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The Bone & Joint Journal
Vol. 96-B, Issue 6 | Pages 713 - 716
1 Jun 2014
Duncan CP Haddad FS

Periprosthetic fractures are an increasingly common complication following joint replacement. The principles which underpin their evaluation and treatment are common across the musculoskeletal system. The Unified Classification System proposes a rational approach to treatment, regardless of the bone that is broken or the joint involved.

Cite this article: Bone Joint J 2014;96-B:713–16.


The Bone & Joint Journal
Vol. 96-B, Issue 4 | Pages 562 - 562
1 Apr 2014
Haddad FS

Craig P, Bancroft G, Burton A, Collier S, Shaylor P, Sinha A. Raised levels of metal ions in the blood in patients who have undergone uncemented metal-on-polyethylene Trident–Accolade total hip replacement. Bone Joint J 2014;96-B:43–47.


The Bone & Joint Journal
Vol. 96-B, Issue 4 | Pages 433 - 435
1 Apr 2014
Haddad FS


The Bone & Joint Journal
Vol. 96-B, Issue 4 | Pages 562 - 562
1 Apr 2014
Haddad FS

Valenzuela GA, Jacobson NA, Buzas D, Koreckij TD, Valenzuela RG, Teitge RA. Unicompartmental knee replacement after high tibial osteotomy: Invalidating a contraindication. Bone Joint J 2013;95-B:1348–1353.


The Bone & Joint Journal
Vol. 96-B, Issue 4 | Pages 562 - 562
1 Apr 2014
Haddad FS

Batta V, Coathup MJ, Parratt MT, et al. Uncemented, custom-made, hydroxyapatite-coated collared distal femoral endoprostheses: Up to 18 years’ follow-up. Bone Joint J 2014;96-B:263–269.


The Bone & Joint Journal
Vol. 96-B, Issue 4 | Pages 562 - 562
1 Apr 2014
Haddad FS

Brånemark R, Berlin Ö, Hagberg K, Bergh P, Gunterberg B, Rydevik B. A novel osseointegrated percutaneous prosthetic system for the treatment of patients with transfemoral amputation: A prospective study of 51 patients. Bone Joint J 2014;96-B:106–113.


The Bone & Joint Journal
Vol. 96-B, Issue 4 | Pages 562 - 562
1 Apr 2014
Haddad FS

Canadian Arthroplasty Society. The Canadian Arthroplasty Society’s experience with hip resurfacing arthroplasty: an analysis of 2773 hips. Bone Joint J 2013;95-B:1045–1051.


The Bone & Joint Journal
Vol. 96-B, Issue 3 | Pages 289 - 290
1 Mar 2014
Haddad FS


The Bone & Joint Journal
Vol. 96-B, Issue 2 | Pages 145 - 146
1 Feb 2014
Haddad FS


The Bone & Joint Journal
Vol. 96-B, Issue 1 | Pages 1 - 2
1 Jan 2014
Haddad FS


The Bone & Joint Journal
Vol. 96-B, Issue 1 | Pages 24 - 30
1 Jan 2014
Haddad B Konan S Haddad FS

We have reviewed the current literature to compare the results of surgery aimed to repair or debride a damaged acetabular labrum. We identified 28 studies to be included in the review containing a total of 1631 hips in 1609 patients. Of these studies 12 reported a mean rate of good results of 82% (from 67% to 100%) for labral debridement. Of the 16 studies that reported a combination of debridement and re-attachment, five reported a comparative outcome for the two methods, four reported better results with re-attachment and one study did not find any significant difference in outcomes. Due to the heterogeneity of the studies it was not possible to perform a meta-analysis or draw accurate conclusions. Confounding factors in the studies include selection bias, use of historical controls and high rates of loss of follow-up.

It seems logical to repair an unstable tear in a good quality labrum with good potential to heal in order potentially to preserve its physiological function. A degenerative labrum on the other hand may be the source of discomfort and its preservation may result in persistent pain and the added risk of failure of re-attachment. The results of the present study do not support routine refixation for all labral tears.

Cite this article: Bone Joint J 2014;96-B:24–30.


The Bone & Joint Journal
Vol. 95-B, Issue 12 | Pages 1585 - 1586
1 Dec 2013
Konan S Haddad FS


The Bone & Joint Journal
Vol. 95-B, Issue 12 | Pages 1587 - 1594
1 Dec 2013
Ibrahim MS Twaij H Giebaly DE Nizam I Haddad FS

The outcome after total hip replacement has improved with the development of surgical techniques, better pain management and the introduction of enhanced recovery pathways. These pathways require a multidisciplinary team to manage pre-operative education, multimodal pain control and accelerated rehabilitation. The current economic climate and restricted budgets favour brief hospitalisation while minimising costs. This has put considerable pressure on hospitals to combine excellent results, early functional recovery and shorter admissions.

