The rate of homologous blood transfusion (HBT) following primary total hip replacement (THR) can be as high as 30–40% and is not without risk. Postoperative blood salvage (POS) with autologous blood transfusion may minimize the necessity for HBT but the clinical, haematological and economic benefits have yet to be clearly demonstrated for primary THR. The aim of this randomized prospective study was, therefore, to determine if the use of post-operative salvage affects post-operative haemoglobin and haematocrit values and reduces the rate of homologous blood transfusion. Secondary outcome measures included length of hospital stay and patient satisfaction. A cost analysis was also conducted on the basis of the results obtained. The patients were randomized during the operation (at the point of reduction of the primary THR) to receive either two Medinorm vacuum drains or the autologous retransfusion system. A power calculation estimated that 72 patients would be required in each group to detect a significant difference of 0.7 gdL-1 in post operative haemoglobin level (at 80% power with an value of 0.05). This assumed a standard deviation of 1.5 gdL-1 obtained from a previous retrospective study. There were 82 patients in the Medinorm vacuum drain group and 76 patients in the autologous retransfusion group. In the group with the autologous system, 76% of the patients were retransfused with a mean of 252mls. There was no significant difference between the groups when comparing haemoglobin and haematocrit values. However, significantly fewer patients in the group with the autologous system had a postoperative haemoglobin value less than 9.0 gdL-1 (8% vs. 20%, p = 0.035). Furthermore, significantly fewer patients with the autologous retransfusion system required a transfusion of homologous blood (8% vs. 21%, p = 0.022). There was a small overall cost saving in this group. This study has shown that use of an autologous retransfusion system for primary THR reduces the necessity for HBT and is cost effective. POS also results in significantly fewer patients dropping their post-operative haemoglobin level below 9.0 gdL-1. As a result our unit routinely uses the autologous retransfusion system for primary THR

Clinical, haematological or economic benefits of post-operative blood salvage with autologous blood re-transfusion have yet to be clearly demonstrated for primary total hip replacement. We performed a prospective randomised study to analyse differences in postoperative haemoglobin levels and homologous blood requirements in two groups of patients undergoing primary total hip replacement. A series of 158 patients was studied. In one group two vacuum drains were used and in the other the ABTrans autologous retransfusion system. A total of 58 patients (76%) in the re-transfusion group received autologous blood. There was no significant difference in the mean post-operative haemoglobin levels in the two groups. There were, however, significantly fewer patients with post-operative haemoglobin values less than 9.0 g/dl and significantly fewer patients who required transfusion of homologous blood in the re-transfusion group. There was also a small overall cost saving in this group

We undertook a prospective randomised controlled trial to investigate the efficacy of autologous retransfusion drains in reducing the need for allogenic blood requirement after unilateral total knee replacement. We also monitored the incidence of post-operative complications. There were 86 patients in the control group, receiving standard care with a vacuum drain, and 92 who received an autologous drain and were retransfused postoperatively. Following serial haemoglobin measurements at 24, 48 and 72 hours, we found no difference in the need for allogenic blood between the two groups (control group 15.1%, retransfusion group 13% (p = 0.439)). The incidence of post-operative complications, such as wound infection, deep-vein thrombosis and chest infection, was also comparable between the groups. There were no adverse reactions associated with the retransfusion of autologous blood. Based on this study, the cost-effectiveness and continued use of autologous drains in total knee replacement should be questioned

We studied the use of autologous pre-donated blood transfusion in surgery for scoliosis in 45 patients who were divided into two groups; 27 who pre-donated autologous blood (group 1) and 18 who were planned recipients of allogenic blood (group 2). Normovolaemic haemodilution and intra-operative blood salvage was used in six patients in group 1 and three patients in group 2. The two groups did not differ significantly with respect to age, American Society of Anaesthesiologists score, mean operative time, number of vertebral segments fused, total blood loss, length of stay in intensive care and length of stay in hospital. The risk of requiring allogenic blood transfusion was found to be significantly less in group 1 (7.4% ν 88.9%, p < 0.001). Only 5.21% of autologous units were wasted. Although intra-operative blood salvage reduced the total blood loss in both groups, it did not affect the need for subsequent allogenic transfusion or reduce the number of pre-donated autologous units which were given (p < 0.67). Autologous blood transfusion required extra time, personnel, resources and cost £28.88 per patient more than allogenic transfusion, however, the projected costs at May 2002 make this programme cost-effective by £51.54 per patient. Pre-donated autologous blood transfusion is acceptable and safe in scoliosis surgery. It significantly reduces the subsequent requirement of allogenic transfusion. Although the cost is currently more than allogenic transfusion, with the increase in the costs of the latter and the decrease in potential donors which is anticipated, pre-donation of autologous blood will become comparatively cost-effective

