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Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_7 | Pages 10 - 10
1 Apr 2017
Su E
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In recent years, cementless stems have dominated the North American market. There are several categories of cementless stems, but in the past 20 years, the two most popular designs in the United States have been the extensively coated cylindrical cobalt-chrome (CoCr) stem and the proximally coated tapered titanium stem, which in recent years has become the most common. The 10-year survival for both stem types has been over 95% with a distinction made on factors other than stem survival, including thigh pain, stress shielding, complications of insertion, and ease of revision. Conventional wisdom holds that proximally coated titanium stems have less stress shielding, less thigh pain, and a higher quality clinical result. Recent studies, however, including randomised clinical trials have found that the incidence of thigh pain and clinical result is essentially equivalent between the stem types, however, there is a modest advantage in terms of stress shielding for a tapered titanium stem over an extensively coated CoCr stem. One study utilizing pain drawings did establish that if a CoCr cylindrical stem was utilised, superior clinical results in terms of pain score and pain drawings were obtained with a fully coated versus a proximally coated stem. In spite of the lack of a clinically proven advantage in randomised trials, tapered titanium stems have been favored because of the occasional occurrence of substantial stress shielding, the increased clinical observation of thigh pain severe enough to warrant surgical intervention, ease of use of shorter tapered stems that involve removal of less trochanteric bone and less risk of fracture both at the trochanter and the diaphysis due to the shorter, and greater ease of insertion through more limited approaches, especially anterior approaches. When tapered stems are utilised, there may be an advantage to a more rectangular stem cross-section in patients with type C bone. In spite of the numerous clinical advantages of tapered titanium stems, there still remains a role for more extensively coated cylindrical stems in patients that have had prior surgery of the proximal femur, particularly for a hip fracture, which makes proximal fixation, ingrowth, and immediate mechanical stability difficult to assure consistently. Cement fixation should also be considered in these cases. While the marketplace and the clinical evidence strongly support routine use of tapered titanium proximally coated relatively short stems with angled rather than straight proximal lateral geometry in the vast majority of cases, there still remains a role for more extensively coated cylindrical and for specific indications.


Bone & Joint Open
Vol. 4, Issue 2 | Pages 96 - 103
14 Feb 2023
Knowlson CN Brealey S Keding A Torgerson D Rangan A

Aims. Early large treatment effects can arise in small studies, which lessen as more data accumulate. This study aimed to retrospectively examine whether early treatment effects occurred for two multicentre orthopaedic randomized controlled trials (RCTs) and explore biases related to this. Methods. Included RCTs were ProFHER (PROximal Fracture of the Humerus: Evaluation by Randomisation), a two-arm study of surgery versus non-surgical treatment for proximal humerus fractures, and UK FROST (United Kingdom Frozen Shoulder Trial), a three-arm study of two surgical and one non-surgical treatment for frozen shoulder. To determine whether early treatment effects were present, the primary outcome of Oxford Shoulder Score (OSS) was compared on forest plots for: the chief investigator’s (CI) site to the remaining sites, the first five sites opened to the other sites, and patients grouped in quintiles by randomization date. Potential for bias was assessed by comparing mean age and proportion of patients with indicators of poor outcome between included and excluded/non-consenting participants. Results. No bias in treatment effect was observed overall for the CI site, or the first five sites, compared with the remaining sites in either trial. An early treatment effect on the OSS was observed for the first quintile of participants recruited to ProFHER only (clinically relevant difference of seven points). Selection bias for age was observed in the ProFHER trial only, with slightly younger patients being recruited into the study. Both trials showed some selection bias for markers of poor prognosis, although these did not appear to change over time. Conclusion. No bias in treatment effects overall were found at the CI or early sites set-up. An early treatment effect was found in one of the two trials, which was likely a chance effect as this did not continue during the study. Selection bias was observed in both RCTs, however this was minimal and did not impact on outcome. Cite this article: Bone Jt Open 2023;4(2):96–103


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 32 - 32
1 Dec 2013
Cobb J Aqil A Manning V Muirhead-Allwood SK
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INTRODUCTION

A recent PRCT failed to demonstrate superiority of HRA over THA at low speeds. Having seen HRA walk much faster, we wondered if faster walking speed might reveal larger differences.

We therefore asked two simple questions:

Does fast or uphill walking have an effect on the observed difference in gait between limbs implanted with one HRA and one THA?

If there is a difference in gait between HRA and THA implanted legs, which is more normal?

METHODS

Participants All patients who had one HR and one THR on the contralateral side were identified from the surgical logs of two expert surgeons. Both surgeons used a posterior approach to the hip and repaired the external rotators on closure. All consenting patients were assessed using the Oxford Hip Score (OHS) to ensure they had good functioning hips.

There were 3 females and 6 males in the study group, who had a mean age of 67 (55–76) vs the control group 64 (53–82, p = 0.52). The BMIs of the two groups did not differ significantly (28 v 25, p = 0.11).

The mean average oxford score of included patients was 44 (36–48). Radiographs of all subjects were examined to ensure that implanted components were well fixed.

The mean time from THA operation to gait assessment was 4 years (1–17 yrs) and that for HRA was 6 years (0.7–10 yrs, p = 0.31). Subjects in this study had a mean TWS of 6.8 km/hr (5–9.5), and a mean TWI of 19 degrees (10–25 degrees).


