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Orthopaedic Proceedings
Vol. 105-B, Issue SUPP_3 | Pages 63 - 63
23 Feb 2023
Tan R Jadresic M Baker J
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Māori consistently have poorer health outcomes compared to non-Māori within Aotearoa. Numerous worldwide studies demonstrate that ethnic minorities receive less analgesia for acute pain management. We aimed to compare analgesic management of a common orthopaedic injury, tibial shaft fracture, between Māori and non-Māori. A retrospective cohort study from January 1. st. , 2015, to December 31. st. 2020 inclusive. Eligible patients were 16–65 years old and had isolated closed tibial shaft fractures. 104 patients were included in the study, 48 Māori and 56 Non-Māori. Baseline demographics were similar between the 2 cohorts. The primary outcome measure was type of analgesia charted on the ward. Secondary outcome measures were pre-hospital medications given, pain scores on arrival to the emergency department (ED) and the ward, time to analgesia in ED and type of analgesia given in ED. Statistics were calculated using Fisher's exact test, Pearson's chi-squared test or Wilcoxson's rank sum test as appropriate. No statistically significant differences were found in opiates or synthetics charted to Māori vs Non-Māori (83% vs 89% and 77% vs 88% respectively), opiates given in ED, time to analgesia in ED or ED and ward arrival pain scores. Of statistical significance is that Māori were less likely to receive pre-hospital medication compared to Non-Māori (54% vs 80% respectively, p=0.004). Māori were significantly less likely to receive pre-hospital pain medication compared to Non-Māori. However no other statistically significant findings were found when comparing pain scores, time to analgesia or type of pain relief charted for Māori vs non-Māori. The reasons for Māori receiving significantly less prehospital medication were not explored in this study and further investigation is required to reduce the bias that exists in this area


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXIII | Pages 208 - 208
1 May 2012
Tay W Gruen R Richardson M de Steiger R
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Delayed union and non-union are complications of fracture healing associated with pain and with functional and psychosocial disability. This study compares the effect on self-reported health outcomes of delayed union or non-union of femoral and tibial shaft fractures treated at two major metropolitan trauma centres in Victoria. Patients admitted to the Royal Melbourne Hospital and The Alfred with extra- articular femoral and tibial shaft fractures during 2003-2004 and 2005-2006, and followed up by the Victorian Orthopaedic Trauma Outcomes Registry (VOTOR) were included. Hospital medical records were reviewed to identify the outcome of each fracture. Fracture healing was assessed by the need for unplanned revision surgery for delayed union or nonunion, and clinical and radiological evidence of union. Prospectively-gathered VOTOR health outcome measurements included the Short Form 12-Item Health Survey (SF-12), and return to work and pain status at 6 and 12 months post injury. Of the 520 patients, 260 femoral and 282 tibial shaft fractures were included. In total, 285 fractures progressed to union, 138 fractures developed delayed union or non-union and 119 fractures had an unknown outcome. Factors that were significantly different between the union and delayed union or non-union groups included: fund source, mechanism of injury, other injuries, wound and Gustilo type, and fixation method. On linear regression modelling, an inverse relationship was demonstrated between delayed union or nonunion and the Physical and Mental Component Summary scores of the SF-12. This was statistically significant at both 6 and 12 months post injury unadjusted and adjusted for age, gender and other injuries. On logistic regression modelling, patients with delayed union or non-union showed unadjusted and adjusted risk ratios of 0.85 and 0.82, respectively at 6 months, and 0.82 and 0.76, respectively at 12 months to return to work. Similarly, patients with delayed union or nonunion had unadjusted and adjusted risk ratios of 1.09 and 1.11, respectively at 6 months, and 1.33 and 1.37, respectively at 12 months to have pain. Both were statistically significant at 12 months post injury unadjusted and adjusted for age, gender and other injuries. Patients with delayed union or non-union of femoral and tibial shaft fractures have poorer physical and mental health at 6 and 12 months post injury. In addition, they are less likely to have returned to work and more likely to still have pain at 12 months post injury