In this review we present an evidence-based summary of some common interventions and methods, including pre-operative patient education, pre-emptive analgesia, local infiltration analgesia, pre-operative nutrition, the use of pulsed electromagnetic fields, peri-operative rehabilitation, wound dressings, different surgical techniques, minimally invasive surgery and fast-track joint replacement units.

Cite this article: Bone Joint J 2013;95-B:1587–94.


The Bone & Joint Journal
Vol. 95-B, Issue 11 | Pages 1441 - 1442
1 Nov 2013
Morgan-Jones R Haddad FS


The Bone & Joint Journal
Vol. 95-B, Issue 11_Supple_A | Pages 98 - 102
1 Nov 2013
Ibrahim MS Raja S Haddad FS

The increasing need for total hip replacement (THR) in an ageing population will inevitably generate a larger number of revision procedures. The difficulties encountered in dealing with the bone deficient acetabulum are amongst the greatest challenges in hip surgery. The failed acetabular component requires reconstruction to restore the hip centre and improve joint biomechanics. Impaction bone grafting is successful in achieving acetabular reconstruction using both cemented and cementless techniques. Bone graft incorporation restores bone stock whilst providing good component stability. We provide a summary of the evidence and current literature regarding impaction bone grafting using both cemented and cementless techniques in revision THR.

Cite this article: Bone Joint J 2013;95-B, Supple A:98–102.


The Bone & Joint Journal
Vol. 95-B, Issue 11 | Pages 1582 - 1582
1 Nov 2013
Haddad FS

Cavaignac E, Lafontan V, Reina N, Pailhé R, Wargny M, Laffosse JM, Chiron P. Obesity has no adverse effect on the outcome of unicompartmental knee replacement at a minimum follow-up of seven years. Bone Joint J 2013;95-B:1064-1068.


The Bone & Joint Journal
Vol. 95-B, Issue 11_Supple_A | Pages 26 - 30
1 Nov 2013
Fayad TE Khan MA Haddad FS

Young adults with hip pain secondary to femoroacetabular impingement (FAI) are rapidly being recognised as an important cohort of orthopaedic patients. Interest in FAI has intensified over the last decade since its recognition as a precursor to arthritis of the hip and the number of publications related to the topic has increased exponentially in the last decade. Although not all patients with abnormal hip morphology develop osteoarthritis (OA), those with FAI-related joint damage rapidly develop premature OA. There are no explicit diagnostic criteria or definitive indications for surgical intervention in FAI. Surgery for symptomatic FAI appears to be most effective in younger individuals who have not yet developed irreversible OA. The difficulty in predicting prognosis in FAI means that avoiding unnecessary surgery in asymptomatic individuals, while undertaking intervention in those that are likely to develop premature OA poses a considerable dilemma. FAI treatment in the past has focused on open procedures that carry a potential risk of complications.

Recent developments in hip arthroscopy have facilitated a minimally invasive approach to the management of FAI with few complications in expert hands. Acetabular labral preservation and repair appears to provide superior results when compared with debridement alone. Arthroscopic correction of structural abnormalities is increasingly becoming the standard treatment for FAI, however there is a paucity of high-level evidence comparing open and arthroscopic techniques in patients with similar FAI morphology and degree of associated articular cartilage damage. Further research is needed to develop an understanding of the natural course of FAI, the definitive indications for surgery and the long-term outcomes.

Cite this article: Bone Joint J 2013;95-B, Supple A:26–30.


The Bone & Joint Journal
Vol. 95-B, Issue 11 | Pages 1582 - 1582
1 Nov 2013
Haddad FS

Kazi HA, Perera JR, Gillott E, Carroll FA, Briggs TW. A prospective study of a ceramic-on-metal bearing in total hip arthroplasty: Clinical results, metal ion levels and chromosome analysis at two years. Bone Joint J 2013;95-B:1040-1044.


The Bone & Joint Journal
Vol. 95-B, Issue 11 | Pages 1582 - 1582
1 Nov 2013
Haddad FS

Gordon M, Stark A, Sköldenberg OG, Kärrholm J, Garellick G. The influence of comorbidity scores on re-operations following primary total hip replacement: Comparison and validation of three comorbidity measures. Bone Joint J 2013;95-B:1184-1191.


