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Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_12 | Pages 44 - 44
1 Dec 2022
Turgeon T Bohm E Gascoyne T Hedden D Burnell C
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This study used model-based radiostereometric analysis (MBRSA) to compare migration of a recently introduced cementless hip stem to an established hip stem of similar design. Novel design features of the newer hip stem included a greater thickness of hydroxyapatite coating and a blended compaction extraction femoral broach.

Fifty-seven patients requiring primary total hip arthroplasty (THA) were enrolled at a single centre. Patients were randomized to receive either an Avenir collarless stem and Trilogy IT cup (ZimmerBiomet) or a Corail collarless stem and Pinnacle cup (DePuy Synthes) via a posterior or lateral approach. Both stems are broach-only femoral bone preparation. RSA beads (Halifax Biomedical) were inserted into the proximal femur during surgery. Patients underwent supine RSA imaging a 6 weeks (baseline), 6, 12, and 24 months following surgery. The primary study outcome was total subsidence of the hip stem from baseline to 24 months as well as progression of subsidence between 12 and 24 months. These values were compared against published migration thresholds for well-performing hip stems (0.5mm). The detection limit, or precision, of MBRSA was calculated based on duplicate examinations taken at baseline. Patient reported outcome measures were collected throughout the study and included the Oxford-12 Hip Score (OHS), EuroQoL EQ-5D-5L, Hip Osteoarthritis Score (HOOS) as well as visual analogue scales (VAS) for thigh pain and satisfaction. Analysis comprised of paired and unpaired t-tests with significance set at p≤0.05.

Forty-eight patients (30 males) were included for analysis; 7 patients received a non-study hip stem intra-operatively, 1 patient suffered a traumatic dislocation within three weeks of surgery, and 1 patient died within 12 months post-surgery. RSA data was obtained for 45 patients as three patients did not receive RSA beads intra-operatively. Our patient cohort had a mean age of 65.9 years (±;7.2) at the time of surgery and body mass index of 30.5 kg/m2 (±;5.2). No statistical difference in total stem migration was found between the Avenir and Corail stems at 12 months (p=0.045, 95%CI: −0.046 to 0.088) and 24 months (p=0.936, 95% CI: −0.098 to 0.090). Progression of subsidence from 12-24 months was 0.011mm and 0.034mm for the Avenir and Corail groups which were not statistically different (p=0.163, 95%CI: −0.100 to 0.008) between groups and significantly less than the 0.5mm threshold (pNo statistically significant differences existed between study groups for any pre-operative function scores (p>0.05). All patients showed significant functional improvement from pre- to post-surgery and no outcome measures were different between study groups with exception of EQ-5D-5L health visual analogue scale at 12 months which showed marginally superior (p=0.036) scores in the Avenir group. This study was not powered to detect differences in clinical outcomes.

This study has demonstrated no statistical difference in subsidence or patient-reported outcomes between the Corail hip stem and the more recently introduced Avenir hip stem. This result is predictable as both stems are of a triple-tapered design, are coated with hydroxyapatite, and utilize a broach-only bone preparation technique. Both stem designs demonstrate migration below 0.5mm suggesting both are low-risk for aseptic loosening in the long-term.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_8 | Pages 6 - 6
1 Aug 2020
Wilson I Gascoyne T Turgeon T Burnell C
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Total hip arthroplasty (THA) is one of the most successful and commonly performed surgical interventions worldwide. Based on registry data, at one-year post THA, implant survivorship is nearly 100% and patient satisfaction is 90%. A novel, porous coated acetabular implant was introduced in Europe and Australia in 2007. Several years after its introduction, warnings were issued for the system when used with metal-on-metal bearings due to adverse local tissue reaction, with one study reporting a 24% failure rate (Dramis et al. 2014). A subsequent 2018 study by Teoh et al. showed that the acetabular system had a survival rate of 98.9% at five years when used with conventional polyethylene or ceramic bearing surfaces. The current study was conducted to determine the safety and effectiveness of the acetabular system using standard highly-crosslinked polyethylene (XLPE) and ceramic liners at five-year follow-up. Our hypothesis was that the acetabular system would exhibit survivorship comparable to other acetabular components on the market at five-year follow-up.

A prospective, non-randomized study was conducted from February 2009 to June 2017 at eight sites in Canada and the USA. One hundred fifty-five hips were enrolled and 148 hips analyzed after THA indicated for degenerative arthritis. At five-year follow-up, 103 subjects remained for final analysis. All patients received a zero, three, or multi-hole R3 acetabular shell with Stiktite porous coating (Smith & Nephew, Inc., Memphis, TN, USA). Standard THA surgical techniques were employed, with surgical approach and either of a XLPE or ceramic bearing surface chosen at the discretion of the surgeon. The primary outcome was revision at five-years post-op with secondary outcomes including the Harris Hip Score (HHS), Hip Disability and Osteoarthritis Outcome Score (HOOS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), radiographic analysis, and post-operative adverse events. Data and outcomes were analyzed using summary statistics with 95% confidence intervals, t-tests, and Wilcoxon Rank tests.