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_1 | Pages 18 - 18
1 Jan 2022
Singhal A Jayaraju U Kaur K Clewer G
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Abstract. Background. With the increasingly accepted method of suprapatellar tibial nailing for tibial shaft fractures, we aimed to compare intraoperative and postoperative outcomes of infrapatellar (IP) vs suprapatellar (SP) tibial nails. Methods. A retrospective cohort analysis of 58 patients. 34 SP tibial nails over 3 years versus 24 IP tibial nails over a similar time frame. We compared; radiation exposure, patient positioning time (PPT), non-union rate and follow-up time. Knee pain in the SP group was evaluated, utilising the Hospital for Special Surgery (HSS) Knee injury and Osteoarthritis outcome score (KOOS). Results. 58 patients with a mean age of 43 years were included. Mean intraoperative radiation dose for SP nails was 61.78cGy (range 11.60 to 156.01cGy) vs 121.09cGy (range 58.01 to 18.03cGy) for IP nails (p < 0.05). Mean PPT for SP nails was 10 minutes vs 18 minutes for IP nails (p < 0.05). All fractures united in the SP group vs one non-union in the IP group. Mean follow-up was 5.5 months vs 11 months in the SP and IP group respectively. Mean KOOS was 7 (range 0 to 22) at 6 months for the SP group. Conclusion. The semi extended position (SP group) leads to reduced radiation exposure because of ease of imaging. All Patients in the SP group showed improved outcomes, with shorter follow-up and fracture union. The KOOS revealed SP nail patients had minimal pain and good knee function. This study establishes a management and PROMs baseline for ongoing evaluation of SP nails


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVIII | Pages 178 - 178
1 Sep 2012
Shore BJ Glotzbecker MP Zurakowsky D Matheney TH
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Purpose. Pediatric tibial shaft fractures (TSF) account for 15% of long bone fractures in children. Compartment syndrome (CS) is difficult to diagnose in children, often leading to disastrous outcomes. This study investigated the incidence of CS in TSF and its associated risk factors. Method. A detailed five-year retrospective chart review of TSF treated at a major pediatric hospital. CS was diagnosed clinically or by intra-compartment pressure. Multivariate logistic regression analysis tested age, gender, mechanism of injury, time to surgery, fracture type, and treatment intervention as possible risk factors for CS. Results. There were 216 TSF in 212 children (160 males, 52 females; mean age 13.6 years, range eight-18 years). One hundred and thirty-two (61%) fractures were treated with closed reduction and casting, 36 with external fixation, 21 with flexible intramedullary nails, and 27 with locked intramedullary nails. There were 23 cases of CS (10.6%). Multivariate predictors of CS included age 14 years and older (21/96 = 22%, p < 0.001) and motor vehicle accident (MVA) (12/57 = 21%, p = 0.002). Incidence of CS was 44% among patients 14 and older who sustained MVA (11 of 25). Gender, AO fracture type, time to surgery and surgical fixation were not predictive of CS. Conclusion. This is the first large study to report the incidence of CS from TSF in children. The incidence of 10.6% is higher than previously reported and much higher in patients 14 years of age and older and involved in an MVA. Surgeons should be especially aware and suspicious of CS in children with tibial shaft fractures who have these risk factors


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVIII | Pages 135 - 135
1 Sep 2012
Schemitsch EH Investigators S
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Purpose. The SPRINT trial randomized 1226 patients with tibial shaft fractures treated by intramedullary (IM) nailing to reamed versus unreamed groups. Using data from this trial, we completed a subgroup analysis of those patients who required two or more reoperations following the initial IM fracture stabilization. Method. We identified 44 patients with tibial shaft fractures who required two or more reoperations following IM nailing. We considered those that were reamed vs unreamed, open vs closed, those that were planned for reoperation after the 12 month follow up, and the indications for reoperation. Results. Patients that had two or more reoperations were characterized by having more open fractures and fractures of greater severity. Fifteen of 21 (71%) reamed and 10 of 23 unreamed (43%) patients required reoperation to treat infection as their first surgical intervention. Those patients that were initially reamed who developed an infection required a greater number of subsequent surgical procedures compared to those who were not initially reamed (42, 60.8% versus 27, 39.2). Conclusion. Our data suggest that patients whose tibial fractures are reamed and subsequently develop an infection are at risk of requiring more re-operations in the future compared to those whose fractures were not reamed. Further study is required to assess the corroborating consequences of needing multiple re-operations including economic impact, pain and function, as well as strategies to prevent further morbidity in this high risk group of patients


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_5 | Pages 47 - 47
1 Apr 2022
Myatt D Stringer H Mason L Fischer B
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Introduction

Diaphyseal tibial fractures account for approximately 1.9% of adult fractures. Several studies demonstrate a high proportion of diaphyseal tibial fractures have ipsilateral occult posterior malleolus fractures, this ranges from 22–92.3%.

