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Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_6 | Pages 71 - 71
1 Jul 2020
Mahaffy M Athwal G Johnson J Knowles N Berkmortel C Abdic S Walch G
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This study examined the regional variations of cortical and cancellous bone density present in superiorly eroded glenoids. It is hypothesized that eroded regions will contain denser bone in response to localized stress. The shift in natural joint articulation may also cause bone resorption in areas opposite the erosion site.

Clinical CT scans were obtained for 32 shoulders (10m/22f, mean age 72.9yrs, 56–88yrs) classified as having E2-type glenoid erosion. The glenoid was divided into four measurement regions - anterior, inferior, posterior, and superior - as well as five depth regions. Depth regions were segmented in two-millimeter increments from zero to 10 millimeters, beginning at the center of the glenoid surface. A repeated-measures multiple analysis of variance (RM-MANOVA) was performed using SPSS statistical software to look for differences and interactions between mean densities in each depth, quadrant, and between genders. A second RM-MANOVA was performed to examine effects of gender and quadrant on cortical to cancellous bone volume ratios. Significance was set at p < 0 .05.

Quadrant and depth variables showed significant multivariate main effects (p 0.147 respectively). Quadrant, depth, and their interaction showed significant univariate main effects for cortical bone (p≤0.001) and cancellous bone (p < 0 .001). The lowest bone density was found to be in the inferior quadrant for cancellous bone (307±50 HU, p < 0 .001). The superior quadrant contained the highest mean density for cortical bone (895±97 HU), however it was only significantly different than in the posterior quadrant (865±97 HU, p=0.022). As for depth, it was found that cortical bone is most dense at the glenoid surface (zero to two millimeters, 892±91 HU) when compared to bone at two to eight millimeters in depth (p < 0 .02). Cancellous bone was also most dense at the surface (352±51 HU), but only compared to the eight to 10 millimeters depth (p=0.005). Cancellous bone density was found to decrease with increasing depth. For cortical-to-cancellous bone volume ratios, the inferior quadrant (0.37±0.28) had a significantly lower ratio than all other quadrants (p < 0 .001)

The superoposterior region of the glenoid was found to have denser cancellous bone and a high ratio of cortical to cancellous bone, likely due to decreased formation of cancellous bone and increased formation of cortical bone, in response to localized stresses. The inferior quadrant was found to have the least dense cortical and cancellous bone, and the lowest volume of cortical bone relative to cancellous bone. Once again, this is likely due to reduction in microstrain responsible for bone adaptation via Wolff's law. The density values found in this study generally agree with the range of values found in previous studies of normal and arthritic glenoids. An important limitation of this study is the sizing of measurement regions. For a patient with a smaller glenoid, a depth measurement of two millimeters may represent a larger portion of the overall glenoid vault. Segments could be scaled for each patient based on a percentage of each individual's glenoid size.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_7 | Pages 52 - 52
1 Jul 2020
Abdic S Knowles N Johnson J Walch G Athwal G
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Superiorly eroded glenoids in cuff tear arthropathy represent a surgical challenge for reconstruction. The bone loss orientation and severity may influence glenoid component fixation. This computed-tomography study quantifies both the degree of erosion and orientation in superiorly eroded Favard E2 glenoids. We hypothesized that the erosion in E2 glenoids does not occur purely superiorly, rather, it is oriented in a predictable posterosuperior orientation with a largely semicircular line of erosion.

Three-dimensional reconstructions of 40 shoulders with E2 glenoids (28 female, 12 male patients) at a mean age of 74 years (range, 56–88 years) were created from computed-tomography images. Point coordinates were extracted from each construct to analyze the morphologic structure. The anatomical location of the supra- and infraglenoid tubercle guided the creation of a superoinferior axis, against which the orientation angle of the erosion was measured. The direction and, thus, orientation of erosion was calculated as a vector. By placing ten point coordinates along the line of erosion and creating a circle of best fit, the radius of the circle was placed orthogonally against a chord that resulted by connecting the two outermost points along the line of erosion. To quantify the extent of curvature of the line of erosion between the paleo- and neoglenoid, the length of the radius of the circle of best fit was calculated. Individual values were compared against the mean of circle radii. The area of bony erosion (neoglenoid), was calculated as a percentage of the total glenoid area (neoglenoid + paleoglenoid). The severity of the erosion was categorized as mild (0% to 33%), moderate (34% to 66%), and severe erosion (>66%).

The mean orientation angle between the vector of bony erosion and the superoinferior axis of the glenoid was 47° ± 17° (range, 14° – 74°) located in the posterosuperior quadrant of the glenoid, resulting in the average erosion being directed between the 10 and 11 o'clock position (right shoulder).

