Aims.
Different pathologies, deformities, bone defects, previous surgeries and polyethylene wear limit the survival of total hip arthroplasty (THA) in
Aims. For this retrospective cohort study, patients aged ≤ 30 years
(very young) who underwent total hip arthroplasty (THA) were compared
with patients aged ≥ 60 years (elderly) to evaluate the rate of
revision arthroplasty, implant survival, the indications for revision,
the complications, and the patient-reported outcomes. Patients and Methods. We retrospectively reviewed all patients who underwent primary
THA between January 2000 and May 2015 from our institutional database.
A total of 145 very
Background and aim. Total hip replacement (THR) in
Total hip replacement (THR) in
It is known that the gait dynamics of elderly substantially differs from that of
Management of ankle arthritis in
Introduction and Objective. Scaphoid waist fractures (SWF) are notable in upper limb trauma and predominantly occur in
Aims. The purpose of this study was to investigate the risk of additional surgery in the lumbar spine and to describe long-term changes in patient-reported outcomes after surgery for lumbar disc herniation in adolescents and
Aims. Dual mobility (DM) implants have been shown to reduce the dislocation rate after total hip arthroplasty (THA), but there remain concerns about the use of cobalt chrome liners inserted into titanium shells. The aim of this study was to assess the clinical outcomes, metal ion levels, and periprosthetic femoral bone mineral density (BMD) at mid-term follow-up in
Aims. The use of high tibial osteotomy (HTO) to delay total knee arthroplasty (TKA) in
Aims. Promising medium-term results from total shoulder arthroplasty
(TSA) have been reported for the treatment of primary osteoarthritis
in
Femoral head necrosis in the context of high impact gymnastics of
Mesenchymal stromal cells (MSC) have been proposed as an emerging cell therapy for bone tissue engineering applications. However, the healing capacity of the bone tissue is often compromised by patient's age and comorbidities, such as osteoporosis. In this context, it is important to understand the impact of donor age on the therapeutic potential of MSC. Importantly, the impact on donor age is not restricted to cells themselves but also to their microenvironment that is known to affect cell function. The extracellular matrix (ECM) has an important role in stem cell microenvironment, being able to modulate cell proliferation, self-renewal and differentiation. Decellularized cell-derived ECM (dECM) has been explored for regenerative medicine applications due to its bioactivity and its resemblance to the in vivo microenvironment. Thus, dECM offers the opportunity not only to develop microenvironments with customizable properties for improvement of cellular functions but also as a platform to study cellular niches in health and disease. In this study, we investigated the capacity of the microenvironment to rescue the impaired proliferative and osteogenic potential of aged MSC. The goal of this work was to understand if the osteogenic capacity of MSC could be modulated by exposure to a dECM derived from cells obtained from
Guidelines for the use of preoperative blood tests for elective surgery were established. However, there is less evidence and no guidelines regarding using these tests when a
Shoulder arthritis in the
Introduction. Patient-specific instruments (PSI) and surgical-guiding templates are gaining popularity as a tool for enhancing surgical accuracy in the correction of oblique bone deformities Three-dimensional virtual surgical planning technology has advanced applications in the correction of deformities of long bones and enables the production of 3D stereolithographic models and PSI based upon a patient's specific deformity. We describe the implementation of this technology in
Abstract. Introduction. Secondary osteonecrosis of the knee affects
Aims. We carried out a further study of the long-term results of the
cemented Exeter femoral component in patients under the age of 40
with a mean follow-up of 13.6 years (10 to 20). Patients and Methods. We reviewed our original cohort of 104 cemented Exeter stems
in 78 consecutive patients with a mean age of 31 years (16 to 39).
Only one patient was lost to radiological follow-up. Results. A total of six patients (eight hips) had died for reasons unrelated
to their surgery. There had been one further periprosthetic fracture
from a fall and one fractured femoral stem. No revisions for aseptic
loosening were undertaken during the whole study period. Overall, 11 hips had progressive radiolucent lines in one or
more zones. The Kaplan Meier survival percentages at ten and 17 years were
97.1% (95% confidence interval (CI) 91.3 to 99.1) and 92.1% (95%
CI 74.1 to 97.8) with revision for any reason as the endpoint, and
100% at both ten and 17 years with aseptic loosening (95% CI 83.8
to 100) as the endpoint. No additional hips were classified as radiologically
loose. Conclusion. The Exeter femoral component continues to function satisfactorily
in