Materials and Methods

A retrospective review of a prospectively collected database was performed at Liverpool University Hospitals NHS Foundation Trust between 1/1/2013 and 9/11/2020. The inclusion criteria were patients over 16, with a diaphyseal tibial fracture and who underwent a CT. The articular fracture extension was categorised into either posterior malleolar (PM) or other fracture


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_5 | Pages 48 - 48
1 Apr 2022
Myatt D Stringer H Mason L Fischer B
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Introduction

Diaphyseal tibial fractures account for approximately 1.9% of adult fractures. Studies have demonstrated a high proportion have ipsilateral occult posterior malleolus fractures. We hypothesize that this rotational element will be highlighted using the Mason & Molloy Classification.

Materials and Methods

A retrospective review of a prospectively collected database was performed at Liverpool University Hospitals NHS Foundation Trust between 1/1/2013 and 9/11/2020. The inclusion criteria were patients over 16, with a diaphyseal tibial fracture, who underwent a CT. The Mason and Molloy posterior malleolus fracture classification system was used.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_29 | Pages 69 - 69
1 Aug 2013
Howard N Rollinson P
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Methods. We conducted a single centre prospective observational study comparing post-operative infection rates in HIV positive and HIV negative patients presenting with tibial shaft fractures managed with surgical fixation. Results. Twenty eight patients were incorporated over a six month period and followed up for three months post operatively. 25 open fractures including 6 HIV positive patients and 3 closed fractures including 1 HIV positive patient were assessed for signs of wound sepsis assessed with the asepsis wound score. 21 patients treated with external fixation including 4 HIV positive patients were also assessed using Checkett's scoring system for pin site infection. There was no significant difference in post-operative wound infection rates between the HIV positive (mean wound score = 7.7) and HIV negative (mean = 3.7) patients (p=0.162). HIV positive patients were also found to be at no increased risk of pin site sepsis (p=0.520). No correlation was found between CD4 counts of HIV positive patients and wound infection rates. Conclusions. Our results show that HIV positive patients with tibial fractures are not significantly more at risk of wound infection postoperatively. External fixation has also been shown to be a safe effective treatment of open tibial fractures in HIV patients


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXV | Pages 82 - 82
1 Jun 2012
Hafez M
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Introduction. There is a controversy with regard to the treatment of osteoarthritis (OA) of the knee in patients with considerable deformities of the femoral or tibial shafts. Some surgeons prefer to correct the deformity while performing TKA at the level of the knee joint. However, this technique requires accurate planning and execution of the planned cuts. In addition, the use of intramedullary guides in such cases may not be possible or desirable and may lead to complications. There is a strong indication for using navigation in such cases. Methods. The navigation technique was used in both laboratory and clinical setting, First, we compared between navigational and conventional techniques in performing TKA in 24 plastic knee specimens (Sawbones, Sweden) that have osteoarthritic changes and complex tibial or femoral deformities. A demo kit for conventional instrumentation of posterior stabilised TKA (Scorpio, Stryker) was used for 12 cases and an image-free navigation system (Stryker) was used for a corresponding 12 cases. There were 4 different deformities; severe mid-shaft tibial varus, severe distal third femoral valgus, complex deformity distal femur and deformity following a revision TKA. The surgical procedures were performed by 3 arthroplasty surgeons, each surgeon operated on 8 knee specimens (4 knees in each arm of the study with 4 different deformities). Deformities were corrected at the level of the knee joint during TKA without prior osteotomies. For conventional techniques, surgeons used a combination of both intramedullary and extramedullary guides. Postoperative long leg radiographs were used to assess coronal alignment. Second, we used the same navigational technique clinically to perform TKA in patients with extra-articular deformities. Results. Using both navigational and conventional techniques, it was possible to indirectly correct shaft deformities by adjusting the inclination of bone cuts at the level of the knee joint. The amount of bone cutting at distal femur and proximal tibia were variable depending on the location and direction of the deformity. There was no compromise of collateral ligaments or patellar tendons in both techniques. However, the accuracy of restoring normal alignment was better in navigational techniques. The results of the clinical cases are still in progress waiting analysis of a longer term follow up. Discussion. Navigational techniques eliminated the use of both intramedullary and extramedullary guides. The improved accuracy with navigational techniques led to better alignment that can improve functional and survival outcome of similar cases of TKA in real patients