The Bone & Joint Journal
Vol. 95-B, Issue 11 | Pages 1582 - 1582
1 Nov 2013
Haddad FS

Cadossi M, Chiarello E, Savarino L, Tedesco G, Baldini N, Faldini C, Giannini S. A comparison of hemiarthroplasty with a novel polycarbonate-urethane acetabular component for displaced intracapsular fractures of the femoral neck: a randomised controlled trial in elderly patients. Bone Joint J 2013;95-B:609-615.


The Bone & Joint Journal
Vol. 95-B, Issue 11 | Pages 1582 - 1582
1 Nov 2013
Haddad FS

Canadian Arthroplasty Society. The Canadian Arthroplasty Society’s experience with hip resurfacing arthroplasty: an analysis of 2773 hips. Bone Joint J 2013;95-B:1045-1051.


The Bone & Joint Journal
Vol. 95-B, Issue 10 | Pages 1297 - 1298
1 Oct 2013
Haddad FS Konan S


The Bone & Joint Journal
Vol. 95-B, Issue 9 | Pages 1153 - 1155
1 Sep 2013
Timperley AJ Haddad FS


The Bone & Joint Journal
Vol. 95-B, Issue 8 | Pages 1009 - 1010
1 Aug 2013
Haddad FS


The Bone & Joint Journal
Vol. 95-B, Issue 7 | Pages 865 - 865
1 Jul 2013
Haddad FS


The Bone & Joint Journal
Vol. 95-B, Issue 7 | Pages 874 - 876
1 Jul 2013
Kallala R Anderson P Morris S Haddad FS

In a time of limited resources, the debate continues over which types of hip prosthesis are clinically superior and more cost-effective. Orthopaedic surgeons increasingly need robust economic evidence to understand the full value of the operation, and to aid decision making on the ‘package’ of procedures that are available and to justify their practice beyond traditional clinical preference.

In this paper we explore the current economic debate about the merits of cemented and cementless total hip replacement, an issue that continues to divide the orthopaedic community.

Cite this article: Bone Joint J 2013;95-B:874–6.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 14 - 14
1 Mar 2013
Benjamin-Laing H Konan S Rayan F Manktelow A Haddad FS
Full Access

Infected periprosthetic fractures around total hip arthroplasties are increasingly common and extremely challenging problem. The purpose of the study was to review the experience of two tertiary referral units managing infected periprosthetic femoral fractures using interlocking long-stem femoral prostheses either as temporary functional spacers or as definitive implants.

Methods

A prospective review of 19 patients managed at two tertiary referral units between 2000 and 2011. Each patient was diagnosed and managed according to similar institutional protocols. Investigation through aspiration and biopsy of periprosthetic tissue supplemented haematological tests to confirm infection. The Cannulock uncoated stem was used in 14 cases, and the Kent hip prosthesis in 5 cases. Allograft struts were used in patients with deficient bone stock.

Results

The mean follow-up for the series was a 53 months (range, 24–99 months). 13 patients underwent definitive revision within 7.9 months (range, 6–10 months; SD, 2.2 months). In 6 cases we implanted an extensively porous-coated stem, in 4 cases a tapered distally fixed cementless stem was used, and in 3 cases a proximal femoral replacement was used. There were no reinfections after the second stage revisions in these patients. 2 patients were offered further staged surgery due to persistently raised inflammatory markers but being mobile and relatively painfree declined. They are being managed in the community on oral antibiotics. Satisfactory outcome was noted in all cases, and in 13 cases, revision to a definitive stem was undertaken after successful control of infection and fracture union. The average postoperative Harris Hip score was 83 (range 79–89). All patients returned to their low to moderate premorbid functional state after discharge.


The Journal of Bone & Joint Surgery British Volume
Vol. 94-B, Issue 11_Supple_A | Pages 78 - 81
1 Nov 2012
Benjamin-Laing H Haddad FS

In this paper, we will consider the current role of metal-on-metal bearings by looking at three subtypes of MoM hip arthroplasty separately: Hip resurfacing, large head (> 36 mm) MoM THA and MoM THA with traditional femoral head sizes.


