Aim. Periprosthetic joint infection (PJI) and periprosthetic fracture (PF) are one of the most devastating complications in arthroplasty. Each complication by itself is challenging to solve. Yet, simultaneously, both complications are inconceivably complex to deal with, while the treatment regimen of PJI and PF are contradictory. Chronic PJI most often requires implant removal, while PF requires stability, regularly achieved by stable osteosynthesis. This study aims to (1) analyse the success rate of PJI with following concomitant PF during the treatment course in total hip arthroplasties (THA) and (2) to determine the risk factors for reinfection and subsequent revision surgery after treatment of PJI and PF. Method. This restrospective study analyzed 41 patients with concomitant PJI and PF during the PJI treatment period from 2013 to 2022 involving THA. Patients were divided in two cohorts termed success and failure and were statistically compared. The median follow-up time was 66 months (>12 months). All patients were considered individually and treated according to their individual needs in fracture and infection treatment. Re-arthroplasty survival was analyzed using the Kaplan-Meier method. Relevant risk factors were analyzed using the Mann-Whitney test or Chi-square, depending on the variable's scale. Results. The overall success rate of our cohort was 70,7%. Twelve patients required re-operation due to reinfection, resulting in a cumulative 12-month-reinfection rate of 19,5%. The estimated cumulative reinfection free survival rate was 68,3%. Significance in risk factors for failure were found in pathogen virulence grade, Difficult to treat pathogen and number of debridement during interval. On average the Harris Hip score was 66 in the group of reinfection compared to 77 in the group of success. Conclusions. Reoperation and re-infection rate remains high in patients with simultaneous PJI and PF in THA. Due to the heterogeneity of the fractures, soft tissue conditions and pathogens found, treatment must be individualised to salvage the limb. However, small cohorts impact the statistical strength negatively due to instances of two rare complications

Aim. Repeat revision surgery of total hip or knee replacement may lead to massive bone loss of the femur. If these defects exceed a critical amount a stable fixation of a proximal or distal femur replacement may not be possible. In these extraordinary cases a total femur replacement (TFR) may be used as an option for limb salvage. In this retrospective study we examined complications, revision free survival (RFS), amputation free survival (AFS) and risk factors for decreased RFS and AFS following a TRF in cases of revision arthroplasty with a special focus on periprosthetic joint infection (PJI). Method. We included all implantations of a TFR in revision surgery from 2006–2018. Patients with a primary implantation of a TFR for oncological indications were not included. Complications were classified using the Henderson Classification. Primary endpoints were revision of the TFR or disarticulation of the hip. The minimum follow up was 24 month. RFS and AFS were analyzed using Kaplan-Meier method, patients´ medical history was analyzed for possible risk factors for decreased RFS and AFS. Results. After applying the inclusion criteria 58 cases of a TFR in revision surgery were included with a median follow-up of 48.5 month. The median age at surgery was 68 years and the median amount of prior surgeries was 3. A soft tissue failure (Henderson Type I) appeared in 16 cases (28%) of which 13 (22%) needed revision surgery. A PJI of the TFR (Henderson Type IV) appeared in 32 cases (55%) resulting in 18 (31%) removals of the TFR and implantation of a total femur spacer. Disarticulation of the hip following a therapy resistant PJI was performed in 17 cases (29%). The overall 2-year RFS was 36% (95% confidence interval(CI) 24–48%). Patients with a Body mass Index (BMI) >30kg/m² had a decreased RFS after 24 month (>30kg/m² 11% (95%CI 0–25%) vs. <30kg/m² 50% (95%CI 34–66%)p<0.01). The overall AFS after 5 years was 68% (95%CI 54–83%). A PJI of the TFR and a BMI >30kg/m² was significantly correlated with a lower 5-year AFS (PJI 46% (95%CI 27–66%) vs no PJI 100%p<0.001) (BMI >30kg/m² 30% (95% KI 3–57%) vs. <30km/m² 85% (95% KI 73–98%)p<0.01). Conclusions. A TFR in revision arthroplasty is a valuable option for limb salvage but complications in need of further revision surgery are common. Patients with a BMI >30kg/m² should be informed regarding the increased risk for revision surgery and loss of extremity before operation

Population-based studies from the United States have reported that sarcoma patients living in rural areas or belonging to lower socioeconomic classes experience worse overall survival; however, the evidence is not clear for universal healthcare systems where financial resources should theoretically not affect access to standard of care. The purpose of this study was to determine the survival outcomes of soft-tissue sarcoma (STS) patients treated in Ontario, Canada over 23 years and determine if the patient's geographic location or income quintile are associated with survival. We performed a population-based cohort study using linked administrative databases of patients diagnosed with STS between 1993 – 2015. The Kaplan-Meier method was used to estimate 2, 5, 10, 15 and 20-year survival stratified by age, stage and location of tumor. We estimated survival outcomes based on the patient's geographic location and income quintile. The Log-Rank test was used to detect significant differences between groups. If groups were significantly different, a Cox proportional hazards model was used to test for interaction effects with other patient variables. We identified 8,896 patients with biopsy-confirmed STS during the 23-year study period. Overall survival following STS diagnosis was 70% at 2 years, 59% at 5 years, 50% at 10 years, 43% at 15 years, and 38% at 20 years. Living in a rural location (p=0.0028) and belonging to the lowest income quintile (p<0.0001) were independently associated with lower overall survival following STS diagnosis. These findings were robust to tests of interaction with each other, age, gender, location of tumor and stage of disease. This population-based cohort study of 8,896 STS patients treated in Ontario, Canada over 23 years reveals that patients living in a rural area and belonging to the lowest income quintile are at risk for decreased survival following STS diagnosis. We extend previous STS survival reporting by providing 15 and 20-year survival outcomes stratified by age, stage, and tumor location

