Introduction

Aseptic loosening is the main reason for total knee arthroplasty (TKA) failure, responsible for more than 25% of the revision procedures, with most of the problems occurring with the tibial component. While early loosening can be attributed to failure of primary fixation, late implant loosening is associated with loss of fixation secondary to bone resorption due to altered physiological load transfer to the tibial bone. Several attempts have been made to investigate these changes in bone load transfer in biomechanical simulations and bone remodeling analyses, which can be useful to provide information on the effect of patient, surgery, or design-related factors. On the other hand, these factors have also been investigated in clinical studies of radiographic changes of bone density following TKA. In this study we made an overview of the knowledge obtained from these clinical studies, which can be used to inform clinical decision making and implant design choices.

Femoral stem design affects periprosthetic bone mineral density (BMD), which may impact long term survival of cementless implants in total hip arthroplasty (THA). The aim of this study was to examine proximal femoral BMD in three morphologically different uncemented femoral stems designs to investigate whether one particular design resulted in improved preservation of BMDMethods: 119 patients were randomised to receive either a proximally coated dual taper wedge stem, a proximally coated anatomic stem or a fully coated collarless triple tapered stem. All surgeries were performed via the posterior approach with mobilization on the day of surgery. Dual energy x-ray absorptiometry scans (Lunar iDXA, GE Healthcare, Madison, WI) assessed BMD across the seven Gruen zones pre-operatively, and post-operatively at 6-weeks, 1-year, and 2-years and compared to the unoperated contralateral femur as a control. Patient reported outcome measures of pain, function and health were also included at these corresponding follow-ups. BMD increased in zones one (2.5%), two (17.1%), three (13.0%), five (10%) and six (17.9%) for all stems. Greater preservation of BMD was measured on the lateral cortex (zone 2) for both the dual taper wedge and anatomic stems (p = 0.019). The dual taper wedge stem also demonstrated preservation of BMD in the medial calcar (zone 7) whilst the anatomic and triple taper stem declined in this region, however this was not statistically significant (p = 0.059). BMD decreased on average by 2.1% inthe mid-diaphysis region, distal to the stem tip (zone 4) for all implants. All stems performed equivalently at final follow-up in all patient reported outcome measures. This study demonstrated maintenance of femoral BMD in three different cementless femoral stem designs, with all achieving excellent improvements in patient reported outcomes. There was no significant stress shielding observed, however longer follow-up is required to elucidate the impact of this finding on implant survivorship

Aims

Disorders of bone integrity carry a high global disease burden, frequently requiring intervention, but there is a paucity of methods capable of noninvasive real-time assessment. Here we show that miniaturized handheld near-infrared spectroscopy (NIRS) scans, operated via a smartphone, can assess structural human bone properties in under three seconds.

Aims

This study explored the shared genetic traits and molecular interactions between postmenopausal osteoporosis (POMP) and sarcopenia, both of which substantially degrade elderly health and quality of life. We hypothesized that these motor system diseases overlap in pathophysiology and regulatory mechanisms.

Managing severe acetabular bone defects during primary and revision total hip arthroplasty is a challenging problem. Standard treatment options for this cases is using of acetabular reconstruction type-Burch-Schneider rings. Unfortunately, the possibility of osseointegration of these implants with surrounding bone has always remained a contentious issue. The emergence in recent years of new designs of trabecular titanium, representing a symbiosis of acetabular reconstructive plates and modular cup helped to solve this problem on a completely new level. The aim of this prospective study is to evaluate the short and mid-term clinical and radiographic outcomes of different types of acetabular revision cups - old and new design. From 2006 to 2015, we performed 48 acetabular reconstruction with reconstruction rings CONTUR Smith and Nephew(group 1) and 34 operations with Delta TT Lima Revision system (group 2). The mean age of patients was 59.2 years (range 30–79). Indications for operations included fractures in acetabular region (10 pat – 12,2 %), acetabular nonunions with bone defects (14 pat – 17,1%), aseptic loosening with multiple dislocation of the primary implants in 38 cases (46,3%) and second stage of infection treatment in 20 cases (24.4%). Clinical and functional outcomes were evaluated by Harris Hip Score (HHS). Bone density in Charnley's zones was measured by dual-energy x-ray absorptiometry. With CONTUR reconstruction rings were used 3 different types of bearing surface articulation (22 metal/polyethylene, 10 ceramic/polyethylene, and 16 oxinium/polyethylenel). With Delta TT Revision system were used metal/poly couples in 22 cases, ceramic/poly in 6 cases, and ceramic/ceramic couple in 4 cases. In two patients with high risk of dislocations were used double mobility system. In all operations with CONTUR rings was used bone impaction grafting to fill cavitary defects (Paprosky 2B-3A), with Delta TT Revision system in 14 cases (41,2%) additionally TT augments were used. In group 1 were 3 dislocations (6,3 %), 2 deep infections (4,2 %) and 4 aceptic loosenings with secondary instability of implants (8,3 %). In group 2 Trabecular Titanium showed a high capacity of osseointegration, providing good results in short-term follow-up. We registered only 2 dislocations (5,8 %) and 1 aceptic loosening (2,9 %). The mean HHS increased from 39.7 (range 23–62) preoperatively to 86.5 (range 68–98) at the last follow-up examination. The implanted cups were radiographically stable at the last follow-up visit (1 and 2 years) without radiolucent lines or periprosthetic osteolysis. Conclusions. Delta Revision TT is a good solution for acetabular reconstruction even when there are cavitary and segmental bone defects. Modularity of this system make it possible to correct inlay position, center of hip rotation and minimising the risk of dislocation