The Journal of Bone & Joint Surgery British Volume
Vol. 94-B, Issue 11 | Pages 1455 - 1456
1 Nov 2012
Oussedik S Gould K Stockley I Haddad FS

Peri-prosthetic infection remains a leading cause of revision surgery. Recent publications from the American Musculoskeletal Infection Society have sought to establish a definition of peri-prosthetic infection based on clinical findings and laboratory investigations. The limitations of their approach are discussed and an alternative definition is proposed, which it is felt may better reflect the uncertainties encountered in clinical practice.


The Journal of Bone & Joint Surgery British Volume
Vol. 94-B, Issue 11_Supple_A | Pages 120 - 122
1 Nov 2012
Gulhane S Vanhegan IS Haddad FS

In this paper we make the case for the use of single-stage revision for infected knee arthroplasty.


The Journal of Bone & Joint Surgery British Volume
Vol. 94-B, Issue 10 | Pages 1321 - 1329
1 Oct 2012
Sarmah SS Patel S Hossain FS Haddad FS

Radiological assessment of total and unicompartmental knee replacement remains an essential part of routine care and follow-up. Appreciation of the various measurements that can be identified radiologically is important. It is likely that routine plain radiographs will continue to be used, although there has been a trend towards using newer technologies such as CT, especially in a failing knee, where it provides more detailed information, albeit with a higher radiation exposure.

The purpose of this paper is to outline the radiological parameters used to evaluate knee replacements, describe how these are measured or classified, and review the current literature to determine their efficacy where possible.


The Journal of Bone & Joint Surgery British Volume
Vol. 94-B, Issue 7 | Pages 875 - 881
1 Jul 2012
Vanhegan IS Morgan-Jones R Barrett DS Haddad FS

This review summarises the opinions and conclusions reached from a symposium on infected total knee replacement (TKR) held at the British Association of Surgery of the Knee (BASK) annual meeting in 2011. The National Joint Registry for England and Wales reported 5082 revision TKRs in 2010, of which 1157 (23%) were caused by infection. The diagnosis of infection beyond the acute post-operative stage relies on the identification of the causative organism by aspiration and analysis of material obtained at arthroscopy. Ideal treatment then involves a two-stage surgical procedure with extensive debridement and washout, followed by antibiotics. An articulating or non-articulating drug-eluting cement spacer is used prior to implantation of the revision prosthesis, guided by the serum level of inflammatory markers. The use of a single-stage revision is gaining popularity and we would advocate its use in certain patients where the causative organism is known, no sinuses are present, the patient is not immunocompromised, and there is no radiological evidence of component loosening or osteitis.

It is our opinion that single-stage revision produces high-quality reproducible results and will soon achieve the same widespread acceptance as it does in infected hip arthroplasty.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXV | Pages 228 - 228
1 Jun 2012
Sukeik M Haddad FS
Full Access

Introduction

Up to 2% of total hip arthroplasties (THA) are still complicated by infection. This leads to dissatisfied patients with poor function, and has far-reaching social and economic consequences. The challenge in these cases is the eradication of infection, the restoration of full function and the prevention of recurrence. We report the outcome of early aggressive debridement in the acutely infected THA.

Methods

We studied 28 consecutive patients referred with acutely infected THA (18 primaries, 10 revisions) which occurred within 6 weeks of the index operation or of haematogenous spread between 1999 and 2006. Microbiology confirmed bacterial colonisation in all cases with 20 early post-operative infections and 8 cases of acute haematogenous spread. Patients with a cemented THA underwent aggressive open debridement, a thorough synovectomy and exchange of all mobile parts. Uncemented THA were treated as a single stage revision with removal of all implants, aggressive debridement and re-implantation of new prosthesis. Antibiotics were continued in all cases until inflammatory markers and the plasma albumin concentration returned to within normal limits.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXV | Pages 115 - 115
1 Jun 2012
Konan S Hossain FS Haddad FS
Full Access

Introduction

There have been concerns regarding the quality of training received by Orthopaedic trainees. There has been a reduction in working hours according to the European working times directive. National targets to reduce surgical waiting lists has increased the workload of consultants, further reducing the trainees' surgical experience. Navigation assisted procedures are successfully used in orthopaedics and provides useful feedback to the surgeon regarding precision of implant placement. We investigated the use of navigation aids as an alternative source of training surgical trainees.