At five-year follow-up the overall success rate was 97.14% (95% CI: 91.88–100). When analyzed by liner type, the success rate was 96.81% (95% CI: 90.96–99.34) for polyethylene (n=94) and 100% (95% CI: 71.51–100) for ceramic (n=11), with no significant difference between either liner type (p=1). There were three revisions during the study (1.9%), two for femoral stem revision post fracture, and one for deep infection. The HHS (51.36 pre-op, 94.50 five-year), all 5 HOOS sub-scales, and WOMAC (40.9 pre-op, 89.13 five-year) scores all significantly improved (p < 0 .001) over baseline scores at all follow-up points. One (0.7%) subject met the criteria for radiographic failure at one-year post-op but did not require revision. Six (1.8%) of the reported adverse events were considered related to the study device, including four cases of squeaking, one bursitis, and one femur fracture.

Results from this five-year, multicenter, prospective study indicate good survivorship for this novel, porous coated acetabular system. The overall survivorship of 97.14% at five-year follow-up is comparable to that reported for similar acetabular components and aligns with previous analyses (Teoh et al. 2018).


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_6 | Pages 49 - 49
1 Jul 2020
Gascoyne T Parashin S Teeter M Bohm E Laende E Dunbar MJ Turgeon T
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The purpose of this study was to examine the influence of weight-bearing on the measurement of in vivo wear of total knee replacements using model-based RSA at 1 and 2 years following surgery.

Model-based RSA radiographs were collected for 106 patients who underwent primary TKR at a single institution. Supine RSA radiographs were obtained post-operatively and at 6-, 12-, and 24-months. Standing (weight-bearing) RSA radiographs were obtained at 12-months (n=45) and 24-months (n=48). All patients received the same knee design with a fixed, conventional PE insert of either a cruciate retaining or posterior stabilized design. Ethics approval for this study was obtained.

In order to assess in vivo wear, a highly accurate 3-dimensional virtual model of each in vivo TKA was developed. Coordinate data from RSA radiographs (mbRSA v3.41, RSACore) were applied to digital implant models to reconstruct each patient's replaced knee joint in a virtual environment (Geomagic Studio, 3D Systems). Wear was assessed volumetrically (digital model overlap) on medial and lateral condyles separately, across each follow-up. Annual rate of wear was calculated for each patient as the slope of the linear best fit between wear and time-point. The influence of weight-bearing was assessed as the difference in annual wear rate between standing and supine exams. Age, BMI, and Oxford-12 knee improvement were measured against wear rates to determine correlations.

Weight bearing wear measurement was most consistent and prevalent in the medial condyle with 35% negative wear rates for the lateral condyle. For the medial condyle, standing exams revealed higher mean wear rates at 1 and 2 years, supine, 16.3 mm3/yr (SD: 27.8) and 11.2 mm3/yr (SD: 18.5) versus standing, 51.3 mm3/yr (SD: 55.9) and 32.7 mm3/yr (SD: 31.7). The addition of weight-bearing increased the measured volume of wear for 78% of patients at 1 year (Avg: 32.4 mm3/yr) and 71% of patients at 2 years (Avg: 48.9 mm3/yr). There were no significant (95% CI) correlations between patient demographics and wear rates.

Volumetric, weight-bearing wear measurement of TKR using model-based RSA determined an average of 33 mm3/yr at 2 years post-surgery for a modern, non-cross-linked polyethylene bearing. This value is comparable to wear rates obtained from retrieved TKRs. Weight-bearing exams produced better wear data with fewer negative wear rates and reduced variance. Limitations of this study include: supine patient imaging performed at post-op, no knee flexion performed, unknown patient activity level, and inability to distinguish wear from plastic creep or deformation under load. Strengths of this study include: large sample size of a single TKR system, linear regression of wear measurements and no requirement for implanted RSA beads with this method. Based on these results, in vivo volumetric wear of total knee replacement polyethylene can be reliably measured using model-based RSA and weight-bearing examinations in the short- to mid–term. Further work is needed to validate the accuracy of the measurements in vivo.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_2 | Pages 2 - 2
1 Feb 2020
Turgeon T Burnell C Hedden D Gascoyne T Bohm E
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Introduction

Total hip arthroplasty (THA) is a highly successful procedure achieving excellent clinical outcomes beyond 10 years post-surgery. With exception of periprosthetic infection, dislocation is the most common cause of failure in THA. A novel reverse total hip (RTH) replacement has been developed to address dislocation through reversal of the typical THA articulation in which a femoral cup and acetabular ball interlock at the extremes of motion to enhance mechanical stability in all planes. The purpose of this study was to assess the safety and efficacy of this novel RTH in a series of 22 patients and to monitor implant fixation using radiostereometric analysis (RSA).