Orthopaedic Proceedings
Vol. 105-B, Issue SUPP_17 | Pages 44 - 44
24 Nov 2023
Bruyninckx S Vles G
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Aim. The objective of this systematic review is to evaluate the current evidence for or against this up-and-coming treatment modality. Method. A comprehensive literature search in accordance with the Preferred Reporting Items for Systematic review and Meta-analysis (PRISMA) guidelines was conducted using PubMed, Embase, MEDLINE and Cochrane databases. Exclusion criteria included patients < 18 years of age, follow-up <11 months, and a score < 6 on the National Institute of Health quality assessment tool. Results. 15 articles, encompassing 631 PJIs in 626 patients, were included in the final analysis, all level IV case series. The quality of many studies was impeded by a retrospective design (14/15), a relative small study population (10 out of 15 studies had less than 50 patients), selection bias, and remarkable heterogeneity in terms of catheter type, antibiotic type, dose and duration of IA antibiotics and techniques of surgical revision. 347 were chronic infections, 66 acute infections and 218 unknown. The majority was treated with single-stage revision with adjuvant IA antibiotic infusion (499/631, 79.1%). The remaining PJIs were treated with stand-alone IA antibiotic infusion (77/631, 12.2%), DAIR with adjuvant IA antibiotic infusion (36/631, 5.7%) or two-stage revision with adjuvant IA antibiotic infusion (19/631, 3.0%). Mean duration of IA antibiotic infusion was 19 days (range 3–50), although most patients received a combination of both IA and systemic (IV or PO) antibiotics. An overall failure rate (defined as failures of infection eradication/total PJIs) of approximately 11% was found. The use of IA antibiotic infusion as a stand-alone treatment was associated with a higher failure rate. In total 117 complications occurred in 631 cases (18.5%). Of these, 71 were non-catheter-related (60.7%) and 46 were catheter-related (39.3%). The most common catheter-related complications were premature loss of the catheter (18/46), developing a fistula (5/46), and elevated blood urea nitrogen (BUN) and creatinine levels (12/46). Conclusions. Due to the lack of comparative studies the (added) benefit of IA antibiotic infusion in the treatment of PJI remains uncertain. From a theoretical point of view it seems likely that is should not be used as a stand-alone treatment. A prospective randomized controlled trial using a well-described infusion protocol is needed to see if the potential benefits justify the increased costs, labour and catheter-related complications of this treatment modality


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_4 | Pages 94 - 94
1 Feb 2017
Kurtz S Lau E Baykal D Springer B
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Introduction. Previous registry studies of ceramic-on-polyethylene (C-PE) and ceramic-on-ceramic (COC) have focused on revision outcomes following primary surgery. Less is known about the effect of ceramic bearings on infection, dislocation, and mortality as outcomes following primary total hip arthroplasty (THA) for the Medicare population. We asked (1) does the use of C-PE bearings influence outcomes following THA as compared with metal-on-polyethylene (M-PE); and (2) does the use of COC bearings influence outcomes following THA as compared with M-PE?. Methods. A total of 315,784 elderly Medicare patients (65+) who underwent primary THA between 2005 and 2014 with known bearing types were identified from the Medicare 100% inpatient sample administrative database. Outcomes of interest included relative risk of 90-day readmission, infection, dislocation, revision, or mortality at any time point after primary surgery. Propensity scores were developed to adjust for selection bias in the choice of bearing type at index primary surgery. Cox regression incorporating propensity score stratification (10 levels) was then used to evaluate the impact of bearing surface selection on outcomes, after adjusting for patient-, hospital-, and surgeon-related factors. Results. For primary THA patients treated with C-PE bearings and COC bearings, there was significantly reduced risk of infection relative to M-PE bearings (C-PE Hazard Ratio, HR: 0.86, p=0.001; COC Hazard Ratio, HR: 0.74, p=0.01). For the C-PE cohort, we also observed reduced risk of 90-day readmission (HR: 0.94, p<0.001); dislocation (HR: 0.81, p<0.001); and mortality (HR: 0.92, p<0.001). There was no significant difference in risk of revision for either the C-PE or COC bearing cohorts when compared with M-PE. For the COC cohort, there was no significant difference in readmission, dislocation, or mortality risk. Conclusions. The results indicate that, after adjusting for selection bias and various confounding patient-, surgeon-, and hospital-related factors, Medicare patients treated with primary THA with ceramic bearings exhibit lower risk of infection than those treated with M-PE bearings. In addition, C-PE bearings were associated with lower risk of dislocation and mortality. As in previous registry studies, we found that ceramic bearings have similar revision risk as M-PE bearings in primary THA at between 8 and 9 years of follow-up. The findings of this study support further research into the long-term association between ceramic bearings in primary THA and clinical outcomes