Purpose. The purpose of this study was to evaluate periprosthetic bone mineral density (BMD) changes around a cementless short tapered-wedge stem and determine correlations between BMD changes and various clinical factors, including daily activity, after total hip arthroplasty (THA) with a short tapered-wedge stem. Methods. The study included 65 patients (65 joints) who underwent THA with a TriLock stem. At baseline, and 6, 12, and 24 months postoperatively, BMDs of the seven Gruen zones were evaluated using dual-energy X-ray absorptiometry. Correlations were determined between BMD changes and clinical factors, including the Harris hip score, body mass index, University of California at Los Angeles (UCLA) activity rating score, age at surgery, and initial lumbar BMD. Results. Minimal BMD changes were noted in the distal femur (Gruen zones 3, 4, and 5). However, significant BMD loss was noted in zone 7 at each time point. BMD loss was also noted in zone 1 at 6 and 12 months postoperatively, but BMD recovered after 18 months. Significant positive correlations were noted between BMD changes and the UCLA activity rating score in zones 1, 6, and 7. Additionally, negative correlations were noted between BMD changes and initial spine BMD in zones 2 and 3. Table legends. Table 1 Background of the patients. Table 2 Bone mineral density changes (%) at 6, 12, and 24 months postoperatively in the seven Gruen zones. Columns represent mean ± standard deviation. ※indicates P < 0.05 compared with baseline bone mineral density. Table 3 Correlations between periprosthetic bone mineral density changes and clinical factors (the Harris hip score, body mass index, University of California at Los Angeles activity rating score, age at surgery, and initial lumbar bone mineral density) in the seven Gruen zones at 24 months postoperatively. Correlation coefficients and P-values are presented. Boldface indicates P < 0.05. Conclusion. Periprosthetic BMD was maintained in the proximal femur, especially Gruen zone 1, with a short tapered stem. Daily activity may reflect improvements in periprosthetic bone quality after THA with a short tapered stem; however, this stem is not recommended in patients with low bone quality. To view tables, please contact authors directly