Introduction: The rate of homologous blood transfusion following primary total hip replacement (THR) can be as high as 30–40% and is not without risk. Postoperative blood salvage (POS) with autologous blood transfusion may minimize the necessity for HBT but the clinical, haematological and economic benefits have yet to be clearly demonstrated for primary THR. The aim of this prospective randomized study was to determine if the use of POS affects postoperative haemoglobin and haematocrit values and reduces the rate of homologous blood transfusion. Secondary outcomes measures included length of hospital stay and patient satisfaction. A cost analysis was conducted on the basis of the results. Methods: Calculations following a preliminary study revealed that 72 patients would be required in each group to detect a significant difference of 0.7 gdL. −1. in the post operative haemoglobin level (with power of 80% and an α value of 0.05). The patients were block randomized on reduction of the primary THR, prior to closure, to receive either two vacuum drains or the autologous retransfusion system. Results: There were 82 patients in the vacuum drain group and 76 patients in the autologous retransfusion group. Haemoglobin and haematocrit values were not significantly different between the groups but significantly fewer patients with the autologous system had a postoperative haemoglobin value < 9.0 gdL. −1. (8% vs. 20%, p = 0.035). Significantly fewer patients with the autologous system required HBT (8% vs. 21%, p = 0.022). There was an overall cost saving in this group. Discussion: This study confirms that POS results in significantly fewer patients with a post-operative Hb below 9.0 gdL. −1. and confirms that POS significantly reduces the necessity for homologous blood transfusion following primary THR. As a result, our unit uses the autologous retransfusion system for primary THR

Homologous blood transfusion (HBT) following primary total hip replacement (THR) is not without risk. Postoperative blood salvage (POS) with autologous blood transfusion may minimize the necessity for HBT but the clinical, haematological and economic benefits have yet to be clearly demonstrated for primary THR. The aim of this randomized prospective study was to determine if the use of POS affects postoperative haemoglobin levels, haematocrit and HBT requirement. Secondary outcomes included length of stay and patient satisfaction. A cost analysis was conducted on the basis of the results. The patients were randomized at the point of reduction of the primary THR to receive either two vacuum drains (82 patients) or an autologous retransfusion system (76 patients). Haemoglobin and haematocrit values were not significantly different between groups but significantly fewer patients with the autologous system had a postoperative haemoglobin value < 9.0 gdL. −1. (8% vs. 20%, p = 0.035). Significantly fewer patients with the autologous system required HBT (8% vs. 21%, p = 0.022). There was an overall cost saving in this group. This study has shown that use of an autologous retransfusion system for primary THR reduces the necessity for HBT and is cost effective

Intra-operative, peri-articular injection of local anaesthesia is an increasingly popular way of controlling pain following total knee replacement. At the same time, the problems associated with allogenic blood transfusion have led to interest in alternative methods for managing blood loss after total knee replacement, including the use of auto-transfusion of fluid from the patient’s surgical drain. It is safe to combine peri-articular infiltration with auto-transfusion from the drain. We performed a randomised clinical trial to compare the concentration of local anaesthetic in the blood and in the fluid collected in the knee drain in patients having either a peri-articular injection or a femoral nerve block. Clinically relevant concentrations of local anaesthetic were found in the fluid from the drains of patients having peri-articular injections (4.92 μg/ml (sd 3.151)). However, none of the patients having femoral nerve blockade had detectable levels. None of the patients in either group had clinically relevant concentrations of local anaesthetic in their blood after re-transfusion.

The evidence from this study suggests that it is safe to use peri-articular injection in combination with auto-transfusion of blood from peri-articular drains during knee replacement surgery.

