There are a number of periprosthetic femoral fracture (PFF) fixation failures. In several cases the effect of fracture configuration on the performance of the chosen fixation method has been underestimated. As a result, fracture movement within the window that seems to promote callus formation has not been achieved and fixations ultimately failed. This study tested the hypothesis that: PFF configuration and the choice of plate fixation method can be detrimental to healing. A series of computational models were developed, corroborated against measurements from a series of instrumented laboratory models and in vivo case studies. The models were used to investigate the fixation of different fracture configurations and plate fixation parameters. Surface strain and fracture movement were compared between the constructs. A strong correlation between the computational and experimental models was found. Computational models showed that unstable fracture configurations increase the stress on the plate fixation. It was found that bridging length plays a pivotal role in the fracture movement. Rigid fixations, where there is clinical evidence of failure, showed low fracture movement in the models (<0.05mm); this could be increased with different screw and plate configurations to promote healing. In summary our results highlighted the role of fracture configuration in PFF fixations and showed that rigid fixations that suppress fracture movement could be detrimental to healing