Aim. There is a lack of data supporting the use of doxycycline as a single agent after removing infected orthopaedic metalwork. We evaluated the efficacy and safety of doxycycline compared with other single antibiotic regimens used at our specialist orthopaedic hospital. Methods. A retrospective observational study including all adult patients diagnosed with an orthopaedic metalwork infection due to staphylococci. All patients were managed with the removal of metalwork, and multiple intraoperative samples were sent for culture, followed by the administration of at least four weeks of oral antibiotics. Antibiotic selection was on the recommendation of an infection consultant. Infection outcome was assessed as the proportion of patients meeting the OVIVA Trial definition of definite failure at follow-up. The probability of definite failure for doxycycline and the alternatives group was estimated using the Kaplan-Meier survival method. All adverse drug reactions (ADR) during treatment were analysed. Results. Seventy-nine orthopaedic metalwork infections were identified between July 2017 and July 2021. Forty-four were prosthetic joints, and 35 were fracture-related metalwork. In 54 cases, the infecting organism was Staphylococcus aureus, and 25 were due to coagulase-negative staphylococci. Forty-four were treated with doxycycline 100mg 12 hourly, and 35 were treated with alternatives (flucloxacillin 1g 6-hourly n=21 and clindamycin 450mg 6-hourly n=14). Overall, 70 patients (88.6%) were infection-free after a median follow-up of 23 months (IQR, 19 – 44). 38 (82.3%) were infection-free in the doxycycline group compared with 32 (91.4%) patients treated with alternatives. Of the failures in the alternatives group, all 3 received flucloxacillin. Survival analysis showed no significant difference in time to treatment failure between doxycycline and alternative antibiotics. Eighteen patients experienced an ADR: 2 nausea, one rash and one vaginal candidiasis due to doxycycline. Four diarrhoea, one reflux, two rashes and one headache due to clindamycin; 1 nausea and five diarrhoea due to flucloxacillin. Four patients required discontinuation therapy, two due to clindamycin and two due to flucloxacillin. Conclusions. In our cohort of patients, doxycycline monotherapy was an effective and well-tolerated oral option for treating staphylococcal infection following debridement and removal of orthopaedic metalwork

Paediatric bone sarcomas around the knee are often amenable to either endoprosthetic reconstruction or rotationplasty. Cosmesis and durability dramatically distinguish these two options, although patient-reported functional satisfaction has been similar among survivors. However, the impact on oncological and surgical outcomes for these approaches has not been directly compared. We retrospectively reviewed all wide resections for bone sarcoma of the distal femur or proximal tibia that were reconstructed either with an endoprosthesis or by rotationplasty at our institution between June 2004 and December 2014 with a minimum two year follow-up. Pertinent demographic information, surgical and oncological outcomes were reviewed. Survival analysis was performed using the Kaplan-Meier method with statistical significance set at p<0.05. Thirty eight patients with primary sarcomas around the knee underwent wide resection and either endoprosthetic reconstruction (n=19) or rotationplasty (n=19). Groups were comparable in terms of demographic parameters and systemic tumour burden at presentation. We found that selection of endoprosthetic reconstruction versus rotationplasty did not impact overall survival for the entire patient cohort but was significant in subgroup analysis. Two-year overall survival was 86.7% and 85.6% in the endoprosthesis and rotationplasty groups, respectively (p=0.33). When only patients with greater than 90% chemotherapy-induced necrosis were considered, overall survival was significantly better in the rotationplasty versus endoprosthesis groups (100% vs. 72.9% at two years, p=0.013). Similarly, while event-free survival was not affected by reconstruction method (60.2% vs. 73.3% at two years for endoprosthesis vs rotationplasty, p=0.27), there was a trend towards lower local recurrence in rotationplasty patients (p=0.07). When surgical outcomes were considered, a higher complication rate was seen in patients that received an endoprosthesis compared to those who underwent rotationplasty. Including all reasons for re-operation, 78.9% (n=15) of the endoprosthesis patients required a minimum of one additional surgery compared with only 26.3% (n=5) among rotationplasty patients (p=0.003). The most common reasons for re-operation in endoprosthesis patients were wound breakdown/infection (n=6), limb length discrepancy (n=6) and periprosthetic fracture (n=2). Excluding limb length equalisation procedures, the average time to re-operation in this patient population was 5.6 months (range 1 week to 23 months). Similarly, the most common reason for a secondary procedure in rotationplasty patients was wound breakdown/infection, although only two patients experienced this complication. Average time to re-operation in this group was 23.8 months (range 5 to 49 months). Endoprosthetic reconstruction and rotationplasty are both viable limb-salvage options following wide resection of high-grade bony sarcomas located around the knee in the paediatric population. Endoprosthetic reconstruction is associated with a higher complication rate and may negatively impact local recurrence. Study of a larger number of patients is needed to determine whether the reconstructive choice affects survival