There is currently no consensus about the mean volume of blood lost during spinal tumour surgery and surgery for metastatic spinal disease. We conducted a systematic review of papers published in the English language between 31 January 1992 and 31 January 2012. Only papers that clearly presented blood loss data in spinal surgery for metastatic disease were included. The random effects model was used to obtain the pooled estimate of mean blood loss.

We selected 18 papers, including six case series, ten retrospective reviews and two prospective studies. Altogether, there were 760 patients who had undergone spinal tumour surgery and surgery for metastatic spinal disease. The pooled estimate of peri-operative blood loss was 2180 ml (95% confidence interval 1805 to 2554) with catastrophic blood loss as high as 5000 ml, which is rare. Aside from two studies that reported large amounts of mean blood loss (> 5500 ml), the resulting funnel plot suggested an absence of publication bias. This was confirmed by Egger’s test, which did not show any small-study effects (p = 0.119). However, there was strong evidence of heterogeneity between studies (I² = 90%; p < 0.001).

Spinal surgery for metastatic disease is associated with significant blood loss and the possibility of catastrophic blood loss. There is a need to establish standardised methods of calculating and reporting this blood loss. Analysis should include assessment by area of the spine, primary pathology and nature of surgery so that the amount of blood loss can be predicted. Consideration should be given to autotransfusion in these patients.

Cite this article: Bone Joint J 2013;95-B:683–8.

The purpose of this paper is to present the results of the comparative study about the use of autologous transfusion system for drainage of surgical trauma after total knee arthroplasty, aiming to decrease the p.o. homologous blood transfusion need. During the period between Nov 2001 and Apr 2003 we studied 110 patients (80 women and 15 men, mean age 70,5 years) who underwent TKR. We used autologous transfusion system in 55 patients (group A) and for the rest 55 (group B) a plain negative pressure drainage system. From the group B patients, 35 (63,63%) were transfused with 2–4 blood units, while only 17 (30,9%) patients from group A had the need for homologous blood transfusion (2–5 units). But, we should mark that in 8 patients autologous transfusion system failed and 7 of them were transfused (2 units each). This means that from group A patients to whom autologous transfusion system was used successfully (47) only for 10 (21,27%) there was need for homologous blood transfusion. The autologous transfusion system gave 200–1650cc (mean 619cc) of blood. None of group A patients and 2 of group B had allergic reaction. In conclusion, the autologous transfusion system contributes to decreasing the homologous blood transfusion after TKR and in addition it decreases the transfusion’s complications

Background: Autologous blood from reinfusion drains are commonly used after major joint arthroplasties with a view to decrease the heterologous blood transfusion requirement. The aim of this study is to find the effect of reinfusion drains on the difference in haemoglobin (Hb) level before and after total knee arthroplasties. Material and Methods: Between January 2001 and October 2003, 158 patients had total knee arthroplasty on one side. The type of thromboprophylaxis used was the same in all the patients. 74 patients had autologous blood transfusion through reinfusion drains (Group I) while 84 patients had no autologous blood transfusion and ordinary suction drains were used to drain the wound in the immediate postoperative period (Group II). The mean age was 72.1 +/− 8.5 in group I and 69.3 +/− 9.1 in group II. In each patient the preoperative Hb level, the amount of autologous blood transfusion, the postoperative Hb level and the amount of heterologous bleed transfusion requirement were noted. Results: The mean preoperative Hb level was 13.6 +/− 1.4 g/dL (10.4–18.1) in group I and 13.7 +/− 1.3 g/dL (7.9–16.5) in group II. The mean postoperative Hb level was 10.7 +/− 1.5 g/dL (10.4–18.1) in group I and 10.7 + 1.6 g/dL (5.4 +/− 13.6) in group II. The difference in Hb level between the two groups was analysed using t-test and found to be not significant (p = 0.76), with the mean difference between the groups being 0.05 and the 95% CI to the mean difference includes zero (range −0.3 to +0.4). The difference in Hb level before and after surgery was plotted against the amount of autologous blood transfused and it was observed that there was no significant improvement with increased amount of autologous blood transfusion. The cost of reinfusion drain is 36.43 (~ 53.37 Euros) more than the suction drain. Conclusion: Autologous blood from reinfusion drains did not significantly improve the postoperative Hb level. Further usage of reinfusion drain is not cost-beneficial

