To evaluate the efficacy of novel biodegradable MAACP/n-HA composite artificial lamina for the prevention of postlaminectomy adhesions and lamina reconstruction. Goats were randomly divided into three groups: an experimental group consisting of twelve goats that underwent cervical 4 laminectomies, followed by MAACP/n-HA composite artificial lamina implantations; a control group of nine goats whose cervical 4 vertebra plate were removed; and a normal group of three goats that did not receive any operations or treatments. On weeks 4, 12 and 24, two goats, two goats, three goats in the test group and two, two, two in the control group were selected using X-ray, CT, MRI and subsequently killed for histological examinations and SEM (scanning electronic microscopY). On week 24, the adhesion level of scar tissue was examined according to Rydell's degree of adhesion criteria. Biomechanical measurements were carried out at week 24 on 3 goats in the test group, 3 in the control group, and 3 in the normal group.Purpose
Methods
The cause of adolescent idiopathic scoliosis (AIS) is still not known. Although several candidate gene studies and linkage analyses have been done, no causal relationship has yet been established. To our knowledge, we report the first case-control based genome-wide association study (GWAS) for this trait. The study was undertaken in a set of 196 cases with a specific AIS phenotype (based on Lenke's classification) in southern China, and in 401 controls without radiological evidence of scoliosis.Introduction
Methods
Cam type femoro-acetabular impingement is defined by a reduced femoral head-neck offset and by excessive bone at antero-lateral femoral head-neck junction. Reconstruction of the femoral head-neck offset by removing the femoral bony prominence is a common treatment for cam type impingement. In many cases, the goal of this treatment is to make the antero-lateral head-neck offset symmetrical to the postero-lateral offset. However, guidelines for bony removal are not well established. The objective of this study is to examine if the antero-lateral and postero-lateral femoral offsets are symmetrical in normal healthy hips. CT analyses of the anatomic geometry of the femoral head and neck were performed. Hip joints with any evidence of cartilage defects and impingement were excluded. Eight cadaveric hips (3 right and 5 left hips) were examined. The average age of the cadavers was 65.1±15.1 years. A peripheral QCT scanner was used which provided 0.2 x 0.2 x 2 mm resolution. To improve the resolution of the final result, each hip joint was scanned in three different scanning directions (sagittal, coronal, and axial scanning planes). A custom imaging fixture was built to position a joint sample in three different scanning planes and a custom irrigation system supplied saline to protect the sample from dehydration. A custom segmentation program was developed to delineate the bony contours of the femoral head and neck in a fully automated manner. The segmentation data from the three differenent imaging planes were merged and a 3D solid model of each hip joint was created. The prominence of the femoral head was determined by the distance of the 3D head from an ideal sphere fitted into the 3D model. All the femoral heads were found to be asymmetric. Prominence of posteromedial femoral head averaged 0.105 mm more than the antero-medial femoral head. The antero-lateral head-neck junction was also found to be more prominent than the postero-lateral head-neck junction by an average of 1.09 mm. Asymmetry in the femoral head and femoral head-neck junction was a general finding in normal hip joints. The conventional approach of symmetric reconstruction of femoral head-neck junction may result in unnecessary removal of bone at the antero-lateral head-neck junction and potentially increase the risk of femoral neck fracture.
