Introduction. Reducing infection in total joint replacement by using ultra clean air and protective enclosed suits (space suits) has become the standard in many operating theatres without good supporting evidence. This study examined the impact of laminar flow and space suits on the rate of revision for early infection following total hip (THR) and knee (TKR) replacement. Method. We used the 10-year results of the New Zealand Joint Registry to compare the rates of revision for early infection between laminar flow and conventional theatres both with and without the use of space suits. We separated hospitals and surgeons who had worked with and without space suits in both environments to exclude other confounding variables. Results. There were 51,485 THR and 36,826 TKR registered with laminar flow theatres used for 50% of the procedures and space suits used in 44% of cases. In THR there was a significant increase in revision for early infection in those procedures performed with the use of a space suit (p< 0.0001), for those performed in a laminar flow theatre (p< 0.003) and those procedures performed in a laminar flow theatre with a space suit (p< 0.001). The results were similar in TKR with the use of a space suit (p< 0.001), in laminar flow theatres (p< 0.019) and when laminar flow and space suits were used (p< 0.001). The results were unchanged when the surgeons and hospitals were analysed individually. Conclusion. The rate of revision for early infection has not been reduced by using laminar flow and space suits. The results of this study question the rationale for the increasing use and cost to the health system of these modalities in routine joint replacement