Background. Well-fixed cementless stems are sometimes needed to be extracted in patients with complications including periprosthetic infection, stem-neck breakage or trunnionosis. The purpose of this study was to report the clinical outcome in patients undergoing re-implantation surgery following removal of a well-fixed porous-coated cementless stem by the femoral longitudinal split (FLS) procedure(Fig.1, Fig.2). Methods. We conducted a retrospective study and radiographic review of 16 patients who had undergone re-implantation following the FLS procedure to remove a well-fixed stem due to periprosthetic infection, stem-neck breakage or trunnionosis. The study group consisted of 2 men and 14women with an average age of 68.4 years. Mean follow-up was 33.1± 25.0 months. Operation time, intraoperative bleeding, complications, causes of re-operation and clinical score were evaluated and the Kaplan-Meier method was used to evaluate the longevity of the stem. Results. The average operation time was 272±63 minutes and intraoperative bleeding was 420±170 ml. Although postoperative dislocation occurred in 5 hips and sinking of the stem was found in 3 hips after surgery, no progression of the stem sinking was observed and the clinical JOA and JHEQ scores were both improved after re-implantation surgery. Re-implantation surgery with Zweymüller-type stems, which are shorter than those removed, revealed evidence of osseointegration of the stem without femoral fracture. Kaplan-Meier survival analysis of stem revision for any reason as the end point revealed 70.3% survival at 9 years (Fig.3). Conclusion. The FLS procedure is expected to confer successful clinical results without loosening of the stem, following safe extraction of well-fixed porous-coated cementless stems without fracture and will allow re-implantation with shorter cementless stems than those removed. For any figures or tables, please contact the authors directly

Aim. Patellofemoral Arthroplasty (PFA) prosthesis with asymmetric trochlear component was introduced as an improvement from existing designs for surgical treatment of symptomatic isolated patellofemoral arthritis. The purpose of this study was to evaluate midterm results in patients who underwent PFA procedure using such prosthesis. Methods. Our study involved a continuous retrospective cohort of patients who underwent PFA using Journey PFJ with asymmetric trochlear component, performed between June 2007 and October 2018 at a non-designer centre. The Patient Reported Outcome Measures and patient satisfaction questionnaires were collected for final evaluation. Results. A total of 128 PFA performed on 96 patients were evaluated. All patients were under regular follow up, and no patient was lost to follow up. Eighteen patients underwent simultaneous bilateral procedures, and 14 patients underwent PFA of the contralateral knee later. Median age at the time of surgery was 59 years (interquartile range 53 – 66 years); the median follow up period was 6 years (interquartile range 2.5 – 7 years). The Oxford Knee Score showed improvement from a median of 18 to 37. There were statistically significant improvements in functional outcome scores. Beverland satisfaction questionnaire revealed that 22.1 % (19/86) were ‘Very happy’ and 39.5% (34/86) were ‘Happy’ following the procedure. Four knees were revised to Total Knee Arthroplasty for reasons not related to the implant. The cumulative survival estimated by the Kaplan-Meier method was 95.2% (95% confidence interval: 90.4%– 99.9%). Conclusion. This series of patients who underwent PFA with the asymmetric trochlear component has shown promising mid-term results with no implant related complications

