The objective of this study was to investigate the effects of different doses rhBMP-2 on bone healing in an ovine lumbar interbody fusion model. In this study 22 sheep underwent two level lumbar interbody fusion using a ventrolateral approach with secondary dorsal fixation at L1/2 and L3/4. After randomization in one level a PEEK-cage was implanted filled with one of three doses rhBMP-2 (0,5mg; 1mg; 2mg) delivered on an ACS. The other level received an empty PEEK-cage or ACS filled cage. Animals were sacrificed after 3 and 6 months and decalcified histology was performed. This included histomorphological analysis well as histomorphometry of the tissues within the cage.

At 3 months after surgery the groups treated with rhBMP-2 showed higher amounts of bone tissue within the cage. At 6 months the amounts of bone tissue increased in all groups, were still lower in the groups without growth factor. At 3 months there was only one active osteolysis in the cage/ACS. 7 of 8 segments of the rhBMP-2 groups had a compromised bone structure around the implant. These areas were filled with fibrous tissue and fibrocartilage. This finding was not detected in the groups without rhBMP-2 at 3 months. At 6 months most of the segments with an empty cage or cage/ACS showed a chronic inflammation. Predominant cells were macrophages and giant cells. The groups treated with rhBMP-2 showed only a few mild chronic inflammatory reactions. The well-known dose dependent effect of rhBMP-2 on bone healing could also be recognized in our study. Attention has to be payed to the proinflammatory properties of the growth factor. Consistent with other studies we found 2 strong inflammatory reactions, each one in the lowest and highest dose group. Also, the potential for causing transient bone resorptions, according to the results of others, was demonstrated. At 3 months 7 of 8 segments treated with rhBMP-2 showed compromised peri-implant bone. Osteoblasts, but not osteoclasts, were seen in the periphery of these areas. It can be concluded that there where bone resorptions which already merged into an increased osteoblastic activity. Usually resorptions occur between 2 and 12 weeks and are followed by a period of increased osteoblastic activity. This finding wasn't recognized at 6 months anymore. Striking is that at 6 months most of the segments without rhBMP-2 showed a compromised bone structure around the implant with a mild to mainly moderate chronic inflammatory reaction. This cannot be attributed to the growth factor. Also, the ACS is degraded at 6 months and is unlikely a possible explanation. Therefore, the cage as a reason must be considered and it has to be questioned whether PEEK is the optimal material for interbody cages.

Introduction

The frequency of revision hip arthroplasty is increasing with the increasing life expectancy and number of individuals treated with joint replacement. Newer porous implants have been introduced which may provide better treatment options for revision arthroplasty. These may require cementation to other prosthesis components and occasionally to bone, however, there is currently no information on how these porous implants interface with cement.

Introduction

Periprosthetic medial tibial plateau fractures (TPF) are rare but represent a serious complication in unicompartmental knee arthroplasty (UKA). Most common treatment of these fractures is osteosynthesis with canulated screws or plates.

Periprosthetic tibial plateau fractures (PTPF) represent a rare but serious complication in unicompartmental knee arthroplasty (UKA). Although excellent long-term results have been reported with cemented UKA, surgeons continue to be interested in cementless fixation. The aim of the study was to compare fracture loads of cementless and cemented UKA.

Tibial components of the Oxford UKA were implanted in six paired fresh-frozen tibiae. In one set surgery was performed with cement fixation and in the other cementless components were implanted. Loads were then applied under standardised conditions to fracture the specimens.

Mean loads of 3.6 (0.7–6.9) kN led to fractures in the cemented group, whereas the tibiae fractured in the cementless group with a mean load of 1.9 (0.2–4.3) kN (p< 0.05).

The loading capacity in tibiae with cementless components is significantly less compared to cemented fixation. Our results suggest that, patients with poor bone quality who are treated with a cementless UKA are at higher risk for periprosthetic fractures.

Introduction: Postoperative periprosthetic fractures are difficult to investigate clinically in scientifically and statistically valid study samples because they are uncommon. However, the combination of advanced age and poor bone quality has been associated with these fractures in conjunction with cementless hip stems. So far, these speculations have neither been supported by clinical evidence nor been investigated experimentally. The purpose of the present study was to analyze in-vitro if the treatment with cementless hip stems increases the risk of suffering a periprosthetic fracture for older patients compared to younger patients. Regarding this manner, we aimed to clarify parameters which possibly can be used preoperatively to assess age related fracture risk and whether the femoral bone quality really plays a role in fracture development.

