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Orthopaedic Proceedings
Vol. 105-B, Issue SUPP_2 | Pages 29 - 29
10 Feb 2023
Gupta A Jomaa M Ker A Hollman F Singh N Maharaj J Cutbush K
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Massive posterosuperior cuff tears (mRCT) retracted to the glenoid are surgically challenging and often associated with high retear rates. Primary repair is a less-favourable option and other salvage procedures such as SCR and tendon transfers are used. This study presents clinical and radiological outcomes of muscle advancement technique for repair of mRCT.

Sixty-one patients (mean age 57±6, 77% males and 23% females) (66 shoulders) underwent all-arthroscopic rotator cuff repair that included supraspinatus and infraspinatus subperiosteal dissection off scapular bony fossae, lateral advancement of tendon laminae, and tension-free double-layer Lasso Loop repair to footprint.

Pre-and post-operative range of motion (ROM), cuff strength, VAS, Constant, ASES, and UCLA scores were assessed. Radiologic assessment included modified Patte and Goutallier classifications. All patients had MRI at 6 months to evaluate healing and integrity of repair was assessed using Sugaya classification with Sugaya 4 and 5 considered retears.

Advanced fatty degeneration (Goutallier 3-4) was present in 44% and 20% of supraspinatus and infraspinatus. Tendon retraction was to the level of or medial to glenoid in 22%, and just lateral in 66%. 50.8% mRCT extended to teres minor. Subscapularis was partially torn (Lafosse 1-3) in 46% and completely torn (Lafosse 4-5) in 20%.

At mean follow-up (52.4 weeks), a significant increase in ROM, Relative Cuff Strength (from 57% to 90% compared to contralateral side), VAS (from 4 ±2.5 to 1±1.7), Constant (50±17.8 to 74 ±13.0), ASES (52 ±17.5 to 87 ±14.9), and UCLA (16± 4.9 to 30 ±4.9) scores were noted. There were six retears (10%), one failure due to P. acnes infection. 93% returned to pre-injury work and 89% of cases returned to pre-injury sport. Satisfaction rate was 96%.

Muscle advancement technique for mRCT is a viable option with low retear rates, restoration of ROM, strength, and excellent functional outcomes.


Orthopaedic Proceedings
Vol. 105-B, Issue SUPP_2 | Pages 30 - 30
10 Feb 2023
Gupta A Launay M Maharaj J Salhi A Hollman F Tok A Gilliland L Pather S Cutbush K
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Complications such as implant loosening, infection, periprosthetic fracture or instability may lead to revision arthroplasty procedures. There is limited literature comparing single-stage and two-stage revision shoulder arthroplasty. This study aims to compare clinical outcomes and cost benefit between single-stage and two-stage revision procedures.

Thirty-one revision procedures (mean age 72+/-7, 15 males and 16 females) performed between 2016 and 2021 were included (27 revision RSA, 2 revision TSA, 2 failed ORIFs). Two-stage procedures were carried out 4-6 weeks apart. Single-stage procedures included debridement, implant removal and washout, followed by re-prep, re-drape and reconstruction with new instrumentations. Clinical parameters including length of stay, VAS, patient satisfaction was recorded preoperatively and at mean 12-months follow up. Cost benefit analysis were performed.

Seven revisions were two-stage procedures and 24 were single-stage procedures. There were 5 infections in the two-stage group vs 14 in the single-stage group. We noted two cases of unstable RSA and 8 other causes for single-stage revision. Majority of the revisions were complex procedures requiring significant glenoid and/or humeral allografts and tendon transfers to compensate for soft tissue loss. No custom implants were used in our series.

Hospital stay was reduced from 41+/-29 days for 2-stage procedures to 16+/-13 days for single-stage (p<0.05). VAS improved from 9+/-1 to 2+/-4 for two-stage procedures and from 5+/-3 to 1+/-2 for single-stages. The average total cost of hospital and patient was reduced by two-thirds. Patient satisfaction in the single-stage group was 43% which was comparable to the two-stage group.

All infections were successfully treated with no recurrence of infection in our cohort of 31 patients. There was no instability postoperatively. 3 patients had postoperative neural symptoms which resolved within 6 months.

Single-stage procedures for revision shoulder arthroplasty significantly decrease hospital stay, improve patients’ satisfaction, and reduced surgical costs.


Orthopaedic Proceedings
Vol. 105-B, Issue SUPP_2 | Pages 72 - 72
10 Feb 2023
Hollman, F Mohammad J Singh N Gupta A Cutbush K
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Acromioclavicular joint (ACJ) dislocations is a common disorder amongst our population for which numerous techniques have been described. It is thought that by using this novel technique combining a CC and AC repair with a reconstruction will result in high maintenance of anatomical reduction and functional results.

12 consecutive patients ACJ dislocations were included. An open superior clavicular approach is used. Firstly, the CC ligaments are repaired after which a CC reconstruction is performed using a tendon allograft. Secondly, the AC ligaments are repaired using an internal brace construct combined with a tendon allograft reconstruction (Figure 1).

The acute:chronic ratio was 6:6. Only IIIB, IV and V AC-joint dislocations were included. The Constant-Murley Score improved from 27.6 (8.0 – 56.5) up to 61.5 (42.0 – 92.0) at 12 months of follow up. Besides one frozen shoulder from which the patient recovered spontaneously no complications were observed with this technique. The CCD was reduced from 18.7 mm (13.0 – 24.0) to 10.0 mm (6.0 – 16.0) and 10.5 mm (8.0 – 14.0) respectively 12 weeks and 12 months postoperatively.

There is some evidence, suggesting to address as well as the vertical (coracoclavicular (CC) ligaments) as the horizontal (acromioclavicular (AC) ligaments) direction of instability. This study supports addressing both entities however comparative studies discriminating chronic as acute cases should be conducted to further clarify this ongoing debate on treating ACJ instability.

This study describes a novel technique to treat acute and chronic Rockwood stage IIIB – IV ACJ dislocations with promising short-term clinical and radiological results. This suggests that the combined repair and reconstruction of the AC and CC ligaments is a safe procedure with low complication risk in experienced hands. Addressing the vertical as well as horizontal stability in ACJ dislocation is considered key to accomplish optimal long-term results.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_5 | Pages 26 - 26
1 Apr 2019
Shitole P Gupta A Ghosh R
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Introduction

Bone fracture toughness is an important parameter in resistance of bone to monotonic and fatigue failure. Earlier studies on bone fracture toughness were focused on either cortical or cancellous bone, separately [1, 2]. Reported fracture toughness values indicated that cortical bone is tougher to break as compared to cancellous bone. In order to understand complete fracture of a whole bone, the interface between cortical and cancellous bone (named as corticellous bone) might play a crucial role and is interesting topic of research. The goal of this study was to identify fracture toughness in terms of J integral and fracture mechanism of the corticellous bone.