Aim. We evaluated the efficacy and safety of treatment regimens in a pathogen and surgery specific mode according to a standardized algorithm for the treatment of periprosthetic joint infection (PJI) based on combinations with 15g/d intravenous fosfomycin followed by oral antibiotics for totally 12 weeks. Method. Consecutive patients with PJI caused by at least one of the following isolates were prospectively included: staphylococci (MIC ≤32 mg/l), streptococci (MIC ≤128 mg/l), enterococci (MIC ≤128 mg/l), Enterobacteriaceae (MIC ≤32 mg/l) and Pseudomonas spp. (MIC ≤128 mg/l). PJI was defined by the proposed European Bone and Joint Infection Society (EBJIS) criteria. Follow up with clinical (joint function and quality of life scores), laboratory and radiological evaluation at 3, 12 and 24 months after last surgery is performed. Infection outcome was assessed as the proportion of infection-free patients. The probability of infection-free survival was estimated using the Kaplan-Meier survival method. Results. 50 patients were screened for eligibility, of which 2 were excluded due to intolerance or allergy to fosfomycin, 1 due to isolation of fosfomycin resistant pathogen and 2 patients died due to unrelated cause to infection. The remaining 45 patients were included. Due to persistence of infection, 3 patients underwent prosthesis explantation after initial debridement and retention, 1 patient underwent debridement of Girdlestone-situation; all 4 infections were caused by S. aureus. At 2 patients debridement of hematoma after Girdlestone approach was performed. 41 patients were infection-free (91%) after a median follow-up of 6 month (range, 1 – 14 months). Nausea (n=14) and hypokalemia (n=13) were the most frequent adverse events and resolved after fosfomycin discontinuation; 5 patients had diarrhea and vomiting was observed in 2 patients. Isolated pathogens were staphylococci (n=30), streptococci (n=3), enterococci (n=5) and gram-negative rods (n=2). Cultures were negative in 9 patients and polymicrobial in 2 patients. The infection occurred postoperatively in 31 patients (69%) and hematogenously in 14 (31%). Two-stage exchange was performed in 27 (60%), debridement with retention in 13 (29%) and one-stage exchange in 5 patients (11%). Conclusions. The applied PJI treatment algorithm including intravenous fosfomycin in the initial postoperative period was associated with infection-free outcome of 91% after a median follow-up of 6 month. The Kaplan-Meier survival method showed the probability of infection-free survival of 88.5% after 1 year. Adverse events occurred in 21 patients (46%) mostly nausea and hypokalemia were reported. Adverse events were mild and resolved completely

Instability after total hip arthroplasty is the most common indication for revision arthroplasty and can be difficult to treat. The purpose of this study is to evaluate the outcomes associated with the use of a constrained acetabular component as a treatment for instability after hip arthroplasty. We reviewed the clinical and radiographic outcomes of 149 arthroplasties, that had been performed with use of a single design of constrained acetabular component between 2007 and 2012 at a single institution. Patient demographics and case specific data were collected The Mann-Whitney U test was used to assess continuous variables. Categorical variables were examined using the Chi-square test and Fisher's exact test when appropriate. Survival probability was calculated using the Kaplan-Meier method. The mean age at time of index surgery was 70 years, 65% were female, and mean BMI was 26.3. The average number of previous surgeries was 3.6. The constrained liner was cemented into a well-fixed cup in 40 hips (20%). In eighty-two (55%) hips the constrained component was implanted for the treatment of recurrent instability, and in sixty-seven (45%) hips it was implanted because the hips demonstrate instability during revision surgery. At an average duration of follow-up of 4.2 (2–7) years the overall revision rate was 10.6 % The constrained acetabular device eliminated or prevented hip instability in all patients except five; 3.3% had a new dislocation and six (4.0%) had failure of the retentive ring. Three revisions (2%) were performed for deep infection, and 2 (1.3%) for acetabular component loosening. Radiographic analysis revealed a non-progressive radiolucent line around the cup in 19 hips (12.7%). When stratified by patient age, survivorship for patients less than 65 years of age versus those greater than 65 years was similar. This study correlates with results of other papers in the literature looking at outcome of constrained tripolar type sockets. The focal constraint socket with a metal ring type design has a much greater failure rate (9–29%). Constrained liners remain an excellent option for hip instability in early to mid- term follow up

Introduction. We sought to determine the 10-year survivorship of single-radius, posterior-stabilized total knee arthroplasty (TKA) in Asian patients. We also aimed to determine whether the long-term clinical and radiographic results differed between patients with and without patellar resurfacing. Materials and Methods. This retrospective study included 148 (115 patients) consecutive single-radius, posterior-stabilized TKAs. Ten-year survivorship analysis was performed using the Kaplan-Meier method with additional surgery for any reason as the end-point. Furthermore, long-term clinical and radiographic results of 109 knees (74%; 84 patients) with more than a 10-year follow-up were analyzed. Ten-year survivorship and long-term outcomes after surgery were determined, and outcomes were compared between patients with and without patellar resurfacing. Results. Cumulative survival rate of the single-radius posterior-stabilized TKA of 148 knees was 97.7% (95% confidence interval, 93.1%–99.3%) at 10 years after surgery. Three knees had additional surgery during the 10-year follow-up because of one case of instability and two periprosthetic infections. Mean postoperative Knee Society knee score and function score were 97 and 75, respectively. There was no aseptic loosening of the prosthesis, even though a non-progressive radiolucent line was found in 10 (9%) knees. There were no differences in postoperative scores and degree of patellar tilt and displacement between patients with and without patellar resurfacing. Conclusions. Single-radius, posterior-stabilized TKA showed satisfactory long-term clinical and radiographic outcomes in Asian patients regardless of patellar resurfacing, with comparable survivorship to that reported in westerners

