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Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXIX | Pages 2 - 2
1 Jul 2012
Jones MA Newell C Howard PW
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Purpose. To establish the reliability of reporting and recording revision hip and knee arthroplasties by comparing data in the National Joint Registry (NJR), Hospital Episode Statistics (HES) and our local theatre records. Methods. The paper theatre registers for all orthopaedic theatres in the Royal Derby Hospitals NHS Trust were examined for details of revision hip and knee replacements carried out in 2007 and 2008. This was then cross-checked and merged with the local electronic theatre data to obtain a definitive local record of all revision hip and knee arthroplasties. Data for the same period was requested from the NJR and HES and these data were checked against our definitive local record for discrepancies. The HES codes used were the same codes used to compile the recent NJR annual reports. Results. The theatre registers and ORMIS identified 271 revision hip and knee arthroplasties in the study period. The NJR had corresponding data for 176 (65%) of these, and HES had 250 (92%). 10 cases (4%) were not recorded by either NJR or HES: 8 secondary resurfacings of patellae and 2 posterior lip augmentations in hips. Of those operations “missed” by HES, most had been assigned a correct “W” code, but had a “Y” or “Z” OPCS code not used in the NJR annual reports. Conclusion. When HES and the NJR data are combined, they are an accurate representation of real practice. More robust methods of reporting revision arthroplasty to the NJR are required. The OPCS codes used to indicate a revision need to be reviewed


The Bone & Joint Journal
Vol. 102-B, Issue 6 Supple A | Pages 3 - 9
1 Jun 2020
Yang J Parvizi J Hansen EN Culvern CN Segreti JC Tan T Hartman CW Sporer SM Della Valle CJ

Aims

The aim of this study was to determine if a three-month course of microorganism-directed oral antibiotics reduces the rate of failure due to further infection following two-stage revision for chronic prosthetic joint infection (PJI) of the hip and knee.

Methods

A total of 185 patients undergoing a two-stage revision in seven different centres were prospectively enrolled. Of these patients, 93 were randomized to receive microorganism-directed oral antibiotics for three months following reimplantation; 88 were randomized to receive no antibiotics, and four were withdrawn before randomization. Of the 181 randomized patients, 28 were lost to follow-up, six died before two years follow-up, and five with culture negative infections were excluded. The remaining 142 patients were followed for a mean of 3.3 years (2.0 to 7.6) with failure due to a further infection as the primary endpoint. Patients who were treated with antibiotics were also assessed for their adherence to the medication regime and for side effects to antibiotics.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXIX | Pages 21 - 21
1 Jul 2012
Karim MA Keenan J
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Introduction. Infection after total joint arthroplasty is a challenging problem. Clinical symptoms, Erythrocyte sedimentation rate, C-reactive protein level, and cultures of synovial fluid obtained by means of percutaneous aspiration are commonly used to rule out the possibility of persistent infection before reimplantation. However, the sensitivity and specificity of the tests are low. Some authors have suggested that frozen-section analysis should always be performed during the reimplantation in order to rule out persistent infection. Methods. Retrospective review of 126 revision hip and knee arthroplasty procedure performed from 2002 - 2007 in Derriford Hospital, Plymouth NHS truts, UK. Frozen section was performed in 86 procedures out of the 126 procedures reviewed(68.2 %). A positive frozen section with more than 10 PNLs per HPF was compared with intra operative cultures results. The preoperative CRP results were recorded as well. Results. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy for frozen section were 45.5 %, 93.1%,50%, 95%, 94% respectively. Combining the intraoperative frozen section with the CRP results, the specificity was 100%. Discussion. A negative finding on intra operative analysis of frozen sections has a high predictive value with regard to ruling out the presence of infection; However, the sensitivity of the test for the detection of persistent infection is low. The data support the conclusion that the Frozen Section is reasonably specific but not a sensitive. Combining it with the preoperative CRP results led to increasing the specificity to 100% in our series


The Bone & Joint Journal
Vol. 103-B, Issue 10 | Pages 1578 - 1585
1 Oct 2021
Abram SGF Sabah SA Alvand A Price AJ

Aims

To compare rates of serious adverse events in patients undergoing revision knee arthroplasty with consideration of the indication for revision (urgent versus elective indications), and compare these with primary arthroplasty and re-revision arthroplasty.

