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Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 573 - 573
1 Aug 2008
Church JS Scadden J Gupta R Cokis C Williams K Janes GC
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Systemic embolic phenomena are well recognised during total knee replacement (TKR) and are widely believed to be the cause of intra-operative hypotension and reduced cardiac output, which may lead to circulatory collapse and sudden death.

We undertook a prospective, double-blind, randomised study comparing the cardiac embolic load during computer-assisted and conventional (intramedullary-aligned) TKR, as measured by transoesophageal echocardiography. 26 consecutive procedures were performed by a single surgeon at a single site. Embolic load was scored using the modified Mayo grading system for echogenic emboli.

Patients undergoing conventional TKR (n=12) had a mean embolic score of 6.15 (SD 0.83) on release of the tourniquet. Those undergoing computer-assisted TKR (n=14) had a mean embolic score of 4.89 (SD 1.10). Comparison of the groups using a two-tailed t-test confirmed a highly significant reduction (p=0.004) in embolic load when performing computer-assisted TKR. The groups were otherwise well matched and there were no complications.

In conclusion, this study demonstrates that computer-assisted TKR results in the release of significantly fewer systemic emboli than conventional TKR using intra-medullary alignment. There is evidence that this should reduce perioperative morbidity and neurological dysfunction. This would appear to add to the ever-growing list of arguments in favour of computer-assisted total knee replacement.


The Journal of Bone & Joint Surgery British Volume
Vol. 89-B, Issue 4 | Pages 481 - 485
1 Apr 2007
Church JS Scadden JE Gupta RR Cokis C Williams KA Janes GC

Systemic emboli released during total knee replacement have been implicated as a cause of peri-operative morbidity and neurological dysfunction. We undertook a prospective, double-blind, randomised study to compare the cardiac embolic load sustained during computer-assisted and conventional, intramedullary-aligned, total knee replacement, as measured by transoesophageal echocardiography. There were 26 consecutive procedures performed by a single surgeon at a single hospital. The embolic load was scored using the modified Mayo grading system for echogenic emboli.

Fourteen patients undergoing computer-assisted total knee replacement had a mean embolic score of 4.89 (3 to 7) and 12 undergoing conventional total knee replacement had a mean embolic score of 6.15 (4 to 8) on release of the tourniquet. Comparison of the groups using a two-tailed t-test confirmed a highly significant difference (p = 0.004).

This study demonstrates that computer-assisted knee replacement results in the release of significantly fewer systemic emboli than the conventional procedure using intramedullary alignment.


The Journal of Bone & Joint Surgery British Volume
Vol. 88-B, Issue 5 | Pages 673 - 675
1 May 2006
Church JS Breidahl WH Janes GC

We describe a case of highly refractory synovial chondromatosis, which recurred despite four arthroscopic synovectomies, a chemical synovectomy, two open synovectomies and an arthrodesis. A review of the literature revealed one similar case. Both presented with marked joint stiffness suggesting a poor prognosis. Although arthrodesis may relieve short-term symptoms it does not prevent further recurrence of disease.