Methods

We choose a navigation assisted knee replacement (TKR) model for this study. A first year Orthopaedic registrar level trainee was taught the TKR procedure by a scrubbed consultant in 5 cases. He was then trained in use of non-CT based navigation surgery. The Trainee then performed navigation assisted non-complex primary TKR surgery. A consultant Orthopaedic surgeon was available throughout for advice and support. Data collected included pre and post procedure valgus and varus alignment of the knee, total operative time and WOMAC scores pre and post operatively.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXV | Pages 116 - 116
1 Jun 2012
Konan S Rayan F Meermans G Witt J Haddad FS
Full Access

Introduction

In recent years, there has been a significant advancement in our understanding of femoro-acetabular impingement and associated labral and chondral pathology. Surgeons worldwide have demonstrated the successful treatment of these lesions via arthroscopic and open techniques. The aim of this study is to validate a simple and reproducible classification system for acetabular chondral lesions.

Methods

In our classification system, the acetabulum is first divided into 6 zones as described by Ilizalithurri VM et al [Arthroscopy 24(5) 534-539]. The cartilage is then graded as 0 to 4 as follows: Grade 0 – normal articular cartilage lesions; Grade 1 softening or wave sign; Grade 2 - cleavage lesion; Grade 3 - delamination and Grade 4 –exposed bone. The site of the lesion is further typed as A, B or C based on whether the lesion is 1/3 distance from acetabular rim to cotyloid fossa, 1/3 to 2/3 distance from acetabular rim to cotyloid fossa and > 2/3 distance from acetabular rim to cotyloid fossa.

For validating the classification system, six surgeons reviewed 14 hip arthroscopy video clips. All surgeons were provided with written explanation of our classification system. Each surgeon then individually graded the cartilage lesion. A single observer then compared results for observer variability using kappa statistics.


The Journal of Bone & Joint Surgery British Volume
Vol. 94-B, Issue 5 | Pages 619 - 623
1 May 2012
Vanhegan IS Malik AK Jayakumar P Ul Islam S Haddad FS

Revision arthroplasty of the hip is expensive owing to the increased cost of pre-operative investigations, surgical implants and instrumentation, protracted hospital stay and drugs. We compared the costs of performing this surgery for aseptic loosening, dislocation, deep infection and peri-prosthetic fracture. Clinical, demographic and economic data were obtained for 305 consecutive revision total hip replacements in 286 patients performed at a tertiary referral centre between 1999 and 2008. The mean total costs for revision surgery in aseptic cases (n = 194) were £11 897 (sd 4629), for septic revision (n = 76) £21 937 (sd 10 965), for peri-prosthetic fracture (n = 24) £18 185 (sd 9124), and for dislocation (n = 11) £10 893 (sd 5476). Surgery for deep infection and peri-prosthetic fracture was associated with longer operating times, increased blood loss and an increase in complications compared to revisions for aseptic loosening. Total inpatient stay was also significantly longer on average (p < 0.001). Financial costs vary significantly by indication, which is not reflected in current National Health Service tariffs.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_IX | Pages 22 - 22
1 Mar 2012
Sukeik M Dobson M Bridgens A Haddad FS
Full Access

Introduction

Up to 2% of total knee arthroplasties (TKA) are still complicated by infection. This leads to dissatisfied patients with poor function, and has far-reaching social and economic consequences. The challenge in these cases is the eradication of infection, the restoration of full function and the prevention of recurrence.

We report the outcome of prosthesis sparing early aggressive debridement in the acutely infected TKA.

Methods

We studied 29 consecutive patients referred with acutely infected TKA (18 primaries, 11 revisions) which occurred within 6 weeks of the index operation or of haematogenous spread. Microbiology confirmed bacterial colonisation in all cases with 20 early post-operative infections and 9 cases of acute haematogenous spread. All patients underwent aggressive open debridement, a thorough synovectomy and a change of insert. Antibiotics were continued until inflammatory markers and the plasma albumin concentration returned to within normal limits.


The Journal of Bone & Joint Surgery British Volume
Vol. 94-B, Issue 3 | Pages 297 - 301
1 Mar 2012
Haddad FS Konan S

An international faculty of orthopaedic surgeons presented their work on the current challenges in hip surgery at the London Hip Meeting which was attended by over 400 delegates. The topics covered included femoroacetabular impingement, thromboembolic phenomena associated with hip surgery, bearing surfaces (including metal-on-metal articulations), outcomes of hip replacement surgery and revision hip replacement. We present a concise report of the current opinions on hip surgery from this meeting with appropriate references to the current literature.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_IX | Pages 70 - 70
1 Mar 2012
Hossain FS Patel S Tahmassebi J Haddad FS
Full Access

Introduction

Unicondylar knee replacements (UKR) may be more effective compared to Total knee replacements (TKR) in unicompartmental arthritis. We report patient outcomes & satisfaction data in an age matched cohort of patients with either a UKR or TKR.