Methods

Patients undergoing primary knee arthroplasty were identified in the national Hospital Episode Statistics (HES) between 1 April 1997 to 31 March 2017. Subsequent revision and re-revision arthroplasty procedures in the same patients and same knee were identified. The primary outcome was 90-day mortality and a logistic regression model was used to investigate factors associated with 90-day mortality and secondary adverse outcomes, including infection (undergoing surgery), pulmonary embolism, myocardial infarction, and stroke. Urgent indications for revision arthroplasty were defined as infection or fracture, and all other indications (e.g. loosening, instability, wear) were included in the elective indications cohort.


The Bone & Joint Journal
Vol. 102-B, Issue 6 Supple A | Pages 138 - 144
1 Jun 2020
Heckmann ND Nahhas CR Yang J Della Valle CJ Yi PH Culvern CN Gerlinger TL Nam D

Aims. In patients with a “dry” aspiration during the investigation of prosthetic joint infection (PJI), saline lavage is commonly used to obtain a sample for analysis. The aim of this study was to investigate prospectively the impact of saline lavage on synovial fluid analysis in revision arthroplasty. Methods. Patients undergoing revision hip (THA) or knee arthroplasty (TKA) for any septic or aseptic indication were enrolled. Intraoperatively, prior to arthrotomy, the maximum amount of fluid possible was aspirated to simulate a dry tap (pre-lavage) followed by the injection with 20 ml of normal saline and re-aspiration (post-lavage). Pre- and post-lavage synovial white blood cell (WBC) count, percent polymorphonuclear cells (%PMN), and cultures were compared. Results. A total of 78 patients had data available for analysis; 17 underwent revision THA and 61 underwent revision TKA. A total of 16 patients met modified Musculoskeletal Infection Society (MSIS) criteria for PJI. Pre- and post-lavage %PMNs were similar in septic patients (87% vs 85%) and aseptic patients (35% vs 39%). Pre- and post-lavage synovial fluid WBC count were far more disparate in septic (53,553 vs 8,275 WBCs) and aseptic (1,103 vs 268 WBCs) cohorts. At a cutoff of 80% PMN, the post-lavage aspirate had a sensitivity of 75% and specificity of 95%. At a cutoff of 3,000 WBCs, the post-lavage aspirate had a sensitivity of 63% and specificity of 98%. As the post-lavage synovial WBC count increased, the difference between pre- and post-lavage %PMN decreased (mean difference of 5% PMN in WBC < 3,000 vs mean difference 2% PMN in WBC > 3,000, p = 0.013). Of ten positive pre-lavage fluid cultures, only six remained positive post-lavage. Conclusion. While saline lavage aspiration significantly lowered the synovial WBC count, the %PMN remained similar, particularly at WBC counts of > 3,000. These findings suggest that in patients with a dry-tap, the %PMN of a saline lavage aspiration has reasonable sensitivity (75%) for the detection of PJI. Cite this article: Bone Joint J 2020;102-B(6 Supple A):138–144


Bone & Joint Open
Vol. 4, Issue 5 | Pages 338 - 356
10 May 2023
Belt M Robben B Smolders JMH Schreurs BW Hannink G Smulders K

Aims

To map literature on prognostic factors related to outcomes of revision total knee arthroplasty (rTKA), to identify extensively studied factors and to guide future research into what domains need further exploration.

Methods

We performed a systematic literature search in MEDLINE, Embase, and Web of Science. The search string included multiple synonyms of the following keywords: "revision TKA", "outcome" and "prognostic factor". We searched for studies assessing the association between at least one prognostic factor and at least one outcome measure after rTKA surgery. Data on sample size, study design, prognostic factors, outcomes, and the direction of the association was extracted and included in an evidence map.


The Bone & Joint Journal
Vol. 104-B, Issue 4 | Pages 444 - 451
1 Apr 2022
Laende EK Mills Flemming J Astephen Wilson JL Cantoni E Dunbar MJ

Aims

Thresholds of acceptable early migration of the components in total knee arthroplasty (TKA) have traditionally ignored the effects of patient and implant factors that may influence migration. The aim of this study was to determine which of these factors are associated with overall longitudinal migration of well-fixed tibial components following TKA.