In 63% of E2 cases, the line of erosion separating the paleo- and neoglenoids was more curved than the average of all bony erosions in the cohort. The mean surface area of the neoglenoid was 636 ± 247 mm2(range, 233 – 1,333 mm2) and of the paleoglenoid 311 ± 165 mm2(range, 123 – 820 mm2), revealing that, on average, the neoglenoids consume 67% of the total glenoid surface. The extent of erosion of the total cohort was subdivided into one mild (2%), 14 moderate (35%) and 25 severe (62%) cases.

Using a clock-face for orientation, the average orientation of type E2 glenoid defects was directed between the 10 and 11 o'clock position in a right shoulder, corresponding to the posterosuperior glenoid quadrant. Surgeons managing patients with E2 type glenoids should be aware that a superiorly described glenoid erosion is oriented in the posterosuperior quadrant on the glenoid clock-face when viewed intra-operatively. Additionally, the line of erosion in 63% of E2 glenoids is substantially curved, having a significant effect on bone removal techniques when using commercially available augments for defect reconstruction.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_1 | Pages 43 - 43
1 Feb 2020
Knowles N Kusins J Faieghi M Ryan M Dall'Ara E Ferreira L
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Introduction

Subject-specific finite element models (FEMs) allow for a variety of biomechanical conditions to be tested in a highly repeatable manner. Accuracy of FEMs is improved by mapping density using quantitative computed tomography (QCT) and choosing a constitutive relationship relating density and mechanical properties of bone. Although QCT-derived FEMs have become common practice in contemporary computational studies of whole bones, many density-modulus relationships used at the whole bone level were derived using mechanical loading of small trabecular or cortical bone cores. These cores were mechanically loaded to derive an apparent modulus, which is related to each core's mean apparent or ash density. This study used these relationships and either elemental or nodal material mapping strategies to elucidate optimal methods for scapular QCT-FEMs.

Methods

Six cadaveric scapulae (3 male; 3 female; mean age: 68±10 years) were loaded within a micro-CT in a custom CT-compatible hexapod robot Pre- and post-loaded scans were acquired (spatial resolution = 33.5 µm) and DVC was used to quantify experimental full-field displacements (BoneDVC, Insigneo) (Figure 1).. Experimental reaction forces applied to the scapulae were measured using a 6-DOF load cell. FEMs were derived from corresponding QCT scans of each cadaver bone. These models were mapped with one of fifteen density-modulus relationships and elemental or nodal material mapping strategies. DVC-derived BCs were imposed on the QCT-FEMs using local displacement measurements obtained from the DVC algorithm. Comparisons between the empirical and computational models were performed using resultant reaction loads and full-field displacements (Figure 2).


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_1 | Pages 45 - 45
1 Feb 2020
Knowles N Kusins J Pucchio A Ferreira L
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INTRODUCTION

Mechanical properties mapping based on CT-attenuation is the basis of finite element (FE) modeling with heterogeneous materials and bone geometry defined from clinical-resolution CT scans. Accuracy between empirical and computational models that use constitutive equations relating CT-attenuation to bone density are well described, but material mapping strategy has not gained similar attention. As such, the objective of this study was to determine variations in the apparent modulus of trabecular bone cores mapped with various material mapping strategies, using a validated density-modulus relationship and co-registered µFEMs as the gold standard.

METHODS

Micro-CT images (isotropic 32 µm) were used to create µFEMs from glenoid trabecular bone cores of 14 cadaveric scapula. Each µFEM was loaded in unconstrained compression to determine the trabecular core apparent modulus (Eapp). Quantitative CT (QCT) images (isotropic 0.625 mm) were subsequently acquired and co-registered QCT-FEMs created for each of the 14 cores. The QCT-FEMs were meshed with either linear hexahedral (HEX8), linear tetrahedral (TET4), or quadratic tetrahedral (TET10) elements at 3 mesh densities (0.3125 mm, 0.46875 mm, 0.625 mm). Three material mapping strategies were used to apply heterogeneous element-wise (element-averaging of the native HU field (Mimics V.20, Materialise, Leuven BE)) or nodal (tri-linear interpolation of HU Field or E Field (Matlab V. R2017a, Natick, RI, USA)) material properties to the QCT FEMs. Identical boundary conditions were used and Eapp between the µFEMs and QCT-FEMs was compared (Figure 1). The QCT density of each hexahedral mesh with element size equal to voxel dimensions was used to compare the QCT density mapping between tetrahedral meshes and material mapping strategy.


The Bone & Joint Journal
Vol. 100-B, Issue 8 | Pages 1074 - 1079
1 Aug 2018
Paul R Knowles N Chaoui J Gauci M Ferreira L Walch G Athwal GS

Aims

The Walch Type C dysplastic glenoid is characterized by excessive retroversion. This anatomical study describes its morphology.

