Osteoporosis following ovariectomy has been suggested to modulate bone response to polyethylene wear debris. In this work, we evaluate the influence of estrogen deficiency on experimental particle-induced osteolysis. Polyethylene (PE) particles were implanted onto the calvaria of wild-type (WT), sham-ovariectomized (OVX), OVX mice and OVX mice supplemented with estrogen (OVX+E2) (12 mice per group). Sham-implanted mice served as internal controls. After 14 days, seven skulls per group were analyzed with a high-resolution micro-computed tomography (CT) and by histomorphometry, and for tartrate-specific alkaline phosphatase. Five calvariae per group were cultured for the assay of IL-1, IL-6, TNF- and RANKL secretion using quantitative ELISA. The expression of RANKL and OPG mRNA were evaluated using real-time PCR. As assessed by CT and by histomorphometry, PE particles induced an extensive bone resorption and an intense inflammatory reaction in WT, sham-OVX and OVX+E2 mice. In OVX mice group, these features appeared considerably attenuated. In WT, sham-OVX and OVX+E2 mice, PE particles induced an increase in serum IL-6, in TNF-and RANKL local concentrations, and resulted in a two-fold increase in RANKL/OPG mRNA ratio. Conversely, these parameters remained unchanged in OVX mice after PE implantation. The combination of two well-known bone resorptive mechanisms ultimately attenuated osteolytic response, suggesting a protective effect of estrogen deficiency on particle-induced osteolysis. This paradoxical phenomenon was associated with a downregulation of pro-resorptive cytokines. It is hypothesized that excessive inflammatory response was controlled, illustrated by the absence of increase of serum IL-6 in OVX mice after PE implantation.

Introduction and Objectives: We analyzed the physical and health status of patients with ankle arthritis that underwent arthrodesis or total ankle replacement and determined which alternative provided a greater perception of improvement in quality of life and whether there was any difference in the perception of the patients that underwent either of these two procedures.

Materials and Methods: This is a comparative-prospective study in patients that underwent arthrodesis (16 cases) or total ankle replacement (14 cases) in which clinical-functional variables were assessed by means of the AOFAS score and quality of life was measured using SF-36 at 2 years of follow-up and this was compared with preoperative assessment.

Results: The study was carried out with 2 series of comparable patients, both surgical techniques showed a statistically significant improvement on clinical assessment and on quality of life assessment in comparison with preoperative status after 2 years of follow-up. The group of patients that underwent arthrodesis changed from mid-range AOFAS values of 37.12 to 45.62 (p=0.055) and mid-range SF-36 values of 32.96 to 46.25 (p=0.008). The group that underwent arthroplasties changed from mid-range AOFAS values of 33 to 62 (p=0.024) and mid-range SF-36 values of 33.62 to 59.84 (p=0.001). The improvement was statistically greater in the group that underwent arthroplasties than in the group that underwent arthrodesis (p=0.48 for AOFAS, and p=0.026 for SF-36)

Discussion and Conclusions: Both procedures are good treatment options, they ‘significantly improve patient’s status both clinically and in their perception of their health and quality of life. The medium term perception of quality of life and general health on the part of patients with ankle arthritis is better when they undergo ankle arthroplasty than when they undergo surgical fusion.