1 . Two hundred and twelve cases of acute haematogenous osteitis treated between 1936 and 1950 have been reviewed. 2. The cases are described in three groups: Group IâSeventy-five cases treated before the introduction of effective chemotherapy; Group IIâFifty-five cases treated with sulphathiazole and Group IIIâEighty-two cases treated with penicillin. 3. The problems of penicillin therapy are discussed.
1. Acute osteitis as seen in a large children's hospital is described briefly. 2. Treatment of a series of cases of acute osteitis with penicillin is discussed under the headings of investigation, penicillin administration, surgical procedure, radiographic appearance and results. The findings are tabulated. 3. Recent investigations suggest that no time limit can be set to the duration of penicillin administration. At present, routine marrow puncture appears to be the only certain method of control. We see no reason to alter the dosage set out in Table III. Administration should be continued until the marrow culture is sterile. 4. The methods adopted in subacute and chronic pyogenic bone infections are described separately.
