Aims

To explore the clinical relevance of joint space width (JSW) narrowing on standardized-flexion (SF) radiographs in the assessment of cartilage degeneration in specific subregions seen on MRI sequences in knee osteoarthritis (OA) with neutral, valgus, and varus alignments, and potential planning of partial knee arthroplasty.

Aims. The preventive effects of bisphosphonates on articular cartilage in non-arthritic joints are unclear. This study aimed to investigate the effects of oral bisphosphonates on the rate of joint space narrowing in the non-arthritic hip. Methods. We retrospectively reviewed standing whole-leg radiographs from patients who underwent knee arthroplasties from 2012 to 2020 at our institute. Patients with previous hip surgery, Kellgren–Lawrence grade ≥ II hip osteoarthritis, hip dysplasia, or rheumatoid arthritis were excluded. The rate of hip joint space narrowing was measured in 398 patients (796 hips), and the effects of the use of bisphosphonates were examined using the multivariate regression model and the propensity score matching (1:2) model. Results. A total of 45 of 398 (11.3%) eligible patients were taking an oral bisphosphonate at the time of knee surgery, with a mean age of 75.8 years (SD 6.2) in bisphosphonate users and 75.7 years (SD 6.8) in non-users. The mean joint space narrowing rate was 0.04 mm/year (SD 0.11) in bisphosphonate users and 0.12 mm/year (SD 0.25) in non-users (p < 0.001). In the multivariate model, age (standardized coefficient = 0.0867, p = 0.016) and the use of a bisphosphonate (standardized coefficient = −0.182, p < 0.001) were associated with the joint space narrowing rate. After successfully matching 43 bisphosphonate users and 86 non-users, the joint narrowing rate was smaller in bisphosphonate users (p < 0.001). Conclusion. The use of bisphosphonates is associated with decreased joint degeneration in non-arthritic hips after knee arthroplasty. Bisphosphonates slow joint degeneration, thus maintaining the thickness of joint cartilage in the normal joint or during the early phase of osteoarthritis. Cite this article: Bone Joint Res 2022;11(11):826–834

Aims. The aim of this study was to identify the origin and development of the threshold for surgical intervention, highlight the consequences of residual displacement, and justify the importance of accurate measurement. Methods. A systematic review of three databases was performed to establish the origin and adaptations of the threshold, with papers screened and relevant citations reviewed. This search identified papers investigating functional outcome, including presence of arthritis, following injury. Orthopaedic textbooks were reviewed to ensure no earlier mention of the threshold was present. Results. Knirk and Jupiter (1986) were the first to quantify a threshold, with all their patients developing arthritis with > 2 mm displacement. Some papers have discussed using 1 mm, although 2 mm is most widely reported. Current guidance from the British Society for Surgery of the Hand and a Delphi panel support 2 mm as an appropriate value. Although this paper is still widely cited, the authors published a re-examination of the data showing methodological flaws which is not as widely reported. They claim their conclusions are still relevant today; however, radiological arthritis does not correlate with the clinical presentation. Function following injury has been shown to be equivalent to an uninjured population, with arthritis progressing slowly or not at all. Joint space narrowing has also been shown to often be benign. Conclusion. Knirk and Jupiter originated the threshold value of 2 mm. The lack of correlation between the radiological and clinical presentations warrants further modern investigation. Measurement often varies between observers, calling a threshold concept into question and showing the need for further development in this area. The principle of treatment remains restoration of normal anatomical position. Cite this article: Bone Joint J 2021;103-B(9):1457–1461