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_8 | Pages 128 - 128
1 May 2016
Kurtz S Lau E Baykal D Springer B
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Introduction. Previous studies of ceramic-on-polyethylene (C-PE) and ceramic-on-ceramic (COC) hip bearings have focused on outcomes following primary surgery. Less is known about the utilization or outcomes of ceramic bearings in revision total hip arthroplasty (R-THA) for the Medicare population in the US. We asked (1) what is the utilization of ceramic bearings for R-THA in the Medicare population and how has it evolved over time; (2) does the use of C-PE bearings influence outcomes following R-THA as compared with metal-on-polyethylene (M-PE); and (3) does the use of COC bearings influence outcomes following R-THA as compared with M-PE?. Methods. A total of 31,809 Medicare patients (aged > 65y) who underwent R-THA between 2005 and 2013 with known bearing types were identified from the Medicare 100% inpatient sample administrative database. Outcomes of interest included relative risk of readmission (90 days) or infection, dislocation, rerevision, or mortality at any time point after revision. Propensity scores were developed to adjust for selection bias in the choice of bearing type at revision surgery. Cox regression incorporating propensity score stratification (10 levels) was then used to evaluate the impact of bearing surface selection on outcomes, after adjusting for patient-, hospital-, and surgeon-related factors. Results. The utilization of C-PE and COC bearings in RHA increased from 5.3% to 26.6% and from 1.8% to 2.5% between 2005 and 2013, respectively. For R-THA patients treated with C-PE bearings, there was reduced risk of 90-day readmission (Hazard Ratio, HR: 0.90, 95% CI: 0.84–0.96, p=0.007). We also observed a trend for reduced risk of infection with C-PE (HR: 0.88, 95% CI: 0.74–1.04) that did not reach statistical significance (p = 0.14). For R-THA patients treated with COC, there was reduced risk of dislocation (Hazard Ratio, HR: 0.76, 95% CI: 0.58–0.99, p=0.04). There was no significant difference in risk of rerevision or mortality for either the C-PE or COC bearing cohorts when compared with M-PE. Discussion. The results indicate that, after adjusting for selection bias and various confounding patient-, surgeon-, and hospital-related factors, Medicare patients treated in a revision scenario with ceramic bearings exhibit similar risk of rerevision, infection, or mortality as those treated with M-PE bearings. Conversely, we found an association between the use of specific ceramic bearings in R-THA and reduced risk of readmission (C-PE) and dislocation (COC). The findings of this study support further research into the association between ceramic bearings in R-THA and lower risk of hospital readmission, dislocation, and, potentially, infection


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 478 - 478
1 Dec 2013
Paulus M Zawadsky MW Murray P
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Introduction:. The direct anterior approach for total hip arthroplasty has shown to improve multiple early outcome measures. However, criticisms suggest improved results may be due to selection bias and protocol changes. This study compares mini-incision posterior approach to direct anterior approach performed by one surgeon, controlling for influences other than the surgical approach itself. Methods:. An IRB approved retrospective review was conducted on 150 consecutive primary total hip arthroplasty patients; the first 50 from mini-incision posterior approach, followed by 50 during the learning curve for direct anterior approach, and 50 subsequent cases when the approach was routine. Peri-operative protocols were alike for all groups. Data collection included patient demographics, anesthesia, operative times, discharge disposition, length of stay, VAS pain scores, progression from assistive devices, and narcotic use at follow-up of two and six weeks. Statistical methods included Wilcoxon rank sum, ANOVA, Kruskal-Wallis, chi-square, fisher exact and t-tests. P-value of <.05 was considered significant. Results:. The groups were well-matched for demographics. The anterior group trended towards higher age, BMI, ASA and pre-op VAS scores. Factors favoring the anterior group reaching statistical significance included: decreased length of stay of 1.02 (learning curve) and 1.26 (routine) days (p < .0001); discharge to home instead of a rehab facility, 80% and 84% anterior versus 56% posterior (p = 0.0028); VAS pain scores at two weeks 2.7 and 2.2 anterior versus 5.2 posterior (p < .0001); less narcotic pain medication use at two weeks, 44% and 30% versus 86% (p < .0001). In the anterior groups, walker use was less at two weeks, 20% and 12% versus 74% (p < .0001) and at six weeks, 4% and 2% versus 20% (p=.0018). Conclusion:. Primary total hip arthroplasty using the anterior approach versus the posterior approach allows for more rapid recovery in patients with no significant selection bias or protocol changes, even during the learning curve period