Introduction. Resorptive bone remodeling secondary to stress shielding has been a concern associated with cementless total hip arthroplasty (THA). At present, various types of cementless implants are commercially available. The difference in femoral stem design may affect the degree of postoperative stress shielding. In the present study, we aimed to compare the difference in bone mineral density (BMD) change postoperatively in femurs after the use of 1 of the 3 types of cementless stems. Methods. Ninety hips of 90 patients who underwent primary cementless THA for the treatment of osteoarthritis were included in this study. A fit-and-fill type stem was used for 28 hips, a tapered-rectangular Zweymüller type stem was used for 32 hips, and a tapered-wedge type stem was used for 30 hips. The male/female ratio of the patients was 7/21 in the fit-and-fill type stem group, 6/26 in the tapered-rectangular Zweymüller type stem group, and 6/24 in the tapered-wedge type stem group. The mean age at surgery was 59.9 (39–80) in the fit-and-fill type stem group, 61.7 (48–84) in the tapered-rectangular Zweymüller type stem group and 59.6 (33–89) in the tapered-wedge type stem group. To assess BMD change after THA, we obtained dual-energy X-ray absorptiometry scans preoperatively and at 6, 12, 24, and 36 months postoperatively. Results. There were no differences in demographic data, such as gender, age at surgery, and body mass index, among the 3 groups (Table1). In terms of BMD change after THA, no differences were observed in Gruen zones 1–5 among the 3 groups during the 3-year follow-up. The BMD in Gruen zone 6 was maintained in the tapered-wedge type stem group, but decreased by 5% in the fit-and-fill type stem group and by 20% in the tapered-rectangular Zweymüller type stem group (p < 0.01). The BMD loss in Gruen zone 7 was observed in all stem types; however, the BMD loss at 36 months in the tapered-wedge type stem group (−15%) was significantly less than that of the other 2 groups (the fit-and-fill type stem group: −29%; the tapered-rectangular Zweymüller type stem group: −30%; p < 0.001 for both groups) (Figure). Discussion and Conclusion. A difference in postoperative BMD loss was observed among the 3 stem designs. This may be a result of the different fixation concept associated with each stem design. In the present study, we compared the postoperative BMD change after THA among a fit-and-fill type stem, a tapered-rectangular Zweymüller type stem, and a tapered-wedge type stem. BMD in the medial-proximal femur was maintained 3 years after THA in the group with the tapered-wedge type stem, which is fixed in a more proximal part of the femur compared to the other stems

INTRODUCTION. Total hip arthroplasty (THA) is a very successful orthopaedic treatment with 15 years implant survival reaching 95%, but decreasing age and increasing life expectancy of THA patients ask for much longer lasting solutions. Shorter and more flexible cementless stems are of high interest as these allow to maintain maximum bone stock and reduce adverse long-term bone remodeling.1 However, decreasing stem length and reducing implant stiffness might compromise the initial stability by excessively increasing interfacial stresses. In general, a good balance between implant stability and reduced stress shielding must be provided to obtain durable THA reconstruction.2. This finite element (FE) study aimed to evaluate primary stability and bone remodeling of a new design of short hip implant with solid and U-shaped cross-section. MATERIALS AND METHODS. The long tapered Quadra-H stem and the short SMS implants (Medacta International, Castel San Pietro, Switzerland) were compared in this study (Figure 1). A FE model of a femur was based on calibrated CT data of an 81 year-old male (osteopenic bone quality). Both titanium alloy implants were assigned an elastic modulus of 105 GPa and the Poisson's ratios were set to 0.3. Initial stability simulations included the hip joint force and all muscle loads during a full cycle of normal walking as calculated in AnyBody software (Anybody Technology AS, Denmark), whereas the remodeling simulation used the peak loads from normal walking and stair climbing activities. Initial stability results are presented as micromotions on the implant surface with a threshold of 40 µm.3 Bone remodeling outcomes are represented in a form of simulated Dual X-ray Absorptiometry (DEXA) scans and the quantitative bone mineral density (BMD) changes in 7 periprosthetic zones. RESULTS. The U-shaped SMS implant showed slightly higher micromotions (2.7% surface area exceeding 40 µm) than the Quadra-H stem (0.2%), whereas micromotions of solid SMS were considerably higher (8.4%) (Figure 2). The largest micromotions were found on medial side of all implants. The smallest bone loss one year post-operatively was predicted around the U-shaped SMS implant. Proximal zones (1, 6 and 7) showed the largest bone loss with average of 9.9%, 11.8% and 12.8% for the U-shaped SMS, solid SMS and Quadra-H respectively (Figure 3). The bone remodeling prediction for the Quadra-H stem was in good agreement with clinical DEXA measurements (overall bone loss of 5.5% vs. 5.7). CONCLUSION. The U-shaped SMS implant is clearly superior to its solid version and has potential to provide comparable initial stability as the long Quadra-H stem and considerably better long-term bone stock preservation