Abstract. Objectives. A promising therapy for early osteoarthritis (OA) is the transplantation of human umbilical cord-derived mesenchymal stromal cells (hUC-MSCs). The synovial fluid (SF) from a pre-clinical ovine model treated with hUC-MSCs has been profiled using proteomics and bioinformatics to elucidate potential mechanisms of therapeutic effect. Methods. Four weeks after a medial meniscus transection surgery, sheep were injected with 10. 7. hUC-MSCs in Phosphate Buffered Saline (PBS) or PBS only (n=7) and sacrificed at 12 weeks. SF was normalised for protein abundance (ProteoMiner. TM. ) and analysed using label-free quantitation proteomics. Bioinformatics analyses (Ingenuity Pathway Analysis (IPA) and STRING) were used to assess differentially regulated functions from the proteomic data. Human orthologues were identified for the ovine proteins using UniProt and DAVID resources and proteins that were ≥±1.3 fold differentially abundant between treatment groups, were included in the bioinformatics analyses. Results. hUC-MSC treated animals demonstrated significantly less joint space narrowing. Nineteen SF proteins were differentially abundant in treated cf. control sheep (FC±2.0; p<0.05). Biglycan (a small leucine-rich proteoglycan of the cartilage extracellular matrix) abundance was increased by 2.1 fold in treated compared to untreated sheep (p=0.024). IPA indicated that lipid synthesis (z-score=1.772; p=0.00267) and immune cell migration pathways (cell movement of mononuclear leukocytes: z-score=1.761; p=0.00259), amongst others, were likely to be activated in the treated sheep. Conversely, tissue damage (z-score=−2; p=0.00019), senescence (z-score=−1.981; p=0.00007) and necrosis (z-score=−1.728; p=0.00829) associated pathways as well as inflammation (z-score=−1.718; p=0.00057) and vascular permeability (z-score=−1.698; p=0.00002) were likely to be inhibited in treated cf. untreated sheep. Conclusions. hUC-MSC treatment prevented/delayed OA progression, demonstrated via a reduction in joint space narrowing. SF proteome bioinformatics revealed potential mechanisms of therapeutic action related to immunomodulation and the inhibition of multiple cell death, and tissue damage associated pathways. Further, a potential predicted upregulation in lipid synthesis in treated sheep represents a novel mechanism warranting further investigation. Additional work is required to validate these discovery phase proteomic findings in studies which specifically target and manipulate the proposed mechanisms highlighted. Declaration of Interest. (b) declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported:I declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project

Aims. Although there are various pelvic osteotomies for acetabular dysplasia of the hip, shelf operations offer effective and minimally invasive osteotomy. Our study aimed to assess outcomes following modified Spitzy shelf acetabuloplasty. Methods. Between November 2000 and December 2016, we retrospectively evaluated 144 consecutive hip procedures in 122 patients a minimum of five years after undergoing modified Spitzy shelf acetabuloplasty for acetabular dysplasia including osteoarthritis (OA). Our follow-up rate was 92%. The mean age at time of surgery was 37 years (13 to 58), with a mean follow-up of 11 years (5 to 21). Advanced OA (Tönnis grade ≥ 2) was present preoperatively in 16 hips (11%). The preoperative lateral centre-edge angle ranged from -28° to 25°. Survival was determined by Kaplan-Meier analysis, using conversions to total hip arthroplasty as the endpoint. Risk factors for joint space narrowing less than 2 mm were analyzed using a Cox proportional hazards model. Results. The mean Merle d'Aubigné clinical score improved from 11.6 points (6 to 17) preoperatively to 15.9 points (12 to 18) at the last follow-up. The survival rates were 95% (95% confidence interval (CI) 91 to 99) and 86% (95% CI 50 to 97) at ten and 15 years. Multivariate Cox regression identified three factors associated with radiological OA progression: age (hazard ratio (HR) 2.85, 95% CI 1.05 to 7.76; p = 0.0398), preoperative joint space (HR 2.41, 95% CI 1.35 to 4.29; p = 0.0029), and preoperative OA (HR 8.34, 95% CI 0.94 to 73.77; p = 0.0466). Conclusion. Modified Spitzy shelf acetabuloplasty is an effective joint-preserving surgery with a wide range of potential indications. Cite this article: Bone Jt Open 2023;4(12):932–941