Material and Methods

Corticellous bone samples (single edge notch bend specimen or SENB) were prepared from bovine proximal femur according to ASTM E399-90 standard (Fig.1). For corticellous bone, samples were prepared in such way that approximately half of the sample width consist of cortical bone and another half is cancellous bone. Precaution was taken while giving notch and pre-crack to corticellous bone that pre-crack should not enter from cortical to cancellous portion. All specimens were tested using a universal testing machine (Tinius Olsen, ± 100 N) under displacement rate of 100 µm/min until well beyond yield point. The fracture toughness parameter in terms of critical stress intensity (KIC) was calculated according to ASTM E399-90 as given by, KIC=PS/BW1.5*f(a/W)

Where, P = applied load in kN, S = loading span in cm, B = specimen thickness in cm, W = specimen width in cm, a = total crack length, f(a/W) = geometric function. After the fracture test the J integral of each specimen was calculated using following equation. [ASTM E1820]. Jtotal=Jel+Jpl=KIC2/E+2Apl/Bb0

Where, Jel is J integral of the elastic deformation, Jpl is J integral of the plastic deformation, E′=E for plane stress condition and E′= E/(1−ν2) for plane strain condition (E is elastic modulus; ν is Poisson's ratio), bo = W−ao, height of the un-cracked ligament, and Apl is the area of the plastic deformation part in the load–displacement curve.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_4 | Pages 3 - 3
1 Feb 2017
Gupta A Knowles N Ferreira L Athwal G
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Background

Glenoid baseplate fixation for reverse shoulder arthroplasty relies on the presence of sufficient bone stock and quality. Glenoid bone may be deficient in cases of primary erosions or due to bone loss in the setting of revision arthroplasty. In such cases, the best available bone for primary baseplate fixation usually lies within the three columns of the scapula. The purpose of this study was to characterise the relationship of the three columns of the scapula independent of glenoid anatomy and to establish the differences between male and female scapular anatomy.

Methods

Fifty cadaveric scapulae (25 male, 25 female) were analysed using CT-based imaging software. The surface geometries of the coracoid, scapular spine and inferior scapular column were delineated in the sagittal plane. A linear best-fit line was drawn to establish the long axis of each column independent of the glenoid. The width of the glenoid was measured and points marked at the midpoint of each measurement. A best-fit line starting at the supra glenoid tubercle passing through the midpoints was chosen as the superior inferior (SI) axis of the glenoid.

An orthogonal plane to the scapular plane was developed parallel to the glenoid face. The axis representing each of the three columns of the scapula and the SI axis of the glenoid, were projected onto this plane. The relationship between each column was analysed with respect to each other and with respect to the SI glenoid axis. Thus, measurements obtained gave the relationships of the three columns of the scapula (independent of the glenoid) and their relationships to the long axis of the glenoid (dependant on the glenoid). Comparisons were made between males and females using the independent t-tests.


Bone & Joint Research
Vol. 5, Issue 10 | Pages 500 - 511
1 Oct 2016
Raina DB Gupta A Petersen MM Hettwer W McNally M Tägil M Zheng M Kumar A Lidgren L

Objectives

We have observed clinical cases where bone is formed in the overlaying muscle covering surgically created bone defects treated with a hydroxyapatite/calcium sulphate biomaterial. Our objective was to investigate the osteoinductive potential of the biomaterial and to determine if growth factors secreted from local bone cells induce osteoblastic differentiation of muscle cells.

Materials and Methods

We seeded mouse skeletal muscle cells C2C12 on the hydroxyapatite/calcium sulphate biomaterial and the phenotype of the cells was analysed. To mimic surgical conditions with leakage of extra cellular matrix (ECM) proteins and growth factors, we cultured rat bone cells ROS 17/2.8 in a bioreactor and harvested the secreted proteins. The secretome was added to rat muscle cells L6. The phenotype of the muscle cells after treatment with the media was assessed using immunostaining and light microscopy.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_1 | Pages 96 - 96
1 Jan 2016
Domb B Redmond J Gupta A Hammarstedt J Petrakos A Stake C Conditt M
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Background

Component positioning in total hip arthroplasty (THA) is critical to achieve optimal patient outcomes. Recent literature has shown acetabular component positioning may be inaccurate using traditional techniques. Robotic-assisted THA is a recent platform introduced to decrease the risk of malpositioned components. However, to date, a paucity of data is available comparing the intra-operative component position generated by the navigation system to post-operative radiographs.

Purpose

The purpose of this study was to compare the component position measurements of a navigation system, used during robotic-assisted THA, to component position measurements obtained on post-operative radiographs.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_1 | Pages 115 - 115
1 Jan 2016
Domb B Gupta A Hammarstedt J Stake C Sharp K Redmond J
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Background

Pre-operative and postoperative analgesia in total hip arthroplasty (THA) involves multimodal analgesia using differing classes of drugs and varying introductions of these agents. Postoperative opioid-related events can slow recovery and increase patients' length of stay. Long-acting local anesthetics can reduce early postoperative pain at the surgical site, potentiating a decrease of opioid intervention needed postoperatively. Decreasing opioid use while maintaining adequate pain control could reduce opioid-related events, increase patient time to first ambulation and decrease length of stay. The purpose of this study was to compare liposomal bupivacaine to bupivacaine for postoperative analgesia.

Methods

Between November 2012 and February 2013, 57 consecutive patients that underwent THA and hip resurfacing received either an intraoperative injection of liposomal bupivacaine or bupivacaine alone. All patients received a combination of medications prior to the procedure including celecoxib 400 mg by mouth, pregabalin 75 mg by mouth and 1gm of intravenous acetaminophen. The study group received 20 cc of liposomal bupivacaine, combined with 40 cc 0.25% bupivacaine with epinephrine and 20 cc of normal saline. The control group received 60 ml of 0.25% bupivacaine with epinephrine. Data was prospectively collected including average visual analog pain scale (VAS), opioid consumption, time to first ambulation, hospital length of stay measured by days, and post-operative opioid-related adverse drug events.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_1 | Pages 95 - 95
1 Jan 2016
Domb B Redmond J Hammarstedt J Petrakos A Stake C Gupta A Conditt M
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Background

Several recent reports have documented high frequency of malpositioned acetabular components, even amongst high volume arthroplasty surgeons. Robotic assisted total hip arthroplasty (THA) has the potential to improve component positioning; however, to our knowledge there are no reports examining the learning curve during the adoption of robotic assisted THA.

Purpose

The purpose of this study was to examine the learning curve of robotic assisted THA as measured by component position, operative time, intra-operative technical problems, and complications.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_16 | Pages 24 - 24
1 Dec 2015
Raina D Gupta A Petersen M Hettwer W Nally M Tägil M Zheng M Kumar A Lidgren L
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To demonstrate the role of an antibiotic containing bone substitute, native bone active proteins and muscle transforming into bone.

Recurrent osteomyelitis was eradicated and filled with a gentamycin eluting bone substitute (Cerament™l G) consisting of sulphate and apatite phases and covered by a muscle flap.

C2C12 muscle cells were seeded on the bone substitute in-vitro and their phenotype was studied.