The aim of this study was to document the survivorship and patient reported outcome of the Avon patello-femoral replacement in a consecutive series with follow up of 10 years or more. All cases performed in Bristol from 1996 onwards were prospectively recorded. Follow up was at 1,2,5,7,10,12 and 15 years with the Bristol Patella Score, the Oxford and WOMAC scores and SF12. Implant survival was analysed using the Kaplan-Meier method. There were 323 PFJ replacements (280 individuals). Follow up was available for 286 cases in 250 patients (89% follow up). The 10 year survival rate was 77%, falling to 67% at 15 years. The most common reason for revision was tibio-femoral progression (45/74 revisions), with loosening or polyethylene wear recorded in 8 cases. The best results were seen in the youngest and the oldest patients. Good improvements were seen in PROMs, with the mean OKS improving from 19.5 to 34.1 at 2 years and 32.7 at the 15 years. The Avon patello-femoral knee replacement is a successful long-term treatment for isolated patello-femoral knee osteoarthritis, although further improvements are expected in subsequent series, particularly as indications for surgery have evolved over time

INTRODUCTION. Successful clinical outcomes following unicompartmental knee arthroplasty (UKA) depend on component positioning, soft tissue balance and lower limb alignment, all of which can be difficult to achieve using manual instrumentation. A new robotic-guided technology has been shown to improve postoperative implant positioning and lower limb alignment in UKA but so far no studies have reported clinical results of robotic-assisted medial UKA. Goal of this study therefore was to assess outcomes of robotic-assisted medial UKA in a large cohort of patients at short-term follow-up. METHODS. This multicenter study with IRB approval examines the survivorship and satisfaction of this robotic-assisted procedure coupled with an anatomically designed UKA implant at a minimum of two-year follow-up. A total of 1007 patients (1135 knees) underwent robotic-assisted surgery for a medial UKA from six surgeons at separate institutions in the United States. All patients received a fixed-bearing metal backed onlay implant as the tibial component between March 2009 and December 2011 (Figure 1). Each patient was contacted at minimum two-year follow-up and asked a series of five questions to determine implant survivorship and patient satisfaction. Survivorship analysis was performed using Kaplan-Meier method and worst-case scenario analysis was performed whereby all patients were considered as revision when they declined study participation. Revision rates were compared in younger and older patients (age cut-off 60 years) and in patients with different body mass index (body mass index cut-off 35 kg/m. 2. ). Two-sided chi-square tests were used to compare these groups. RESULTS. Data was collected for 797 patients (909 knees) with an average follow-up of 29.6 months (range: 22 – 52 months). At 2.5-years follow-up, eleven knees were reported as revised, which resulted in a survivorship of 98.8% (Figure 2). Thirty-five patients declined to participate in the study yielding a worst-case survivorship of 96.0%. Higher revision rates were seen in younger patients (2.60% versus 0.93%, p = 0.09) and in morbidly obese patients (3.36% versus 0.91%, p = 0.03). Of all patients without revision, 92% was either very satisfied or satisfied with their knee function (Figure 3). CONCLUSION. In this multicenter study, robotic-assisted UKA was found to have high survivorship and satisfaction rate at short-term follow-up. Prospective comparison studies with longer follow-up are necessary in order to compare survivorship and satisfaction rates of robotic-assisted UKA to conventional UKA and robotic-assisted UKA to total knee arthroplasty. For any figures or tables, please contact authors directly (see Info & Metrics tab above).

Biological reconstruction techniques after diaphyseal tumour resection have increased in popularity in recent years. High complication and failure rates have been reported with intercalary allografts, with recent studies questioning their role in limb-salvage surgery. We developed a technique in which large segment allografts are augmented with intramedullary cement and fixed using compression plating. The goal of this study was to evaluate the survivorship, complications and functional outcomes of these intercalary reconstructions. Forty-two patients who had reconstruction with an intercalary allograft following tumour resection between 1989 and 2010 were identified from our prospectively collected database. Allograft survival, local recurrence-free, disease-free and overall survival were assessed using the Kaplan-Meier method. Patient function was assessed using the Musculoskeletal Tumour Society (MSTS) scoring system and the Toronto Extremity Salvage Score (TESS). The 23 women and 19 men had a mean age of 33 years (14–77). The most common diagnoses were osteosarcoma (n=16) and chondrosarcoma (n=9). There were 9 humerus, 18 femur and 15 tibia reconstructions. At a mean follow-up of 95 months (5–288), 31 patients were alive without disease, 10 were dead of disease and 1 was deceased of other causes. There were 4 local recurrences and 11 patients developed metastatic disease. 5-year local recurrence free survival was 92%, 5-year disease-free survival was 70% and overall survival was 75%. Fourteen of 42 patients (33%) experienced complications: 5 wound healing complications, 4 infections, 2 non-unions, 2 fractures and 1 nerve palsy. Four allografts (9.5%) were revised for complications and 2 (5%) for local recurrence. Mean allograft survival was 85 months (4–288). Mean time to union was 8.2 (3–36) months for the proximal osteotomy site and 8.1 (3–23) months for the distal osteotomy site. The mean score for MSTS 87 was 29.4 (+/− 4.4), MSTS 93 was 83.7 (+/−14.8) and TESS was 81.6 (+/−16.9). An intercalary allograft augmented with intramedullary cement and compression plate fixation provides a reliable and durable method of reconstruction after tumour resection. Complication rates are comparable to the literature and are associated with high levels of patient function and satisfaction