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_3 | Pages 44 - 44
1 Mar 2021
Vogel D Finless A Grammatopoulos G Dobransky J Beaulé P Ojaghi R
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Surgical treatment options for Femoroacetabular impingement (FAI) includes both surgical dislocation and hip arthroscopy techniques. The primary aim of this study was to evaluate and compare the survivorship of arthroscopies (scope) and surgical dislocations (SD) at minimum 5-year follow-up. The secondary aim was to describe differences in functional outcomes between the 2 groups. This was a retrospective, single surgeon, consecutive, case-series from a large tertiary care centre. We evaluated all surgeries that were performed between 2005 and 2011. Our institutional database was queried for any patient undergoing surgery for FAI (pincer (n=23), cam (n=306), or mixed (n=103) types). Patients with childhood pathologies i.e. Legg Calve Perthes and slipped capital femoral epiphysis were excluded. This resulted in 221 hips (169 males, 52 females) who underwent either SD (94, 42.5%) or scope (127, 57.5%). A manual chart review was completed to identify patients who sustained a complication, underwent revision surgery or progressed to a total hip arthroplasty (THA). In addition, we reviewed prospectively collected patient reported outcome measure (PROMs) using (SF12, HOOS, and UCLA). Survivorship outcome was described for the whole cohort and compared between the 2 surgical groups. PROMs between groups were compared using The Mann-Whitney U test and the survival between groups was assessed using the Kaplan-Meier Analysis and the Log-Rank Mantel Cox test. All analyses were performed in SPSS (IBM, v. 26.0). The cohort included 110 SDs and 320 arthroscopies. The mean age of the whole cohort was 34±10; patients in the SD group (32±9) were younger compared to the arthroscopy group (39±10) (p<0.0001). There were 16 post-operative complications (similar between groups) and 77 re-operations (more common in the SD group (n=49) due to symptomatic metal work (n=34)). The overall 10-year survival was 91±3%. Survivorship was superior in the arthroscopy group at both 5- (96% (95%CI: 93 – 100)) and 8- years 94% (95%CI: 90 – 99%) compared to the SD Group (5-yr: 90% (95%CI: 83 – 98); 8-yr: 84% (95%CI:75 – 93)) (p=0.003) (Figure 1). On average HOOS improved from 54±19 to 68±22 and WOMAC from 65±22 to 75±22. The improvement in PROMs were similar between the 2 groups. We report very good long-term joint preservation for the treatment of FAI, which is similar to those reported in hip dysplasia. In addition, we report satisfactory improvement in function following such treatment. The differences reported in joint survival likely reflect selection biases from the treating surgeon; more complex cases and those associated with more complex anatomy were more likely to have been offered a SD in order to address the pathology with greater ease and hence the inferior joint preservation identified in this group. For any figures or tables, please contact the authors directly


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_1 | Pages 146 - 146
1 Feb 2020
King C Chakour K Kim Y Luu H Martell J
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Introduction. Background: Trochanteric bursitis is a common and poorly understood complication following total hip arthroplasty (THA). The purpose of this study was to evaluate the incidence of symptomatic trochanteric bursitis and the change in hip offset among THA patients before and after the introduction of robotic assistance. Methods. Retrospective chart review of THAs performed by a single over a 3-year period between 1/5/2013 and 6/28/2016. Between 1/5/2013 and 11/11/2014 101 consecutive patients were identified that underwent manual posterior-lateral THA that utilized traditional cup positioning method based on AP Pelvis radiograph. The subsequent six-month period during a complete transition to robotic arm assistance for posterior-lateral THA was excluded to eliminate any learning curve or selection bias. Between 6/2015 and 6/2016 109 consecutive patients that underwent robotic arm-assisted. Medical records were reviewed for symptomatic trochanteric bursitis within two years of surgery. Hip offset was measured on preoperative and postoperative AP pelvis radiographs and postoperative joint reactive forces were calculated using Martell's Hip Analysis Suite. Results. The rate of symptomatic trochanteric bursitis was 21% in the manual THA population and 10.4% in the population of THAs performed with robotic assistance (P=0.02). The post-operative change in hip offset was significantly higher in patients undergoing traditional THA than patients undergoing robotic arm-assisted THA (5.95 mm vs 4.40 mm; p = 0.0071). Discussion/Conclusion. Transition to robotic arm-assisted THA was associated with decreased incidence of symptomatic trochanteric bursitis and a decreased post-operative change in hip offset


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_6 | Pages 134 - 134
1 Jul 2020
Bzovsky S Johal H Axelrod D Sprague S Petrisor B Jeray K Heels-Ansdell D Bhandari M
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Despite long-standing dogma, a clear relationship between the timing of surgical irrigation and the development of subsequent deep infection has not been established in the literature. Traditionally, irrigation of an open fracture has been recommended within six-hours of injury based on animal studies from the 1970s, however the clinical basis for this remains unclear. Using data from a multi-centre randomized controlled trial of 2,447 open fracture patients, the primary objective of this secondary analysis is to determine if a relationship exists between timing of wound irrigation (within six hours of injury versus beyond six hours) and subsequent reoperation rate for infection or healing complications within one year for patients with open extremity fractures requiring surgical treatment. To adjust for the influence of patient and injury characteristics on the timing of irrigation, a propensity score was developed from the data set. Propensity-adjusted regression allowed for a matched cohort analysis within the study population to determine if early irrigation put patients independently at risk for reoperation, while controlling for confounding factors. Results were reported as odds ratios (ORs), 95% Confidence Intervals (CIs), and p-values. All analyses were conducted using STATA 14 (StataCorp LP, College Station, TX, USA). Two thousand, two hundred eighty-six of 2,447 patients randomized to the trial from 41 orthopaedic trauma centers across five countries had complete data regarding time to irrigation. Prior to matching, the patients managed with early irrigation had a higher proportion requiring reoperation for infection or healing complications (17% versus 12.8%, p=0.02), however this does not account for selection bias of more severe injuries preferentially being treated earlier. After the propensity score-matching algorithm was applied, there were 373 matched pairs of patients available for comparison. In the matched cohort, reoperation rates did not differ between early and late groups (16.1% vs 16.6%, p=0.84). When accounting for propensity matching in a logistic regression analysis, early irrigation was not associated with reoperation (OR 0.93, 95% CI 0.62 to 1.40, p=0.73). When accounting for other variables, late irrigation does not independently increase risk of reoperation