Methods

Radiostereometric analysis (RSA) data over a two-year period were available for 419 successful primary TKAs (267 cemented and 152 uncemented in 257 female and 162 male patients). Longitudinal analysis of data using marginal models was performed to examine the associations of patient factors (age, sex, BMI, smoking status) and implant factors (cemented or uncemented, the size of the implant) with maximum total point motion (MTPM) migration. Analyses were also performed on subgroups based on sex and fixation.


The Bone & Joint Journal
Vol. 103-B, Issue 4 | Pages 602 - 609
1 Apr 2021
Yapp LZ Walmsley PJ Moran M Clarke JV Simpson AHRW Scott CEH

Aims

The aim of this study was to measure the effect of hospital case volume on the survival of revision total knee arthroplasty (RTKA).

Methods

This is a retrospective analysis of Scottish Arthroplasty Project data, a nationwide audit which prospectively collects data on all arthroplasty procedures performed in Scotland. The primary outcome was RTKA survival at ten years. The primary explanatory variable was the effect of hospital case volume per year on RTKA survival. Kaplan-Meier survival curves were plotted with 95% confidence intervals (CIs) to determine the lifespan of RTKA. Multivariate Cox proportional hazards were used to estimate relative revision risks over time. Hazard ratios (HRs) were reported with 95% CI, and p-value < 0.05 was considered statistically significant.


Aims

Enhanced perioperative protocols have significantly improved patient recovery following primary total knee arthroplasty (TKA). Little has been investigated the effectiveness of these protocols for revision TKA (RTKA). We report on a matched group of aseptic revision and primary TKA patients treated with an identical pain and rehabilitation programmes.

Methods

Overall, 40 aseptic full-component RTKA patients were matched (surgical date, age, sex, and body mass index (BMI)) to a group of primary cemented TKA patients. All RTKAs had new uncemented stemmed femoral and tibial components with metaphyseal sleeves. Both groups were treated with an identical postoperative pain protocol. Patients were followed for at least two years. Knee Society Scores (KSS) at six weeks and at final follow-up were recorded for both groups.


The Bone & Joint Journal
Vol. 102-B, Issue 6 Supple A | Pages 163 - 169
1 Jun 2020
Lawrie CM Jo S Barrack T Roper S Wright RW Nunley RM Barrack RL

Aims

The aim of this study was to determine if the local delivery of vancomycin and tobramycin in primary total knee arthroplasty (TKA) can achieve intra-articular concentrations exceeding the minimum inhibitory concentration thresholds for bacteria causing acute prosthetic joint infection (PJI).

Methods

Using a retrospective single-institution database of all primary TKAs performed between January 1 2014 and May 7 2019, we identified patients with acute PJI that were managed surgically within 90 days of the initial procedure. The organisms from positive cultures obtained at the time of revision were tested for susceptibility to gentamicin, tobramycin, and vancomycin. A prospective study was then performed to determine the intra-articular antibiotic concentration on postoperative day one after primary TKA using one of five local antibiotic delivery strategies with tobramycin and/or vancomycin mixed into the polymethylmethacrylate (PMMA) or vancomycin powder.


The Journal of Bone & Joint Surgery British Volume
Vol. 94-B, Issue 11_Supple_A | Pages 100 - 102
1 Nov 2012
Vasarhelyi EM MacDonald SJ

Obesity is an epidemic across both the developed and developing nations that is possibly the most important current public health factor affecting the morbidity and mortality of the global population. Obese patients have the potential to pose several challenges for arthroplasty surgeons from the standpoint of the influence obesity has on osteoarthritic symptoms, their peri-operative medical management, the increased intra-operative technical demands on the surgeon, the intra- and post-operative complications, the long term outcomes of total hip and knee arthroplasty. Also, there is no consensus on the role the arthroplasty surgeon should have in facilitating weight loss for these patients, nor whether obesity should affect the access to arthroplasty procedures.