Method

A single unit and single surgeon series of patients were recruited. Data was retrospectively collated for 68 patients with more than 24 months follow-up. UKR was undertaken in patients with isolated medial compartment osteoarthritis; stable ACL and less than grade 3 lateral patellar changes of the Outerbridge classification. TKR was undertaken for the rest. The patients were assessed with validated knee scores including the Total Knee Function Questionnaire (TKFQ) which focuses on recreational & sporting outcomes as well as activities of daily living (ADL). Patient satisfaction and perception of knee normality was measured on a visual analogue scale.


The Journal of Bone & Joint Surgery British Volume
Vol. 93-B, Issue 5 | Pages 572 - 579
1 May 2011
Haddad FS Thakrar RR Hart AJ Skinner JA Nargol AVF Nolan JF Gill HS Murray DW Blom AW Case CP

Lately, concerns have arisen following the use of large metal-on-metal bearings in hip replacements owing to reports of catastrophic soft-tissue reactions resulting in implant failure and associated complications. This review examines the literature and contemporary presentations on current clinical dilemmas in metal-on-metal hip replacement.


The Journal of Bone & Joint Surgery British Volume
Vol. 93-B, Issue 3 | Pages 332 - 336
1 Mar 2011
Konan S Rayan F Meermans G Witt J Haddad FS

There have been considerable recent advances in the understanding and management of femoroacetabular impingement and associated labral and chondral pathology. We have developed a classification system for acetabular chondral lesions. In our system, we use the six acetabular zones previously described by Ilizaliturri et al. The cartilage is then graded on a scale of 0 to 4 as follows: grade 0, normal articular cartilage lesions; grade 1, softening or wave sign; grade 2, cleavage lesion; grade 3, delamination; and grade 4, exposed bone. The site of the lesion is further classed as A, B or C based on whether the lesion is less than one-third of the distance from the acetabular rim to the cotyloid fossa, one-third to two-thirds of the same distance and greater than two-thirds of the distance, respectively. In order to validate the classification system, six surgeons graded ten video recordings of hip arthroscopy.

Our findings showed a high intra-observer reliability of the classification system with an intraclass correlation coefficient of 0.81 and a high interobserver reliability with an intraclass correlation coefficient of 0.88.

We have developed a simple reproducible classification system for lesions of the acetabular cartilage, which it is hoped will allow standardised documentation to be made of damage to the articular cartilage, particularly that associated with femoroacetabular impingement.


The Journal of Bone & Joint Surgery British Volume
Vol. 93-B, Issue 2 | Pages 151 - 157
1 Feb 2011
El-Husseiny M Patel S MacFarlane RJ Haddad FS

Bacterial infection in orthopaedic surgery can be devastating, and is associated with significant morbidity and poor functional outcomes, which may be improved if high concentrations of antibiotics can be delivered locally over a prolonged period of time. The two most widely used methods of doing this involve antibiotic-loaded polymethylmethacrylate or collagen fleece. The former is not biodegradable and is a surface upon which secondary bacterial infection may occur. Consequently, it has to be removed once treatment has finished. The latter has been used successfully as an adjunct to systemic antibiotics, but cannot effect a sustained release that would allow it to be used on its own, thereby avoiding systemic toxicity.

This review explores the newer biodegradable carrier systems which are currently in the experimental phase of development and which may prove to be more effective in the treatment of osteomyelitis.


The Journal of Bone & Joint Surgery British Volume
Vol. 93-B, Issue 1 | Pages 39 - 46
1 Jan 2011
Sukeik M Alshryda S Haddad FS Mason JM

We report a systematic review and meta-analysis of published randomised controlled trials evaluating the efficacy of tranexamic acid (TXA) in reducing blood loss and transfusion in total hip replacement (THR). The data were evaluated using the generic evaluation tool designed by the Cochrane Bone, Joint and Muscle Trauma Group. We identified 11 clinical trials which were suitable for detailed extraction of data. There were no trials that used TXA in revision THR. A total of seven studies (comprising 350 patients) were eligible for the blood loss outcome data. The use of TXA reduced intra-operative blood loss by a mean of 104 ml (95% confidence interval (CI) −164 to −44, p = 0.0006, heterogeneity I2 0%), postoperative blood loss by a mean of 172 ml (95% CI −263 to −81, p = 0.0002, heterogeneity I2 63%) and total blood loss by a mean of 289 ml (95% CI −440 to −138, p < 0.0002, heterogeneity I2 54%).