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_23 | Pages 13 - 13
1 Dec 2016
Hackl S Hellinger L Von Rüden C Friederichs J Bühren V Perl M Hierholzer C
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Aim

The pathogenesis of non-union is multifactorial. Path biological factors, mechanical factors, and low-grade-infection contribute to impaired bone healing. Aim of this study was to determine the rate of low-grade-infection in patients with long bone non-union of the lower extremity without signs of acute infection, the influence of CRP (C-reactive protein), and the outcome.

Method

In a retrospective study (2003–2013), all patients who underwent surgery for treatment of tibial- or femoral-shaft-non-union without any clinical evidence of infection were assessed. Bacterial cultures harvested during non-union revision, the CRP and WBC (white blood cells) values at hospital admission, the outcome, and epidemiological data were analysed.


Orthopaedic Proceedings
Vol. 105-B, Issue SUPP_15 | Pages 69 - 69
7 Nov 2023
Ward J Louw F Klopper S Schmieschek M
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Motorcycle accident-related traffic accidents contribute significantly to the burden of orthopaedic injuries seen in the South African Healthcare system. Subsequent to the Covid-19 pandemic, there has been an increase in the number of delivery drivers on the roads of South Africa. Many of these delivery drivers have no formal employment contracts. We aim to describe the demographics and injury patterns in motorcyclists involved in time dependent delivery work in South Africa; and to quantify the cost to the state of their orthopaedic surgeries. We performed a consecutive case series study at all of the hospitals draining the study region over the period of one year. Epidemiological, clinical and cost to hospital data was collected from medical records, digital radiographs, theatre invoices and a dedicated patient questionnaire. Provisional. So far 41 delivery drivers were captured by the study over a period of 11 months. All drivers were male and the vast majority foreign nationals. 11 patients were polytraumatised and 5 required admission to an intensive care unit. The most common injury patterns were closed femur fractures (17) followed by tibial shaft fractures (13). The average cost of surgery was R35 049 and average cost of ward stay R44 882 at an average of 10 days admission in a general ward. Overall, an estimated total of R 3.1 million rand was spent on these injuries. Informally employed “app users” performing delivery work on motorcycles in South Africa have added a significant burden to the cost of state healthcare since 2020. The vast majority of these patients are foreign nationals who do not hold South African licences or health insurance. They are sustaining high energy injuries typical of motorcycle-car accidents and many of them are left with lifelong loss of function


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_5 | Pages 39 - 39
1 Apr 2022
Patel K Galanis T Nie D Saini A Iliadis A Heidari N Vris A
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Introduction. Fracture related infections (FRI) following intramedullary nailing for tibial shaft fractures remain challenging to treat with associated high patient morbidity and healthcare costs. Recently, antibiotic-coated nails have been introduced as a strategy to reduce implant related infection rates in high-risk patients. We present the largest single-centre case series on ETN PROtect® outcomes reporting on fracture union, infection rates and treatment complications. Materials and Methods. 56 adult patients underwent surgery with ETN PROtect® between 01/09/17 and 31/12/20. Indications consisted of acute open fractures and complex revision cases (FRI, non-union surgery and re-fracture) with a mean of 3 prior surgical interventions. 51 patients had an open fracture as their index injury. We report on patient characteristics and outcomes including radiological/clinical union and deep infection. The one-year minimum follow-up rate was 87.5%. Results. One (1.8%) patient developed a deep surgical infection and associated non-union requiring further surgery. In addition, we identified three cases (5.4%) of aseptic non-union following facture treatment with ETN PROtect®. Of the 5 patients who underwent staged complex revision surgery for established FRI with ETN PROtect®, all had treatment failure with ongoing symptoms of deep infection requiring further treatment. Conclusions. Use of the ETN PROtect® nail in high-risk patients in the acute trauma setting demonstrates promising outcomes in the prevention of implant-related infection. In our limited series we have failed to observe any benefit over uncoated nails, when used in treating cases of established FRI/osteomyelitis and would therefore advise caution in their use, especially in view of the high cost