Aims. This study aimed to evaluate sagittal spinopelvic alignment (SSPA) in the early stage of rapidly destructive coxopathy (RDC) compared with hip osteoarthritis (HOA), and to identify risk factors of SSPA for destruction of the femoral head within 12 months after the disease onset. Methods. This study enrolled 34 RDC patients with joint space narrowing > 2 mm within 12 months after the onset of hip pain and 25 HOA patients showing femoral head destruction. Sharp angle was measured for acetabular coverage evaluation. Femoral head collapse ratio was calculated for assessment of the extent of femoral head collapse by RDC. The following parameters of SSPA were evaluated using the whole spinopelvic radiograph: pelvic tilt (PT), sacral slope (SS), pelvic incidence (PI), sagittal vertical axis (SVA), thoracic kyphosis angle (TK), lumbar lordosis angle (LL), and PI-LL. Results. The HOA group showed higher Sharp angles compared with the RDC group. PT and PI-LL were higher in the RDC group than the HOA group. SS and LL were lower in the RDC group than the HOA group. No difference was found in PI, SVA, or TK between the groups. Femoral head collapse ratio was associated with PT, SS, SVA, LL, and PI-LL. A PI-LL > 20° and a PT > 30° correlated with greater extent of femoral head destruction by RDC. From regression analysis, SS and SVA were significantly associated with the femoral head collapse ratio within 12 months after disease onset. Conclusion. Compared with HOA, RDC in the early stage correlated with sagittal spinopelvic malalignment. SS and SVA may partially contribute to the extent of femoral head destruction by RDC within 12 months after the onset of hip pain. The present study indicates a potential role of SSPA assessment in identification of RDC patients at risk for subsequent bone destruction. Cite this article: Bone Jt Open 2022;3(1):77–84

Introduction. Although surgical remedies tend to be the long-term solutions for patients with osteoarthritis (OA), many alternatives exist that offer the potential to slow progression, alleviate pain, and/or restore function. One such option is the unloader OA knee brace. The objective of this study was to assess the in vivo medial joint space narrowing with and without the brace during weight-bearing portion of gait. Methods. Twenty subjects were evaluated after being clinically assessed by a single surgeon to be bone-on-bone on the medial side. In vivo gait kinematics were collected using a validated 3D-to-2D fluoroscopic registration technique (Figure 1). Subjects were asked to first walk on a treadmill without a brace (Figure 2), and then, after a qualified technician fit a properly sized brace to each subject, they were asked to walk again (Figure 3). In vivo fluoroscopic images were captured and registered at heel-strike (HS) and mid stance (MS) for both scenarios. CT scans were used to acquire the patient-specific bone models that were used in the registration process. Results. All twenty subjects experienced a positive increase in medial joint space and verbally stated their knee pain lessened while wearing the brace. The average medial joint space change was 1.7±0.8 mm (3.1 max, 0.3 min) at HS and 1.6±0.8 mm (3.7 max, 0.4 min) at MS (Figure 4). Five patients experienced more than 2.5 mm of medial joint space change when wearing the unloader brace, indicating substantial effectiveness of the brace. Conclusion. While previous unloader brace studies have focused on outcome scores and patient satisfaction to analyze brace effectiveness, this study quantifiably demonstrated improvement in joint space narrowing due to the unloader brace. These results suggest that unloader braces may provide benefit in the interim when symptoms of OA are present prior to need for surgical intervention. For any figures or tables, please contact the authors directly

We investigated the association between the radiological findings and the symptoms arising from the patellofemoral joint in advanced osteoarthritis (OA) of the knee. Four radiological features, joint space narrowing, osteophyte formation, translation of the patella and focal attrition were assessed in 151 consecutive osteoarthritic knees in 107 patients undergoing total knee replacement. The symptoms which were assessed included anterior knee pain which was scored, the ability to rise from a chair and climb stairs, and quadriceps weakness. Among the radiological features, only patellar translation and obliteration of the joint space had a statistically significant association with anterior knee pain (odds ratio (OR) 4.85; 95% confidence interval (CI) 1.83 to 12.88 and OR 11.23; 95% CI 2.44 to 51.62) respectively. Patellar translation had a statistically significant association with difficulty in rising from a chair (OR 9.06; 95% CI 1.75 to 45.11). Other radiological features, including osteophytes, joint space narrowing, and focal attrition had no significant association. Our study indicates that the radiological findings of patellar translation and significant loss of cartilage are predictive of patellofemoral symptoms and functional limitation in advanced OA of the knee

