Background. Office seating includes a variety of chair styles. There is limited research investigating their effects on spinal angles. Purpose of Study. Investigate effects of active (Swopper and Vari-Kneeler), and static (Saddle and a Standard Office) chairs on lumbo-pelvic and cervical regions. Methods. Experimental same subject design (n = 14) using healthy subjects conducting a typing task sitting on the four chair types. Analysis was via digital photographs analysed within MatLab. The chair position was self selected for comfort and the work-station standardised. A repeated measures ANOVA (with Bonferroni corrections) was conducted. Results. Results are ranked most to least with standard deviations. Paired symbols indicate statistical significance (p<0.05). Conclusion. High standard deviations are attributable to the self selected seating position resulting in a variety of positions being adopted. The Vari-Kneeler chair produced the “best” posture for the lumbo-pelvic region; the Vari-Kneeler and office chairs were “best” for the cervical region. Conflicts of interest. None. Sources of funding. None

Background. There is limited research investigating the effects of the Saddle Chair on spinal angles and it has not been determined if there is a difference between a self –selected comfortable posture (SSCP) and a standardised ergonomic posture (SEP). Purpose of Study. Investigate if there is a difference in head tilt (HT); neck angle (NA); cervico-thoracic angle (CTA); thoracic angle (TA); lumbar angle (LA) and pelvic tilt (PT) when sitting on a saddle chair and adopting a SSCP compared with a SEP. Methods. Experimental same subject design (n = 13) using healthy subjects conducting a typing task sitting on a Saddle Chair. A standardised introduction was given to the adjustment possibilities of the saddle chair, the hydraulic table, the computer screen and the screen riser. Subjects were asked to adopt a SSCP and to carry out a split-screen typing task. Further standardised instructions were then given and adjustments made to achieve a SEP and the task repeated. Analysis was via digital photographs analysed within MatLab. Wilcoxon Signed Rank Tests were conducted for each spinal variable. Results. There was only a statistically significant difference in NA and CTA (p ≤ 0.05) when comparing the two postures. The mean neck angle was 3.61° less in the SEP and the mean CTA 1.09° less in the SEP. Conclusion. These preliminary finding suggest that in order to adopt a more upright posture in relation to NA and CTA users need to be provided with standardised ergonomic instructions, rather than adopt a SSCP. No Conflict of interest. No funding obtained. This abstract has not been previously published in whole or substantial part nor has it been presented previously at a national meeting

Objectives

The Attune total knee arthroplasty (TKA) has been used in over 600 000 patients worldwide. Registry data show good clinical outcome; however, concerns over the cement-tibial interface have been reported. We used retrieval analysis to give further insight into this controversial topic.

Curettage and packing with polymethylmethacrylate cement is a routine treatment for giant-cell tumour (GCT) of bone. We performed an in vitro evaluation of the cytotoxic effect of a combination of cement and methotrexate, doxorubicin and cisplatin on primary cell cultures of stromal GCT cells obtained from five patients. Cement cylinders containing four different concentrations of each drug were prepared, and the effect of the eluted drugs was examined at three different time intervals.

We found that the cytotoxic effect of eluted drugs depended on their concentration and the time interval, with even the lowest dose of each drug demonstrating an acceptable rate of cytotoxicity. Even in low doses, cytotoxic drugs mixed with polymethylmethacrylate cement could therefore be considered as effective local adjuvant treatment for GCTs.