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_5 | Pages 42 - 42
1 Apr 2018
Londhe S Shah R
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Tibial shaft fractures co-existing with osteoarthritis can increase the challenges for the orthopedic surgeon. The novel Londhe-Shah technique manages both the problems using one-stage total knee arthroplasty with a long stemmed tibial component which has a good diaphyseal fit. Three osteoarthritis patients with fractures of tibial shaft were treated with this technique and were followed up at 6-weeks, 12-weeks and 1-year (figure 1–3). A complete union of the fractured segment was achieved at follow-up without any adverse events such as infection, damage to the implant, and soft-tissue injury during and after surgery. The American Knee Society Score (AKSS) improved and WOMAC pain and stiffness scores reduced at follow-ups suggesting excellent improvement in functionality and patient satisfaction. One-stage TKR with a long-stem extension of the tibial component to bypass the fracture site mends and stabilises the fracture along with the adverse biomechanics at the fracture site while also correcting the arthritis. The single stage procedure allows early ambulation in six weeks. For any figures or tables, please contact the authors directly


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_6 | Pages 30 - 30
1 May 2021
Shah I Brennan C Nayagam S
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Introduction. To determine the advantages and risks of plating after lengthening (PAL) of tibia in children and adolescents. Materials and Methods. 35 consecutive tibial lengthenings were done for limb length discrepancy (LLD) in 26 patients. Gradual lengthening by an external fixator from a tibial (usually diaphyseal) osteotomy was followed by internal fixation with a lateral tibial submuscular plate. The mean age at the time of the lengthening was 10.3 years (4.8 – 16.8 years). The aetiology for LLD was congenital in 21, acquired in 3, and developmental in 2 patients. The mean follow-up was 4.3 years (8 months – 9.9 years). Results. The mean lengthening was 5cm (3–8.6cm) or 19.1% (10.8 – 35.2%) of the initial length of tibia. It took 78.8 days to reach the target length at a lengthening rate of 0.75mm/day. The mean time to plate substitution after cessation of lengthening was 24.7days/109 days after osteotomy. This led to an average external fixation index (EFI) of 23.1days/cm. Optimisation of this technique by judicious estimation of timing of plate substitution would reduce the EFI. Consolidation was recorded at 192 days after osteotomy. Bone healing index (BHI) was 39.8days/cm and was age dependent: <12 year olds = 37.5 days/cm; 12 years = 44.7 days/cm. Using the estimated consolidation time if treatment was solely by external fixator, calculated by tripling the time taken to reach target length after osteotomy, the BHI in this series would have been 52.9 days/cm (p < 0.001). Knee flexion recovery to > 90 degrees was noted at 153.5 days after plating. One greenstick fracture occurred 116 days after plate insertion, 1 tibial shaft fracture occurred 315 days post removal of plate - both following injury and were treated conservatively. Six episodes of sepsis, 5 superficial and 1 deep were treated with antibiotic suppression. The plates were removed from 28 tibiae, 437.4 days after insertion. Conclusions. Plating after lengthening not only reduces the fixator time but appears to achieve consolidation faster than if treatment was by external fixation alone. This facilitates early recovery of joint motion and limb function