Aims. Rotational acetabular osteotomy (RAO) has been reported to be effective in improving symptoms and preventing osteoarthritis (OA) progression in patients with mild to severe develomental dysplasia of the hip (DDH). However, some patients develop secondary OA even when the preoperative joint space is normal; determining who will progress to OA is difficult. We evaluated whether the preoperative cartilage condition may predict OA progression following surgery using T2 mapping MRI. Methods. We reviewed 61 hips with early-stage OA in 61 patients who underwent RAO for DDH. They underwent preoperative and five-year postoperative radiological analysis of the hip. Those with a joint space narrowing of more than 1 mm were considered to have 'OA progression'. Preoperative assessment of articular cartilage was also performed using 3T MRI with the T2 mapping technique. The region of interest was defined as the weightbearing portion of the acetabulum and femoral head. Results. There were 16 patients with postoperative OA progression. The T2 values of the centre to the anterolateral region of the acetabulum and femoral head in the OA progression cases were significantly higher than those in patients without OA progression. The preoperative T2 values in those regions were positively correlated with the narrowed joint space width. The receiver operating characteristic analysis revealed that the T2 value of the central portion in the acetabulum provided excellent discrimination, with OA progression patients having an area under the curve of 0.858. Furthermore, logistic regression analysis showed T2 values of the centre to the acetabulum’s anterolateral portion as independent predictors of subsequent OA progression (p < 0.001). Conclusion. This was the first study to evaluate the relationship between intra-articular degeneration using T2 mapping MRI and postoperative OA progression. Our findings suggest that preoperative T2 values of the hip can be better prognostic factors for OA progression than radiological measures following RAO. Cite this article: Bone Joint J 2021;103-B(9):1472–1478

Sequelae of Legg-Calve -Perthes disease (LCPD) and treatment of developmental dysplasia of the hip (DDH) can present a coxa breva or coxa magna deformity, sometimes associated with coxa vara. This unique deformity decreases the efficiency of the abductor mechanism, causing a Trendelenburg gait and hip pain, leg length discrepancy and leads to intra- and extra-articular impingement, and eventually osteoarthritis. Several surgical techniques have been advocated to treat this kind deformity, such as great trochanter transfer, relative femoral neck lengthening. We evaluated primary results of true femoral neck-lengthening osteotomy (TFNLO) in combination with periacetabular osteotomy (PAO) for treatment of Coxa Breva through surgical hip dislocation (SHD). Fourteen patients with Coxa Breva received true femoral neck lengthening osteotomy in combination of PAO through SHD between March 2020 and October 2023. Ten patients with minimum 1 year followed-up were retrospectively reviewed clinically and radiographically. Eight patients had Perthes disease, 2 had DDH received closed reduction and fixation during childhood. The mean age at surgery was 16 years (range, 12 to 31 years). Clinical findings, radiographic analyses including the change in horizontal femoral offset and the leg length discrepancy as well as complications were assessed. Horizontal femoral offset improved 19.5mm(6–28mm). Limb length increase 16.8mm(11–30mm). Mean HHS increased from 80.6(66–91) to 91.8(88–96). Complication: screw broken in 1(no need operation). Asymptomatic fibrous union of the great trochanter was found in 1. No infection and joint space narrow as well as nerve palsy happened. TFNLO combined with PAO can be effective for the treatment of patients with Coxa breva. But long term follow up is warranted

We report on a minimum 5-year follow-up (mean 7 years) of 28 patients who underwent arthroscopically assisted ACL reconstruction using a patellar tendon graft. Knee function was assessed using Lysholm and Tegner scores and AP translation of the tibia was measured using a Stryker Laxity Tester, comparing the symptomatic with the normal knee. All measurements were made preoperatively and at the latest follow-up. In addition, all patients had standardised weight-bearing radiographs of the knee to assess joint space narrowing using the IKDC radiographic grading. The mean preoperative Lysholm score of 71 (range 46–95) improved to 88 (range 57–100) at follow-up. The mean Tegner Activity score increased from 4.1 (range 1–6) to 7.2 (range 5–10). Preoperatively 17 patients had increased tibial translation of more than 5mm, 9 had 3–5mm and 2 had less than 3mm. At follow-up, 22 knees had less than 3mm tibial translation and 6 had 3–5mm. No patients had more than 5mm of tibial translation compared to the opposite knee. The IKDC radiographic grading of joint space narrowing revealed 14 patients with no narrowing, 11 with a joint space of more than 4mm and knees with a joint space of 2–4mm. Joint space narrowing was seen in patients who had partial or total meniscectomy before or at the time of ACL reconstruction. These results indicate that the satisfactory outcome of ACL reconstruction using contemporary methods is maintained beyond 5 years. However, the 50% incidence of joint space narrowing associated with previous meniscectomy is a cause for concern

