Introduction and Objective. Medial Knee Osteoarthritis (MKO) is associated with abnormal knee varism, this resulting in altered locomotion and abnormal loading at tibio-femoral condylar contacts. To prevent end-stage MKO, medial compartment decompression is selectively considered and, when required, executed via High Tibial Osteotomy (HTO). This is expected to restore normal knee alignment, load distribution and locomotion. In biomechanics, HTO efficacy may be investigated by a thorough analysis of the ground reaction forces (GRF), whose orientation with respect to patient-specific knee morphology should reflect knee misalignment. Although multi-instrumental assessments are feasible, a customized combination of medical imaging and gait analysis (GA), including GRF data, rarely is considered. The aim of this study was to report an original methodology merging Computed-Tomography (CT) with GA and GFR data in order to depict a realistic patient-specific representation of the knee loading status during motion before and after HTO. Materials and Methods. 25 MKO-affected patients were selected for HTO. All patients received pre-operative clinical scoring, and radiological/instrumental assessments; so far, these were also executed post-operatively at 6-month follow-up on 7 of these patients. State-of-the-art GA was performed during walking and more demanding motor tasks, like squatting, stair-climbing/descending, and chair-rising/sitting. An 8-camera motion capture system, combined with wireless electromyography, and force platforms for GRF tracking, was used together with an own established protocol. This marker-set was enlarged with 4 additional skin-based non-collinear markers, attached around the tibial-plateau rim. While still wearing these markers, all analyzed patients received full lower-limb X-ray in
Weight-bearing is a known stimulus for bone remodelling and a reduction in weight-bearing is associated with reduced bone mineral density (BMD) in affected limbs post lower limb fracture. This study investigated short and long-term precision of a method for measuring relative left/right weight-bearing using two sets of identical calibrated scales. The effect of imbalance on BMD at the hip and on lower limb lean tissue mass (LLTM) was also assessed. 46 postmenopausal women, with no history of leg or ankle fracture, were measured three times whilst standing astride two scales (Seca, Germany). 34 of the participants were re-measured after 6 months by the same method. Bilateral hip and total body dual x-ray absorptiometry measurements were performed using a GE Lunar Prodigy (Bedford, MA). Precision errors in weight-bearing measures were calculated using the root mean square coefficient of variation (RMSCV%). The correlations at the first visit between left/right differences in weight-bearing and differences in BMD and LLTM were calculated. The short-term RMSCV% for left and right weights were 4.20% and 4.25% respectively and the long-term RMSCV% were 6.91% and 6.90%. Differences in left/right weight-bearing ranged from 0 to 24% (SD 8.63%) at visit 1 and 0 to 30% (SD 10.71%) at visit 2. Using data from visit 1, the relationship between hip BMD differences and left/right weight-bearing differences were investigated, with no significant correlations found. However, a weak, but statistically significant correlation of r=0.35 (p=0.02) was found for differences in LLTM and left/right weight-bearing differences. In conclusion, left/right weight-bearing measured using two scales is a precise method for evaluating differences in weight-bearing in the short and long-term. Differences in left/right weight-bearing in this population varied by up to 30%. Participants showed a high degree of consistency in their long-term balance in a natural