We undertook a prospective, randomised study in order to evaluate the efficacy of clamping the drains after intra-articular injection of saline with 1:500 000 adrenaline compared with post-operative blood salvage in reducing blood loss in 212 total knee arthroplasties. The mean post-operative drained blood volume after drain clamping was 352.1 ml compared to 662.3 ml after blood salvage (p < 0.0001). Allogenic blood transfusion was needed in one patient in the drain group and for three in the blood salvage group. Drain clamping with intra-articular injection of saline with adrenaline is more effective than post-operative autologous blood transfusion in reducing blood loss during total knee arthroplasty

Autologous retransfusion and no-drainage are both blood-saving measures in total hip replacement (THR). A new combined intra- and post-operative autotransfusion filter system has been developed especially for primary THR, and we conducted a randomised controlled blinded study comparing this with no-drainage. A total of 204 THR patients were randomised to autologous blood transfusion (ABT) (n = 102) or no-drainage (n = 102). In the ABT group, a mean of 488 ml (. sd. 252) of blood was retransfused. The mean lowest post-operative haemoglobin level during the hospital stay was higher in the autotransfusion group (10.6 g/dl (7.8 to 13.9) vs 10.2 g/dl (7.5 to 13.3); p = 0.01). The mean haemoglobin levels for the ABT and no-drainage groups were not significantly different on the first day (11.3 g/dl (7.8 to 13.9) vs 11.0 g/dl (8.1 to 13.4); p = 0.07), the second day (11.1 g/dl (8.2 to 13.8) vs 10.8 g/dl (7.5 to 13.3); p = 0.09) or the third day (10.8 g/dl (8.0 to 13.0) vs 10.6 g/dl (7.5 to 14.1); p = 0.15). The mean total peri-operative net blood loss was 1464 ml (. sd. 505) in the ABT group and 1654 ml (. sd. 553) in the no-drainage group (p = 0.01). Homologous blood transfusions were needed in four patients (3.9%) in the ABT group and nine (8.8%) in the no-drainage group (p = 0.15). No statistically significant difference in adverse events was found between the groups. The use of a new intra- and post-operative autologous blood transfusion filter system results in less total blood loss and a smaller maximum decrease in haemoglobin levels than no-drainage following primary THR. Cite this article: Bone Joint J 2013;95-B:616–22

Purpose: The purpose of this study was to use the thromboelastogram to determine whether autologous blood transfusion following primary total knee replacement surgery results in an alteration to systemic coagulation. Methods: 44 patients were randomised to receive either Hartmann’s solution alone postoperatively (control group), or Hartmann’s solution and autologous blood at six hours (ABT group). Thromboelastogram measurements of systemic blood clotting were performed pre-operatively, and post operatively at 6h just prior to the commencement of the ABT, 6h 30mins, and 8h. Results: At 8h post operation (2h post ABT), the ABT group when compared with the control group showed an earlier onset of coagulation (3.83 minutes versus 4.49 minutes, p=0.003) and the formation of a stronger clot as assessed by the TEG maximum amplitude (maximum clot strength 83.9mm versus 75.9mm, p< 0.001). Conclusion: The transfusion of drained autologous blood following total knee replacement may lead to an exaggerated hypercoagulable postoperative state. Further investigation of this potentially serious consequence of autologous blood transfusion is required

Introduction: Elective joint replacement patients routinely require transfusion following surgery. Haemoglobin must remain within red blood cells in order to be functional. The process of surgery and collection in the reinfusion drain may disrupt cell membranes resulting in non functional haemoglobin. The filtration and collection process does not eliminate free haemoglobin. This results in intracellular and free haemoglobin being transfused into patients giving false functional haemoglobin levels. Aim: To determine the proportion of intracellular haemoglobin in autologous blood transfusion drain following joint replacement. Research Methodology: Research ethical approval was obtained prior to conducting this study. 20 consecutive patients undergoing elective total hip replacement (THR) and 20 consecutive patients undergoing elective knee replacement (TKR) from April 08–July 08 were consented to participate in this study. A standard full blood count sample of 3 mls was taken from the rein-fused blood. Each sample had the total haemoglobin (THb) concentration determined (i.e. free and intra-cellular) from the blood in the specimen tube. The sample was then centrifuged, and the THb of the supernatant was determined. This determined the concentation of ‘free’ haemoglobin. From these two respective values, the proportion of haemolysed haemoglobin was determined from each sample. Results: There were a total of 35 participants of which 20 were TKR and 15 were THR. The average THb concentration for the THR and TKR were 7.7g/dl and 10.3g/dl respectively. The proportion of haemolysed Hb was 1.46% and 0% respectively. The THb and proportion of haemolysed Hb for all 35 patients were 8.76g/dl and 0.63%. Conclusion: Autologous blood transfusion is not only safe and economical but remains an effective procedure with a negligible proportion of haemolysis