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_2 | Pages 12 - 12
1 Feb 2020
King C Jordan M Edgington J Wlodarski C Tauchen A Puri L
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Introduction. This study sought to evaluate the patient experience and short-term clinical outcomes associated with the hospital stay of patients who underwent robotic arm-assisted total knee arthroplasty (TKA). These results were compared to a cohort of patients who underwent TKA without robotic assistance performed by the same surgeon. Methods. A cohort of consecutive patients undergoing primary TKA for the diagnosis of osteoarthritis by a single fellowship trained orthopaedic surgeon over a 39-month period was identified. Patients who underwent TKA during the year this surgeon transitioned his entire knee arthroplasty practice to robotic assistance were excluded to eliminate selection bias and control for the learning curve. A final population of 538 TKAs was identified. Of these, 314 underwent TKA without robotic assistance and 224 underwent robotic arm-assisted TKA. All patients received the same prosthesis and post-operative pain protocol. Patient demographic characteristics and short-term clinical data were analyzed. Results. Robotic arm-assisted TKA was associated with shorter length of stay (2.3 versus 2.6 days, p< 0.001), a 50% reduction in morphine milligram equivalent utilization (from 213 to 105, p< 0.001), decreased visual analog scale pain score on post-op day 1 and 2 (p< 0.001), and a mean increase in procedure time of 8.2 minutes (p=0.08). There were no post-operative infections in either cohort. Additionally, there were no significant differences in rates of manipulation under anesthesia, emergency department visits, readmissions, or return to the operating room. Conclusions. This analysis corroborates existing literature suggesting that robotic arm-assisted TKA can be correlated with improved short-term clinical outcomes. This study reports on a single surgeon's experience with regard to analgesic requirements, length of stay, pain scores, and procedure time following a complete transition to robotic arm-assisted TKA. These results underscore the importance of continued evaluation of clinical outcomes as robotic arthroplasty technology continues to grow. For any figures or tables, please contact authors directly


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_8 | Pages 84 - 84
1 May 2019
Abdel M
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Simultaneous bilateral total hip arthroplasties (THAs) present unique and unwarranted dangers to the patient and surgeon alike. These include a significantly increased risk of blood transfusion (up to 50% in contemporary series even with the use of tranexamic acid), longer operative times, longer length of stays, and higher mortality rates in patients with minimal risk factors (age > 75 years, rheumatoid arthritis, higher ASA class, and/or male sex). This is even in light of the fact that the vast majority of literature has a substantial selection bias in which only the healthiest, youngest, non-obese, and most motivated patients are included. Traditionally, simultaneous bilateral THAs were completed in the lateral decubitus position. This required the surgeon and surgical team to reposition the patient onto a fresh wound, as well as additional prepping and draping. To mitigate these additional limitations of simultaneous bilateral THAs, there has been a recent trend towards utilizing the direct anterior approach. However, this particular approach presents its own unique set of complications such as an increased risk of periprosthetic femoral fracture and early femoral failure, an increased risk of impaired wound healing (particularly in obese patients), potential injury to the lateral femoral cutaneous nerve with subsequent neurogenic pain, and traction-related neurologic injuries. When compounded with the risks of simultaneous bilateral THAs, the complication profile becomes prohibitive for an elective procedure with an otherwise very low morbidity


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_8 | Pages 92 - 92
1 May 2019
Gehrke T
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Ceramic bearings are currently the most widely used alternative to metal-on-polyethylene bearings in total hip arthroplasty (THA). A workgroup at International Consensus Meeting (ICM) analyzed the potential link between the type of bearing surface and the subsequent periprosthetic joint infection (PJI), and found a higher incidence of PJI when using a metal-on-metal (MoM) bearing surface. A potential reason is that the failure of a MoM bearing surface can result in adverse local tissue reactions (ALTR), which might provide a favorable environment for bacterial proliferation. In the last few years, several observational studies including national registries, showed that metal-on-polyethylene (MoP) bearing surfaces are associated with a higher rate of infection following total hip arthroplasty (THA) compared to ceramic bearings, in particular with the use of ceramic-on-ceramic bearing (CoC) surfaces. After adjusting for selection bias and various confounding factors, patients treated with ceramic bearings experienced reduced risk of infection and MoP bearing surface is an independent risk factor correlating with higher incidence of PJI. The meta-analysis by Lee et al. comparing MoM with CoC cementless THA confirmed that the MoM is associated with a significantly higher revision rate than CoC group for any reason as well as for PJI. Furthermore, initial in-vitro studies have shown lower bacterial biofilm formation on ceramic bearing surfaces. Summarizing the current literature, ceramic bearings are associated with a lower risk of infection following THA