Acetabular reconstruction of extensive bone defect is troublesome in revision total hip arthroplasty (rTHA). Kerboull or Kerboull type reinforcement acetabular device with allobone grafting has been applied since 1996. Clinical results of the procedure were evaluated. Patients. One hundred and ninety-two consecutive revision total hip arthroplasties were performed with allograft bone supported by the Kerboull or Kerboull type reinforcement acetabular device from 1996 to 2009. There were 23 men and 169 women. Kerboull plates were applied to 18 patients, and Kerboull type plates to 174. The mean follow up of the whole series was 8 years (4–18years). Surgical Technique. The superior bone defect was reconstructed principally by a large bulky allo block with plate system. Medial bone defect was reconstructed by adequate bone chips and/or sliced bone plates. After temporally fixation of bulky bone block with two 2.0mm K-wires, it was remodeled by reaming to fit the gap between host bone and plate, followed by fixation to the iliac bone by screws. Finally, residual space of the defect between host bone and the fixed plated was filled up with morselized cancellous bones, bone chips, and/or wedged bony fragments with impaction. This method was sufficiently applicable to AAOS Typeâ�, II, and III bone defects. In case of AAOS Typeâ�£, the procedure was also available after repairing discontinuation between distal and proximal bones by reconstrusion plate or allografting with tibial bone plates or sliced femoral head. Results. Nine patients (4.7%) required revision surgery (infection 5, breakage 3, and malalignment 1). The plate breakage was observed in 8 joints (4.2%). Three patients had no symptoms after the breakage. Three required revision, but the other cases were carefully observed without additional surgical intervention. Ten-year survival rate by Kaplan-Meier method was 96.6% when the endpoint was set revision by asceptic loosning. Conclusions. This study indicated that acetabular allograft reconstructions reinforced by Kerboull or Kerboull type acetabular device were able to recover bone stock with anatomic reconstruction of femoral head center, thus providing satisfactory clinical results in middle term period

Introduction. Female gender, old age (men >60y and women > 55y), severe acetabular dysplasia, poor proximal femoral bone geometry, large (>1cm) femoral head cysts, limb-length discrepancy (> 2cm) and small prosthetic head size (less than 50mm for men and less than 46mm for women) are risk factors for hip resurfacing arthroplasty (HRA). Purpose. To present clinical and radiographic results of HRA in patients having risk factors. Patients and methods: A total of 39 HRA was inserted in 33 patients (11 men and 22 women). Birmingham hip resurfacing (Smith & Nephew, UK) was used in 9 hips and Adept (Finsbury, UK) was used in 30 hips. Among the 30 hips inserted Adept, 11 cups were fixed with rim screws. The mean age of the patients at the time of operation was 52 years. The mean weight and height of the male and female patients were 70.4kg and 167cm, 58.5kg and 154.4cm, respectively. The median head size of the male and female patients was 50mm and 42mm, respectively. Preoperative diagnosis was primary osteoarthritis in 6 hips and secondary osteoarthritis due to aceatbular dysplasia (DDH) in 33 hips. Risk factors of HRA were listed for each patient. The Harris hip score and visual analogue pain scale (VAS) were measures of clinical outcome. Radiographic review was performed retrospectively. MRI and CT images were acquired in 29 hips and 2 hips, respectively, at a mean of 4.8 years after HRA to find periprosthetic soft tissue abnormality such as a psedotumor. Kaplan-Meier method was used to calculate implant survivorship. Results. Two hips had no risk factor, whereas 37 hips had at least one risk factor. Risk factors were listed as follows: female gender in 27, old age in nine, severe acetabular dysplasia in 25, poor proximal femoral bone geometry in 11, head cysts in 13, limb-length discrepancy in three and small head size in 21. There were two revisions in two men. One hip was revised because of acute infection. The patient had a risk factor (old age). Another hip was revised because of cup loosening. The patient had two risk factors (severe acetabular dysplasia and small head size). The mean follow-up period for unrevised hips was 5 years (range, 2 to 8 years). The Harris hip score improved from 47.3 points preoperatively to 96.5 points at the latest follow-up (p<0.001). VAS improved from 65 preoperatively to 5 at the latest follow-up (p<0.001). Using revision for any reason as the endpoint, the Kaplan-Meier survivorship was 94.9% at 5years. No implant was loose at the latest radiographic examination. MRI and CT of the hip revealed no pseudotumor. Discussion. In this series, only two patients had no risk factor for HRA. Although majority of our patients were women with acetabular dysplasia and small head size, clinical and radiographic results of HRA were good up to five years (Figs 1 and 2: pre- and post-operative X-ray of 49y women having five risk factors). Conclusion. Clinical and radiographic results of HRA were good in patients who have risk factors