Modern prosthetic stem construction strives to achieve the attractive goals of stress shielding prevention and optimal osteointegration. PhysioLogic stem is a new generation composite isoelastic femoral stem consisting of titanium core sheathed in implantable PEEK polymer and coated with titanium layer. This construction combines the benefits of both stress shielding prevention, due to its elasticity under bending load corresponding closely to that of natural bone, and rapid osteointegration, due to the stem's titanium coating. The aim of this study is long-term clinical progress evaluation and retrospective analysis in patients undergoing primary PhysioLogic stem implantation at our institution. From 1998 to 2003, we performed 51 primary total hip arthroplasty (THA) operations with implantation of PhysioLogic Stem at our institution. Indications for THA included osteoarthritis (21), hip dysplasia (14), rheumatoid arthritis (10), and femoral neck nonunion (6). In all patients we used totally uncemented system — PhysioLogic Stem and monoblock cup with different types of bearing surface articulation (40 metal/polyethylene, 3 ceramic/polyethylene, and 8 metal/metal). In all cases head size was 28mm. Two patients died in the early post-op period at day 1 and day 9 from disseminated intravascular coagulation and pulmonary embolism, respectively, and were excluded from subsequent analysis. Analyzed patients included 20 women and 29 men; median age 45, range 21–69. Post-operatively, the patients were evaluated at 3 and 6 months, 1 year, and yearly thereafter. Median follow-up period was 14 years, range 11 to 16 years. Clinical and functional outcomes were evaluated by Harris Hip Score. Bone density in Gruen's and Charnley's zones was measured by dual-energy x-ray absorptiometry. Four patients died at 5–8 years postoperatively from cardiac causes. Two patients underwent revision surgery: one patient underwent “dry revision” due to hip dislocation with exchange for longer head while keeping the original PhysioLogic stem in place; second patient underwent stem removal after chronic periprosthetic infection. Among the 45 patients with surviving PhysioLogic Stem, 33 patients (75%) underwent subsequent contralateral total hip arthroplasty with standard uncemented stems types Spotorno or Zweymuller. These patients were surveyed at postoperative evaluation about subjective comparative performance of PhysioLogic Stem versus standard stem. Twenty seven patients (82%) reported the PhysioLogic stem to be equivalent or superior to the standard stem, with 15 patients (45%) rating the PhysioLogic stem as subjectively more comfortable than the standard stem. The average Harris hip score improved from 40 points preoperatively (range 27 to 48) to 93 points (range 89 to 95) at the time of final follow-up. All stems continue to show adequate bone-ingrown fixation with no radiological signs of aseptic loosening to date. The PhysioLogic stem removed in the aforementioned case of chronic periprosthetic infection also showed clear signs of good osteointegration. Our study showed that the PhysioLogic stem implantation resulted in favorable clinical and functional performance at long-term follow-up, making it an attractive alternative to standard stems

An osteoporosis screening service for patients presenting to the fracture clinic in Derriford Hospital Plymouth was established in February 2009. We report on the findings of the first year of patients referred for dual energy X-ray absorptiometry (DEXA) screening. Patients between 50 and 75 years of age, who sustained a fracture as a result of a fall from standing height or less, who had not previously had a DEXA scan within the last two years, were referred. Patients outside these age limits with other risk factors for osteoporosis were scanned at the discretion of the fracture clinic consultant. Of those patients who were referred, 96% subsequently attended for a scan timed to coincide with their scheduled fracture clinic follow-up appointment. 402 patients were scanned in total, of which 351 were female and 51 were male. The mean patient age was 65. The results for women were as follows: 21% normal, 45% osteopenic, 34% osteoporotic. The results for men were: 19% normal, 43% osteopenic, 38% osteoporotic. The scan results were forwarded to the patient's general practitioner for action as deemed necessary. These findings support the establishment of this screening service for both men and women