Scaphoid fractures are a common injury accounting for more than 58% of all carpal bone fractures(1,2). Biomechanical studies have suggested that scaphoid mal-union may lead to altered carpal contact mechanics causing decreased motion, pain and arthritis(1,2). The severity of mal-union required to cause deleterious effects has yet to be established. This limits the ability to define surgical indications or impacts on prevention of posttraumatic arthritis. Computed tomography has been shown to be a useful in determining the 3D implications of altered bony alignment on the joint contact mechanics of surrounding joints. The objective of this study was to report mid-term follow-up image-based outcomes of patients with scaphoid mal-unions to determine the extent to which arthritic changes and decreased joint space is present after a minimum of 4 years following fracture. Participants (n=14) who had previously presented with a mal-united scaphoid fracture (indicated by a Height:Length Ratio >0.6) between November 2005 and November 2013 were identified and contacted. A short-arm thumb spica case was used to treat X patients and X required surgical management. Baseline and follow-up CT images, were performed with the wrist in radial deviation and positioned such that the long axis of the scaphoid was perpendicular to the axis of the scanner. Three-dimensional inter-bone distance (joint space), a measure of joint congruency and 3D alignment, was quantified from reconstructed CT bone models of the distal radius, scaphoid, lunate, capitate, trapezium and trapezoid from both the baseline and follow-up scans(3). Repeated measures ANOVA was used to detect differences in contact area (mm2) between baseline and follow-up CT's for the radioscaphoid, scaphocapitate and scaphotrapezium-trapezoid joint. The average age of participants was 43.1 years (16–64 years old). There was significant loss of joint space, indicated by a greater joint contact area 3–4 years post fracture, between baseline and follow-up reconstruction models, at the scaphocapitate (mean difference: 21.5±146mm2, p=0.007) and scaphotrapezoid joints (mean difference: 18.4 ±28.6mm2, 0.042). Significant differences in the measured contact area was not found for the radioscaphoid (0.153) and scaphotrapezium joints (0.72). Additionally, the scaphoid, qualitatively, appears to track in the vorsal direction in the majority of patients following fracture. Increased joint contact area in the scaphocapitate and scaphotrapezoid joint 3–4 years following fracture results from decreased 3D joint space and overall narrowing. Joint space narrowing, while not significantly different for all joints examined, was reduced for all joints surrounding the scaphoid. Decreased joint space and increased contact area detectable within this short interval might be suggestive of a trajectory for developing arthritis in the longer term, and illustrates the potential value of these measures for early detection. Longer term follow-up and correlation to clinical outcomes are needed to determine the importance of early joint space narrowing, and to identify those most at risk

Knee joint distraction (KJD) has been associated with clinical and structural improvement and synovial fluid (SF) marker changes. However, structural changes have not yet been shown satisfactorily in regular care, since radiographic acquisition was not fully standardized. AI-based modules have shown great potential to reduce reading time, increase inter-reader agreement and therefore function as a tool for treatment outcome assessment. The objective was to analyse structural changes after KJD in patients using this AI-based measurement method, and relate these changes to clinical outcome and SF markers. 20 knee OA patients (<65 years old) were included in this study. KJD treatment was performed using an external fixation device, providing 5 mm distraction for 6 weeks. SF was aspirated before, during and immediately after treatment. Weight-bearing antero-posterior knee radiographs and WOMAC questionnaires were collected before and ~one year after treatment. Radiographs were analysed with the Knee Osteoarthritis Labelling Assistant (KOALA, IB Lab GmbH, Vienna, Austria), and 10 pre-defined biomarker levels in SF were measured by immunoassay. Radiographic one-year changes were analysed and linear regression was used to calculate associations between changes in standardized joint space width (JSW) and WOMAC, and changes in JSW and SF markers. After treatment, radiographs showed an improvement in Kellgren-Lawrence grade in 7 of 16 patients that could be evaluated; 3 showed a worsening. Joint space narrowing scores and continuous JSW measures improved especially medially. A greater improvement in JSW was significantly associated with a greater improvement in WOMAC pain (β=0.64;p=0.020). A greater increase in MCP1 (β=0.67;p=0.033) and lower increase in TGFβ1 (β=-0.787;p=0.007) were associated with JSW improvement. Despite the small number of patients, also in regular care KJD treatment shows joint repair as measured automatically on radiographs, significantly associated with certain SF marker change and even with clinical outcome