Methods

Twenty two patients with end-stage osteoarthritis of the hip were enrolled between 2017 and 2019 at a single center. All surgeries were performed by a group of four high-volume fellowship-trained arthroplasty surgeons. All patients received at least 1 acetabular cup screw and RSA markers inserted into the acetabulum and proximal femur. Follow-up time points were 6 weeks, 6, 12 and 24 months and included patient reported outcome measures (HOOS, Oxford-12, Harris Hip Score, SF-36 and Satisfaction) as well as RSA assessment.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_2 | Pages 73 - 73
1 Feb 2020
Gascoyne T Parashin S Teeter M Bohm E Laende E Dunbar M Turgeon T
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Purpose

The purpose of this study was to examine the influence of weight-bearing on the measurement of in vivo wear of total knee replacements using model-based RSA at 1 and 2 years following surgery.

Methods

Model-based RSA radiographs were collected for 106 patients who underwent primary TKR at a single institution. Supine RSA radiographs were obtained post-operatively and at 6-, 12-, and 24-months. Standing (weight-bearing) RSA radiographs were obtained at 12-months (n=45) and 24-months (n=48). All patients received the same knee design with a fixed, conventional PE insert of either a cruciate retaining or posterior stabilized design. Ethics approval for this study was obtained.

In order to assess in vivo wear, a highly accurate 3-dimensional virtual model of each in vivoTKA was developed. Coordinate data from RSA radiographs (mbRSA v3.41, RSACore) were applied to digital implant models to reconstruct each patient's replaced knee joint in a virtual environment (Geomagic Studio, 3D Systems). Wear was assessed volumetrically (digital model overlap) on medial and lateral condyles separately, across each follow-up. Annual rate of wear was calculated for each patient as the slope of the linear best fit between wear and time-point. The influence of weight-bearing was assessed as the difference in annual wear rate between standing and supine exams. Age, BMI, and Oxford-12 knee improvement were measured against wear rates to determine correlations.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_3 | Pages 133 - 133
1 Feb 2017
Gascoyne T Turgeon T
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Introduction

Detailed analysis of retrieved total hip replacements (THRs) is valuable for assessing implant and material successes and failures. Reduction of bearing wear and corrosion and fretting of the head-neck trunnion is essential to implant durability and patient health. This research quantifies and characterizes taper and bearing surface damage on retrieved oxidized zirconium THRs.

Methods

Initially, 11 retrieved oxidized zirconium femoral heads were examined along with their associated femoral stems. Relevant patient and retrieval data was collected from clinical charts and radiographs. Taper corrosion (Figure 1) and fretting damage (Figure 2) scoring was performed following the Dyrkacz [1] method. A coordinate measuring machine was used to obtain a detailed surface map of the male and female taper surfaces. Taper surface maps were best-fit with an idealized cone followed by volume subtraction to quantify the amount of material removed as a result of fretting and corrosion processes. Scanning electron microscopy was performed on select samples to identify specific damage modes.

Unique surface bumps were noted on the articular surface of select femoral heads (Figure 3). Seventeen femoral heads were added to the analysis specifically for identification of these bumps. Articular surfaces were searched under SEM magnification and bumps were identified and counted. Parametric statistical correlations were performed with SAS v9.3.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_21 | Pages 83 - 83
1 Dec 2016
Burnell C Flynn B Gascoyne T Stockwell K Turgeon T
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Non-large head Metal-on-metal (MoM) hip replacements were seen as a solution to concerns about implant wear in younger patients. Mid-term loosening of once well-fixed hydroxyapatite (HA) coated femoral stems was recently observed in select MoM patients upon revision surgery. Accordingly, an implant retrieval study was undertaken to examine the incidence of aseptic loosening of in HA-coated femoral stems with MoM, ceramic on ceramic (CoC) and metal on polyethylene (MoP) bearing couples.

A single-centre implant retrieval lab reviewed 44 hydroxyapatite (HA)-coated titanium wedge taper stems of the same design retrieved over a period of 9 years. Ten were MoM articulations, 23 MoP and 11 CoC. Head sizes ranged from 28 to 40 with only four 40mm heads, all of which were MoM. Reason for revision, duration of implantation, femoral head size, patient age and body mass index was recorded for each retrieval. Goldberg corrosion scores were determined for the taper surfaces of each retrieval, with ‘0’ indicating no corrosion and ‘3’ indicating severe corrosion. Logistic regression analysis, Wilcoxan Rank Sum and Fischer's exact test were used for statistical analysis.