INTRODUCTION. Implantation of total hip arthroplasty (THA) components caused a significant alteration in stress environment. Several studies have reported that bone mineral density (BMD) decreases after THA, especially in the proximal femur. This phenomenon is explained as an adaptive remodeling response of bone tissue to a significant alteration in its stress environment. SL-PLUS MIA stem (Smith & Nephew Orthopaedics AG) is a modified implant of Zweymuller type SL-PLUS standard stem (Smith & Nephew Orthopaedics AG). The major change is an omission of the trochanteric wing, which enables a bone-sparing and may lead to changes of femoral stress distribution and rotational stability. The change of stress distribution in the femur could affect BMD after THA. In the present study, we constructed finite element (FE) models of femurs and stems before and at 1week after THA and analyzed equivalent stresses in the femur. In addition, we measured BMD in the femur by dual-energy X-ray absorptiometry (DEXA) after THA. The purpose of this study was to investigate the equivalent stress in the femur and to compare the results of the FE analyses with changes in BMD after THA. METHODS. Twenty-one patients (18 women and 3 men) who underwent primary cementless THA with SL-PLUS MIA stem or SL-PLUS standard stem formed the basis of this study. Eleven patients received SL-PLUS MIA stem and ten patients received SL-PLUS standard stem. The mean age of the patients at THA was 67 years (range: 48∼82). BMD was measured with DEXA at 1 week and 3, and 6 months after THA. Zones were defined according to Gruen's system (zones 1∼7). Computed-tomography (CT) images of the femur of all patients were taken before and at 1 week after THA. FE models of the femur and prosthesis were obtained from CT data by Mechanical Finder (Research Center of Computational Mechanics Inc., Tokyo, Japan), software that creates FE models showing individual bone shape and density distribution. Equivalent stresses were analyzed in zones 1 to 7 and compared to the DEXA data. RESULTS. FE studies revealed that there was no significant difference in equivalent stress between SL-PLUS MIA stem group and SL-PLUS standard stem group after THA. BMD was maintained at 6months after THA in zones 3, 4, and 5, whereas BMD decreased in zones 2, 6, and 7. This means that BMD had decreased, especially in the proximal femur after THA. In zone 1, BMD decreased in SL-PLUS MIA stem group by 15%, while BMD was maintained in SL-PLUS standard stem. There was a significant difference in BMD percentage changes in zone 1 between SL-PLUS MIA stem group and SL-PLUS standard stem group at 6months after THA. DISCUSSION. The present study demonstrated that there was no significant difference in equivalent stress between SL-PLUS MIA stem group and SL-PLUS standard stem group after THA. In zone 1, BMD decreased in SL-PLUS MIA stem group by 15%, whereas BMD was maintained in SL-PLUS standard stem group. This result cannot be explained by our results of equivalent stress

In cases of poor bone quality intraoperative torque measurement might be an alternative to preoperative dual energy x-ray absorptiometry (DXA) to assess bone quality in Total Hip Arthroplasty (THA). 14 paired fresh frozen human femurs were included for trabecular peak torque measurement. We evaluated an existing intraoperative torque measurement method to assess bone quality and bone strength. We modified the approach to use this method in total hip arthroplasty (THA), which has not been published before. Since there are several approaches used in THA to exposure the hip joint, we decided to prefer the measurement in the femoral head which allows every surgeon to perform this measurement. Here a 6.5 × 23 mm blade was inserted into the proximal femur without harming the lateral cortical bone (figure 1). Further tests of the proximal femur evaluated the results of this new method: DXA, micro-computed tomography (μCT) and biomechanical load tests. Basic statistical analyses and multiple regressions were done. In the femoral head mean trabecular peak torque was 4.38 ± 1.86 Nm. These values showed a strong correlation with the values of the DXA, the μCT and the biomechanical load test. In comparison to the bone mineral density captured by DXA, the results of the intraoperative torque measurement showed a superior correlation with high sensitive bone quality evaluating methods (mechanical load tests and micro-computed tomography). Hence, the use of this intraoperative torque measurement seems to be more accurate in evaluating bone strength and bone quality than DXA during THA. The torque measurement provides sensitive information about the bone strength, which may affect the choice of implant in cases of poor bone stock and osteoporosis. In clinical use the surgeon may alter the prosthesis if the device indicates poor bone quality. Furthermore, we assume that the disadvantages associated with DXA scans like radiation exposure or errors caused by potential extraosteal sclerosis and interindividual soft-tissue artifacts could be excluded

Purpose of study:. The purpose of the study is to evaluate the changes in peri-prosthetic bone mineral density following cemented and cementless total hip arthroplasty over a follow up period of 1 year. Description of methods:. Ethics approval was sought and granted by the South African Medical Association Research Ethics Committee (SAMAREC). Patient consent for participation was obtained. Recruitment of the cohort took place over 2 years. Patients received an uncemented (Synergy) or cemented (Spectron) prosthesis as clinically appropriate. Functional status according to the University of California Los Angeles activity scale (UCLA scale) and bone mineral density as measured by Dual Energy X-ray Absorptiometry (DEXA) was assessed pre-operatively and at 3 months, 6 months and 12 months post-operatively. An independent Contract Research Organisation was used to monitor the site. Summary of results:. As at August 2010, 59 unique patients had undergone 59 hip replacements, and 7 patients (8.5%) were still due their 12 month evaluation. The mean UCLA scored showed a marked and steady improvement post-operatively, with most of the gain demonstrated by 3 months. When evaluating all patients, the mean pre-operative values for Gruen Zones 2, 4, and Net were significantly lower than the mean 12 month values. When evaluating patients who received the uncemented prosthesis (n=40), the mean pre-operative values for Gruen Zones 2 and Net were significantly lower than the mean 12 month values, and the mean pre-operative values for Gruen Zones 1 and 3 were significantly higher than the mean 12 month values. When evaluating patients who received the cemented prosthesis (n=19), the median pre-operative values for Gruen Zones 1, 2, 3, 4, 7 and Net were significantly lower than the median 12 month values. Conclusion:. At 1 year post surgery overall bone density showed a significant increase in both the cemented and uncemented cohort