Another muscle cell line L6 was seeded with osteoblast conditioned medium containing bone active proteins and specific markers were studied for bone differentiation.

A chronic, longstanding, fistulating osteomyelitis was operated with radical eradication and filling of the cavity with gentamycin eluting bone substitute. At one year, the patient had no leg pain and a healed wound. Significant bone was also seen in the overlaying muscle, at one month post-op disappearing after 6-months. Local delivery of gentamycin had a protective effect on bone formation.

C2C12 cells seeded on the gentamycin eluting bone substitute depicted no difference in proliferation when compared to plain bone substitute and expressed 4 folds higher Alkaline phosphatase (ALP) compared to controls.

C2C12 cells expressed proteins and genes coding for collagen type 1 (Col 1), osteocalcin (OCN), osteopontin (OPN) and bonesialoprotein (BSP).

L6 cells cultured with osteoblast conditioned medium remained uninucleated and expressed osteoblastic proteins like Col 1, OCN, OPN and BSP.

Bone substitute with gentamycin leads to differentiation of mesenchymal cells into bone in-vitro.

Native bone active proteins from an osteoblast culture can induce differentiation of muscle cells in-vitro.

Clinical observations with rapid bone formed in the bone substitute and in some cases in the muscle are a consequence of both leakage of bone active proteins and also from osteoprogenitor cells coming from the overlaying muscle interacting with the osteoinductive bone substitute.


Bone & Joint Research
Vol. 4, Issue 5 | Pages 70 - 77
1 May 2015
Gupta A Liberati TA Verhulst SJ Main BJ Roberts MH Potty AGR Pylawka TK El-Amin III SF

Objectives

The purpose of this study was to evaluate in vivo biocompatibility of novel single-walled carbon nanotubes (SWCNT)/poly(lactic-co-glycolic acid) (PLAGA) composites for applications in bone and tissue regeneration.

Methods

A total of 60 Sprague-Dawley rats (125 g to 149 g) were implanted subcutaneously with SWCNT/PLAGA composites (10 mg SWCNT and 1gm PLAGA 12 mm diameter two-dimensional disks), and at two, four, eight and 12 weeks post-implantation were compared with control (Sham) and PLAGA (five rats per group/point in time). Rats were observed for signs of morbidity, overt toxicity, weight gain and food consumption, while haematology, urinalysis and histopathology were completed when the animals were killed.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 435 - 435
1 Dec 2013
Hollingdale J Mordecai S Gupta A
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Patella resurfacing is becoming more routine in total knee replacements with recent reports indicating improved long term outcomes. Despite this, patella osteotomy relies heavily on how the cutting jig is applied rather than on fixed anatomical landmarks. Recognised complications of asymmetric patella resection are patella fractures, patella maltracking, bony impingement and pain. Accurate instruments have been developed for other aspects of total knee replacements. However cutting guides for the patella tend to be cumbersome with poor reproducibility.

Patella tilt is defined as the angle subtended by a line joining the medial and lateral edges of the patella and the horizontal. Keeping this angle to a minimum results in congruent alignment of the patella button within the trochlear groove. Current patella cutting jigs do not take this angle into consideration as they require full eversion of the patella laterally, not only making accurate placement of the jig difficult but also putting excessive strain on the surrounding soft tissue.

This study describes a new cutting technique for the patella osteotomy which is referenced off the distal femoral condyles ensuring a more accurate and reproducible cut without having to evert the patella.

With the femoral component trial in situ and the patella in its normal anatomical lie, the knee is flexed to 30°. The patella cutting jig is then applied in the usual manner making sure that adequate thickness of patella remains but it is placed parallel to a line joining the two condyles of the femoral component. By cutting the patella in this position parallel to the distal femoral condyles, patella tilt is minimised and the patella button will be aligned evenly within the trochlear groove.

Currently all patients requiring patella resurfacing at our institution are undergoing this technique and the short term results have been very promising.

This study presents a novel patella cutting technique that utilises a fixed landmark to ensure a more accurate and reproducible osteotomy. We are planning a large scale trial comparing pre- and post-operative knee scores and radiological assessment of patients having this new technique compared to standard cutting techniques. This will allow us to report on the longer term effects and pave the way for better patella resurfacing instrumentation.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XLI | Pages 117 - 117
1 Sep 2012
Gupta A Cooke C Wilkinson M Grazette A
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Prospective Randomised Control trial of 300 patients over a period of 3 years, 1 year post op follow up. Local ethic approval was attained for the study.

Inclusion criteria: Age > 60, Consented to Participate in the study, Unstable Inter trochanteric fracture a) Sub trochanteric b) Medial Comminution c) Reverse Obliquity D)Severe Osteoporosis. Patients selected were randomized to Intra medullary Nail vs Hips screw. Variety of markers have been assessed: Pre OP: - Mechanism of injury, Mobility status, Pre OP ASA, Pre Op haemoglobin, living Conditions. Intra OP:- I.I Time, Time taken, Surgeon experience, Intra OP complications. Post OP:- Haemoglobin, mobility, radiographic analysis-Fracture stability and Tip Apex Distance, Thrombo embolic Complications. Follow up: - 6 weeks, 3,6,12 month follow up.

There is considerable debate in literature regarding superiority of Compression Hip screw over Intra medullary nail for fixation of stable per trochanteric fractures of the femur. Biomechanical studies have shown superiority of Intra medullary device over a Compression Hip screw.

Tenser et all showed an advantage over combined bending and compression failure. Mohammad et al found unstable subtrochanteric fractures with a gamma nail were stiffer. Kerush-Brinker showed that gamma nail had significantly greater fatigue strength and fatigue life. In unstable fractures Baumgartner et al found less intra op complications and less fluoroscopic time for a compression hip screw compared to a short intra medullary nail. There have been significant reports of fracture at the Tip of a short intra medullary nail. We think this complication can be avoided by using a long intra medullary device.

Both in Australia and abroad the choice of which device to use depends largely on the preference of the surgeon.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XLI | Pages 138 - 138
1 Sep 2012
Gupta A McAuliffe M Brazel P Tetsworth K Bansi P
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We propose a model of care where by Regular scheduled outreach visits by a Single team provides more dependability of care and understanding of the local needs and cultural practises. Thereby titrating the care to meet local needs rather than enforcing the Western model of care to a very different cultural background.

I have been fortunate as a SET 4 Registrar to be involved with an Outreach team to Latouka Hospital. Spear headed by Dr M McAuliffe over the last 3 years the annual visit has taken shape as a dependable way of providing care to the community of Latouka. The team has evolved over the years to involve Dr Brazel, Dr Tetsworth, Dr Bansi, and our scrub staff. The team consists of 2 teams which visit Latouka every 6 months and help institute a multimodal care plan. 1) Regularity of visits helps build confidence locally and engraves the foundations of dependability of care. 2) Difficult and complex cases are discussed in specially earmarked clinics held every 6 months providing a brain storming sessions to the local clinicians and helping them achieve the best care for the patients under the restrictions of the local infrastructure. 3) Regular teaching sessions / practical workshops are held for the registrars and junior doctors empowering them to carry the baton once the visiting team leaves. 4) Regular follow up of the patients operated upon is attained to titrate care to the locals based upon the local needs and cultural practises. 5) Helping the surgical teams, nurses, radiographers, physiotherapists formulate protocols of care and comparing them to the protocols used in Australia/NZ. 6) Creating an educational fund for the local registrars enabling them to attend observer ships and courses in Australia/New Zealand.