Aseptic loosening was the listed reason for revision in 18 of 44 cases. MoM bearing was associated with increased probability of aseptic loosening (Odds ratio 7.1 (95%CI 1.1–47.0) p=0.042). Severity of corrosion was also associated with aseptic loosening (Odds ratio 2.75 (95%CI 1.1–6.6) p=0.02). Head size and patient age had no correlation. Median time to revision of implants for aseptic loosening was 4.5 years (range: 4.2–7.0 years) for MoM versus 1.4 years (range: 0.3–3.0) for other bearing couples (p=0.004). Aseptic loosening was categorised as early (<=2 years) or mid-term (>2 years). No MoM hips were revised for aseptic loosening in the first 2 years while 8 of the 11 mid-term revisions had MoM articulations (p=0.004). Taper corrosion was more severe in mid-term aseptic loosing cases (p=0.049).

MoM HA-coated hip replacements appear to be associated with increased mid-term aseptic loosening compared to other bearing couples. Patients with MoM HA-coated hip replacements should be monitored regularly beyond the initial 1 to 2 years following surgery. Future analyses will examine the presence and progression of femoral radiolucency prior to revision surgery to determine an approximate timeline of stem loosening in this patient cohort. This research highlights the importance of implant retrieval programs to assess post-revision implant characteristics for early identification of possible device issues.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_21 | Pages 61 - 61
1 Dec 2016
Gascoyne T Parashin S Turgeon T Bohm E Laende E Dunbar M
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Articulation of the polyethylene (PE) insert between the metal femoral and tibial components in total knee replacements (TKR) results in wear of the insert which can necessitate revision surgery. Continuous PE advancements have improved wear resistance and durability increasing implant longevity. Keeping up with these material advancements, this study utilises model-based radiostereometric analysis (mbRSA) as a tool to measure in vivo short-term linear PE wear to thus predict long-term wear of the insert.

Radiographic data was collected from the QEII Health Sciences Centre in Halifax, NS. Data consisted of follow-up RSA examinations at post-operative, six-, 12-, and 24-month time periods for 72 patients who received a TKR. Implanted in all patients were Stryker Triathlon TKRs with a fixed, conventional PE bearing of either a cruciate retaining or posterior stabilised design. Computer-aided design (CAD) implant models were either provided by the manufacturer or obtained from 3D scanned retrieved implants. Tibial and femoral CAD models were used in mbRSA to capture pose data in the form of Cartesian coordinates at all follow-ups for each patient. Coordinate data was manually entered into a 3D modeling software (Geomagic Studio) to position the implant components in virtual space as presented in the RSA examinations. PE wear was measured over successive follow-ups as the linear change in joint space, defined as the shortest distance between the tibial baseplate and femoral component, independently for medial and lateral sides. A linear best-fit was applied to each patient's wear data; the slope of this line determined the annual wear rate per individual patient. Wear rates were averaged to provide a mean rate of in vivo wear for the Triathlon PE bearing.

Mean linear wear per annum across all 72 patients was 0.088mm/yr (SD: 0.271 mm/yr) for the medial condyle and 0.032 mm/yr (SD: 0.230 mm/yr) for the lateral condyle. Cumulative linear wear at the 2-year follow-up interval was 0.207mm (SD: 0.565mm) and 0.068mm (SD: 0.484mm) for the medial and lateral condyles, respectively.

Linear PE wear measurements using mbRSA and Geomagic Studio resulted in 0.056mm/yr additional wear on the medial condyle than the lateral condyle. Large standard deviations for yearly wear rates and cumulative measurements demonstrate this method does not yet exhibit the accuracy needed to provide short-term in vivo wear measurement. Inter-patient variability from RSA examinations is likely a source of error when dealing with such small units of measure. Further analysis on patient age and body mass index may eliminate some variability in the data to improve accuracy. Despite high standard deviations, the results from this research are in proximity to previously reported linear wear measurements 0.052mm/yr and 0.054mm/yr. Linear wear analysis will continue upon completion of >100 patients, in addition to volumetric PE wear over the entire articulating surface.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 146 - 146
1 Jul 2014
Wyss U Dyrkacz R Ojo O Turgeon T Brandt J
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Summary

Corrosion and fretting damage at the head-neck interface of artificial hip joints is more severe with larger head sizes. This is a concern, as the release of metal particles and ions can cause adverse tissue reactions, similar to those observed high wear metal-on-metal articulations.

Introduction

In the last few years corrosion was increasingly observed at head-neck interfaces of artificial hip joints, especially in joints with larger heads. There has always been evidence of some corrosion at modular junctions of artificial joints, but except for few designs, it was not seen as a real problem. It is important to better understand the factors contributing to corrosion at modular interfaces, so that necessary improvements can be made to minimise or completely avoid corrosion, in order to avoid possible adverse tissue reactions.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 299 - 299
1 Dec 2013
Dyrkacz R Wyss U Brandt J Turgeon T
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Introduction

This retrieval analysis study consisted of two goals. The first goal was to determine if there was a difference in the corrosion and fretting damage along the taper interface between large femoral heads in comparison to monopolar hemiarthroplasty heads. The second goal was to examine if the diameter of monopolar hemiarthroplasty heads can influence corrosion and fretting damage along the taper interface.