The alumina on alumina articulation in THA has induced less macrophage reaction and cytokine section than polyethylene bearings. Thus THA using alumina on almina articulation has induced little periprosthetic osteolysis. However alumina fracture is still a concern. We had underwent 100 THAs that it was a cemented polyethylene backed acetabular component with an alumina inlay(ABS Cup; Kyocera, Kyoto, Japan), PHS stem(Kyocera) and 28mm alumina femoral head. This system was formerly used in only Japan, over 10 years results have not reported yet. We retrospectively reviewed 94 patients(100 hips) with cemented alumina on alumina THAs to identify factors relating to alumina failure, and to evaluate mid-term(>10years) results. 16 patients died from unrelated causes within 10 years of the operation and 14 patients was lost to follow up. The remaining 70 patients(79 Hips) were evaluated after a mean follow-up of 10 years. We performed clinical evaluation using the JOA score, and radiological evaluation was performed that inclination and anteversion angle of cup measurement with 2D template system at anteroposterior radiograph. On the radiographs at the final examination, radiolucency and osteolysis were evaluated around the acetabular component, and around the femoral component. These evaluations were scheduled for 3,6,9, and 12 months and yearly thereafter. All the operations were performed by same surgeon, at same center. Cumulative survival rates were calculated using the Kaplan-Meier method with failure defined as the end point of revision for alumina failure or for any reason. To compare groups with and without alumina failures in age, BMI, gender, activity, function, abduction angle, size of component, or existence of radiolucent lines, we used the nonparametric Mann-Whitney U-test. The mean age of the patients at surgery was 63.0 years. The mean follow up term was 13.8 years. Inclination and anteversion mean angle of cup were 45.6°and 14.2°.ã��Revision surgery was performed because of alumina inlay failure in 4hips(2 fractures and 2 dissociation;5.1%), loosening in 2 hips(2 cup loosenings; 2.5%) recurrent dislocation in 1 hip, and femoral fracture in 1 hip, no deep infection and DVT. The 10-year survival rate was 92.4% with revision for any reason and 95.9% with revision for alumina failure as the end point. We detected 3 ceramic failures at a mean of 8.9 years(4.1ï¼ï¿½12.5) after the index operation. There were no differences in BMI, function, cup angles(inclination and anteversion), and cup loosening among the 4hips with alumina failure. But there were differences in age, gender, and activity with alumina failure. This alumina on alumina THA yielded passably mid-term results, but it was occurred a high rate of catastrophic alumina inlay failure. In July 2000, we discontinued use of this type of THA to avoid alumina failure. This ABS cup was banned in 2002, because of numerous alumina failures. We suggest all patients with this type of acetabular component be followed carefully. Cemented polyethylene-backed alumina-on-alumina THA with a composite of alumina inlay had a relatively high rate of catastrophic alumina inlay failure(5.1ï¼ï¿½) during a mean of 13.8 years' follow up. There were differences in age, gender, and activity with alumina failure

Background. Unicompartmental knee arthroplasty provides a good alternative to total knee arthroplasty in patients with isolated medial compartment osteoarthritis. Reported ten-year survival for the Oxford medial unicompartmental knee arthroplasty is variable, ranging from 80.2% to 97.7% in the originator series. The aim of this study was to determine the survival and reasons for revision of the Oxford medial unicompartmental knee arthroplasty when performed at a specialist orthopaedic centre. Methods. Details of consecutive patients undergoing Oxford unicompartmental knee arthroplasty at our centre between January 2000 and December 2009 were collected prospectively. Failure of the implant was defined as conversion to total knee arthroplasty. Survival was determined using the Kaplan-Meier method. Results. There were 494 Oxford unicompartmental knee arthroplasties implanted in 425 patients for isolated medial compartment osteoarthritis. Mean age was 62.8 yrs (range 34.6-90.1 yrs) and 53.4% were female. During a mean follow-up time of 3.0 yrs (range 0.5-9.2 yrs), twenty-two knees (4.5%) were revised to a total knee arthroplasty. Reasons for revision were aseptic loosening of the femoral (n=8) or tibial component (n=2), undiagnosed pain (n=5), patellofemoral pain (n=2), infection (n=1), lateral meniscus tear (n=1), periprosthetic fracture (n=1), joint instability (n=1), and dislocation of meniscal bearing (n=1). Mean time to revision surgery from the primary procedure was 3.0 yrs. Eight-year survival for the cohort was 87.4%. The median pre-operative Oxford knee score was 62.5% which reduced to 27.7% at four years post-operatively. Conclusion. This study has demonstrated our revision rate for the Oxford unicompartmental knee replacement is comparable to independent series and national registry data. Post-operative function in patients not revised was good. The commonest reason for failure was aseptic component loosening which usually occurred within two to four years. Extended follow-up may therefore be beneficial in these patients so these cases are identified early and subsequently revised

