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Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_VIII | Pages 59 - 59
1 Mar 2012
SYNERGISTIC INTERACTION BETWEEN VEGF AND BMP- 6 ENHANCES BONE FORMATION MEDIATED BY A CLONED MOUSE BONE MARROW STEM CELL
Cui F Wang X Dighe A Balian G Cui Q
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Introduction

Enhanced angiogenesis and osteogenesis may provide new strategies for the treatment of osteonecrosis.

Methods

Synergistic effects of vascular endothelial growth factor (VEGF) and bone morphogenetic protein - 6 (BMP-6) on in vitro osteogenic differentiation and in vivo ectopic bone formation mediated by a cloned mouse bone marrow stromal cell line, D1, previously isolated from Balb/c mice in our laboratory, were determined.