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The Bone & Joint Journal
Vol. 97-B, Issue 2 | Pages 177 - 184
1 Feb 2015
Felden A Vaz G Kreps S Anract P Hamadouche M Biau DJ

Conventional cemented acetabular components are reported to have a high rate of failure when implanted into previously irradiated bone. We recommend the use of a cemented reconstruction with the addition of an acetabular reinforcement cross to improve fixation. We reviewed a cohort of 45 patients (49 hips) who had undergone irradiation of the pelvis and a cemented total hip arthroplasty (THA) with an acetabular reinforcement cross. All hips had received a minimum dose of 30 Gray (Gy) to treat a primary nearby tumour or metastasis. The median dose of radiation was 50 Gy (Q1 to Q3: 45 to 60; mean: 49.57, 32 to 72). . The mean follow-up after THA was 51 months (17 to 137). The cumulative probability of revision of the acetabular component for a mechanical reason was 0% (0 to 0%) at 24 months, 2.9% (0.2 to 13.3%) at 60 months and 2.9% (0.2% to 13.3%) at 120 months, respectively. One hip was revised for mechanical failure and three for infection. Cemented acetabular components with a reinforcement cross provide good medium-term fixation after pelvic irradiation. These patients are at a higher risk of developing infection of their THA. . Cite this article: Bone Joint J 2015;97-B:177–84


The Journal of Bone & Joint Surgery British Volume
Vol. 93-B, Issue 9 | Pages 1279 - 1281
1 Sep 2011
Rolton DJ Blagg SE Hughes RJ

Osteoradionecrosis is a rare but recognised complication of radiotherapy. Cases have been described in the cervical spine following treatment for head and neck malignancies up to 25 years after administration of radiotherapy. We present a rare case of osteoradionecrosis affecting the L5 and S1 vertebral bodies in a 58-year-old woman who presented with low back pain 25 years after undergoing a hysterectomy with adjuvant radiotherapy for cancer of the cervix.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 223 - 223
1 Mar 2010
Chivers K Hardy S
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Acetabular components of total hip joint replacement (THJR) in previously irradiated pelvis show high rates of failure. We present a literature review and a retrospective series evaluating the survival of acetabular cages in this difficult situation. Our hypothesis was that cage reinforcement of the acetabulum after previous pelvic irradiation would lead to early failure. A cohort of 11 patients (12 hips) was identified, who had undergone THJR utilising an acetabular cage, after previous pelvic irradiation for malignant tumours. All operations were performed by a single surgeon in Waikato over the period of 1997–2007. Six patients (six hips) died within one year of their operation, the further five patients (six hips) were analysed for survival and radiograpical loosening of the acetabular component. Complications attributed to previous irradiation are also reported. There is a paucity of literature of THJR survivorship after pelvic irradiation. The first series from the 1970’s showed 50% acetabular loosening at 5 years in cemented cups. Two conflicting series are published with 44% vs. 0% failure of uncemented cups. Only one previous series (22 hips) reports the use of acetabular reinforcement rings, and showed a 20% loosening and 10% deep infection rate at 4 years. In our cohort of 12 hips in 11 patients, only five patients survived greater than one year after joint replacement. The average follow up of the remaining six hips is five years (two to ten years). Two out of six of the acetabular cages have catastrophically failed. Of the remaining four cages, one is probably, and three are possibly radiologically loose. Two out of six have raised concerns in regards to deep infection that were not proven microbiologically. Overall of the patients who survived greater than one year after their THJR for pelvic irradiation, only four out of six of the acetabular cages remained insitu, and all had concerns raised in regards to radiographical loosening. We report a high rate of clinical and radiographic failure of cage reconstruction of the acetabulum after previous pelvic irradiation. A superior method of acetabular reconstruction in this difficult situation is yet to emerge. Alternative methods of reconstruction continue to develop, with trabecular metal options a possible consideration


The Journal of Bone & Joint Surgery British Volume
Vol. 87-B, Issue 6 | Pages 851 - 857
1 Jun 2005
Davidson AW Hong A McCarthy SW Stalley PD

We treated 50 patients with bony malignancy by en-bloc resection, extracorporeal irradiation with 50 Gy and re-implantation of the bone segment.

The mean survivor follow-up was 38 months (12 to 92) when 42 patients were alive and without disease. There were four recurrences. The functional results were good according to the Mankin score (17 excellent, 13 good, nine fair, three failures), the Musculoskeletal Tumour Society score (mean 77) and the Toronto Extremity Salvage score (mean 81). There was solid union, but bone resorption was seen in some cases. The dose of radiation was lethal to all cells and produced a dead autograft of perfect fit.

Extracorporeal irradiation is a useful technique for limb salvage when there is reasonable residual bone stock. It allows effective re-attachment of tendons and produces a lasting biological reconstruction. There should be no risk of local recurrence or of radiotherapy-induced malignancy in the replanted bone.