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_7 | Pages 78 - 78
1 Jul 2020
Somerville L Clout A MacDonald S Naudie D McCalden RW Lanting B
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While Oxidized Zirconium (OxZr) femoral heads matched with highly cross-linked polyethylene (XLPE) have demonstrated the lowest rate of revision compared to other bearing couples in the Australian National Joint Registry, it has been postulated that these results may, in part, be due to the fact that a single company offers this bearing option with a limited combination of femoral and acetabular prostheses. The purpose of this study was to assess clinical and radiographic outcomes in a matched cohort of total hip replacements (THR) utilizing an identical cementless femoral stem and acetabular component with either an Oxidized Zirconium (OxZr) or Cobalt-Chrome (CoCr) femoral heads at a minimum of 10 years follow-up. We reviewed our institutional database to identify all patients whom underwent a THR with a single cementless femoral stem, acetabular component, XLPE liner and OxZr femoral head with a minimum of 10 years of follow-up. These were then matched to patients who underwent a THR with identical prosthesis combinations with CoCr femoral head by gender, age and BMI. All patients were prospectively evaluated with WOMAC, SF-12 and Harris Hip Score (HHS) preoperatively and postoperatively at 6 weeks, 3 months, 1 and 2 years and every 2 years thereafter. Charts and radiographs were reviewed to determine the revision rates and survivorship (both all cause and aseptic) at 10 years for both cohorts. Paired analysis was performed to determine if differences exist in patient reported outcomes. There were 208 OxZr THRs identified which were matched with 208 CoCr THRs. There was no difference in average age (OxZr, 54.58 years, CoCr, 54.75 years), gender (OxZr 47.6% female, CoCr 47.6% female), and average body max index (OxZr, 31.36 kg/m2, CoCr, 31.12 kg/m2) between the two cohorts. There were no significant differences preoperatively in any of the outcome scores between the two groups (WOMAC (p=0.449), SF-12 (p=0.379), HHS(p=0.3718)). Both the SF12 (p=0.446) and the WOMAC (p=0.278) were similar between the two groups, however the OxZr THR cohort had slightly better HHS compared to the CoCr THR cohort (92.6 vs. 89.7, p=0.039). With revision for any reason as the end point, there was no significant difference in 10 years survivorship between groups (OxZr 98.5%, CoCr 96.6%, p=0.08). Similarly, aseptic revisions demonstrated comparable survivorship rates at 10 year between the OxZr (99.5%) and CoCr groups (97.6%)(p=0.15). Both THR cohorts demonstrated outstanding survivorship and improvement in patient reported outcomes. The only difference was a slightly better HHS score for the OxZr cohort which may represent selection bias, where OxZr implants were perhaps implanted in more active patients. Implant survivorship was excellent and not dissimilar for both the OxZr and CoCr groups at 10 years. Therefore, with respect to implant longevity at the end of the first decade, there appears to be no clear advantage of OxZr heads compared to CoCr heads when paired with XLPE for patients with similar demographics. Further follow-up into the second and third decade may be required to demonstrate if a difference does exist


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_5 | Pages 98 - 98
1 Apr 2019
Brooks P Brigati D Khlopas A Greenwald AS Mont M
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Introduction. Hip resurfacing arthroplasty (HRA) is an alternative to traditional total hip arthroplasty (THA) in young active patients. While comparative implant survival rates are well documented, there is a paucity of studies reporting the patient mortality rates associated with these procedures. The purpose of this study was to evaluate the mortality rates in patients age 55 years and younger who underwent HRA versus THA and to assess whether the type of operation was independently associated with mortality. Patients and Methods. The database of a single high-volume surgeon was reviewed for all consecutive patients age 55 years and younger who underwent hip arthroplasty between 2002 and 2010. HRA became available in the United States in 2006. This yielded 504 patients who had undergone HRA from 2006 to 2010 and 124 patients who had undergone a THA. Patient characteristics were collected from the electronic medical record including age, gender, body mass index, Charleston comorbidity index, smoking status, and primary diagnosis. Mortality was determined through a combination of electronic chart reviews, patient phone calls, and online obituary searches. Univariate analysis was performed to identify a survival difference between the two cohorts. Multivariable Cox-Regression analyses were used to determine whether the type of operation was independently associated with mortality. Results. The mean follow up for consecutive patients was 7 years (up to 11 years) in the HRA group and 8 years (up to 16 years) in the THA group. A total of 467 HRA patients (92%) and 105 THA patients (85%) were followed for a minimum of 5-years. 92% of the THA procedures were performed prior to the availability of HRA. There were 8 mortalities (1.6%) in the HRA cohort and 11 (8.9%) in the THA cohort, a statistically significant difference (p<0.001) on univariate analysis. Low mortality rates produced underpowered multivariate models. Conclusion. We have demonstrated that patients under age 55 who undergo HRA have a significantly lower mortality rate than those undergoing THA at mid-term follow-up. This is consistent with previously published large database studies. Such studies typically analyze large heterogeneous populations of patients and surgeons. Our study uniquely examined only patients age 55 or younger from a single high-volume surgeon, and we primarily reviewed THA performed prior to the availability of HRA as a surgical option. Thus, surgeon selection bias was largely eliminated. To our knowledge, this is the first single surgeon study comparing HRA and THA in terms of mortality


