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Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 89 - 89
1 Mar 2008
Waddell J Morton J Griffith K Schemitsch E White K
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Revision hip arthroplasty does not bring to the patient the same degree of benefit as the primary operation. We compared two hundred and thirteen patients undergoing revision arthroplasty with five hundred and forty-seven patients undergoing primary total hip replacement. The complication rate in the revision arthroplasty group was approximately twice as high in the primary group (p< .05) primarily as a result of postoperative dislocation. Both groups of patients had a statistically significant improvement between their pre- and postoperative WOMAC and SF-36 physical scores; however, there was also a statistically significant difference in outcome when the two groups were compared, with primary patients having significantly improved WOMAC and SF-36 physical scores.

To compare the outcomes between primary and revision total hip arthroplasty patients at one institution with regard to demographics, complication rates and functional outcome.

Revision hip arthroplasty does not bring to the patient the same degree of benefit as does the primary operation. The reason for this is multi-factorial and includes a higher complication rate and lower functional outcome.

Further study of the problems associated with revision total hip replacement especially focused on complication rates would appear to be warranted.

All patients were entered prospectively in a database and were assessed by means of physical examination, radiographs, SF-36 and WOMAC questionnaires. Patients were followed for a minimum of two years with a range of two to five years. Patients were seen on an annual basis.

Five hundred and forty-seven patients underwent primary total hip replacement and two hundred and thirteen patients underwent revision total hip replacement. 53.4% of patients undergoing primary and 52% of patients undergoing revision arthroplasty were female. Mean age at primary hip replacement 61.8 years, revision hip replacement 67.1 years. Post-operative complication rate was 7.6% in primary patients and 14.7% in revision patients (p< .05); there was no statistically significant difference between the two groups with regard to intra-operative fracture, implant loosening or postoperative infection; there was a statistically significant difference in terms of dislocation with 0.8% of primary arthroplasties and 5.6% of revision patients sustaining at least one dislocation following their surgery (p< .01). Both groups of patients had a statistically significant improvement between their pre- and post-operative WOMAC and SF-36 physical scores (p< .0001); however, there was also a statistically significant difference in outcome when the two groups were compared with primary patients having significantly improved WOMAC scores (p< .0001) and significantly improved SF-36 physical scores (p< .0001).


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 121 - 121
1 Mar 2008
MacDonald C Zahrai A Walker R Rooney J Schemitsch E Wright J Waddell J
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The purpose of this study was to determine which activities are important to patients and to determine the severity of those problems. The five most important activities were walking outside, driving, walking indoors, stair climbing and daytime pain. Importance of these did not change postoperatively. The five most severe problems causing limitation were a limp, stiffness, loss of energy, daytime pain and locking. All these activities become statistically less severe over twenty-four months. Activities that are important to patients are different than the problems that are ranked by severity. Surgeons can educate patients that the severity of problems do improve over time following TKA.

The objectives of this study were:

to determine the five most important activities and five most severe problems for patients prior to total knee arthroplasty (TKA) using the Patient Specific Index (PASI) and

to determine the pattern of change in these activities over twenty-four months following TKA.

Activities that are most important to patients are different than problems that patients find severe. Important activities remain important over time. Severe problems become less severe over time.

Functional activities and PASI scores improve after TKA. Surgeons can educate patients that the problems they find most severe preoperatively do improve over time following TKA. Important activities remain important.

Patients scheduled for elective primary (or revision) TKA at two tertiary care teaching hospitals were enrolled in the study, excluding those not fluent in English and those undergoing TKA for a tumour, acute fracture, or an infection of the prosthesis. Patients completed the PASI pre-operatively, six, twelve and twenty-four months post-operatively.

One hundred and nineteen subjects were enrolled, nineteen were excluded. The five most important activities (ten- point scale, ten is most important) preoperatively were (mean; 95% CI): walking outside (6.25; 6.23–6.27), driving (6.17; 6.12–6.22), walking indoors (6.14; 6.12–6.16), climbing stairs (6.12; 6.10–6.14), and daytime pain (5.84; 5.81–5.87). These activities were not statistically less important over time. The most severe problems were limping (4.81; 4.77–4.85), stiffness (4.59; 4.56–4.62), lack of energy (4.51; 4.47–4.55), daytime pain (4.46; 4.43–3.39) and locking (4.38; 4.27–4.49). These were significantly less severe at twenty-four months (p < .001).