Patients and Methods

A total of 29 shoulders with a dysplastic glenoid were analyzed. CT was used to measure retroversion, inclination, height, width, radius-of-curvature, surface area, depth, subluxation of the humeral head and the Goutallier classification of fatty infiltration. The severity of dysplasia and deficiency of the posterior rim of the glenoid were recorded.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_6 | Pages 13 - 13
1 Apr 2018
Knowles N Langohr G Athwal G Ferreira L
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BACKGROUND

Stability of the glenoid component is essential to ensure successful long-term outcomes following Total shoulder arthroplasty (TSA), and may be improved through better glenoid component design. As such, this study assessed identical all-polyethylene glenoid components stability, having various fixation types, using component micromotion under simulated joint loading in an osteoarthritic patient cohort.

METHODS

Five all-polyethylene glenoid component designs were compared (Keel, Central-Finned 4-Peg, Peripheral 4-Peg, Cross-Keel, and Inverted-Y). A cement mantle surrounded each fixation type, except the Central-Finned 4-Peg which was surrounded by bone. The humeral component had a non-conforming radius of curvature. Scapular models of six type A1 osteoarthritic male patients (mean: 61 years old, range: 48 to 76 years old) were assigned heterogeneous bone properties based on CT intensity. Each of the 30 scapula models were truncated and fully constrained on the medial scapular border. The bone/cement interface was fully bonded, and the fixation feature/cement interface was frictionally constrained. A ‘worst case’ load magnitude of 125% BW of a 50th percentile male was used. A purely compressive load was applied to the center of the glenoid component, followed by superior, superior-posterior, posterior, inferior-posterior, and inferior loads. Stability of the glenoid component based solely on the fixation type was determined using the mean and maximum normal (liftoff) and tangential (sliding) micromotion in six regions of the glenoid component.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_6 | Pages 93 - 93
1 Mar 2017
West E Knowles N Ferreira L Athwal G
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Introduction

Shoulder arthroplasty is used to treat several common pathologies of the shoulder, including osteoarthritis, post-traumatic arthritis, and avascular necrosis. In replacement of the humeral head, modular components allow for anatomical variations, including retroversion angle and head-neck angle. Surgical options include an anatomic cut or a guide-assisted cut at a fixed retroversion and head-neck angle, which can vary the dimensions of the cut humeral head (height, anteroposterior (AP), and superoinferior (SI) diameters) and lead to negative long term clinical results. This study measures the effect of guide-assisted osteotomies on humeral head dimensions compared to anatomic dimensions.

Methods

Computed tomography (CT) scans from 20 cadaveric shoulder specimens (10 male, 10 female; 10 left) were converted to three-dimensional models using medical imaging software. An anatomic humeral head cut plane was placed at the anatomic head – neck junction of all shoulders by a fellowship trained shoulder surgeon. Cut planes were generated for each of the standard implant head-neck angles (125°, 130°, 135°, and 140°) and retroversion angles (20°, 30°, and 40°) in commercial cutting guides. Each cut plane was positioned to favour the anterior humeral head-neck junction while preserving the posterior cuff insertion. The humeral head height and diameter were measured in both the AP plane and the SI plane for the anatomic and guide-assisted osteotomy planes. Differences were compared using separate two-way repeated measures ANOVA for each dependent variable and deviations were shown using box plot and whisker diagrams.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_6 | Pages 94 - 94
1 Mar 2017
West E Knowles N Athwal G Ferreira L
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Background

Humeral version is the twist angle of the humeral head relative to the distal humerus. Pre-operatively, it is most commonly measured referencing the transepicondylar axis, although various techniques are described in literature (Matsumura et al. 2014, Edelson 1999, Boileau et al., 2008). Accurate estimation of the version angle is important for humeral head osteotomy in preparation for shoulder arthroplasty, as deviations from native version can result in prosthesis malalignment. Most humeral head osteotomy guides instruct the surgeon to reference the ulnar axis with the elbow flexed at 90°. Average version values have been reported at 17.6° relative to the transepicondylar axis and 28.8° relative to the ulnar axis (Hernigou, Duparc, and Hernigou 2014), although it is highly variable and has been reported to range from 10° to 55° (Pearl and Volk 1999). These studies used 2D CT images; however, 2D has been shown to be unreliable for many glenohumeral measurements (Terrier 2015, Jacxsens 2015, Budge 2011). Three-dimensional (3D) modeling is now widely available and may improve the accuracy of version measurements. This study evaluated the effects of sex and measurement system on 3D version measurements made using the transepicondylar and ulnar axis methods, and additionally a flexion-extension axis commonly used in biomechanics.