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_10 | Pages 36 - 36
1 Jun 2018
Barrack R
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Total hip arthroplasty (THA) is among the most successful interventions in all of medicine and has recently been termed “The Operation of the Century”. Charnley originally stated that “Objectives must be reasonable. Neither surgeons nor engineers will ever make an artificial hip joint that will last 30 years and at some time in this period enable the patient to play football.” and he defined an appropriate patient as generally being over 65 years of age. Hip rating scales developed during this time were consistent with this approach and only required relief of pain and return to normal activities of daily living to achieve a perfect score. Since this time, however, hip arthroplasty has been applied to high numbers of younger, more active individuals and patient expectations have increased. One recent study showed that in spite of a good hip score, only 43% of patients had all of their expectations completely fulfilled following THA. The current generation metal-metal hip surface replacement arthroplasty (SRA) has been suggested as an alternative to standard THA which may offer advantages to patients including retention of more native bone, less stress shielding, less thigh pain due to absence of a stem, less limb length discrepancy, and a higher activity level. A recent technology review by the AAOS determined that currently available literature was inadequate to verify any of these suggested potential benefits. The potential complications associated with SRA have been well documented recently. The indications are narrower, the implant is more expensive, the technique is more demanding and less forgiving, and the results are both highly product and surgeon specific. Unless a clinical advantage in the level of function of SRA over THA can be demonstrated, continued enthusiasm for this technique is hard to justify. To generate data on the level of function of younger more active arthroplasty patients, a national multicenter survey was conducted by an independent university medical interviewing center with a long track record of conducting state and federal medical surveys. All patients were under 60, high demand (pre-morbid UCLA score > 6) and had received a cementless stem with an advanced bearing surface or an SRA at one of five major total joint centers throughout the country. The detailed questionnaire quantified symptoms and function related to employment, recreation, and sexual function. Patients with SRA had a higher incidence of noises emanating from the hip than other bearing surfaces although this was transient and asymptomatic. SRA patients were much more likely to have less thigh pain than THA, less likely to limp, less likely to perceive a limb length difference, more likely to run for exercise, and more likely to run longer distances. In another study of over 400 THA and SRA patients at two major academic centers, patients completed pain drawings that revealed an equivalent incidence of groin pain between THA and SRA, but an incidence of thigh pain in THA that was three times higher than in SRA in young active patients. While some or most of the observed advantages of SRA over THA may be attributable to some degree of selection bias, the inescapable conclusion is that SRA patients are demonstrating clinical advantages that warrants continued utilization and investigation of this procedure


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_22 | Pages 65 - 65
1 Dec 2016
Dunbar M
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Significant advances in perioperative pain management, such as multimodal periarticular injection, and subtler advances in surgical technique have resulted in improved postoperative experiences for patients with less pain, earlier rehabilitation, and shorter stays in hospital. Concurrently, and by applying the learnings from above, significant advances have been made in unicompartmental knee arthroplasty care pathways leading to safe programs for outpatient surgery. A natural extension of this process has been the exploration of outpatient total joint arthroplasty (TJA). There are some papers written on the topic, but not many. The papers are generally report that outpatient TJA can be a safe and effective procedure, but the devil is in the detail. Firstly, most authors in this field carry a bias towards positive outcomes given they fact they are expert, academic, and innovative surgeons, often having controlling interest in the management of the complete perioperative pathway. Secondly, and largely as a result of the above, there is a major selection bias as to who receives outpatient TJA. In all cases, the patients are younger, fitter, and with less comorbidities. Patients reported in the published literature on outpatient TJA therefore do not represent the average patient that the average surgeon would operate on. Recall, TJA patients are becoming heavier and older patients (85+) are also receiving TJA at increasing rates. It is useful to remember that TJA is a stressful event from a physiological perspective for the patient. Serious complications, including death, can and do occur. Further, some significant events, like cardiac ischemia occur around the second to third day postoperatively. These patients often require medical intervention for stabilization and need readmission when sent home before these events occur. This obviously is not a trivial issue given the penalties applied to hospitals in the US for early readmissions after TJA. The fundamental questions at this early stage of outpatient TJA are 1) whether it is scalable to a larger audience, and 2) whether or not processes can be developed to make it a routine, standard of care. Given that the current literature is limited and written by expert surgeons on a highly select group of patients, and given that patients in general are getting older and less healthy, it is difficult to imagine a future of TJA as drive through surgery


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_19 | Pages 3 - 3
1 Dec 2014
Düsterwald K Kruger N Dunn R
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Background:. Cervical spine injured patients often require prolonged ventilatory support due to intercostal paralysis and recurrent chest infections. This may necessitate tracheotomy. Concern exists around increased complications when anterior cervical spine surgery and tracheotomies are performed. Objective:. The primary aim of this study was to evaluate the effect of tracheostomy in anterior cervical surgery patients in term of complications. In addition, the aetiology of trauma and incidence of anterior surgery and ventilation in this patient group was assessed. Methods:. Patients undergoing anterior cervical surgery and requiring ventilation were identified from the unit's prospectively maintained database. These patients were further sub-divided into whether they had a tracheotomy or not. The aetiology of injury and incidence of complications were noted both from the database and a case note review. Results:. Of the 1829 admissions over an 8.5 year period, 444 underwent anterior cervical surgery. Of these 112 required ventilation, and 72 underwent tracheotomy. Motor vehicle accidents, followed by falls, were the most frequent cause of injury. There was a bimodal incidence of tracheostomy insertion; on the day of spine surgery and 6–8 days later. There was no difference in the general complication rate between the two groups. With regards to specific complications attributable to the surgical approach / tracheotomy, there was again no statistically significant difference. The timing of the tracheotomy equally had no effect on complication rate. Although the complications occurred mostly in the formal insertion group as opposed to percutaneous insertion technique, this was most likely due to selection bias. Conclusion:. Anterior cervical surgery and subsequent tracheostomy are safe despite the intuitive concerns. Timing does not affect the incidence of complications and there is no reason to delay the insertion of the tracheotomy. Ventilation in general is associated with increased complications rather the tracheotomy tube