TXA led to a significant reduction in the proportion of patients requiring allogeneic blood transfusion (risk difference −0.20, 95% CI −0.29 to −0.11, p < 0.00001, I2 15%). There were no significant differences in deep-vein thrombosis, pulmonary embolism, infection rates or other complications among the study groups.


The Journal of Bone & Joint Surgery British Volume
Vol. 92-B, Issue 10 | Pages 1325 - 1331
1 Oct 2010
Patel S Rodriguez-Merchan EC Haddad FS

Fibrin glue, also known as fibrin sealant, is now established as a haemostatic agent in surgery, but its role in orthopaedic surgery is neither well known nor clearly defined. Although it was originally used over 100 years ago, concerns about transmission of disease meant that it fell from favour. It is also available as a slow-release drug delivery system and as a substrate for cellular growth and tissue engineering. Consequently, it has the potential to be used in a number of ways in orthopaedic surgery. The purpose of this review is to address its use in surgery of the knee in which it appears to offer great promise.


The Journal of Bone & Joint Surgery British Volume
Vol. 92-B, Issue 9 | Pages 1222 - 1226
1 Sep 2010
Oussedik SIS Dodd MB Haddad FS

Periprosthetic infection following total hip replacement can be a catastrophic complication for the patient. The treatments available include single-stage exchange, and two-stage exchange. We present a series of 50 consecutive patients with a diagnosis of infected total hip replacement who were assessed according to a standardised protocol. Of these, 11 underwent single-stage revision arthroplasty with no recurrence of infection at a mean of 6.8 years follow-up (5.5 to 8.8). The remaining 39 underwent two-stage revision, with two recurrences of infection successfully treated by a second two-stage procedure. At five years, significant differences were found in the mean Harris Hip Scores (single-stage 87.8; two-stage 75.5; p = 0.0003) and in a visual analogue score for satisfaction (8.6; 6.9; p = 0.001) between the single- and two-stage groups. Single-stage exchange is successful in eradicating periprosthetic infection and results in excellent functional and satisfaction scores.

Identification of patients suitable for the single-stage procedure allows individualisation of care and provides as many as possible with the correct strategy in successfully tackling their periprosthetic infection


The Journal of Bone & Joint Surgery British Volume
Vol. 92-B, Issue 9 | Pages 1294 - 1299
1 Sep 2010
Ashby E Haddad FS O’Donnell E Wilson APR

As of April 2010 all NHS institutions in the United Kingdom are required to publish data on surgical site infection, but the method for collecting this has not been decided. We examined 7448 trauma and orthopaedic surgical wounds made in patients staying for at least two nights between 2000 and 2008 at our institution and calculated the rate of surgical site infection using three definitions: the US Centers for Disease Control, the United Kingdom Nosocomial Infection National Surveillance Scheme and the ASEPSIS system. On the same series of wounds, the infection rate with outpatient follow-up according to Centre for Disease Control was 15.45%, according to the UK Nosocomial infection surveillance was 11.32%, and according to ASEPSIS was 8.79%. These figures highlight the necessity for all institutions to use the same method for diagnosing surgical site infection.

If different methods are used, direct comparisons will be invalid and published rates of infection will be misleading.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_III | Pages 414 - 414
1 Jul 2010
Patel S Hossain FS Paton B Haddad FS
Full Access

Purpose: To determine if a multi-modal programme including non-operative measures of physiotherapy and education can improve the symptoms of osteoarthritis of the knee.

Methods/Results: 72 patients with osteoarthritis of the knee confirmed on radiographic or arthroscopic evidence were referred over a 13 month period (April 2007 – May 2008) for a lower limb programme. The programme consisted of 12 classes over 6 weeks of group physiotherapy and included education on osteoarthritis, diet and exercise.

The total number of knees affected was 98. The mean number of compartments affected was 1.2 with the medial and patellofemoral compartment most affected. The mean number of classes attended was 8.3. Pre-intervention, the mean WOMAC score was 64.7 and the mean Oxford knee score was 31.9. Post-intervention at a mean follow up of 12 months (range 7 – 22 months), the mean WOMAC score was 29.4 and the mean Oxford knee score 22.4. The change in scores following intervention was statistically significant (p < 0.05). Of the cohort, 9 patients were subsequently offered or went on to have knee joint arthroplasty.