Methods

Computed tomography (CT) scans of 51 cadaveric shoulders (26 male, 25 female; 32 left) were converted to 3D models using medical imaging software. The ulna was reduced to 90° flexion to replicate the arm position during intra-operative version measurement. Geometry was extracted to determine landmarks and co-ordinate systems for the humeral long axis, epicondylar axis, flexion-extension axis (centered through the capitellum and trochlear groove), and ulnar long axis. An anatomic humeral head cut plane was placed at the head-neck junction of all shoulders by a fellowship trained shoulder surgeon. Retroversion was measured with custom Matlab code that analysed the humeral head cut plane relative to a reference system based on the long axis of the humerus and each elbow axis. Effects of measurement systems were analyzed using separate 1-way RM ANOVAs for males and females. Sex differences were analyzed using unpaired t-tests for each measurement system.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_4 | Pages 3 - 3
1 Feb 2017
Gupta A Knowles N Ferreira L Athwal G
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Background

Glenoid baseplate fixation for reverse shoulder arthroplasty relies on the presence of sufficient bone stock and quality. Glenoid bone may be deficient in cases of primary erosions or due to bone loss in the setting of revision arthroplasty. In such cases, the best available bone for primary baseplate fixation usually lies within the three columns of the scapula. The purpose of this study was to characterise the relationship of the three columns of the scapula independent of glenoid anatomy and to establish the differences between male and female scapular anatomy.

Methods

Fifty cadaveric scapulae (25 male, 25 female) were analysed using CT-based imaging software. The surface geometries of the coracoid, scapular spine and inferior scapular column were delineated in the sagittal plane. A linear best-fit line was drawn to establish the long axis of each column independent of the glenoid. The width of the glenoid was measured and points marked at the midpoint of each measurement. A best-fit line starting at the supra glenoid tubercle passing through the midpoints was chosen as the superior inferior (SI) axis of the glenoid.

An orthogonal plane to the scapular plane was developed parallel to the glenoid face. The axis representing each of the three columns of the scapula and the SI axis of the glenoid, were projected onto this plane. The relationship between each column was analysed with respect to each other and with respect to the SI glenoid axis. Thus, measurements obtained gave the relationships of the three columns of the scapula (independent of the glenoid) and their relationships to the long axis of the glenoid (dependant on the glenoid). Comparisons were made between males and females using the independent t-tests.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_21 | Pages 10 - 10
1 Dec 2016
West E Knowles N Ferreira L Athwal G
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Shoulder arthroplasty is used to treat osteoarthritis, post-traumatic arthritis, and avascular necrosis. Modular components allow for natural variability in shoulder anatomy, including retroversion and head-neck angles. Surgical options include anatomic or guide-assisted cut at a fixed retroversion and head-neck angle. The purpose of this study was to determine the variability between head height (HH) and anteroposterior (AP) and superoinferior (SI) diameters using anatomic and guide-assisted humeral head cuts.

Computed tomography scans of 10 cadaveric shoulder specimens (5 male, 5 female) were converted to 3D models. An anatomic humeral head cut plane was placed at the anatomic head–neck junction maintaining the posterior cuff insertion for all shoulders by a fellowship trained shoulder surgeon. Cut planes were generated for standard implant head neck angles (125°,130°,135°, and 140°) and retroversion angles (20°,30°, and 40°) in commercial cutting guides, for a combination of 12 repeated cut conditions per specimen. The humeral HH and the head diameter were measured in the AP and the SI planes for anatomic and guide-assisted osteotomy planes. Differences were compared using a separate two-way repeated measures ANOVA for each dependent variable.

Guide-assisted cuts showed no significant effect on HH due to head-neck (p=0.205) or retroversion angles (p=0.190). These results persisted by gender (male: head-neck p=0.659 and retroversion p=0.386; female: head-neck p=0.204 and retroversion p=0.190). SI diameter increased by 1.3 mm with increasing head-neck angle (p<0.001), but there was no effect due to retroversion (p=0.148). A head-neck angle of 125° caused the greatest decrease in SI diameter of −2.8 mm compared to the anatomic cut, averaged over the retroversion range. The greatest reduction of SI diameter, −3.4 mm compared to anatomic, occurred with 125° head-neck angle and 20° retroversion. By gender, males showed a significant effect from head-neck angle (p=0.008), but females did not (p=0.077). There was no significant difference from retroversion in either gender group (male p=0.792; female p=0.057). There was no significant difference in AP diameter by head-neck (p=0.192) or retroversion angles (p=0.168). These results persisted in the males (head-neck p=0.420 and retroversion p=0.780). In females, there was no effect from head-neck angle (p=0.232); however, retroversion angle trended toward significance (p=0.050).

For patients whose natural anatomy falls outside the range of the commercial cut guides, templated resection may result in deviation from natural humeral head dimensions. Due to the large variability in anatomic retroversion and head-neck angles in the subjects of this study, further study with a larger sample size is needed to investigate observed trends. These preliminary results have implications for manufacturers to create guides to represent a larger segment of the population, and surgeons' intra-operative choice.