Six week old male Sprague-Dawley rats were administered intravenous clozapine, quetiapine, haloperidol or vehicle once daily for a period of 42 days with access to only high fat diet and their weight was monitored regularly. At the end of the study the rats were killed and the tibiae excised and bone mineral density (BMD) measured with dual X-ray absorptiometry and bone architecture assessed with micro-computed tomography (micro-CT) and associated software. Results were subjected to one-way ANOVA and post hoc Dunnetts multiple comparison test. All treatment groups were compared to control. There were no significant differences in body weight between the different groups at completion of the study. Clozapine treated animals alone showed a significant reduction in bone mineral density (p<0.05) however no differences were seen with haloperidol and quetiapine. Both haloperidol and quetiapine, but not clozapine, treatment showed a significant reduction in the bone to tissue volume ratio (BV/TV) by approximately 23% (p<0.05) and an increase in trabecular number (TbN) by approximately 21% (p<0.05). Trabecular bone architecture parameters for haloperidol and quetiapine, but not clozapine, showed more rod like and disconnected structure as reflected in the increases in structure model index (SMI) of around 15% (p<0.05) and trabecular pattern factor (TbPf) by 22% (p<0.05). This data demonstrates that in rats receiving a high fat diet, haloperidol and quetiapine have an adverse effect on bone micro-architecture without significant change in whole body bone mineral density. Clozapine did not affect bony architecture in a significant manner as reported in our earlier study, though bone mineral density was reduced. Reasons for the different effect of clozapine in this study are still uncertain but may be related to the significant weight loss seen at the end point of the previous study. Causes for osteoporosis and increased fracture risk in schizophrenia may include smoking history, malnutrition, limited sun exposure and compliance. Long term administration of both typical and atypical anti-psychotics may have a negative effect on bone and is a further factor that can influence this risk. An awareness of this relationship is useful in the orthopaedic management of schizophrenic patients

INTRODUCTION. Trabecular Titanium™ is an innovative material characterised by an high open porosity and composed by multi-planar regular hexagonal cells. It is not a traditional coating and its tri-dimensional structure has been studied to optimise osteointegration. Furthermore, it has excellent mechanical properties, as a very high tensile and fatigue resistance and an elastic module very similar to the that of the trabecular bone. The aim of this study is to evaluate the osteointegration and bone remodelling measuring the longitudinal pattern of change in BMD around a cementless acetabular cup made from Trabecular Titanium™ (Delta TT cup, Lima Corporate, Italy) in primary total hip arthroplasty (THA). METHODS. Dual-energy x-ray absorptiometry (DEXA) analysis, radiographic evaluation on standard AP and lateral views and clinical evaluation with Harris Hip Score (HHS) and SF-36 were performed at 1 week, 3, 6, 12 months after surgery. RESULTS. Between February 2009 and June 2010, 72 patients underwent primary THA with Delta TT cup at 4 centres. There were 36 (50%) female and 36 (50%) male with an average age of 63 (range 39-75). Preliminary results include 72 patients with 56 at 3 months, 42 at 6 months and 28 at 12 months. The mean HHS improved from 48 points (range 14-79) preoperatively to 88 (range 74-100) at 3 months, to 94 (range 71-100) at 6 months and to 97 (range 94-100) at 12 months. SF-36 reported a progressive improvement of all domains. An initial transient decrease of the bone mineral density (BMD) occurred between 1 week and 3 months after surgery, then bone mass returns to baseline values after 6 months and increased at 12 months. No radiolucent lines nor osteolysis have reported and no revision occurred. There were 2 complications not related to the implant on study: one dislocation solved with a close reduction and one dislocation solved with a revision of the neck and the head, but not compromising the cup. CONCLUSIONS. Delta TT acetabular cup allows to obtain a very good primary stability, thanks to the high friction coefficient of the Trabecular Titanium™, followed by a good and fast osteointegration, as reported by early DEXA outcomes. Preliminary results showed also a very good clinical and functional improvement. Long-term follow-up is ongoing in order to prove these promising results