Conclusions: At 12 months, a multi-modal programme consisting of non-operative interventions has an excellent impact upon osteoarthritis of the knee with improved patient reported scores. This modality should be considered for all patients with mild to moderate osteoarthritis in whom surgical options are not otherwise indicated. Further work is required to see which components most influenced patients’ outcomes, the impact of education and group classes on maintaining physiotherapy exercises in the long term, the benefits conferred even for those patients who subsequently undergo joint arthroplasty, and whether referral to the programme from a primary care setting will lower the number of referrals of knee osteoarthritis to orthopaedic units which are ultimately managed without surgical intervention.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_III | Pages 407 - 407
1 Jul 2010
Hossain FS Patel S Tahmassebi J Haddad FS
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Aim: To ascertain if a medial rotation platform knee replacement design (MRK; Finsbury Orthopaedics) exhibits improved range of motion (ROM) and functional outcome compared to a conventional single radius condylar knee replacement system (PFC Sigma; Depuy) at one year.

Methods: Eighty patients undergoing total knee arthroplasty(TKA) were prospectively randomised and allocated to either receive the MRK or PFC Sigma pros-thesis. Patients were blinded to the choice of implant. Follow-up clinical and radiological evaluations were carried out by a single clinician so as to avoid interob-server error. Validated patient based scores including the Total Knee Function Questionnaire (TKFQ) were used to assess patient function.

Results: The average ROM in the MRK group was 108.53°. In the PFC Sigma group it was 94.16°. Statistical significance was demonstrated between the two groups.

The MRK group showed superior results in the TKFQ score which assesses activities of daily living as well as recreational and sporting activities. The movement and lifestyle component of the TKFQ, and the Knee Society Score were better in the MRK group with statistical significance.

No difference was demonstrated between the two groups with respect to radiological analysis, WOMAC Knee, Oxford Knee and SF-36 scores.

6 out of 40 patients in the MRK group compared to 5 out of 40 patients in the PFC group said that they had forgotten about their TKA at one year.

Conclusions: The medial rotation platform design confers increased ROM at one year with an associated benefit in movement and lifestyle and resultant patient satisfaction.


The Journal of Bone & Joint Surgery British Volume
Vol. 92-B, Issue 4 | Pages 496 - 499
1 Apr 2010
Nawabi DH Chin KF Keen RW Haddad FS

We measured the plasma 25-hydroxyvitamin D3 (25(OH)D3) levels in 62 consecutive Caucasian patients undergoing total hip replacement for osteoarthritis. The patients were divided into two groups based on whether they were vitamin D sufficient or deficient. The groups were matched for age, gender and the American Society of Anaesthesiologists (ASA) grade. The prevalence of vitamin D deficiency in our patients was comparable with recent population-based studies performed in the United Kingdom. Patients with vitamin D deficiency had lower pre-operative Harris hip scores (Mann-Whitney test, p = 0.018) and were significantly less likely to attain an excellent outcome from total hip replacement (chi-squared test, p = 0.038). Vitamin D levels were found to positively correlate with both pre- and post-operative Harris hip scores.

These results warrant further study of vitamin D deficiency in patients undergoing joint replacement as it is a risk factor for a suboptimal outcome which is relatively simple and cheap to correct.


The Journal of Bone & Joint Surgery British Volume
Vol. 92-B, Issue 1 | Pages 47 - 50
1 Jan 2010
Konan S Rayan F Haddad FS

The radiological evaluation of the anterolateral femoral head is an essential tool for the assessment of the cam type of femoroacetabular impingement. CT, MRI and frog lateral plain radiographs have all been suggested as imaging options for this type of lesion. The alpha angle is accepted as a reliable indicator of the cam type of impingement and may also be used as an assessment for the successful operative correction of the cam lesion.

We studied the alpha angles of 32 consecutive patients with femoroacetabular impingement. The angle measured on frog lateral radiographs using templating tools was compared with that measured on CT scans in order to assess the reliability of the frog lateral view in analysing the alpha angle in cam impingement.

A high interobserver reliability was noted for the assessment of the alpha angle on the frog lateral view with an intraclass correlation coefficient of 0.83. The mean alpha angle measured on the frog lateral view was 58.71° (32° to 83.3°) and that by CT was 65.11° (30° to 102°). A poor intraclass correlation coefficient (0.08) was noted between the measurements using the two systems.

The frog lateral plain radiograph is not reliable for measuring the alpha angle. Various factors may be responsible for this such as the projection of the radiograph, the positioning of the patient and the quality of the image. CT may be necessary for accurate measurement of the alpha angle.