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXIII | Pages 207 - 207
1 May 2012
Adie S Harris I Rae H Dao A Yong S
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Tibial shaft fractures have a high incidence of delayed and non-union, often requiring multiple procedures. Pulsed electromagnetic field (PEMF) stimulation is a safe and effective treatment for tibial non union but little is known about the efficacy of PEMF in preventing non-union in acute fractures. Between August 2005 and December 2008, eligible patients presenting at six major metropolitan hospitals with acute tibial shaft fractures (AO classification 4-2) were included. Participants were randomised by an independent allocation centre to identical active or inactive PEMF devices, both prescribed to be worn ten hours daily for twelve weeks. Baseline data were collected, and patients and surgeons were surveyed serially via post and/or phone at three, six and twelve months. Participants, data collectors and data analysts were blinded. The main outcome was any surgical intervention for delayed/non union. Data from 150 patients (76 active and 74 inactive) were available for analysis (12 month follow up 78%). There was no between-group difference in age, gender, mechanism of injury, open grade, smoking status, or compliance with the device (hours of use). Overall compliance was moderate (5.7 hours daily use). Fifteen of 76 (20%) of active device patients required surgery for delayed/non-union vs. 8 of 74 (11%) in the placebo group; odds ratio of surgery=2.03, p=0.13, 95% CI 0.80 to 5.12. An intention to treat analysis adjusted for open grade and hours the device was used showed an odds ratio of requiring surgery of 1.78 (p=0.24, 95% CI 0.68 to 4.64). A sub-group analysis of 80 compliant patients (defined a priori as a minimum average of six hours daily use) was performed. Nine of 35 (26%) patients with an active device required surgery for delayed/non-union vs. 3 of 45 (7%) in the placebo group; odds ratio of surgery=7.60 (p=0.017, 95% CI 1.43 to 40.24). Based on these unexpected initial results, PEMF stimulation does not prevent revision surgery for delayed/non-union in acute fractures of the tibial shaft


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_28 | Pages 51 - 51
1 Aug 2013
Sampath S Lewis S Fosco M Tigani D
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Introduction. Wolff's Law proposes that trabecular bone adapts in response to mechanical loading and that trabeculae align with the trajectory of predominant loads. The current study is aimed to investigate trabecular orientation in the tibia in patients with osteoarthritis of the knee. Consistent with Wolff's Law, it was hypothesised that orientation would reflect the mechanical loading of the joint and hence that there would be a correlation between the trabecular orientation and the mechanical axis of the lower limb. Methods. 51 anonymised radiographs from patients with osteoarthritis were analysed using ImageJ (National Institute of Health). Each patient had both a standard anteroposterior radiograph of the knee and a long leg view taken while weight bearing. For each anteroposterior radiograph, the angle of the femoral shaft and tibial shaft were measured. The femoral shafttibial shaft (FS -TS) angle was then calculated as the difference between the two, as described by Sheehy et al. (2011). A medial rectangle was selected with the top, bottom, medial and lateral borders being the sclerotic bone, the growth line, the bone edge and the centre of the medial tibial spine. Corresponding measurements were done on the lateral side. Trabecular orientation of both areas was measured using OrientationJ (an ImageJ plugin). In all cases the medial and lateral orientation angles were expressed relative to the angle of the tibial shaft. The mechanical axis of the lower limb was measured from the full length radiographs by calculating the angle formed by the femoral and tibial axes, as described by Goker and Block. All measurements were done independently by two observers, SAS and SL. Results. Except where indicated, the results are based on analysis of 51 radiographs. Inter-tester analysis indicated excellent reliability (ICC = 0.99) for the mechanical axis measurement and preliminary inter-tester analysis (based on 25 radiographs) indicated good reliability for the orientation measurements (ICC = 0.76). The FS-TS angle calculated from the anteroposterior radiographs was significantly correlated with the mechanical axis calculated from the full-leg views (r = 0.96, p < 0.01), with an average offset of 5.7°, which is consistent with previous research. There was a significant correlation between the lateral trabecular orientation and both the FS-TS angle measured from the anteroposterior radiographs (r = −0.48, p < 0.01) (Figure) and the mechanical axis measured from the long leg views (r = −0.39, p < 0.01). There was also a significant correlation between the medial trabecular orientation and the FS-TS angle (r = 0.35, p = 0.01). Discussion. There were significant correlations between leg alignment (both the mechanical axis and the FS − TS angle) and trabecular orientation in the human tibia. These findings were consistent with Wolff's Law, which proposes that trabecular bone adapts in response to mechanical loading. To the best of our knowledge, the current study is the first to investigate in vivo trabecular orientation in the human tibia and to establish a correlation with the mechanical axis of the lower limb. The findings also suggest that inspection of the trabecular orientation might provide valuable information on leg alignment and mechanical loading prior to surgery