Introduction. Revision hip arthroplasty is a technically challenging operation as proximal bony deficits preclude the use of standard implants. Longer distally fixing stems are therefore required to achieve primary stability. Aims. This work aims to compare the primary stability and biomechanical properties of a new design of tapered fluted modular femoral stem (Redapt®, Smith & Nephew) to that of a conical fluted stem (Restoration®, Stryker). It is hypothesized that the taper will provide improved rotational stability under cyclical loading. Materials & Methods. 7 Pairs of cadaveric femora were obtained according to strict inclusion/exclusion criteria. Each underwent dual energy x-ray absorptiometry and calibration plain-film radiographs were taken. Digital templating was performed using TraumaCad (Voyant Health, Brainlab) to determine implant sizing. Both stems are fluted, modular and manufactured from titanium (figure 1). The control stem (Restoration) featured a straight conical design and the investigation stem (Redapt) a straight tapered design. Implantation was performed by a revision arthroplasty surgeon familiar with both systems. Proximal bone deficiency was reproduced using an extended trochanteric osteotomy with removal of metaphyseal bone before reattaching the osteotomy. Primary stability in the axial, sagittal and coronal planes was assessed using micromotion transducers (HBM, Darmstadt, Germany) (figure 2a) and also by Radiostereometric Analysis (RSA). RSA employs simultaneous biplanar radiographs to measure relative movement. Two 1 mm tantalum beads were mounted on the prosthesis with the centre of the femoral head taken as the third reference point. Beads were placed proximally in the surrounding bone as rigid body markers. Each bone was potted according to the ISO standard for fatigue testing and cyclically loaded at 1 Hz for at least 3 increments (750–350N, 1000–350N, 1500–350N) for 1000 cycles. RSA radiographs were taken at baseline and on completion of each cycle. A strain analysis was concurrently performed using a PhotoStress ® (Vishay Precision Group, Raleigh, USA) photoelastic coating on the medial femoral cortex. Each bone was loaded intact and then with the prosthesis in-situ at 500N increments until strain fringes were identified. Once testing was completed, the stems were sectioned at the femoral isthmus and data is presented on the cross-sectional fit and fill observed. Results. Both stem designs showed comparable primary stability with all stems achieving clinically acceptable micromotion (<150 μm) when loaded at body weight. A larger proportion of the control stems remained stable as loading increased to x2–3 body weight. Transducer-recorded migration appeared greatest in the axial plane (y axis) (figure 2b) with negligible distal movement in the coronal or sagittal planes. Point motion analysis (RSA) indicated most movement to be in the coronal plane (x-axis) (figure 2c) whereas segment motion analysis showed rotation about the long axis of the prosthesis to be largest. Photoelastic strain patterns were transferred more distally in both designs, however substantial stress shielding was also observed (figure 3). Discussion/Conclusion. Both designs achieved adequate distal fixation and primary stability under representative clinical loading conditions. This work supports the continued use of this novel stem design for revision surgery in the presence of extensive proximal bone loss