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_I | Pages - 74
1 Mar 2002
Stiehl J
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This report reviews the long-term results of treating acetabula with unusually severe problems, such as pelvic discontinuity or major column loss after failed total hip arthroplasty (THA) and reconstruction problems. Loss of acetabular bone stock results from removal of bone during the original procedure, prosthetic failure, and osteolysis. In massive structural failure, the acetabular rim, quadrilateral plate, and associated columns become deficient. At worst, this may be combined with pelvic discontinuity and disruption of the ilium and ischium. Prosthetic protrusio may result from fixation loss and be associated with scarring of the femoral vessels, femoral nerve, ureter and bowel. A variety of implants has been used to in ace-tabular reconstruction. The results are often poor because of insufficient bone stock to support the implant. In a consecutive series of 251 THA revisions done between 1988 and 1996, 17 patients were treated for major pelvic column loss, pelvic discontinuity or both. In five patients, a posterolateral approach without trochanteric osteotomy was used. The extensile triradiate approach with ilioinguinal extension was used in 12 patients in whom severe prosthetic protrusio increased the risk of intrapelvic iatrogenic injury. A long anterior column pelvic plate was applied. A posteriorly placed AO 4.5-mm pelvic reconstruction plate with 10 to 12 holes was used in nine cases of pelvic discontinuity and in five cases of posterior column bone loss. This plate extended from the most inferior extent of the ischium across the wall of the posterior column to a point high on the ilium. Anterior column fixation was done in eight of nine cases of pelvic discontinuity and all three cases of anterior column deficiency. This called for an 8 to 12-hole 3.5-mm AO pelvic reconstruction plate that extended from the pubic symphysis across the pelvic rim. This spanned the anterior column defect, ranging from 4 cm to 8 cm, to the medial wall of the ilium. Bulk allograft was used in 16 of the 17 patients. The patient in whom allograft was not used had pelvic discontinuity following pelvic irradiation. Whole pelvic acetabular transplants were used in seven with severe bone loss or following resection for chondrosarcoma and the other for pigmented or villonodular synovitis. Posterior segmental acetabular allograft was used in two cases of posterior column absence. Femoral heads were used in two posterior column defects, three pelvic discontinuities with anterior column defect, and two anterior column defects. Acetabular components were cemented in six of seven whole bulk ace-tabular transplants, six of nine pelvic discontinuities and two anterior column defects. Cemented implants were classified as loose if there was a complete radiolucent line at the bone cement interface, measurable component migration or measurable change in position. Uncemented acetabular components were considered loose if component migration had occurred or screws had broken. Pelvic plates were considered loose if there was measurable migration or change in plate position or if fixation screws had backed out or broken. Radiographic union was considered present when bridging callus or trabecular bone was visible across the discontinuity site. Junctional healing was considered probable when radiographs did not show obvious signs of failure. Grafts were considered unhealed if there was obvious displacement, bone gaps or hardware breakage. Seven of the nine patients with pelvic discontinuity had late evidence of healing of the fracture and allograft consolidation. One underwent removal of the graft at three weeks after developing acute postoperative infection: early junctional healing of a whole bulk acetabular allograft required an osteotomy to break up the interface. Another patient, who underwent removal of the graft and implant at three months for chronic infection, had consolidation of a whole bulk ace-tabular allograft. One patient underwent revision of a pressfitted acetabular component at 60 months, and the pelvic discontinuity was solidly united. In a fourth patient, explored at 124 months for loosening of a cemented cup, there was near complete dissolution of the graft posterior acetabular wall and a loose posterior pelvic plate. In a patient with pelvic discontinuity after radiation therapy for uterine carcinoma, satisfactory healing of the pelvic discontinuity was confirmed at 32 months, when excisional arthroplasty for late chronic infection followed urinary sepsis. Seven patients had major column loss with severe cavitary defects. Consolidation of the allograft was noted in all seven within the first 12 months of follow-up. Revision (47%) was required for infection in three patients, implant loosening in four, and recurrent implant dislocation in one. The four loose cups were revised to a cemented all-polyethylene component. All four implants had been placed on less than 50% host bone. None of the four has required subsequent revision. Dislocation postoperatively occurred in eight patients. In six, the extensile triradiate approach had been used. This approach led to dislocation in 50%. The main reasons for using the extensile triradiate approach were to avoid catastrophic injuries by direct exposure of vital structures and to allow stable anterior column plate fixation. In that no neurovascular injuries occurred and stable durable allograft consolidation and healing of pelvic discontinuity took place, these goals were largely met. Three patients developed late sciatic palsy. In one, plaster immobilisation had possibly caused direct pressure over the fibular head and led to chronic peroneal palsy. The other two underwent additional exploration of the sciatic nerve for late entrapment caused by migration of screws from the posterior column plate. Two patients developed bladder infections postoperatively. Another developed superficial phlebitis of the lower leg. Acetabular revision for loosening was necessary in three of seven cementless implants, while only two of 10 cemented implants failed. The acetabular component should be cemented into the allograft when more than 50% of the prosthetic interface is non-viable. Virtually all graft material, including dense cortical grafts, may ultimately fail if used for implant fixation. Patients should be told about the inevitable risks. However, techniques used led to stable healing of the pelvic discontinuity in most cases. Long pelvic plates that securely stabilise the pelvis and allografts carefully opposed to host bone may explain the relative success in this series


The Journal of Bone & Joint Surgery British Volume
Vol. 77-B, Issue 6 | Pages 847 - 852
1 Nov 1995
Massin P Duparc J

We retrospectively reviewed 56 patients (71 hips) treated by total replacement for severe disability after pelvic irradiation. Symptoms were associated with various radiological lesions due to irradiation, including atraumatic femoral-neck fracture, osteonecrosis of the femoral head or of the acetabulum, and radiation osteitis of the whole pelvis. From 1970 to 1982 we used standard cemented components in 49 hips and had a high rate of acetabular loosening (52%) at a mean follow-up of 69 months. This was probably due to the mechanical insufficiency of irradiated periacetabular bone. From 1983 to 1990 we routinely used acetabular reinforcement rings. The rate of aseptic acetabular loosening in 22 hips at a mean follow-up of 40 months was 19%, but there were two septic loosenings emphasising the risk of infection in these patients. When total replacement is required for an irradiated hip, we recommend reinforcement of the acetabulum using a metallic ring, but there is still an increased risk of infection and in difficult cases such as severe acetabular destruction or soft-tissue or vascular injuries, a Girdlestone procedure may be indicated