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXI | Pages 104 - 104
1 May 2012
M. B D. DT I. VK V. MP G. B D. S J. S S. V
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Background. Identification of novel therapeutics to accelerate acute fracture healing remains critical. A prostaglandin EP-2 receptor agonist (CP-533,536) has demonstrated acceleration of fracture healing in preclinical models. The objective of this study is to assess the efficacy of a single dose of CP-533,536 in subjects with a closed fracture of the tibial shaft using radiographic measurements compared to placebo treatment. Methods. In a phase II randomised, blinded, placebo-controlled trial, the efficacy of a single local injection of three doses of CP-533,536 (0.5mg, 1.5mg and 15mg) was compared to a placebo and a standard of care arm in patients with closed tibial shaft fractures. The tibial fractures were treated with reamed inter-locked intramedullary nails. Patients were followed at two week intervals to six months with a final evaluation at one year. Fracture healing was independently adjudicated by a radiologist panel and an orthopaedic surgeon panel. Results. Ninety-nine patients were enrolled ranging from 17-76 years in age. Baseline characteristics were comparable across treatment groups. No statistically significant differences in median healing time between any of the CP-533,536 treatment groups and placebo were observed based on the radiology panel assessment; however, significant differences were demonstrated by an orthopaedic panel. At weeks 8, 10, 12, 14 and 16 a higher percentage of subjects in the CP-533,536-1.5 and 0.5 mg groups were considered healed compared to the placebo and the 15 mg groups by the orthopaedic panel assessment. Moreover, the CP-533,536- 0.5 mg group showed a statistically higher (p=0.05) mean radiographic healing score than placebo treated group at weeks 8, 14, 16, 18, and 24. Conclusion. CP-533,536 demonstrated accelerated healing in patients with acute tibia fractures by an orthopaedic panel. Confirmatory trials are required to assure validity of the observed treatment effects


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 446 - 446
1 Dec 2013
Nagamine R Weijia C Todo M Hirokawa S Kondo K Kawasaki M Osano K
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Purpose:. Differences in the sizes of femoral and tibial components between females and males, between osteoarthritis (OA) and rheumatoid arthritis (RA), and between measured bone resection and the gap control technique during TKA were assessed. Method:. 500 PS-TKAswith the Stryker NRG system in 408 cases were assessed. There were 83 male knees and 417 female knees, and 472 OA knees and 28 RA knees. This study was performed in Japan, and almost all OA knees had varus deformities. In each case, the sizes of the femoral and tibial components were measured on radiographs. The measured sizes represented those of the measured bone resection. TKA was performed by the gap control technique using a tensor/balancer with 30 inch-pounds expansion strength, and the sizes of the femoral and tibial components (used size) were recorded. Results:. The measured size was the same for the femoral and tibial components in 80.6% of females. The measured size of the tibial component was larger than the femoral size in 42.2% and the same in 53.0% of males. The used size of the femoral component was larger than the measured size in 43.6%, and it was the same in 43.6% of all cases. The used size of the tibial component was smaller than the measured size in 42.2%, and it was the same as the measured size in 53.4% of OA cases. The used size of the tibial component was the same as the measured size in 75.0% of RA cases. The used size of the femoral component was larger than the used size of the tibial component in 65.6% of all cases. These results showed that: the tibial condyle is larger than the femoral condyle in males; a larger size of the femoral component than the tibial component was used in the gap control technique; the used size of the tibial component was the same as the measured size in RA knees; and the used size of the tibial component was smaller than the measured size in OA knees. Discussion:. During PS-TKA, the PCL is resected and the flexion gap is enlarged when the tensor/balancer is applied. Therefore, the size of the femoral component is larger with the gap control technique than with measured bone resection. In varus knees in Japan, the proximal articular surface shifts medially from the central line of the tibial shaft. Therefore, when the tibial component is set based on the central line of the tibial shaft, the medial condyle edge is not covered by the tibial component and is resected. A smaller size of the tibial component is used with this method. On the other hand, RA knees have no varus deformity, and the size of the femoral component was the same for the gap control technique and measured bone resection. The sizes of the femoral and tibial components in PS-TKA differ between the sexes, between OA and RA, and between measured bone resection and the gap control technique