Trabecular TitaniumTM is a tri-dimensional material composed by multi-planar regular hexagonal cells and characterised by a highly open porosity that has been studied to optimise bone osteointegration. The aim of this study is to evaluate bone remodelling measuring BMD changes around an acetabular cup made from Trabecular TitaniumTM in primary total hip arthroplasty (THA). Between February 2009 and December 2010, 89 patients (91 hip) underwent primary THA with a modular acetabular cup in Trabecular TitaniumTM (DELTA-TT cup, Limacorporate, Villanova di San Daniele, Italy). The average age was 63.5± 9.4 years, the average height and weight were 75.9± 12.9 kg and 168.8± 8.9 cm, respectively (av. BMI 26.8± 4.2). There were 46 (51.7%) males and 43 (48.3%) females affected by primary coxarthrosis in 80 (87.9%) cases, avascular necrosis in 5 (5.5%), posttraumatic coxarthrosis in 3 (3.3%), dysplasia in 2 (2.2) and oligoarthritis in 1 (1.1%) case. The study includes the clinical evaluation with Harris Hip Score (HHS) and SF-36, radiographic evaluation and dual-energy x-ray absorptiometry (DEXA) analysis preoperatively and postoperatively at 1 week, 3, 6, 12 and 24 months. Preliminary results are currently available for 47 patients at 12 months, 68 at 6 months and 80 at 3 months. The average HHS significantly improved from 48.7± 14.99 preoperatively to 93.8± 5.91 at 12 months, with a constant progression in the intermediate follow-ups. All patients showed a significant ROM increase, with an average flexion from 86.6°± 15.9° preoperatively to 105°±13.14 at 12 months. Sf-36 highlighted a satisfactory improvement of general health status from an average preoperative value of 50.8± 18.7 to 80.7± 12.9 at 12 months (from 42.9 to 80.1 for physical health; from 58.4 to 81.3 for mental one). All cups were stable at 12 months with no radiolucent lines. Preliminary DXA analysis reported an initial bone mineral density decrease from 1 week baseline values (BMD R1: 1.40± 0.37; R2: 1.20± 0.45; R3:1.16± 0.31) to 3 months (BMD R1: 1.31± 0.41; R2: 1.17± 0.3; R3: 1.06± 0.37) followed by BMD recovery up to initial values (BMD R1: 1.37± 0.3; R2:1.18± 0.34; R3: 1.12± 0.36) at 12 months. Trabecular TitaniumTM demonstrates a good primary and secondary stability. Preliminary densitometric outcome confirms an optimal osseointegration of the DELTA-TT cup and early clinical and patient subjective results are very promising at a short term follow-up. However, the completions of follow-up evaluation are necessary to draw a conclusive analysis

Purpose. Alpine skiing is associated with large skeletal loads with distinct patterns of loading rate and direction, and alpine skiers were previously found to have a robust bone structure compared to normally active controls. However, it is not known whether the mechanical stimuli experienced by skiers are also associated with enhanced bone microarchitecture and strength. Thus, the purpose of this study was to use high-resolution peripheral quantitative computed tomography (HR-pQCT) to compare bone macro- and microarchitecture and bone strength between elite alpine skiers and normally active controls. Method. Participants included 7 female and 12 male members of the Canadian Alpine Ski Team, and 10 female and 16 male normally active control subjects. A whole body dual energy X-ray absorptiometry (DXA) scan was performed to measure lean mass and percent body fat. HR-pQCT (XtremeCT, Scanco) was used to assess bone macro- and microarchitecture including total, cortical and trabecular bone area, total and cortical bone mineral density (BMD), and bone volume ratio (BV/TV) of the dominant distal tibia and radius. Finite element analysis was applied to the HR-pQCT scans to estimate bone strength (failure load, N). Analysis of covariance (ANCOVA) was used to compare outcomes between groups adjusting for body weight (tibia) and height (tibia and radius). Results. Bone area of the distal radius was significantly greater in female (30%, p<.001) and male (21%, p=.003) skiers compared with controls. Similarly, distal radius failure load was greater in female (37%, p=.001) and male (42%, p<.001) skiers. Higher BV/TV was apparent in the distal tibia of the male (18%, p=.005) and female skiers (19%, p=.012) and at the radius for the male skiers (19%, p=.02) compared with controls. High BV/TV is associated with a higher trabecular area at the distal tibia for the female athletes (14%, p=.06) and the distal radius for male athletes (32%, p=.002). Distal tibia failure load was higher in male (18%, p<.001) and female skiers (22%, p=.012) compared with controls. Distal tibia failure load remained significantly higher for the male athletes even after adjusting for lean mass. Conclusion. Compared to controls, skiers have larger bone areas at the radius in men and women, and at the tibia in women. Trabecular bone volume is augmented in skiers compared with controls, even after adjusting for height and weight. After adjusting for lean mass, group differences in bone strength were still apparent at the distal tibia in men, suggesting that direct mechanical input associated with alpine skiing affects bone microarchitecture. In conclusion a larger bone size and greater trabecular bone volume may represent skeletal adaptations to the extreme mechanical environment experienced during competitive skiing, and likely contribute to the greater bone strength observed in skiers compared with controls at both skeletal sites