The accuracy of component implantation is an important factor affecting long term results of unicompartmental knee replacement (UKR), particularly, since overcorrection of the leg axis has been associated with an inferior patients outcome. This problem is aggravated when using a minimally invasive approach with a limited view. In a prospective study, two groups of 40 UKR each were operated either using a non-image-based navigation system or the conventional technique. Radiographic assessment of postoperative alignment was performed by postoperative long-leg coronal and lateral x-rays. The results revealed a significant difference between the two groups in favour of navigation with regard to the mechanical axis, as well as the coronal femoral and tibial alignment. In the computer assisted group 38/40 (95%) of UKR were in a range of 4 Degree to 0 degree varus (mechanical axis) compared with 29/40 (72,5%) in the conventional group. There was no significant difference between the groups concerning postoperative range of motion, blood loss and pain score. The only inconvenience was a lengthening of the operation time (20 min). Due to the limited exposure in minimal invasive unicompartmental TKA the navigation system is helpful in achieving a more precise component orientation. The danger of overcorrection is diminished by real time information about the leg axis at each step during the operation. This improvement could be related to a longer survival rate.