Introduction: Total knee replacement commonly results in postoperative requirement of blood transfusion. Allogeneic blood transfusion carries transfusion related risks, continuing effort to reduce allogeneic blood transfusion is important. The purpose of this study was to asses the economic justification of the use of an autologous blood transfusion after total knee replacement and to determine whether it reduces allogeneic blood transfusion and length of postoperative hospital stay. Patients and Methods: Retrospectively, 149 patients undergoing primary unilateral total knee replacement using vacuum drain were selected. Demographics, pre and postoperative haemoglobin were recorded. Need for allogeneic blood and postoperative hospital stay were also recorded. Results: 8% (n12) received allogeneic blood. The average amounts received were 2 units. Mean length of stay in those received allogeneic blood were (n12) 8.1 days. Mean length of hospital stay in those not transfused (n137) were 5.5 days (p< 0.05). The cost of allogeneic blood per patient £29.31. Total cost of retansfusion system per patients £60.8. Excess bed occupancy in those transfused £55.21. The cost saving for employing a retransfuion system (55.21+29.31)−60.8 = £24.44 per patient. Conclusion: Employing autologous retransfusion system is effective method of reducing allogeneic blood requirement. Retransfusion system will reduce in hospital stay to the level seen patients not transfused. There would be a significant economic benefit in utilising such system in district general hospitals

Introduction. Early rehabilitation and discharge following minimally-invasive total hip arthroplasty has potential risks including the possibility that patients may become progressively anemic at home. The current study assess the use of pre-emptive autologous blood transfusion on the length of stay, readmission, and allogenous transfusion. Methods. Patients treated by primary total hip arthroplasty using the superior capsulotomy technique were studied. Patients were divided into two groups. Group 1 were patients who did donate autologous blood and received an intra-operative pre-emptive transfusion. There were 283 patients in Group 1. Group 2 were patients who were medically capable of donating autologous blood but did not for non-medical reasons. There were 71 patients in Group 2. Patients who did not donate autologous blood for medical reasons (preoperative Hgb less than 11.5, age over 80) were excluded. All patients received general anesthesia. Length of stay, allogenous transfusion and readmission were compared. Results. The mean length of stay after surgery for the Group 1 patients who received autologous blood donation during primary THA was 1.56 days (SD 78 days, range 0–4). The mean length of stay for the Group 2 patients who did not donate or receive autologous blood during primary THA was 1.87 days (SD 84 days, range 1–4). Patients who received autologous blood donation had a significantly shorter post-surgical length of stay than patients who did not (p = .002, Mann-Whitney test). Patients who did not donate and preemptively receive autologous blood received significantly more allogenous blood (Mann-Whitney, p=.0004). Moreover 15% of those who auto-donated were given allogenic transfusions, while 37% of those who did not auto-donate were given allogeneic transfusions. One patient who did receive autologous transfusion and was discharged on day 2 sustained an NSAID induced GI-bleed 3 weeks postop and was admitted for transfusion and treatment. There were no other readmissions in either group. Conclusions. Patients who receive pre-emptive autologous blood transfusion intra-operatively when treated specifically by total hip arthroplasty using the superior capsulotomy technique under general anesthesia have shorter hospital stays and lower allogenous transfusion rates than a matched cohort of patients that did not donate and receive autogenous blood