Patients and Methods

This retrieval analysis compared the corrosion and fretting behaviour of 40 mm femoral heads (n = 13) to monopolar hemiarthroplasty heads (n = 17 for a diameter < 50 mm; n = 6 for a diameter ≥ 50 mm) such that all implants had a minimum implantation period of three months, a 12/14 mm taper, and the heads and stems consisted of CoCr alloy. The 40 mm heads articulated with a polyethylene cup whereas the monopolar hemiarthroplasty heads articulated with cartilage. The 40 mm heads were manufactured from one company whereas the monopolar hemiarthroplasty heads were manufactured from four different companies. Corrosion and fretting damage were assessed using a previous technique [1]. Table 1 lists the patient information and reasons for revision whereas Table 2 provides the implant information.

The Mann Whitney U test and the Kruskal-Wallis test were performed for identifying significant differences for corrosion and fretting scores that were not normally distributed (α = 0.05). An unpaired student's t-test was conducted for comparing the head corrosion scores for the two head size groups of monopolar hemiarthroplasty implants since these scores were normally distributed.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 304 - 304
1 Mar 2013
Petrak M Brandt J O'Brien S Turgeon T Bohm E
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The wear particles released from the polyethylene (PE) tibial insert of modular total knee replacements (TKRs) have been shown to cause wear particle induced osteolysis, which may necessitate revision surgery [1]. Wear occurs at the backside surface of the PE insert of modular TKRs, resulting from the relative movement between the PE insert and the tibial tray [2]. Wear particles generated from the backside surface of the PE insert have been shown to be smaller in size than those originating from the articular surface [1], and may therefore have increased biological activity and osteolytic potential [3-4]. The ability to predict backside micromotion and contact pressure by finite element simulation has previously been demonstrated by O'Brien et al. [6-7]. Although the effect of insert thickness on articular surface contact pressure has been investigated [5], the effects of insert thickness on backside contact pressures, backside micromotion, and wear has not received adequate attention. Brandt et al. [2] has suggested that increased insert thickness was associated with increased backside damage (Fig. 1). In the present study, finite element simulations were conducted using the Sigma - Press Fit Condylar TKR (Sigma-PFC®, DePuy Orthopedics Inc., Warsaw, IN) with inserts of different insert thickness ranging between 5, 10, 15, 20 and 25 mm. The TKRs were simulated under ISO 14343-2 [8]. A non-linear PE material model was implemented by means of the J2-plasticity theory [6] and the effects of insert thickness on backside micromotion and contact pressure were analyzed. At the peak loading of the simulated gait cycle (time=13%), the 5 mm thick PE insert showed a greater backside peak contact pressure than the 25 mm thickness PE insert. Increasing insert thickness from 5 mm to 25 mm lead to approximately 15% greater peak micromotion at the modular interface (Fig. 2). This effect may be attributed to the ability of the PE material to distribute the load more evenly through deformation at the modular interface and reduce micromotion for thinner inserts. It is suggested that increased insert thickness results in increased moments at the modular interface that could lead to increased backside wear in silico. Although an increase in PE insert thickness was only associated with a moderate increase in backside micromotion in the present study, it was deemed likely that backside micromotion could be accelerated for thicker inserts in vivo as the PE locking mechanism has been shown to degrade after extended implantation periods.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 137 - 137
1 Mar 2013
Brandt J Guenther L O'Brien S Vecherya A Turgeon T Bohm E
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Femoral components with an oxidized zirconium-niobium (OxZr) gradient ceramic surface (Oxinium, Smith & Nephew, Memphis, TN) were introduced as an alternative to cobalt-chromium (CoCr) alloy femoral components for the purpose of PE wear reduction in total knee replacements [1]. In the present study, the surface damage and clinical performance of both CoCr alloy and OxZr femoral components were investigated. By matching CoCr alloy and OxZr femoral components for clinical factors, as done by Heyse et al. [2], the surface damage on retrieved CoCr alloy and OxZr femoral component was assessed. Twenty-six retrieved cobalt-chromium (CoCr) alloy femoral components were matched with twenty-six retrieved oxidized zirconium (OxZr) femoral components for implantation period, body-mass index, patient gender, implant type (cruciate ligament retaining/substituting), and polyethylene insert thickness. Detailed surface profilometry was performed on retrieved femoral condyles in areas that had not been damaged by gouging [3] with the specific purpose of investigating the in vivo wear behaviour of undamaged OxZr surface. In addition, the cumulative survivorships were calculated for patients who had received CoCr alloy or OxZr femoral components from our orthopaedic database. In order to identify factors that affect the clinical performance of CoCr alloy and OxZr femoral components, the findings from the retrieval analysis and the survivorship analysis were combined. The Rp, Rpm, and Rpk-values for the retrieved CoCr alloy femoral components were found significantly higher than the Rp, Rpm, and Rpk-values for the retrieved OxZr femoral components (p ≤ 0.031). The roughness parameters values (Ra, Rq, Rz, Rp, Rpm, Rpk, Rv, and Rsk) for the retrieved CoCr alloy femoral components were found significantly higher than the values of the new, never implanted CoCr alloy femoral components (p ≥ 0.001). The surface roughness was higher on the medial condyles than the lateral condyles of the retrieved CoCr alloy femoral components; such a difference was not observed on the retrieved OxZr femoral components. The OxZr bearing surface appeared to protect the femoral components from abrasive wear in vivo. At 8.5-years follow up, the cumulative survivorship for the CoCr alloy femoral components (98%) was not found to be statistically significantly different (p = 0.343, Breslow test) from the OxZr femoral components (97.5%). Therefore, OxZr femoral components appeared to possess low wear characteristics and could be particularly suitable for younger, heavier patients to ensure long-term durability.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 21 - 21