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 89 - 90
1 Mar 2008
Davis A Gollish J Schemitsch EH Davey J Waddell J Szalai J Kreder H Gafni A Badley E Mahomed N Saleh K Agnidis Z Gross A
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This study (n=126, mean age=68.8 years, males=62) evaluated pre-operative WOMAC pain and physical function, age, gender, general health status, revision severity classification, number of revisions, comorbidity and unilateral vs. bilateral surgery as predictors of WOMAC pain and physical function at twenty-four months post revision hip arthroplasty. Pain improved from 9.3 to 3.6 and physical function improved from 35.4 to 17.1. No factors were predictive of patient function. Decreased pain was predicted by less pain pre surgery (p=0.01) and being male (p=0.04).

To determine if pre-operative WOMAC pain and physical function, age, gender, general health status (SF-36), revision severity classification, number of revisions, comorbidity and unilateral vs. bilateral surgery are predictive of WOMAC pain and physical function at twenty-four months post revision hip arthroplasty.

Physical function at twenty-four months is not independently predicted by the pre-treatment factors evaluated in this study. Male patients with less pain pre surgery and little comorbidity have less pain post surgery.

With the exception of pre-treatment pain, the pre-treatment factors tested in this study provide minimal guidance in identifying factors that might be modified to enhance patient outcome.

This prospective cohort study included one hundred and twenty-six patients (mean age=68.8 years, males: females=62:64) who had revision for other than infection or peri-prosthetic fracture. On average from pre-surgery to twenty-four months post-surgery, WOMAC pain improved 9.3 to 3.6 and physical function improved from 35.4 to 17.1. In univariate analysis (t-test, p< 0.05), males tended to have better function (19.6 vs. 14.7) and reported less pain (4.4 vs. 2.8). No other factors were significant in univariate analysis. None of the a priori factors noted above were independently predictive of patient function at twenty-four months in the multivariate model (F=2.06, p=0.04, R2=0.16). Decreased pain with activity at twenty-four months independently was predicted by having less pain pre surgery (p=0.01), being male (p=0.04) and having fewer comorbidities (p=0.07) in the multi-variate model (F=2.9. p=0.004, R2=0.21).

Funding: This work was supported by a grant from The Arthritis Society


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 163 - 163
1 Mar 2006
Waddell J Schemitsch E McKee M McConnell A James S
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Introduction and Aims: Open femoral fracture is a serious injury. We have asked the question: do open femur fractures in polytrauma patients correlate with higher injury severity scores, increased length of stay and higher mortality rates than in closed femur fracture polytrauma patients.

Method: We undertook a retrospective review of a prospectively gathered trauma database at a Level 1 trauma centre. We identified multiple-injured patients with femur fractures who presented in a 36 month period. The cases were divided into 2 groups; open femur fractures (n=33) and closed femur fractures (n=80). Data was collected on demographics, precipitating event, length of stay spent in the ICU, number of associated injuries, ISS, AIS for affected systems, number of femoral surgeries and disposition. Data was analyzed using parametric statistical tests with a significance level of 0.05.

Results: Our analysis revealed that an average, patients in the open femur fracture group spent 8 + 9 days in ICU, sustained 4 + 1 associated injuries, underwent 2 + 1 femoral surgeries, had an ISS of 29 + 13, and died of their injuries in 30.3% of cases. Patients in the closed femur fracture groups spent 8 + 9 days in ICU, sustained 4 + 1 associated injuries, underwent 1 + 1 femoral surgeries, had an ISS of 29 + 14, and died of their injuries in 12.5% of cases. One-way ANOVA showed no statistically significant difference between groups in terms of time spent in ICU, ISS and number of associated injuries. The average number of surgeries was significantly greater in the open femur fracture group (p-value 0.000). A Chi-squared analysis of disposition indicated that patients with femur fractures were more likely to die of their injuries (p-value 0.020).

Conclusions: Findings of the current study demonstrate that while the presence of an open femur fracture does not correlate with an increase in ISS or increase ICU length of stay it may act as a marker for more serious prognosis in polytrauma patients.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 360 - 361
1 Sep 2005
Waddell J Morton J Griffith K Schemitsch E White K
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Introduction and Aims: To compare the outcomes between primary and revision total hip arthroplasty in patients at one institution with regard to demographics, complication rates and functional outcome. Further study of the problems associated with revision total hip replacement, focused on complication rates, would appear to be warranted.