There is some evidence to suggest that outcomes of THA in patients with minimal radiographic osteoarthritis may not be associated with predictable outcomes. The aim of this study was to:. Assess the outcome of patients with hip pain who underwent THA with no or minimal radiographic signs of osteoarthritis,. Identify patient comorbidities and multiplanar imaging findings which are predictive of outcome,. Compare the outcome in these patients to the expected outcome of THA in hip OA. A retrospective review of 107 hips (102 patients, 90F:12M, median age 40.6, IQR 35.1–45.8 years, range 18–73) were included for analysis. Plain radiographs were evaluated using the Tonnis grading scale of hip OA. Outcome measures were all-cause revision; iHOT12; EQ-5D; Oxford Hip Score; UCLA Activity Scale; and whether THA had resulted in the patient's hip pain and function being Better/Same/Worse. The median Oxford Hip Score was 33.3 (IQR 13.9, range 13–48), and 36/107 (33.6%) hips achieved an OHS≥42. There was no association between primary hip diagnosis and post-operative PROMs. A total of 91 of the 102 patients (89.2%, 93 hips) reported that their hip pain and function was Better than prior to THA and would have the surgery again, 7 patients (6.8%, 10 hips) felt the Same, and 4 patients (3.9%, 4 hips) felt Worse and would not have the surgery again. Younger patients undergoing total hip arthroplasty with no or minimal radiographic osteoarthritis had lower postoperative Oxford Hip Scores than the general population; though most felt symptomatically better and knowing what they know now, would have surgery again. Those with chronic pain syndrome or hypermobility were likely to benefit less. Those with subchondral cysts or joint space narrowing on CT imaging were more likely to achieve higher functional scores and satisfaction

There is a surge of patients on the waiting-list for primary total hip replacement (THR), due to unprecedented reduction of elective activity caused by COVID-19. A higher incidence of femoral head collapse (FC) and acetabular erosion (AE) leading to increase in pain and instability as well as requirement of more complex surgery and potentially higher risk to patients was noted in this period. Rapidly progressive Arthritis (RPA) of the hip is a known entity often described as progression of joint space narrowing greater than 2mm over one year time period. The study aims to identify any potential relationship between waiting time and establishment of femoral head collapse and/ or acetabular erosion. A retrospective review of arthroplasty surgeon's waiting list during COVID. Serial hip radiographs recorded between February 2020 and February 2022 were analysed. FC was quantified as a percentage of the femoral head radius, while AE was assessed by drawing two parallel lines, one through both tear drops and the other through superior most aspect of intact acetabulum, parallel to the inter tear-drop line and expressed as percentage of normal side. Only 105 patients out of 264 patients added to the waiting list had elective arthroplasty for hip/knee. Only 35 patients out of 90 listed for THR, had the surgery. 36 of 90 (40%) were found to have developed FC and fitted the criteria for RPA. Acetabular erosion was seen in 19 (21%). Therefore 53% (19 of 36) of those who developed FC progressed to AE. Incidence of collapse was higher in females (32%), with mean age of 62 (range 51–81), compared to 21% in males with mean age 59 (range 53–87). Mean extent of femoral head collapse was 20% (10 – 44%). A significant proportion of patients added to waiting list during COVID developed RPA of the hip with 40% having femoral head collapse and 21% progressing to acetabular erosion leading to a complex case-mix. Patients on long waiting lists need regular x-ray checks/PROMS since significant proportion progress to FC and Acetabular Erosion