We think that this model of care provides a much more organised and long term benefit to the local community compared to erratic visits by volunteer teams.

A similar model of care, if instituted over many divisional hospitals of the South Pacific, will be vital in improving the health care needs of the locals and provide the local staff with the much needed support they deserve.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXIX | Pages 23 - 23
1 Sep 2012
Lee P Smitesh P Hua J Gupta A Hashemi-Nejad A
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Introduction

Many patients who had previous proximal femoral osteotomies develop deformities that may not be amenable to total hip replacement (THR) with standard off-the-shelf femoral stems. Previous studies have shown high revision rates (18% at 5–10 years follow-up). Computer-assisted-design computer-assisted-manufacture (CAD-CAM) femoral stems are indicated but the results are not known. We assessed the clinical results of THR using CAD-CAM femoral stems specifically for this group of patients.

Methods

We included patients with previous proximal femoral osteotomy and significant deformity who underwent THR with CAD-CAM femoral stem operated by the senior author (AHN) from 1997 with a minimum of 5 years follow-up. We noted revision rates, associated complications and functional outcome. Radiological outcomes include assessment for loosening defined as development of progressive radiolucent lines around implant or implant migration.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXIX | Pages 231 - 231
1 Sep 2012
Matthews D Bhamra J Gupta A Ranawat V Miles J Skinner J Carrington R
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Aims

Revision total hip arthroplasty is a common operation. The MP Link (Waldemar Link, Hamburg, Germany) system is a distally loading, modular, tapered femoral stem component for revision hip surgery. MP Link in revision total hip arthoplasty was investigated clinically, radiologically and with Oxford hip scores.

Methods

A prospective study was conducted of 43 patients undergoing revision total hip arthroplasty with MP Link prostheses between 2004 and 2010. The patients were operated upon by one of the senior authors (JM, JS, RC). Outcome data was collected in clinic and via patient questionnaires.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_II | Pages 34 - 34
1 Feb 2012
Gupta A Kamineni S Ankem H
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To study the surgical outcome of multi-fragmentary, un-reconstructable radial head fractures managed acutely by a radial head prosthetic replacement, we retrospectively reviewed nineteen radial head fractures that were treated acutely with a radial head replacement, over a four-year period in three district general hospitals. Nineteen patients were clinically and radiologically assessed for this study. Functional assessment was performed with the Mayo elbow performance score (MEPS).

No patient achieved full functional range of motion. The average range of flexion was 110° (range 80° to 120°), average extension deficit of 35° (range 30° to 45°), average pronation was 35° (range 0° to 65°), and average supination was 50° (range 30° to 85°). Complications included implant removal due to loosening (n=1), elbow stiffness (n=2), and instability (n=1), the latter case requiring a revision of the radial head prosthesis. Some degree of persistent discomfort was noticed in all cases. Five patients were tolerant of the final functional outcome. The average Mayo elbow score was 68/100 (range 55 to 80). One patient had an intra-operative fracture of the radial metaphysis during insertion of the implant.

Conclusions

Radial head replacement in general orthopaedic, low volume practice failed to achieve satisfactory results. Contrary to popular belief, it is a technically demanding operation, for which surveillance should be continued for a minimum of one year. Strict indications for prosthetic replacement should be followed and implant selection has yet to be proven to make a significant positive contribution.

Our review highlights the need for a stricter adherence to indications; surgery should not be under-estimated and devolved to trainees, and our understanding of the radial axis of the elbow and forearm remains relatively rudimentary


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_III | Pages 52 - 52
1 Feb 2012
Gupta A Bhosale A Roberts S Harrison P McCall I McClure J Ashton B Richardson J
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A new surgical hybrid technique involving the combination of autologous bone plug(s) and autologous chondrocyte implantation (AOsP-ACI) was used and evaluated as a treatment option in 15 patients for repair of large osteochondral defects in knee (N=12) and hip joints (N=3). Autologous Osplugs were used to contour the articular surface and the autologous chondrocytes were injected underneath a biological membrane covering the plug. The average size of the osteochondral defects treated was 4.5cm2. The average depth of the bone defect was 26mm. The patients had a significant improvement in their clinical symptoms at 12 months with significant increase in the Lysholm Score and Harris Hip Score (p = 0.031). The repaired tissue was evaluated using Magnetic Resonance Imaging, Computerised Tomography, arthroscopy, histology and immunohistochemistry (for expression of type I and II collagen). Magnetic Resonance Imaging, Computerised Tomography and histology at 12 months revealed that the bone plug became well integrated with the host bone and repair cartilage. Arthroscopic examination at 12 months revealed good lateral integration of the AOsP-ACI with the surrounding cartilage. Immunohistochemistry revealed mixed fibro-hyaline cartilage. We conclude that the hybrid AOsP-ACI technique provides a promising surgical approach for the treatment of patients with large osteochondral defects. This study highlights the use of this procedure in two different weightbearing joints and demonstrates good early results which are encouraging. The long term results need to be evaluated.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_II | Pages 113 - 113
1 Feb 2012
Gupta A Burne DH Blunn G Briggs T Cannon S
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Chondrosarcoma is a malignant tumour and accounts for approximately 20% of bone sarcomas. The pelvis is one of the commonest sites. Chondrosarcoma of the pelvis lends itself to surgical excision and is relatively resistant to irradiation and chemotherapy. A long term survival analysis of this challenging condition is rarely reported in literature. We review and evaluate the oncological and functional results of all the patients operated at our centre and we analyse the survival analysis of these patients with special focus on the prognostic factors.

Fifty-four consecutive patients with chondrosarcoma of the pelvis who were treated at the Royal National Orthopaedic Hospital, Stanmore, UK between 1987 and 2001 were included in the study. Demographic data, case notes, histopathological results and follow-up data were obtained and statistically analysed.

There were 38 males and 16 females with a mean age of 48.4 years [18-77]. The chondrosarcomas were primary [n=38], secondary [n-7] or recurrences [n=9]. The anatomical sites in the pelvis were in the epicentre I [n=24], II [n=20] and III [n=10]. The surgical procedures performed were local resection [n=28], local resection and hip arthroplasty [n=6], hemipelvectomy (+endoprothesis) [n=16], hemipelvectomy [+fibular strut graf] [n=2] and hinquarter amputation [n=2]. The histological grade was Gr [n=27], Gr 2[n=20] and Gr 3 [n=7]. The complication rate was 24%:wound revision [9%], dislocation [8%] and infection [7%]. There was a 5, 10 and 15 year cumulative survival rate of 74%, 65% and 40%. The overall recurrence rate was 24%.