Purpose. The optimal sequencing of radiotherapy (RT) with surgery in soft-tissue sarcomas (STS) remains undefined. We assessed the impact of RT sequencing on overall survival (OS), cause-specific survival (CSS), local failure, and distant failure. Methods. A retrospective analysis was conducted using the National Oncology Database, a proprietary database of aggregated tumour registries owned by Impac. (r). Medical Systems (Sunnyvale, CA). Eligible sites were soft tissues of the head/neck, thorax, abdomen, pelvis, extremities, trunk, and peritoneum. Only patients with known stage and grade were included. Prognostic factors were identified with multivariate analysis (MVA) using the Cox proportional hazards model. Survival was calculated using the Kaplan-Meier method, and compared for statistical significance (p< 0.05) using the log-rank test. Results. A total of 821 patients met the inclusion criteria. The median follow-up time for living patients was 62 months. The 5-year CSS was 69%. MVA identified the following independent predictors for CSS (p< 0.01): age, stage, grade, histology, surgery, RT sequence, and tumour size. CSS was significantly improved with pre-op RT versus post-op RT [hazard ratio (HR) 0.7, 95% confidence interval (CI) 0.51-0.94, p< 0.05], with a 5-year CSS of 81% and 73%, respectively (log-rank, p< 0.01). Pre-op RT improved CSS in patients with lower extremity tumours, leiomyosarcoma, and synovial sarcoma (p< 0.05). OS was not significantly improved with pre-op RT. Pre-op RT also resulted in significantly reduced local and distant relapse rates than post-op RT. Adverse prognostic factors were balanced between both groups. Conclusion. Pre-operative RT has a significant benefit in reducing cancer-specific mortality compared to post-operative RT in STS

Introduction. The management of degenerative arthritis of the knee in the younger, active patient presents a challenge to the orthopaedic surgeon. Surgical treatment options include: high tibial osteotomy (HTO), unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA). The aim of this study was to examine the long-term survival of closing wedge HTO in a large series of patients up to 19 years after surgery. Methods. Four hundred and fifty-five consecutive patients underwent lateral closing wedge HTO for medial compartment osteoarthritis (MCOA) between 1990 and 2001. Between 2008-2009, patients were contacted via telephone. Assessment included: incidence of further surgery, current body mass index (BMI), Oxford Knee Score, and British Orthopaedic Association (BOA) Patient Satisfaction Scale. Failure was defined as the need for revision HTO or conversion to UKA or TKA. Survival analysis was completed using the Kaplan-Meier method. Results. High tibial osteotomy survival was determined on 413 patients (91%) and, of the 397 patients who were alive at the time of final review, 394 (99%) were contacted for follow-up via telephone interview. The probability of survival for HTO at 5, 10 and 15 years was: 95%, 79% and 56% respectively. Multivariate regression analysis showed that age < 50 years (p=0.001), BMI < 25 kg/m. 2. (p=0.006) and ACL deficiency (p=0.03) were associated with better odds of survival. Mean Oxford Knee Score was 40/48 (range 17-48). Overall, 85% of patients were enthusiastic or satisfied and 84% would undergo HTO again at mean 12 years follow-up. Conclusion. High tibial osteotomy can be effective for periods longer than 15 years. However, results do deteriorate over time. Age < 50 years, normal BMI and ACL deficiency were independent factors associated with improved long-term survival of HTO

Aims. To report the rate of early revision (within two years) after shoulder arthroplasty and identify any patient, disease or prosthesis factors that may be associated with these early failures. Methods. The AOA National Joint Replacement Registry has recorded 7113 shoulder arthroplasty procedures up to December 2009. Data recorded includes diagnosis, patient demographics and prosthesis details. The main outcome of this analysis was the time to first revision of all primary shoulder arthroplasty recorded by the Registry. The cumulative per cent revision (CPR) of shoulder arthroplasty procedures was estimated using the Kaplan-Meier method. Cox proportional hazard models were used to test significance between groups. Results. The CPR (95% CI) at two years for all diagnosis was 5.2 (3.1, 8.7) for hemi-resurfacing arthroplasty, 4.0 (2.9, 5.6) for hemiarthroplasty, 4.1 (3.1, 5.3) for conventional total shoulder arthroplasty (TSA) and 4.0 (3.0, 5.2) for reverse total shoulder arthroplasty (reverse TSA). Neither patient age nor sex were shown to affect the rate of revision for conventional and reverse TSA performed for osteoarthritis. The use of an uncemented conventional TSR performed for osteoarthritis is associated with a higher rate of revision when compared with cemented TSR (HR 4.71 (1.43, 15.45)) and hybrid TSR using a cemented glenoid component (HR 2.48 (1.45, 4.24)). Both the Univers 3D conventional total shoulder replacement prosthesis (adjusted HR 3.8 (1.52, 9.50) p< 0.01) and the SMR/SMR reverse total shoulder replacement (adjusted HR 2.0 (1.15, 3.28) p=0.01) were prosthesis identified by the Registry as having a significantly higher rate of revision compared to all other prosthesis in the same class. Conclusions. The Registry has identified an increased early rate of revision with the use of uncemented convention TSR. Two types of prosthesis were identified as having a higher than anticipated rate of revision compared to all other prosthesis in the same class