We retrospectively reviewed eight children with idiopathic chondrolysis (IC) of the hip and nine with atrophic tuberculosis (TB) of the hip treated over the 10 years 1990 to 1999. Both conditions present with a stiff hip and radiographic joint space narrowing. Our aim was to delineate clinical, radiological and histological differences between the two conditions, thereby obviating the need for biopsy in IC, which could worsen the prognosis. In the IC group all patients were girls. Their mean age was 12 years (11.5 to 13). They presented with a flexion abduction and external rotation deformity of the hip. Chest radiographs were normal in all patients, and all except one had an ESR below 20. The Mantoux was negative in six of the eight. Radiographs showed joint space narrowing and osteopoenia, but the subchondral bony line remained present. Four of the eight had a synovial biopsy, which showed non-specific chronic synovitis. The cartilage looked pale and lustreless. In one hip the cartilage was biopsied and showed cartilage necrosis. In the TB group, five of the nine patients were boys. The mean age was 7 years (5 to 13.5). The only constant hip deformity was flexion. Chest radiographs were normal in all patients. In all patients the ESR was below 20 and the Mantoux was positive. Hip radiographs showed osteopoenia with loss of the subchondral bony line. Peri-articular lytic lesions were present in all patients except one. Histology of synovial biopsy showed caseous necrosis in all hips, and seven of the nine had a positive culture for TB. Macroscopically the cartilage looked normal, and in one hip the cartilage biopsy was histologically normal. We confirmed that in IC the joint space narrowing is due to cartilage necrosis. We postulate that in atrophic TB the loss of subchondral bone due to subchondral erosion gives the impression of joint space narrowing. We also concluded that IC was a diagnoses per se and not by exclusion, and that biopsy was not required

Introduction. Hip Osteoarthritis (HOA) is a highly heterogeneous disease with potentially different genetic aetiologies. Thus far, few genetic variants have been robustly associated with broad definitions of HOA. We aimed to identify novel HOA susceptibility variants by examining a set of more homogeneous, radiographically-derived endophenotypes relating to anatomic pattern of joint involvement and bone remodelling response in HOA. Materials, Methods and Results. Individuals with HOA and AP-hip radiographs (n=2,109) were selected from the arcOGEN study, genotyped on 2 platforms. The most arthritic hip per patient was categorised using Bombelli's classification (atrophic/normotrophic/hypertrophic), and for pattern of joint space narrowing (superior/medial-axial/concentric). Following 1000-Genomes-Project-based imputation and stringent quality control over 7 million variants were tested for association with each phenotype under the additive model. Fixed-effects meta-analysis was used to combine the results from the two GWA studies. In the discovery GWAS of atrophic HOA vs cases with non-atrophic HOA a strong signal (rs16869403, OR[95% CI]=2.47[1.81–3.38], p=1.53×10. −8. ) was detected in the G protein-coupled receptor, GPR98. Polymorphisms in GPR98 have been associated with osteoporotic fracture and low bone mineral density and GPR98 knockout mice have a low bone mass phenotype. The meta-analysis of medial joint space narrowing showed strong association with variants in LRCH1 (rs754106, OR[95% CI]=1.46[1.26–1.68], P=2.85×10. −7. ) previously associated with OA but with conflicting replication evidence, and BMP1 (chr8:22065846, OR[95% CI]=3.36[2.12–5.33], P=2.6×10. −7. ) which induces bone and cartilage development. None of these variants showed significant evidence for association when broadly classified HOA cases were compared to population-based controls from the arcOGEN GWAS. Conclusion. Through comprehensive examination of radiographically-derived, HOA-related phenotypes we have identified several promising signals that point to novel biologically plausible genes for HOA. Our results indicate that, in a heterogeneous disease like OA the study of narrower phenotype definitions closer to the biology of the disease has the potential to enhance power to detect OA-relevant associations