Method: All patients were entered prospectively in a database and were assessed by means of physical examination, radiographs, SF-36 and WOMAC questionnaires. Patients were followed for a minimum of two years with a range of two to five years. Patients were seen on an annual basis.

Results: Five hundred and forty-seven patients underwent primary total hip replacement and 213 patients underwent revision total hip replacement. 53.4% of patients undergoing primary and 52% of patients undergoing revision arthroplasty were female. Mean age at primary hip replacement 61.8 years, revision hip replacement 67.1 years. Post-operative complication rate was 7.6% in primary patients and 14.7% in revision patients (p< .05); there was no statistically significant difference between the two groups with regard to intra-operative fracture, implant loosening or post-operative infection; there was a statistically significant difference in terms of dislocation with 0.8% of primary arthroplasties and 5.6% of revision patients sustaining at least one dislocation following their surgery (p< .01). Both groups of patients had a statistically significant improvement between their pre- and post-operative WOMAC and SF-36 physical scores (p< .0001); however, there was also a statistically significant difference in outcome when the two groups were compared with primary patients having significantly improved WOMAC scores (p< .0001) and significantly improved SF-36 physical socres (p< .0001).

Conclusions: Revision hip arthroplasty does not bring to the patient the same degree of benefit as the primary operation. The reason for this is multi-factorial and includes a higher complication rate and lower functional outcome.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 307 - 307
1 Sep 2005
Waddell J Schemitsch E McKee M McConnell A James S
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Introduction and Aims: Open femoral fracture is a serious injury. We have asked the question: do open femur fractures in polytrauma patients correlate with higher injury severity scores, increased length of stay and higher mortality rates than in closed femur fracture polytrauma patients.

Method: We undertook a retrospective review of a prospectively gathered trauma database at a Level 1 trauma centre. We identified multiple-injured patients with femur fractures who presented in a 36-month period. The cases were divided into two groups: open femur fractures (n=33) and closed femur fractures (n=80). Data was collected on demographics, precipitating event, length of stay spent in the ICU, number of associated injuries, ISS, AIS for affected systems, number of femoral surgeries and disposition. Data was analysed using parametric statistical tests with a significance level of 0.05.

Results: Our analysis revealed that on average, patients in the open femur fracture group spent eight + nine days in ICU, sustained four + one associated injuries, underwent two + one femoral surgeries, had an ISS of 29 + 13, and died of their injuries in 30.3% of cases. Patients in the closed femur fracture groups spent eight + nine days in ICU, sustained four + one associated injuries, underwent one + one femoral surgeries, had an ISS of 29 + 14, and died of their injuries in 12.5% of cases. One-way ANOVA showed no statistically significant difference between groups in terms of time spent in ICU, ISS and number of associated injuries. The average number of surgeries was significantly greater in the open femur fracture group (p-value 0.000). A Chi-squared analysis of disposition indicated that patients with femur fractures were more likely to die of their injuries (p-value 0.020).

Conclusions: Findings of the current study demonstrate that while the presence of an open femur fracture does not correlate with an increase in ISS or increase ICU length of stay, it may act as a marker for more serious prognosis in polytrauma patients.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_I | Pages 8 - 8
1 Jan 2004
Waddell J Lever J Schemitsch E Nousiainen M Aksenov S
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Twelve pairs of fresh-frozen, cadaveric femora were harvested. Each right femur was prepared for the cemented insertion of the femoral component of a total hip implant. Left femora served as matched intact controls. Following insertion of the implants, the distal tip of the stem was identified and an oblique osteotomy was made to represent a periprosthetic fracture. Proximally, plates were secured with cables and distally by bicortical screw fixation (c+s). The twelve pairs of femora were randomly divided into three groups: 1. Zimmer Cable-Ready System, 2. AO 4.5 mm broad, LC-DCP, with Wire Mounts and Double Luque Wires, 3. Dall-Miles Cable Grip System. Specimens were mounted and deforming forces were applied to test the biomechanical stiffness of the constructs. Following testing the plate-cable combinations, the proximal cables were removed and replaced with unicortical screws (s+s). Repeat testing was then performed as per the above protocol.