The factors associated with a worse prognosis were high histologic tumour grade, increasing patient age, anatomical location in site I and III, primary surgery outside of tumour centre, inadequate surgical margins, and those treated by local extension. Aggressive surgical approach significantly improves the prognosis of the patients with chondrosarcoma of the pelvis.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_III | Pages 89 - 89
1 Feb 2012
Gupta A Stokes O Meswania J Pollock R Blunn G Cannon S Briggs T
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When performing limb salvage operations for malignant bone tumours in skeletally immature patients, it is desirable to reconstruct the limb with a prosthesis that can be lengthened without surgery at appropriate intervals to keep pace with growth of the contra-lateral side. We have developed a prosthesis that can be lengthened non-invasively. The lengthening is achieved on the principle of electromagnetic induction.

The purpose of this study was to look at our early experience with the use of the Non Invasive Distal Femoral Expandable Endoprosthesis. A prospective study of 17 skeletally immature patients with osteosarcoma of the distal femur, implanted with the prosthesis, was performed at the Royal National Orthopaedic Hospital, Stanmore. The patients were aged between 9 and 15 years (mean 12.1 years) at the time of surgery. Patients were lengthened at appropriate intervals in outpatient clinics. Patients were functionally evaluated using the Musculoskeletal Tumour Society (MSTS) Scoring System and the Toronto Extremity Severity Score (TESS). Average time from the implantation to the last follow-up was 18.2 months (range 14-30 months). The patients have been lengthened by an average of 25mm (4.25-55mm). The mean amount of knee flexion is 125 degrees. The mean MSTS score is 77% (23/30; range 11-29) and the mean TESS score is 72%. There have been two complications: one patient developed a flexion deformity of 25 degrees at the knee joint and one patient died of disseminated metastatic malignancy.

The early results from patients treated using this device have been encouraging. Using this implant avoids multiple surgical procedures and general anaesthesia. This results in low morbidity, cost savings and reduced psychological trauma. We do need additional data regarding the long-term structural integrity of the prosthesis.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 396 - 396
1 Jul 2008
Jaiswal PK Gupta A Al-Hakim W Pollock R Blunn G Cannon SR Briggs TWR
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Aims: The main purpose of this study was to evaluate hemiplevis replacements in patients with periacetabular tumours in terms of the functional results and implant survivorship of the prosthesis. The second aim was to evaluate the complications and how they might be prevented in the future.

Methods: Case notes, hospital databases and radiographs were reviewed in 51 patients treated in a 16 year period with a custom made hemipelvis replacement (Stanmore Implants Worldwide). There were 13 deaths and 4 were lost to follow up. Of the remaining 34 patients there were 18 males and 16 females with a mean age of 48.6 (range 14 – 71).

Results: At a mean follow-up of 78 months (range 7 – 204), 70% of patients were still alive and the most common diagnosis was chondrosarcoma (17 cases). There were 2 cases of prosthesis failure and 22 of the 34 patients had one or more complications (12 cases of infection (8 deep and 4 superficial), 4 nerve palsies, 2 dislocations and 7 others). 13 patients had to have a second operation. The mean MSTS score was 63.8% and the TESS score was 59.8%

Conclusion: Infection was the most common complication and was the most significant reason for reoperation. This method of reconstruction is associated with a high morbidity rate and should be performed only at specialist centres, but the functional and oncological outcomes are satisfactory.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 396 - 396
1 Jul 2008
Jaiswal P Gupta A Strokes O Pollock R Cannon S Briggs T Blunn G
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Aim: To study the remodelling of cortical bone around the passive growing component of an expandable endoprosthesis.

Introduction: When inserting the passive component of an expandable prosthesis a polyethylene sleeve is commonly used. The sleeve migrates towards the lateral cortex and causes a cortical reaction and hence the use of the sleeve has been discarded recently. This study quantifies the amount of cortical reaction and degree of cortical drift in patients that had sleeves and those that did not.

Material And Methods: We reviewed X-rays and case notes of all patients that had an expandable endoprosthesis in a 20 year period. The thickness of medial and lateral cortices of the tibial diaphysis was measured at 6 months and on the last follow up radiograph. The distance from the edge of the sleeve (or prosthesis) from the cortical edge was also compared. Retrieved components also had their histology reviewed.

Results: The sleeve shifted laterally on average by 2mm (range 0.5 – 3mm) and touched the cortex. This was associated with an increase in lateral cortical thickness by 2.27mm (range 1 – 3mm). When the sleeve was used the prosthesis was inserted in the mid-line. When the sleeve was not used the tibial component tended to be inserted in valgus.

Conclusions: The presence of a sleeve is associated with a cortical reaction and the sleeve tends to migrate laterally. The clinical implications of this and the evolution of the design will be discussed in the meeting.


The Journal of Bone & Joint Surgery British Volume
Vol. 89-B, Issue 11 | Pages 1482 - 1487
1 Nov 2007
Gupta A

We describe a series of 20 patients with ununited fractures of the femoral neck following neglected trauma or failed primary internal fixation who were seen at a mean of 7.5 months (2 to 18) following injury. Open reduction and internal fixation of the fracture was performed in all patients, together with a myoperiosteal flap on the quadratus femoris muscle pedicle.

Union occurred at a mean of 4.9 months (2 to 10) in all patients. The mean follow-up was for 70 months (14 to 144). There was no further progression in six of seven patients with pre-operative radiological evidence of osteonecrosis of the femoral head. One patient had delayed collapse and flattening of the femoral head ten years after union of the fracture, but remained asymptomatic.

This study demonstrates the orthopaedic application of myoperiosteal grafting for inducing osteogenesis in a difficult clinical situation.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_III | Pages 370 - 370
1 Oct 2006
Gupta A Marwah G Bassi J
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Introduction: Road side accidents resulting in polytrauma with an associated fracture of femur is a common pattern of injury in asian countries. We hypothesised that the use of unreamed nailing in the management of such fractures has better outcome than reamed nailing.

Material and Methods: We retrospectively reviewed 116 cases of polytrauma with associated fracture of shaft of femur admitted in our tertiary teaching hospital in North India bewteen Jan 1996 to Dec 2001. The patients were initially resuscitated according to the advanced trauma life support protocol. They were randomally managed by interlocking nail using reamed (n=48) and unreamed (n=68) technique after being haemodynamically stabilized. Five intraoperative parameters were recorded – the surgical time, fluoroscopy time, the intraoperative blood loss, intraoperative oxygen saturation, and any intraoperative complications. The patients were assessed postoperatively for ninety six hours for features of adult respiratory distress syndrome. All patients were clinically and radiologically assessed at 6 weekly intervals till union. The follow-up reassessments were performed by a single surgeon (AG).