Purpose. The outcome of idiopathic chondrolysis in South Africa has been reported as a progressive downhill course resulting in a painful, stiff hip (Jones 1971, Sparks&Dall 1982). The cause of the disease remains unknown. Theories suggested are mechanical (decreased movement with loss of synovial nutrition; increased joint pressure) and an auto-immune response in genetically predisposed individuals. Our experience with continuous passive motion (CPM) and anti-inflammatory treatment has been disappointing. Method. In order to improve our understanding of the disease and our results, we prospectively studied 5 consecutive patients. All the patients had a subtotal capsulectomy (Roy&Crawford 1988) to relieve intra-articular pressure and correction of the flexion and abduction deformities. Post-operative treatment was with anti-inflammatories and CPM. Results. The patients were adolescent females between 10 and 12.5 years old. They presented with stiff, painful hips with flexion, abduction and external rotation deformities. They had normal auto-immune markers. Radiographs revealed osteopenia and joint space narrowing. CT confirmed osteopenia and joint space narrowing. Three patients had subchondral erosions (two on either side of the joint and one on the acetabular side only). MRI showed bone oedema and confirmed the erosions. Histology of the synovium showed non-specific chronic inflammation with lymphocyte and plasma cell infiltration suggesting an auto-immune cause. Histology of the cartilage showed a superficial layer of fibrous tissue, then a layer of degenerate chondrocytes, with normal chondrocytes in the deep layer. Post-operatively patients had improved range of motion. At mean follow up of 7.8 months the patients had a repeat MRI to assess cartilage regeneration. NO DISCLOSURES

The long term outcome of open debridement for the treatment of anterior impingement in the ankle in 27 patients was assessed. Using pre-operative radiographs, patients were grouped according to both the McDermott and the van Dijk scoring systems for anterior impingement. The accuracy of these classifications in predicting outcome was assessed. Clinical outcome was evaluated using the Ogilvie-Harris scoring system, a visual analogue of patient satisfaction, time to return to full activities, and the ability to return to sports at the pre-morbid level. Follow-up radiographs were used to assess the recurrence of osteophytes. The incidence of talar osteochondral lesions at surgery was assessed. At a mean follow-up of 7.3 years, 23 of 25 (92%) patients without joint space narrowing had a good or excellent result. Improvement in the Oglivie-Harris score was seen in all patients. In athletes, 19 of 24 (79%) were able to return to sports at the pre-morbid level. Two patients with pre-operative joint space narrowing had poor results. Recurrence of osteophytes was the norm and most patients did not feel their range of dorsiflexion ever returned to normal, but symptomatic relief enabled most patients to return to high level sport. Our results for non-arthritic joints suggest that this is a safe and successful procedure

Background. Unicompartmental knee arthroplasty (UKA) patients with knee partial thickness cartilage loss have inferior functional performance compared to those with full thickness loss. Therefore, the aim of the present study was to investigate on the association between postoperative patients' joint awareness and satisfaction and preoperative radiographic osteoarthritis (OA) Ahlbäck grade in subjects undergoing robotic arm-assisted UKA. Methods. This retrospective observational study includes 675 patients (681 knees) undergoing robotic arm-assisted UKA at two centres between January 2014 and May 2019. Pre-operatively, knee radiographs were performed, and Ahlbäck OA grade was measured by two independent observers. Post-operatively, patients were administered the Forgotten-Joint-Score-12 (FJS-12) and 5-Level-Likert-Scale to assess joint awareness and satisfaction. Postoperative complications and revisions were recorded. Correlations were described between FJS-12, satisfaction and OA grade by means of an adjusted multivariate statistical analysis. Results. A total of 574 patients (580 UKAs) were assessed at a mean follow-up of 3.6 years post-operatively (85.2% follow-up rate; min. 12, max. 75 months). Nine UKAs were revised. Primary or secondary medial knee OA was the preoperative diagnosis in 538 cases, osteonecrosis was present in 42 cases. Cases were divided based on their preoperative Ahlbäck grade in Group A (joint space narrowing, Ahlbäck 1, 279 cases), Group B (joint space obliteration or minor bone attrition, Ahlbäck 2 and 3, 197 cases) and Group C (moderate or severe bone attrition, Ahlbäck 4 and 5, 104 cases). Moderate to severe OA grades (Group B and C) were associated with higher probability of higher postoperative FJS-12 compared to joint space narrowing group (Odds Ratio 1.6 and 1.7, respectively, p<0.05). No associations were described between OA grade and patients' satisfaction. Conclusions. Patients with preoperative joint space obliteration and minor to severe bone attrition have higher probability of a having a forgotten joint after robotic arm-assisted UKA, compared to those without full cartilage thickness loss