The authors report the results of the use of autologous growth factors in a patient affected by systemic sclerodermia. Two total hip prostheses were implanted in this woman. Because of the delayed wound healing in this patient, either because of the long-term corticosteroid therapy or the basic connective dissease, she decided not to have surgery. Some time later the patient decided positively for surgery, as her condition was becoming serious. Therefore, as part of a pre-operative protocol, she discontinued corticosteroids for 8 months beforehand and increased pharmacological therapy to improve blood perfusion in soft tissues. During surgery, we injected in the periprosthetic zone and in both sides of the surgical wound. Our patient had a normal period of healing and after 2 weeks the result was so good that we were able to remove the skin suture easily.