Results: There were 80 males, 30 females (6 were bilateral), with an average age of 26 years (range 19 to 64 years). The fractures were closed in 74 and open in 42 (Gustillo Grade 1;n=28, Grade 2;n=9, Grade 3;n=5). 48 were managed by reamed interlock nailing (Group 1) and 68 by unreamed interlock nailing (Group 2). 58 patients had an associated blunt trauma chest, 36 had blunt trauma abdomen, 18 had an associated head injury and 12 had spine injuries. The average surgical time for Group 1 was 118 minutes and for Group 2 was 94 minutes (p=0.014). The average fluorscopy time for Group 1 was 4.30 minutes and for Group 2 was 4.06 minutes. The average intra-operative blood loss for Group 1 was 254 millilitres and for Group 2 was 202 millilitres. The average intraoperative oxygen saturation fall as measured at the time of reaming and nail insertion was 2% in Group 1 and 6% in Group 2. The intraoperative complications were 11 (22.91%) in Group 1 and 18 (26.47%) in Group 2. The features of ARDS were observed in 6 patients in Group 1 (12.5%) and 4 patients in Group 2 (5.88%). The average union time was 25 weeks in Group 1 as compared to 19.4 weeks in Group 2 (p=0.012). The reoperation rate was 6.25% in Group 1 and 11.76% in Group 2.

Discussion: The unreamed interlock nailing is the definitive management of fractures of femur in patients with polytrauma or blunt trauma chest as it requires lesser operative time (and thus exposing the patient to shorter period of anaesthesia), lesser blood loss and lesser fluoroscopy exposure. The incidence of ARDS is significantly lower with unreamed nailing in polytrauma patients. However the union time was significantly longer in unreamed nailing as compared to reamed nailing.


The Journal of Bone & Joint Surgery British Volume
Vol. 88-B, Issue 10 | Pages 1367 - 1372
1 Oct 2006
Gupta A Pollock R Cannon SR Briggs TWR Skinner J Blunn G

We used a knee-sparing distal femoral endoprosthesis in young patients with malignant bone tumours of the distal femur in whom it was possible to resect the tumour and to preserve the distal femoral condyles. The proximal shaft of the endoprosthesis had a coated hydroxyapatite collar, while the distal end had hydroxyapatite-coated extracortical plates to secure it to the small residual femoral condylar fragment. We reviewed the preliminary results of this endoprosthesis in eight patients with primary bone tumours of the distal femur. Their mean age at surgery was 17.years (14 to 21). The mean follow-up was 24 months (20 to 31). At final follow-up the mean flexion at the knee was 102° (20° to 120°) and the mean Musculoskeletal Tumour Society score was 80% (57% to 96.7%).

There was excellent osteointegration at the prosthesis-proximal bone interface with formation of new bone around the hydroxyapatite collar. The prosthesis allowed preservation of the knee and achieved a good functional result. Formation of new bone and remodelling at the interface make the implant more secure. Further follow-up is required to determine the long-term structural integrity of the prosthesis.


The Journal of Bone & Joint Surgery British Volume
Vol. 88-B, Issue 5 | Pages 649 - 654
1 May 2006
Gupta A Meswania J Pollock R Cannon SR Briggs TWR Taylor S Blunn G

We report our early experience with the use of a non-invasive distal femoral expandable endoprosthesis in seven skeletally immature patients with osteosarcoma of the distal femur. The patients had a mean age of 12.1 years (9 to 15) at the time of surgery. The prosthesis was lengthened at appropriate intervals in outpatient clinics, without anaesthesia, using the principle of electromagnetic induction. The patients were functionally evaluated using the Musculoskeletal Tumour Society scoring system. The mean follow-up was 20.2 months (14 to 30). The prostheses were lengthened by a mean of 25 mm (4.25 to 55) and maintained a mean knee flexion of 110° (100° to 120°). The mean Musculoskeletal Tumour Society score was 68% (11 to 29). Complications developed in two patients; one developed a flexion deformity of 25° at the knee joint, which was subsequently overcome and one died of disseminated disease. The early results from patients treated with this device have been encouraging. The implant avoids multiple surgical procedures, general anaesthesia and assists in maintaining leg-length equality.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 43 - 43
1 Mar 2006
Mittal M Cosker T Ghandour A Roy S Gupta A Johnson S
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Introduction: Fractures of the neck of femur has a considaerable impact on the NHS and due to the elderly group of population it involves morbidity can be very costly. We assesed the outcome of trauma patients with these fractures after providing orthogeriatric care in our hospital.

Aim: 179 patients had been studied who had been managed in our hospital over a period of 18 months with hemiarthroplasty for displaced intracapsular fracture of the neck of femur. 104 patients had routine orthopaedic care and 75 patients had regular orthogeriatric care. All the complication were noted, analysed and compared with the national averages.

Methodology: This was a retrospective study-clincal notes of all patients who had hemiarthroplasty during the 18 month period were reviewed and a performa was completed.

Result: Total sample size was 179 patients(104 before and 75 after the introduction of orthogeriatric service) who had hemiartroplasty for the displaced intracapsular fracture of the neck of femur. The median length of stay being 16.5 days before and 20 days after. The medical complications before and after the introduction of this service were-Cardiac complication 4% before and 1% after, Chest infection 2% before and 1% after, DVT 2% before and 1% after. The Overall complication rate has been reduced from 41% to 18% and the one year mortality reduced from 16.34% to 12 with the introduction of orthogeriatric service.

Conclusion: We believe that the weekly ward round and a continued supervision by the orthogeriatric team is one of the factors in improving the outcome of geriatric trauma patients in terms of reduced morbidity and mortality.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 335 - 335
1 Sep 2005
Gupta A Kamineni S
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Introduction and Aims: To evaluate the results of radial head replacement in the primary management of radial head fractures.

The recommended indications for prosthetic radial head replacement include unreconstructable Mason 3 fractures associated with ligament disruption or axial forearm instability.

Method: We retrospectively reviewed all radial head fractures that were treated with a radial head replacement, over a four-year period, in two district general hospitals. All seven patients were finally assessed specifically for this study, either in person or by telephone/ postal questionnaire, with final radiographs obtained for this study.

Results: Routine clinical follow-up was three months, following which the patient was discharged. No patient achieved full functional range of motion. The average range of flexion was 110 degrees (range 80 to 120 degrees), average extension deficit of 35 degrees (range 30 to 45 degrees), average pronation was 35 degrees (range 0 to 65 degrees), and average supination was 50 degrees (range 30 to 85 degrees). Three patients required implant removal due to loosening (1/3), elbow stiffness (2/3), and instability (1/3), the latter case requiring a revision of the radial head prosthesis. Persistent discomfort was noticed in all cases. Four patients were tolerant of the final functional outcome, although the average Mayo elbow score was 78/100 (range 55 to 80).

Conclusion: Radial head replacement in general orthopaedic, low volume, practice failed to achieve satisfactory results. Contrary to popular belief, it is a technically demanding operation, for which surveillance should be continued for a minimum of one year. Strict indications for prosthetic replacement should be followed and implant selection has yet to be proven to make a significant positive contribution


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_II | Pages 161 - 161
1 Apr 2005
Gupta A Kamineni S Ankem H
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Purpose- To study the surgical outcome of multi-fragmentary, un-reconstructable radial head fractures managed acutely by a radial head prosthetic replacement.