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_7 | Pages 5 - 5
1 Apr 2017
Springer B
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There are numerous examples in medicine where “eminence trumps evidence.” The direct anterior approach (DA) is no exception. Its meteoric rise has largely been driven by industry and surgeon promotion. This surgical approach continues to garner interest, but this interest is largely for marketing purposes, as emerging data would suggest a high risk, low reward operation. In addition, factors such as selection bias and impact bias, have substantially swayed peoples interest into making an inferior operation look better. There are several factors related to the direct anterior approach that should give us pause. Those include the surgeon learning curve, limited functional benefit and increased complications. There is no question the DA approach for total hip arthroplasty (THA) has a long and steep learning curve. The majority of studies would suggest at minimum, 50–100 cases before a surgeon is comfortable with this approach and some studies would suggest the technical difficulties of this approach remain an issue even with increasing experience. This proves difficult with an attempted rapid adoption of this technique by a surgeon who may perform less than 50 THAs per year but feel the need to offer this approach to their patients for marketing purposes. One of the many touted benefits of the DA approach is the perception of improved functional outcomes. Many of the early studies showed early improvement in gait, pain and mobility. However, these studies compared the DA approach to an anterolateral approach. Even when compared to the anterolateral approach, considered the most invasive and least muscle sparing, the benefits of the DA approach were only short term (6 weeks). The majority of retrospective studies, prospective randomised studies and meta-analyses comparing DA to a posterior approach show little, if any, benefit of one approach over another with regards to functional benefit. Another touted benefit includes a low or no dislocation risk associated with the posterior approach. On the contrary many studies have failed to demonstrate lower dislocation rates with the DA approach compared to a contemporary posterior approach. A recent registry study from the Michigan Arthroplasty Registry Quality Initiative (MARQI) showed equal dislocation rates between the DA and posterior approach. Concerns have also been raised regarding unique and more frequent complications with the DA approach compared to other surgical approaches for total hip arthroplasty. Unique complications such as ankle fractures and a high incidence of nerve injury, especially damage to the lateral femoral cutaneous nerve, have been reported. In addition, the data now clearly show a higher incidence of complications on the femoral side, including early loosening and periprosthetic fracture. As responsible surgeons, if we want to say the DA approach is different, then fine, we can say it's different. Claims of superiority of one approach over another have not been born our in the literature and in fact much of the data would suggest a high risk no reward operation for the DA approach compared to other surgical approaches for total hip arthroplasty


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_15 | Pages 75 - 75
1 Aug 2017
Barrack R
Full Access

Total hip arthroplasty is among the most successful interventions in all of medicine and has recently been termed “The Operation of the Century”. Charnley originally stated that “Objectives must be reasonable. Neither surgeons nor engineers will ever make an artificial hip joint that will last 30 years and at some time in this period enable the patient to play football.” and he defined appropriate patient as generally being over 65 years of age. Hip rating scales developed during this time were consistent with this approach and only required relief of pain and return to normal activities of daily living to achieve a perfect score. Since this time, however, hip arthroplasty has been applied to high numbers of younger, more active individuals and patient expectations have increased. One recent study showed that in spite of a good hip score, only 43% of patients had all of their expectations completely fulfilled following THA. The current generation metal-metal hip surface replacement arthroplasty (SRA) has been suggested as an alternative to standard THA which may offer advantages to patients including retention of more native bone, less stress shielding, less thigh pain due to absence of a stem, less limb length discrepancy, and a higher activity level. A recent technology review by the AAOS determined that currently available literature was inadequate to verify any of these suggested potential benefits. The potential complications associated with SRA have been well documented recently. The indications are narrower, the implant is more expensive, the technique is more demanding and less forgiving, and the results are both highly product and surgeon specific. Unless a clinical advantage in the level of function of SRA over THA can be demonstrated, continued enthusiasm for this technique is hard to justify. To generate data on the level of function of younger more active arthroplasty patients, a national multicenter survey was conducted by an independent university medical interviewing center with a long track record of conducting state and federal medical surveys. All patients were under 60, high demand (pre-morbid UCLA score > 6) and had received a cementless stem with an advanced bearing surface or an SRA at one of five major total joint centers throughout the country. The detailed questionnaire quantified symptoms and function related to employment, recreation, and sexual function. Patients with SRA had a higher incidence of noises emanating from the hip than other bearing surfaces although this was transient and asymptomatic. SRA patients were much more likely to have less thigh pain than THA, less likely to limp, less likely to perceive a limb length difference, more likely to run for exercise, and more likely to run longer distances. In another study of over 400 THA and SRA patients at two major academic centers, patients completed pain drawings that revealed an equivalent incidence of groin pain between THA and SRA, but an incidence of thigh pain in THA that was three times higher than in SRA in young active patients. While some or most of the observed advantages of SRA over THA may be attributable to some degree of selection bias, the inescapable conclusion is that SRA patients are demonstrating clinical advantages that warrants continued utilisation and investigation of this procedure