoints to classify the hips using standard radiological measurements. Thereafter, a consensus meeting was held where a modified flow diagram was devised, before a third reading by four raters using a separate set of 74 radiographs took place.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_IV | Pages 567 - 567
1 Nov 2011
Beaulé PE Smith F Powell JN Antoniou J Bourne RB Lavigne M Belzile E Schemitsch EH Garbuz D
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Purpose: Recently, there has been concern raised on the occurrence of pseudotumors after metal on metal hip resurfacing. A pseudotumor is defined as a local soft tissue mass associated with localized bony and/or tissue (muscle) destruction. The primary purpose of this study is to determine the incidence of this complication in several high volume Canadian academic centres.

Method: Nine of the 11 Canadian academic centres who perform metal on metal hip resurfacings were surveyed. The number of metal on metal hip resurfacing arthroplasties performed at each centre was first determined, as were the number of those who have presented with a pseudotumour, and subsequently gone on to revision surgery. The basic demographics of the group were recorded, as were the radiographic and implant design variables for those cases presenting with a pseudotumour.

Results: A sample of 3,400 hip resurfacing arthroplasties performed between 2002 and December 2008 were surveyed. Demographics were tabulated for a sub-sample of these patients. 76% were male, the mean length of follow-up was 3.02 years, mean BMI was 28.65, and mean age was 52.10 years. Three of 3,400 cases presented with a pseudotumour, an incidence of .09%.

Conclusion: Although pseudotumors remain a concern after metal on metal hip resurfacing, the incidence at short to mid term follow-up is very low in this multi-centre academic survey. This information is significantly lower than what other groups have recently reported. Continued close monitoring is required in order to determine what clinical factors are at play.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_IV | Pages 523 - 523
1 Nov 2011
Lavigne M Laffosse J Belzile E Morin F Roy A Girard J Vendittoli P
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Purpose of the study: Tribology studies of total hip arthroplasty (THA) have demonstrated that large diameter head in metal-on-metal bearings produce fewer wear particles than small diameter heads. The other advantages of this option are better stability, less dislocation, and optimal joint range of motion. The purpose of this work was to compare blood levels of chromium, cobalt and titanium six months and one year after implantation of different models of large diameter metal-on-metal THA.

Material and methods: We conducted a retrospective comparative and randomised study including 110 patients who had been implanted with a larger diameter head THA/Zimmer? Smith and Nephez, Biomet or Depuy. The metal ion concentrations (Cr, Co, Ti) were measured in whole blood by an independent laboratory using high-resolution mass spectrometry (HR-ICP-MS). Blood samples were drawn preoperatively and postoperatively at six months and one year.

Results: At six months, the concentrations of metal ions in whole blood expressed as mean (range) for Cr (μg/L) Co (μg/L) and Ti (μg/L) were, respectively: Zimmer 1.3 (0.4/2.8) 1.7 (0.9/6.8) 2.5 (0.6/6.7); Smith and Nephew 2.0 (0.7/4.2) 2.1 (0.5/6.6) 1.1 (0.5/4.1); Biomet 1.2 (0.4/2.2) 0.9 (0.3/3.4) 1.4 (0.8/2.4); Depuy 1.7 (0.5/3.2) 1.9 (0.3/4.2) 1.3 (0.5/3.9). There was a significant difference between groups for Cr (p=0.006), Co (p=0.047) and Ti (p< 0.001). The Biomet implants presented the lowest concentrations for Cr and Co; the Zimmer implants gave the highest levels of Ti.

Discussion and Conclusion: Several implant-related factors affect blood concentrations of metal ions: contact surfaces leading to “active” abrasion but also wear in other parts of the implant giving rise to “passive” corrosion. Bearing wear is related to the diameter of the head, its roughness, its spherical shape, joint clearance, the manufacturing technique (forging, casting) and its carbon content. The Biomet head corresponds to a better compromise for these different factors. Passive corrosion can result from an exposed metal surface or from metal to metal contact. This explains the high level of Ti ions found for all implants tested since titanium is not present in the bearings.