Introduction: A prospective analysis of the total blood losses (TBL) and the rate of blood transfusions was conducted for the unilateral primary TKA performed at our clinic from January 2008 to March 2009. A transfusion-sparing strategy was used, based on the use of the tourniquet, the intraoperative injection of tranexamic acid and the preoperative administration of erythropoietin for patients with hemoglobin baseline level less than 13 gr/dl. The formula of Gross and the values of Gilcher were utilized to calculate TBL and to estimate the blood volume of the patient. No autologous blood transfusion systems were employed. The postoperative program consisted of pain control and anticoagulants. Results were compared with a historical cohort of patients operated on with the aid of cell salvage. Materials and Methods: One hundred – five patients (mean age, 73 years) were admitted to the study group and compared to an historic group including 44 patients (mean age, 70 years). No significant differences were found between the study arms regarding BMI (31 kg/m2), ASA score and operating time (65 minutes). Results: Mean TBL was 1560 ml versus 1821 ml in the historic group throughout the entire 8-day period. In the study group, TBL was significantly reduced in the patients who received tranexamic acid. In both groups, one patient received homologous blood transfusion. In the historic group, 41 of the 44 patients received autologous blood transfusion from reinfusion drains (mean volume 314 ml). Finally, the mean Hb at postoperative day 8 (POD 8) was 10,95 g/dl in the study group versus 10,35 gr/dl in the historic group (p< 0.01). Costs were superior in the study group in relation to the use of erythropoietin. No complications were related to the use of the blood –sparing pharmacologic agents. Discussion: This study confirms that recent improvements in surgical and anesthetic procedure allow for performing routine unilateral TKA with a marginal rate of blood transfusion when the procedure is achieved by an experienced team using a blood-conserving strategy. The strengths of this study include the calculation of blood loss and the homogeneity between the study arms. However the reduction of TBL related to the use of tranexamic acid was not evaluated within the setting of a randomized clinical trial. Furthermore, the results were obtained in patients having a high BMI. Conclusion: The blood transfusion sparing plan improved quality of care by reducing the risks of transfusion and maintaining a satisfactory Hb level at POD 8

Amin A, Watson A, Mangwani J, Nawabi DH, Ahluwalia R, Loeffler M. A prospective randomised controlled trial of autologous retransfusion in total knee replacement. Bone Joint J 2008;90-B:451–454

The entirety of the patient experience after contemporary total knee and total hip replacements in 2017 is markedly different from that encountered by patients just a decade ago. Ten years ago most patients were treated in a traditional sick-patient model of care and because they were assumed to require substantial hospital intervention, many cumbersome and costly interventions (e.g. indwelling urinary catheters, patient-controlled-analgesic pumps, autologous blood transfusion, continuous passive motion machines) were a routine part of the early post-operative experience. Today the paradigm has shifted to a well-patient model with a working assumption that once a patient has been medically optimised for surgery then the intervention itself, hip or knee replacement, will not typically create a sick-patient. Instead it is expected that most patients can be treated safely and more effectively with less intensive hospital intervention. While as orthopaedic surgeons we are enamored with the latest surgical techniques or interesting technologies most busy surgeons recognise that advances in peri-operative pain management, blood management, and early-mobilization therapy protocols account for the greatest share of improvements in patient experience over the past decade. One can think pragmatically to get ahead and stay ahead of 3 predictable physiologic disturbances that adversely impact rapid recovery after knee and hip replacement: fluid/blood loss; pain; and nausea. The modern orthopaedic surgeon and his/her care team needs a simple strategy to pro-actively, not reflexively, manage each of those 3 predictable impediments to early recovery. Those surgical teams that routinely get ahead and stay ahead in each of those areas will routinely witness faster recovery, lower costs and greater patient satisfaction and that is clearly a win for patient and surgeon alike. Effective pain management improves patient satisfaction, decreases hospital stay, and facilitates discharge to home. Today's emphasis is on a multi-modal strategy that minimises the use of opioids. Most protocols use pre-operative medications including an NSAID, acetaminophen, an oral opioid and some include gabapentin. Regional anesthesia is typically preferred over general. Both peripheral nerve blocks and periarticular local anesthetic cocktail injections have proved as effective adjuncts in decreasing early post-operative pain. Post-operative oral medications delivered on a schedule, not just as needed, often include acetaminophen, an NSAID and some include gabapentin. Oral and parenteral opioids are reserved for breakthrough pain