Materials- We retrospectively reviewed fifteen radial head fractures that were treated acutely with a radial head replacement, over a four-year period, in three district general hospitals. Fifteen patients were clinically and radiologically assessed for this study. Functional assessment was performed with the Mayo elbow performance score (MEPS).

Results- No patient achieved full functional range of motion. The average range of flexion was 110° (range 80° to 120°), average extension deficit of 35° (range 30° to 45°), average pronation was 35° (range 0° to 65°), and average supination was 50° (range 30° to 85°). Complications included implant removal due to loosening (n=1), elbow stiffness (n=2), and instability (n=1), the latter case requiring a revision of the radial head prosthesis. Some degree of persistent discomfort was noticed in all cases. Five patients were tolerant of the final functional outcome. The average Mayo elbow score was 68/100 (range 55 to 80). One patient had an intra-operative fracture of the radial metaphysis during insertion of the implant.

Conclusions- Radial head replacement in general orthopaedic, low volume, practice failed to achieve satisfactory results. Contrary to popular belief, it is a technically demanding operation, for which surveillance should be continued for a minimum of one year. Strict indications for prosthetic replacement should be followed and implant selection has yet to be proven to make a significant positive contribution.

Our review highlights the need for a stricter adherence to indications, surgery should not be under-estimated and devolved to trainees, and our understanding of the radial axis of the elbow and forearm remains relatively rudimentary.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_II | Pages 166 - 166
1 Apr 2005
Ankem H Kamineni S Gupta A Nissantham T
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Purpose: Distal humeral fractures are often difficult injuries to treat. We hypothesise that more complex distal humeral fractures have unacceptable functional outcomes due to multi-factorial reasons.

Methods: 42 patients with AO/ASIF type B and C fractures of the distal humerus who were treated with open reduction and internal fixation over a six year period were included in the study. All patients were from a single district general hospital. 37 (88%) were clinically, radiologically, and functionally assessed for this study, with the remainder either lost to follow-up or expired.

Results: There were 21 type B and 16 type C fractures, all managed by open reduction and internal fixation. Various fixation techniques were utilised. These were performed by consultant surgeons in 14 cases and by surgeons in training in 23 cases. Average follow up was 38 months (range 22–54 months). The arc of elbow motion was 94 degrees (range 58–130), with an average extension deficit of 28 degrees (range 20–55) and an average flexion deficit of 32 degrees (range 15–45). The average arc of forearm rotation was 136 degrees (range 45–140), with an average supination of 68 (range 35–85) and an average pronation of 72 (range 45–90). The complications (n=20/37) included superficial skin infection (n=4), ulnar nerve neurapraxia (n=3), non-union of the humerus fracture (n=2), non-union of olecranon osteotomy site (n=1), intra-articular screw placement (n=1), loosened plate (n=1), loose/backed out screw (n=2), fixed flexion deformity (n=4) and mild elbow instability (n=2). Second surgery was performed in 24% (n=9/37), revision of metal work (n=2), bone grafting (n=2), anterior capsulectomy (n=4), and removal of screw (n=1).

Conclusions: Fractures of the distal humerus are often more complex than appreciated, and challenging to treat, with respect to fracture union and functional outcome. A generalist practice appears adequate for achieving bony union, but inadequate for obtaining low complication rates and functional outcomes. Our data suggest that such injuries may constitute a fracture group requiring the acute intervention by centres that have specific sub-specialisation and adequate rehabilitation facilities


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_II | Pages 169 - 170
1 Apr 2005
Marwah G Gupta A Kamineni S
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Aim: Complex radial head fractures are often underestimated in their complexity with consequent poor outcomes.

Method: We retrospectively reviewed thirty-two Mason 2 and 3 radial head fractures treated surgically with open reduction and internal fixation by generalist orthopaedic surgeons and trainees over a four-year period. They were clinically, radiologically and functionally assessed for this study. Functional assessment was done using the Mayo elbow performance score (MEPS).

Results: There were fourteen Mason 2 and eighteen Mason 3 radial head fractures. The Mason 2 were fixed by K-wires (n=2), Herbert TM screws (n=5), Acutrack TM screws (n=3), and T-plates (n = 4). The Mason 3 were fixed by Herbert TM screws (n=6), Acutrack TM screws (n=4) and T plates.

Average follow up was 47 months (range 22–65 months). The arc of elbow motion was 1040 (range 680_1400), with an average extension deficit of 230 (range 00–500) and an average flexion deficit of 200 (range 100–400). The average arc of forearm rotation was 1300 (range 00–1400), with an average supination of 660 (range 00–750), and an average pronation of 680 (range 00–800 ). The complications (N=17/32) included superficial skin infection (n=2), transient posterior interosseous nerve palsy (n=4), broken T -plate (n=1), intra-articular placement of a screw (n=1), loose and backed out screw (n=1), non-, union of radial head (n=2). Fixed flexion deformity if elbow (n=4) and mild elbow in stability (n=2). Second surgery was preformed in 18.7 % (n=6/32)(radial head replacement n=1, anterior capsulectomy n=4 and removal of screw n=1).

Conclusion: Radial head trauma surgery is an underestimated source of poor clinical outcomes. Complex radial head fractures should be clinically and radiologically evaluated with the knowledge that they are difficult to accurately and comprehensively assess. The treatment of such fractures may warrant management by a sub-specialist, although this latter conclusion has not been corroborated to date.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_I | Pages 78 - 78
1 Mar 2005
Gupta A Sraals E Kochar T Blunn G Briggs T Cannon S
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Purpose- To review the long term survival of patients, complications and functional outcome of diaphyseal replacements in 40 consecutive femoral endoprosthetic reconstructions for treatment of primary bone sarcoma.

Methods- A retrospective case study analysis was performed on all patients treated in our hospital between 1991 and 2002 with diaphyseal replacements for the management of sarcomas of femur.

Results- 40 cases (28 males and 12 females) with a mean age of 38.4 years (10–56) were identified.The indications were ostesarcoma (18), chondrosarcoma (12), MFH (4) and ewings sarcoma (6). The presenting complaints were pain (24), swelling (16) or both (6). Fibular strut graft was used in 12 cases as an adjuvant to the diaphyseal replacement. Adequate surgical clearence was obtained in 37 cases (92.5%). The average follow up period was 98 months (11–158). The patients were assessed by the Musculoskeletal Tumour Society (MSTS) scoring system. The average MSTS score was 19 (range 16–22). The average range of motion at the knee was 94° (range 74°–126°). Twenty nine remained disease free at review. 16 patients died at a median of 28 months (11 to 124) – 6 from metastatic disease and 10 from other causes. The cumulative complication rate was 18%- wound debridement (5%), infection (3%), revision surgeries (10%–4 cases- periprosthetic fracture n=1, implant breakage n=1 and implant loosening n=2.) One patient needed amputation for recurrence.