1 Mar 2013
Brandt J Gascoyne T Vecherya A Turgeon T Bohm E
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Ceramic-on-ceramic (C-C) total hip replacements (THRs) are an attractive option for young, active patients [1, 2]. However, more clinical data is necessary to establish the reasons of failure of contemporary C-C THRs in vivo. The objective of the present study was to assess the surface damage on retrieved C-C THRs and determine possible influential factors that may explain their in vivo performance. Thirty-five C-C retrievals of material type Biolox® forte (n=28) and Biolox® delta (n=7) (CeramTec AG, Plochingen, Germany) were collected after a mean of 3.7 ± 3.2 years in vivo. Semi-quantitative surface damage assessment [3] was performed on all retrievals to obtain both a damage score (DS) (Fig. 1). Contact profilometry was performed on the retrieved femoral heads to characterize the type of surface damage (metal transfer, stripe wear). Scanning electron microscope (SEM) images were obtained from two femoral heads displaying areas of typical surface damage. The implantation period correlated with the damage score (DS) of the femoral heads (R=0.573, p<0.001) and the acetabular cups (R=0.592, p<0.001). However, the metal transfer DS of the femoral heads did not correlate with implantation period (R=0.185, p=0.29). Surface roughness of metal-transfer areas were positively skewed (additive metal transfer) while the stripe damage areas were negatively skewed (grain removal), as evidenced by SEM analysis. Stripe damage was observed on both the Biolox® forte and Biolox® delta retrieved femoral heads; however, the extent of grain removal appeared less severe on the Biolox® delta retrieved femoral heads due to their overall smaller grain size (Fig. 2). Inclination angles > 45° was associated with a greater DS rate [DS/time of implantation], which had also been suggested elsewhere [4]. Four patients reported squeaking in their C-C THRs; one of which was a 54 yr-old male patient who completed three full marathons with his implant. In this his case, the DS for this retrieval was below average, with metal-transfer being the only macroscopic damage feature. Fracture of the acetabular liner occurred in three patients, all of which had malpositioned components. Metal-transfer on the ceramic surface could possibly cause a local break down of the fluid film and may facilitate, in addition to an increased inclination angle, stripe damage via an adhesive wear mechanism. Therefore, direct contact between the Ti-alloy acetabular shell and the ceramic femoral head should be avoided at primary surgery. C-C THRs remain an attractive option for young, active patients, but care must be taken during implantation to appropriately position the acetabular cup and to avoid unwanted metal-transfer as such alteration at the bearing interface may change implant tribology.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 20 - 20
1 Mar 2013
Zywiel M Syed K Overgaard CB Cheung AC Turgeon T Brandt J
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Revision of fractured ceramic-on-ceramic total hip replacements with a cobalt-chromium (CoCr) alloy-on-polyethylene articulation can facilitate metallosis and require further expensive revision surgery [1–3]. In the present study, a fifty-two year old male patient suffered from fatal cardiomyopathy after undergoing revision total hip arthroplasty. The patient had received a polyethylene-ceramic acetabular liner and a ceramic femoral head as his primary total hip replacement. The polyethylene-ceramic sandwich acetabular liner fractured in vivo after 58 months and the patient underwent his first revision surgery where he received a Vitamin E stabilized acetabular Polyethylene (PE) liner and a CoCr alloy femoral head with documented synovectomy at that time. After 15 months, the patient was admitted to hospital in cardiogenic shock, with retrieval of the bearing components. Before the second revision surgery, peak serum cobalt levels measured 6,521 μg/L, 78-times greater than serum cobalt levels of 83μg/L associated with cobalt poisoning [4]. Serum titanium levels found in the patient measured 17.5 μg/L) normal, healthy range 0–1.4 μg/L). The retrieved CoCr alloy femoral head had lost a total of 28.3g (24% or an estimated amount of 102 × 10−9 wear particles (∼2 μm diameter) [1]) within 16 months of in vivo service. Despite initiating a cobalt chelating therapy, the patients' cardiac left ventricular ejection fraction remained reduced at 6%. This was followed by multi-organ failure, and ultimately the patient passed away shortly after being taken off life support. Embedded ceramic particles were found on the backside and articular surfaces of the Vitamin E-stabilized PE acetabular liner. Evidence of fretting wear on the titanium (Ti) alloy acetabular shell was present, possibly explaining the increased serum Ti levels. Scanning electron microscopy and energy dispersive X-ray analyses confirmed Ti alloy transfer on the embedded ceramic particles on the backside PE liner surface and CoCr alloy transfer on the embedded ceramic particles on the articular PE liner surface. A fractured ceramic-on-ceramic total hip replacement should not be revised to a CoCr alloy-on-polyethylene articulation irrespective of concurrent synovectomy [5] as it can cause severe, third-body wear to the CoCr alloy femoral head that can lead to metallosis with fatal, systemic consequences.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVIII | Pages 48 - 48
1 Sep 2012
Gascoyne TC Petrak MJ Bohm E Turgeon T Put RVD Burger A
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Purpose