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_1 | Pages 38 - 38
1 Feb 2020
Kawamoto T Iida S Sakashita K
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Background. Total knee arthroplasty (TKA) was primarily considered a successful procedure, several new knee implants were introduced in recent years that seek to obtain improved stability and higher flexion. One of the implant, Vanguard XP. TM. BiCruciate retaining (BCR), Zinmmer-Biomet, USA recreates a specific kinematic model through the principle of normal joint. Patients and Method. An unselected consecutive series of sixty-two patients undergoing primary TKA using the cemented total knee system between August 2016 and April 2018 were studied. Twenty-seven knees was operated using Vanguard XP, subsequently thirty-five knees were received a TKA using cruciate retaining cemented total knee system FINE. TM. CR, Nakashimamedical, Japan. Postoperatively standing AP hip-to-ankle radiographs were obtained, from which the lower extremity mechanical axis, component angle were measured. The alignment goals were a neutral mechanical axis defined as a hip-to-ankle angle of 0°with the femoral and tibial components aligned perpendicular to the mechanical axis. The total operating time were quantified utilising an operating room database. The total operating time between TKAs performed with Vanguard XP BCR and those performed with FINE CR was compared in each group. All patients postoperatively was evaluated of clinical results the Japan Orthopedics Association(JOA) Knee scores. We evaluated femoral component posterior offset (PFCO) in both of two group. The maximal protrusion of the posterior condyle, posteriorly to the extension line parallel to the tibial shaft from the edge of the posterior tibial component was measured on true lateral radiographs. Results. The JOA Knee score of Vanguard XP BCR group was 86.5±4.7 points, and the score of FINE group was 82.7±5.9 points, there was no statistical significance between the two groups on the clinical score. The operative time in Vanguard XP BCR was 137.2±14.6 minutes and significantly more compared to the time of FINE group 111.3±11.9 minutes. The mechanical axis angle in Vanguard XP BCR group was −1.3°±2.7, while FINE CR group was −0.7°±3.2, there was no statistical significance. The number of outliers for mechanical axis angle was Vanguard XP BCR group 25%, the FINE group 24%, between the two groups there was no statistical significance. The mean value of the femoral component posterior offset ratio of Vanguard XP BCR was 14.4%±0.1. The mean value of the posterior offset ratio of FINE group was 16.7%±0.1, between the two groups there was statistical significance. Discussion. Bellemans et al. first defined the concept of posterior condylar offset. They demonstrated that the maximum active flexion possible was limited by direct impingement of the posterior aspect of the tibial component against the posterior aspect of the femur. However, the offset also reduces the extension gap. An enlarged posterior femoral component may reduce the extension gap due to posterior tissue tightness. In this study, the femoral component posterior offset ratio of Vanguard XP BCR was good results compared to the CR type FINE. Clinical results and the mechanical axis angle was good both of the group, but the operative time in Vanguard XP BCR was significantly more compared to the time of FINE group. Conclusion. Good early clinical results were obtained with Vanguard XP BCR knee implant, long-term follow-up studies are needed to confirm our findings


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_5 | Pages 9 - 9
1 Apr 2018
Shao H Chen A Chen C Faizan A Scholl D
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Purpose. Tibial and femoral component overhang in total knee arthroplasty (TKA) is a source of pain, thus is it important to understand anatomic differences between races to minimize overhang by matching the tibial and femoral shaft axis to the knee articular surface. Thus, this study compared knee morphology between Caucasian and East Asian individuals to determine the optimal placement of tibial and femoral stems. Methods. A retrospective study was conducted on a matched cohort of 50 East Asians (21F, 29M) and 50 Caucasians (21F, 29M) by age and gender. CT scans were obtained in healthy volunteers using <2mm slices. The distance from the proximal tibial diaphysis axis to the tibial plateau center was measured, and the distance from the distal femoral diaphysis axis to the center of distal femoral articular surface was measured. Tibial measurements were made using Akagi's AP axis and the widest ML diameter, and femoral measurements were based on Whiteside's line and the surgical epicondylar axis. Results. The ML distance between the tibial shaft center and Akagi line was significantly higher for Asians (9.9mm±2.7, Caucasians 7.7mm±3.1, p<0.001). The distance between the femoral shaft center and Whiteside line was lower, although not significantly different (Asians 1.9mm±1.0, Caucasians 2.2mm±1.1, p=0.11). However, there were no differences in the AP dimension for the femur or tibia comparing Asians to Caucasians. Conclusion. East Asian individuals have more offset in the ML dimension for the tibia. This should be taken into consideration when designing primary and revision TKA stemmed tibial implants for East Asian patients