Conclusion-.Surgical management of bone tumours using diaphyseal endoprosthesis is an effective method of treatment which allows the patient to retain a high level of function and range of motion.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_I | Pages 76 - 76
1 Mar 2005
Gupta A Sood M Williams R Straal E Blunn G Briggs T Cannon S
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When managing malignant bone tumours in the distal femur with limb salvage, resection and reconstruction with a distal femoral replacement (DFR) conventionally entails prosthetic replacement of the knee joint. In younger patients it is desirable to try to preserve the knee joint. We now use a new Joint-Sparing distal femoral prosthesis in those cases where it is possible to resect the tumour and preserve the femoral condyles. Purpose of study: To look at our early results with knee joint preserving DFR’s. Methods: Between June 2001 and March 2004 the prosthesis was implanted in 8 patients (5 males and 3 females) aged between 8 and 24 years at the time of surgery. The diagnosis was osteosarcoma in 6 cases and chondrosarcoma in 2 cases. All patients were followed regularly and knee range of movement was recorded as well as any complications that occurred. Patients were functionally evaluated using the MSTS Scoring System. Results: Six of the patients had a mean follow-up of 20 months (range 8–33) and in this group 4 had good knee flexion with a mean flexion of 122° (110–130), 1 patient had fair flexion of 60° and 1 patient had poor flexion of 20°. The mean fixed flexion deformity in the 3 patients who had such a deformity was 10° (5–15). There were no intraoperative complications but the patient with poor flexion required an arthrolysis and because of the poor result is under consideration for conversion to a conventional DFR. Two patients had follow-up periods of 3 months or less and are still in their early rehabilitation period. One patient in this group developed sepsis that resolved after an open washout. Conclusions: Our early results with this prosthesis, in the patients with adequate follow-up, have been good in the majority but the two cases of fair and poor knee flexion are disappointing. This particular problem may relate to design and technical factors, which will be discussed in detail.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_I | Pages 76 - 76
1 Mar 2005
Gupta A Houlihan-Burne D Briggs T Cannon S Pringle J
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Purpose- To review the operative treatment of patients with chondrosarcoma of the pelvis and to study the long-term survival analysis of this cohort group.

Methods- A retrospective case study analysis was performed of patients with a diagnosis of chondrosarcoma of the pelvis treated in our hospital between 1990 and 2003. The operative notes and histopathological records were used along with the latest follow up letters.

Results- 54 cases (32 males and 22 females) with a mean age of 48.4 years ( 18–77) were identified. The aetiology was primary ( 38), recurrences ( 9) and secondaries ( 7).The sites in the pelvis were in the anatomical epicentre I(24), II(20) and III(10).The surgical procedures performed were local resection (28) , local resection and hip arthoplasty (6), hemipelvectomy (+ endoprosthesis) (16), hemipelvectomy (+ fibular strut graft) (2) and hindquater amputation (2).The histological grade was grade 1 (27), grade 2 (20) and grade 3(7). The complications rate was 24% – Wound revision (9%), dislocation (8%) and infection (7%). There was a 14-year cumulative survival rate of 46 % and 24 patients are surviving to date. The median follow up was 52 months.

The cumulative 14-year recurrence rate was 40% and the mean time to recurrence was 20.2 months.

Conclusion- There is an increased recurrence rate with epicentre I and III tumours and with those treated by local excision.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_I | Pages 76 - 76
1 Mar 2005
Sood M Gupta A Blunn G Meswania J Briggs T Cannon S
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When managing malignant long bone tumours in skeletally immature patients it is desirable, after resection, to reconstruct with a prosthesis that can be lengthened at appropriate intervals to keep pace with growth of the contralateral side. In an attempt to avoid multiple surgical procedures to achieve such lengthening we have recently developed a prosthesis that can be lengthened non-invasively.

Purpose of study: To look at our early experience with the use of non-invasive growing femoral prostheses.

Methods: Between November 2002 and February 2004 the prosthesis was implanted in 6 patients (3 males and 3 females) with a diagnosis of osteosarcoma. The patients were aged between 9 and 14 years (mean 11.5 years) at the time of surgery. Patients were lengthened at appropriate intervals and the process was monitored with scanograms. The prosthesis contains a magnet that is connected to gears that drive the extending mechanism. The patients’ limb is placed into a coil and the principle of electromagnetic induction coupling is used to achieve lengthening. Total degree of lengthening to date was recorded for each patient together with the range of knee movement and any complications that occurred. Patients were functionally evaluated at their last follow-up visit using the Musculoskeletal Tumour Society (MSTS) Scoring System.

Results: To date patients have been lengthened by an average of 18mm (8–48mm). The mean amount of knee flexion is 125 degrees. The mean MSTS score is 18 (16–21). There have been two complications; one patient developed patella subluxation during the lengthening programme and one patient has required serial casting to treat a flexion deformity of 25 degrees.

Conclusions: We have been encouraged by our early results with this prosthesis and have been able to demonstrate that the technology works reliably in vivo. We are continuing to use this prosthesis in skeletally immature patients.


The Journal of Bone & Joint Surgery British Volume
Vol. 80-B, Issue 6 | Pages 1037 - 1039
1 Nov 1998
Gupta A Kakkar A Chadha M Sathaye CB

A primary hydatid cyst in the pelvis is rare, and usually presents with pressure symptoms affecting the adjacent abdominal organs. We describe such a cyst which protruded through the sciatic notch and presented as a gluteal swelling with a foot drop due to compression of the lumbosacral nerve roots. Surgical excision and postoperative treatment with albendazole for six weeks were effective in controlling the disease and preventing recurrence.


The Journal of Bone & Joint Surgery British Volume
Vol. 73-B, Issue 2 | Pages 312 - 315
1 Mar 1991
Gupta A

In a prospective study, 204 consecutive patients with displaced Colles' fractures had closed reduction then plaster immobilisation. Three different positions of the wrist in plaster were randomly allocated: palmar flexion, neutral and dorsiflexion. The results in the three groups were compared. Fractures immobilised with the wrist in dorsiflexion showed the lowest incidence of redisplacement, especially of dorsal tilt, and had the best early functional results. Immobilisation of the wrist in palmar flexion has a detrimental effect on hand function; it is suggested that it is also one of the main causes for redisplacement of the fracture. This is discussed in relation to the functional anatomy of the wrist and the mechanics of plaster fixation.


The Journal of Bone & Joint Surgery British Volume
Vol. 71-B, Issue 4 | Pages 692 - 695
1 Aug 1989
Gupta A el Masri W

Spinal injury at more than one level is not uncommon. Awareness of multilevel injury of the spine and associated neurological patterns is important for the proper initial management of the patient. This study presents the incidence, pattern of signs and the neurological consequences of multilevel spinal injury. A review of 935 patients with spinal injuries revealed that lesions occurred in multiple levels in 9.7%; in over half of the cases, neurological lesions were incomplete. Multiple level non-contiguous lesions at more than two levels had the worst prognosis with 70% of patients suffering complete paraplegia.