Radiostereometric Analysis (RSA) is a well developed imaging technique used to estimate implant fixation of orthopaedic implants in randomized clinical trials. The precision of RSA depends on a number of factors including image quality related to the individual modality properties. This study assesses the precision of RSA with a novel Digital Radiography (DR) system compared to a CR imaging system using different imaging techniques. Additionally, the study assesses the precision of locating beads embedded in a modified spine pedicle screw.

Method

A modified titanium spinal pedicle screw 4.5 mm diameter, 35 mm length, marked with two 1.0 mm tantalum beads, one inside the head and one near the screw tip was inserted into a bovine tibia segment. Six additional 1.0 mm tantalum beads were inserted into the bone segment – superiorly, distally and adjacent to the pedicle screw. The phantom was placed on a standard clinical diagnostic imaging bed above a custom RSA carbon fiber calibration cage (Halifax Biomedical Inc.). A pair of DR or CR imaging plates were placed below the calibration cage and irradiated 15 times at 100, 125 kV at 2.5 mAs. To determine precision, the standard deviation of 3D vector distances between beads was determined using RSA for each of the different imaging parameters.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVII | Pages 264 - 264
1 Sep 2012
Malhi A Bohm E Hedden D Burnell C Turgeon T
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Introduction

The purpose of this study was to compare the clinical outcomes and complications following bilateral simultaneous total knee arthroplasty in high body mass index (BMI) patients(>30kg/m2) to those of patients with a BMI<30 kg/m2.

Materials and Methods

Using data from an academic arthroplasty database and review of clinic charts we obtained health related quality of life (SF-12), and disease specific functional outcome scores (WOMAC or Oxford Knee Score). We also assessed length of hospital stay, ASA grade and transfusion requirements. Sixty six patients had a BMI<30 and 151 patients had a BMI>30.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXV | Pages 186 - 186
1 Jun 2012
Petrak M Burger A Put RVD Turgeon T Bohm E
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Introduction

Radiostereometric Analysis (RSA) is an imaging method that is increasingly being utilized for monitoring fixation of orthopaedic implants in randomized clinical trials. Extensive RSA research has been conducted over the last 35+ years using standard clinical x-ray acquisition modalities that irradiate screen/film media or Computed Radiography (CR) plates. The precision of RSA can depend on a number of factors including modality image quality.

Objective

This study assesses the precision of RSA with a novel Digital Radiography (DR) system compared to a CR imaging system using different imaging techniques. Additionally, the study assesses the precision of locating beads embedded in a modified spine pedicle screw.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 15 - 15
1 Mar 2010
Petrak MJ Rex E Turgeon T Badger C Bohm E
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Purpose: Implant retrieval analysis provides valuable information to researchers, clinicians and manufactures about the in vivo wear characteristics. Wear analysis can quantify visible damage on retrieved UHMWPE bearing surfaces used in total knee arthroplasty (TKA). Various researchers have developed wear scores to help provide insight into the modes of prosthetic failure. Four scoring methods are compared in order to determine their inter-rater reliability.

