Aims. To investigate whether
Aims. The prevalence of scoliosis is not known in patients with
Aims. This study aims to define a set of core outcomes (COS) to allow consistent reporting in order to compare results and assist in treatment decisions for
Aims. The aim of this study was to gain a consensus for best practice of the assessment and management of children with
Aims. The aim of this study was to gain an agreement on the management of
Specific brace-fitting complications in
Introduction. Pes cavovarus is a foot deformity that can be
The Ponseti method is the gold standard treatment for clubfoot. It begins in early infancy with weekly serial casting for up to 3 months. Globally, a commonly reported barrier to accessing clubfoot treatment is increased distance patients must travel for intervention. This study aims to evaluate the impact of the distance traveled by families to the hospital on the treatment course and outcomes for
The aim of this study is to clarify the implication of ciliary pathway on the onset of the spinal curvature that occurs in Adolescent
The pathophysiological basis of alterations in trabecular bone of patients with osteonecrosis of the femoral head (ONFH) remains unclear. ONFH has classically been considered a vascular disease with secondary changes in the subchondral bone. However, there is increasing evidence suggesting that ONFH could be a bone disease, since alterations in the functionality of bone tissue distant from the necrotic lesion have been observed. We comparatively studied the transcriptomic profile of trabecular bone obtained from the intertrochanteric region of patients with ONFH without an obvious aetiological factor, and patients with osteoarthritis (OA) undergoing total hip replacement in our Institution. To explore the biological processes that could be affected by ONFH, we compared the transcriptomic profile of trabecular bone from the intertrochanteric region and the femoral head of patients affected by this condition. Differential gene expression was studied using an Affymetrix microarray platform. Transcriptome analysis showed a differential signature in trabecular bone from the intertrochanteric region between patients with ONFH and those with OA. The gene ontology analyses of the genes overexpressed in bone tissue of patients with ONFH revealed a range of enriched biological processes related to cell adhesion and migration and angiogenesis. In contrast, most downregulated transcripts were involved in cell division. Trabecular bone in the intertrochanteric region and in the femoral head also exhibited a differential expression profile. Among the genes differentially expressed, we highlighted those related with cytokine production and immune response. This study identified a set of differently expressed genes in trabecular bone of patients with
Aims. The study was undertaken to compare the efficacy of Woodcast splints and plaster-of-Paris casts in maintaining correction following sequential manipulation of
Aims. To identify the minimum set of outcomes that should be collected in clinical practice and reported in research related to the care of children with
Ponseti method has become the most common and validated initial non-operative and/or minimally invasive treatment modality of
Aims. There is a lack of high-quality research investigating outcomes of Ponseti-treated
There is a need for non-radiographic, objective outcome measures for children with Adolescent
There is a significant positive association between hours of brace wear and rate of success in the treatment of Adolescent
Introduction. Traditionally correction of
Aims. To analyze outcomes reported in studies of Ponseti correction of
Previous studies have identified clinical and
demographic risk factors for recurrence in the treatment of