The stiffness of the constructs relative to intact bone decreased (p< 0.05) with fixation utilising cables plus screws (c+s) during four-point bending (69–77%) and offset rotational loading (61–64%). When testing unicor-tical plus bicortical screw fixation (s+s) in these modes, a similar effect was seen. There was no difference between plate systems (ANOVA, p> 0.05). Comparisons of stiffness between cable plus screw combination versus unicor-tical plus bicortical screw combination revealed that the latter method of fixation (s+s) was more rigid (p< 0.05).

Our study showed that the three plate-cable systems displayed similar biomechanical stiffness. In addition, when the cables were replaced proximally with unicortical screws, more rigid fixation was obtained in all but one plane of testing.

We conclude that the method of plate stabilisation by screws or cables is more significant than the type of plate used for periprosthetic fracture stabilisation.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_I | Pages 8 - 8
1 Jan 2004
Waddell J Schemitsch E Hoe F Morton J
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Two hundred and seventeen consecutive patients (238 hips) underwent total hip arthroplasty using the St Michael’s stem and a non-porous screw ring cup. Patients were followed prospectively clinically using the St Michael’s hip score and radiographically. At an average of 11.9 years (10-13.5 years), 55 patients (59 hips) had died, 23 patients (23 hips) were lost to follow-up. The St Michael’s hip score improved from 13.4 pre-operatively to 21.7 (out of a possible 25) at the latest follow-up. Thirty-seven (24%) of the acetabular components have been revised for aseptic loosening and an additional seven components are radiographically loose. No femoral components have been revised. Using Engh’s criteria one femoral component is definitely loose and two femoral components have stable fibrous ingrowth. Significant stress shielding was noticed in 23 hips (17%) without clinical consequences. Minor osteolysis was seen in 13 hips most commonly around the proximal femur and has not caused symptoms. The St Michael’s stem with its large pore size madreporic surface has comparable results to other porous coated stems with smaller pore size.

The St Michael’s stem provided reliable ingrowth and fixation with an acceptable degree of stress shielding. The non-porous screw ring cup had a high failure rate.


The Journal of Bone & Joint Surgery British Volume
Vol. 75-B, Issue 5 | Pages 715 - 723
1 Sep 1993
Wheelwright E Byrick R Wigglesworth D Kay J Wong P Mullen J Waddell J

An episode of hypotension is common during cemented joint replacement, and has been associated with circulatory collapse and sudden death. We studied the mechanism of hypotension in two groups of six dogs after simulated bilateral cemented arthroplasty. In one group, with no lavage, the insertion of cement and prosthesis was followed by severe hypotension, elevated pulmonary artery pressure, decreased systemic vascular resistance and a 21% reduction in cardiac output. In the other group, pulsatile intramedullary lavage was performed before the simulated arthroplasties. Hypotension was less, and although systemic vascular resistance decreased, the cardiac output did not change. The severity of the hypotension, the decrease in cardiac output and an increase in prostaglandin metabolites were related to the magnitude of pulmonary fat embolism. Pulsatile lavage prevents much of this fat embolism, and hence the decrease in cardiac output. The relatively mild hypotension after lavage was secondary to transient vasodilation, which may accentuate the hypotension caused by the decreased cardiac output due to a large embolic fat load. We make recommendations for the prevention and management of hypotension during cemented arthroplasty.


The Journal of Bone & Joint Surgery British Volume
Vol. 60-B, Issue 4 | Pages 510 - 515
1 Nov 1978
Fraser R Hunter G Waddell J

The hospital records of 222 cases of ipsilateral fractures of the femur and tibia were reviewed, and patients were grouped according to the type of fracture and the method of treatment. Thirty-five per cent of patients required late operation for delayed union or non-union, osteomyelitis, refracture and malunion, regardless of the treatment group. A disturbing factor was the 30% incidence of osteomyelitis in patients treated by fixation of both fractures, almost three times the incidence when only one fracture was fixed. A 30% incidence of delayed union or non-union occurred in patients managed conservatively. Of sixty-three patients personally examined, the worst results found were those following conservative management of both fractures. More use of rigid external fixation and of cast bracing is recommended in the management of the fractured tibia, combined with internal fixation of the femoral fracture. Examination of the knee suggested that, with ipsilateral fractures, disruption of ligaments is a common occurrence and should always be suspected.