Method: A cohort of 60 retrieved G2, Smith & Nephew/Richards, TKA implants were analyzed by two observers using four scoring techniques. The scoring methods used had been developed by Hood, Wasielewski, Currier, and Brandt. The intraclass correlation coefficient (ICC) was used in assessing the inter-rater reliability.

Results: The ICC demonstrated significant correlation between raters (P< 0.05). Hood’s method produced a correlation of 0.89, Wasielewski’s method 0.83, Currier’s method 0.58, and Brandt’s method 0.82. All but Currier’s method had excellent correlation between raters.

Conclusion: The analysis techniques for articular surface wear for total knee bearings by Hood, Brandt, and Wasielewski showed excellent inter rater reliability; however currier’s method was only fair. One common issue among all these methods is that the scoring systems do not identify or assign differentiating weights to clinically relevant wear modalities to capture inferior implants designs. A new wear analysis technique that is efficient and assigns clinical severity weights to wear modes in TKA bearings should be investigated.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 35 - 35
1 Mar 2008
Turgeon T Dust W Sanche S Mochoruk K
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The twelve matte and twelve polished surfaces of hemi-arthroplasties were contaminated with Staph. epidermidis and then irrigated with bulb or pulse irrigation. The surfaces were then quantitatively cultured using a standardized swabbing technique. Results are expressed as the percentage of contaminant bacteria recovered. The matte finish groups showed median values of 1.46 and 2.88x10−2 while the polished finish groups showed 1.49x10−3 and 2.83x10−6 with bulb and pulse irrigation, respectively. The difference between irrigation types was significant (p=0.002) for both matte and polished surfaces. Pulse irrigation was more effective than bulb irrigation in removing contaminant bacteria from the prosthetic surfaces studied.

Tremendous suffering is associated with infection following total joint arthroplasty. To reduce infection risk, some surgeons use pulse irrigation prior to wound closure. This practice is based on the assumption that pulse irrigation will more effectively remove adherent bacteria. However, there has been no study of the effectiveness of pulse irrigation in clearing bacteria from prosthetic surfaces. The hypothesis of this study is that pulse irrigation is more effective than bulb irrigation in removing intra-operative bacterial contaminants from prosthetic surfaces.

The matte and polished surfaces of hemiarthroplasties were studied separately. Each surface was contaminated with Staph. epidermidis and then irrigated with pulse or bulb irrigation. A third group without irrigation was also studied. The surface was then swabbed three times using a standardized technique. The swab tips were quantitatively cultured.

Twelve matte and twelve polished surfaces were examined using both irrigation types with corresponding non-irrigation reference values. Results are expressed as the percentage of contaminant bacteria recovered. The matte finish groups showed median values of 1.46 and 2.88x10−2 while the polished finish groups showed 1.49x10−3 and 2.83x10−6 with bulb and pulse irrigation, respectively. The difference between irrigation types is significant (p=0.002) for both matte and polished surfaces.

Pulse irrigation was more effective than bulb irrigation in removing contaminant bacteria from the prosthetic surfaces studied.

Funding: Hip Hip Hooray, Zimmer-Sadler


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 90 - 90
1 Mar 2008
Turgeon T Lavigne M Sanchez A Coutts R
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Surgical treatment of recurrent dislocation after total hip arthroplasty (THA) is challenging with often disappointing results. The influence of the posterior hip capsule is important, and restoration of its function is a major goal of treatment. We describe our experience using an Achilles tendon allograft as a checkrein to limit hip internal rotation and to prevent posterior instability. Twenty unstable THAs were treated using this technique, eliminating instability in fifteen. At an average follow-up of 3.6 years, Achilles tendon allograft augmentation has proven a useful adjunct for the treatment of recurrent posterior dislocation after THA in selected patients.

The purpose of this study is to review our results with a novel treatment for recurrent dislocation after total hip arthroplasty (THA) using an Achilles tendon allograft as a checkrein to prevent instability.

Achilles tendon allograft augmentation has proved to be a useful adjunct for the treatment of recurrent posterior dislocation after THA in selected patients.

Surgical treatment of recurrent dislocation after total hip arthroplasty (THA) is challenging with often disappointing results. Among possible causes of dislocation, the influence of the static soft tissue restraint provided by the hip capsule is important, and restoration of its integrity and function is a major goal of treatment. We describe a new technique in which an Achilles tendon allograft is employed as a checkrein to limit hip internal rotation and to prevent posterior instability.

Twenty unstable THAs with recurrent instability were treated using this technique, eliminating instability in fifteen at an average follow-up of 3.6 (0.5 to 6.6) years.

Prospective data was collected and reviewed on the first twenty patients with recurrent THA instability stabilized with an Achilles tendon allograft. Head and liner exchanges accompanied the allograft. Use of a constrained cup was considered a failure.

Instability was successfully controlled in 75% of patients with use of the Achilles allograft. The technique is an important addition to the treatment arsenal of this difficult problem.