Methods: An established biomechanical setup was used to provide an investigation on 16 femoral specimens of different age. Prior, the BMDs were measured in 5 ROIs and a cementless hip stem was implanted into each femur. The load bearing of “normal walking” was applied quasistatically under standardized conditions until the fracture occurred. The specimens were arranged by age in ascending order to divide them in the middle. A group of under septuagenarians (< 70y) (mean: 62y) and a group representing an elderly population (≥77y) (mean: 79y) resulted. Important donor data such as body height and bodyweight were considered in the statistical analysis.

Results: The elderly specimens fractured at significantly lower forces (< 70y: Fmax=5,308N; ≥77y: Fmax=2,519N; p< 0.01). Pearson’s test revealed a correlation for Fmax [N] and age (p < 0.01; r = −0.64); and for Fmax [%BW] and age (p < 0.01; r = −0.69). Fracture loads were found to correlate strongly with age (p=0.01), all used ROIs (e.g. for Ward’s triangle: p< 0.01) and BMI (p=0.04). Decreasing CCD angles were found with increasing age (p < 0.01).

Discussion: In patients with advanced age treated with cementless hip stems the risk of suffering a periprosthetic fracture is significantly higher. The identification of specific fracture development variables in geriatric populations can be extended to a preoperative check list to aid clinicians in practicing effective risk assessment. Criteria such as BMD, BMI and CCD angle should be included: A fracture risk remains in patients around 80 years of age or older, with a Ward’s triangle BMD below a value of 0.500g/cm2, or a BMI > 33kg/m2. Depending on patient activity, one single factor should not be viewed as an exclusion criterion for a cementless hip stem, whereas the cumulation of them should alert the surgeon.

Background and Purpose: Periprosthetic tibial plateau fractures are a rare but serious complication of UKA. Since they usually appear perioperatively they can be associated with sawing defects during implantation. The aim of the study was to evaluate fracture loads and fracture patterns under particular consideration whether extended vertical saw cuts reduce the stability of the tibial plateau and increase the risk of periprosthetic tibial plateau fractures.

Material and Methods: In 6 matched paired fresh frozen tibiae (donor data: f/m = 2/4, mean age 81.2 years, mean weight 61.7kg) tibial implantation of the cemented Oxford Uni was performed in group A and with an extended vertical saw cut of 10° in group B in a randomized fashion. Before fracturing the tibiae with a maximum load of 10.0kN under standard conditions, DEXA bone density measurement and standard X-Ray were accomplished. After load induction fracture patterns and maximum fracture loads were analyzed and correlated to BMD, BMI, bodyweight (BW), age and surface area of the tibial implant.

Results: In group A a maximum load of Fmax = 3.912 (2.346–8.500) kN lead to fractures, whereas in group B all tibiae fractured with a mean load of Fmax = 2.622 (1.085–5.036) kN. The difference was statistically different with p=0.028. The induced fractures were similar to those observed in clinical practice.

Between BMI and the maximum fracture loads inducing tibial plateau fractures a significant correlation could be proven for all tibiae (r=0.643).

Discussion: The observed fracture pattern showed metaphyseal fractures similar to those observed in clinical practise. Extended vertical saw cuts weaken the bone structure and therefore raise the risk of medial tibial plateau fractures. In our study extended vertical saw cuts of 10° reduce maximum fracture loads about 30%.

We recommend special training and modified instruments for inexperienced surgeons to minimize the incidence of extended vertical saw cuts and to reduce the risk of periprosthetic fractures.

Introduction: The medial unicompartmental knee prosthesis (UKA) is less invasive than total knee arthroplasty (TKA) and preserves undamaged structures of the joint. The range of movement and recovery are better in UKA, while postoperative pain reduction is at least equal to TKA. UKA have a higher revision rate than TKA (15% vs 10% after 10 years). One main reason for revision is mechanical loosening¹. There is a paucity of information regarding cement fixation of UKA. We compared jet lavage to conventional lavage with focus on cement pressures, interface temperatures and cement penetration.

Materials and Methods: UKA was performed in 10 paired entire human cadaver legs (Oxford Phase III, Biomet, Dordrecht, NL). Customized tibial implants and a pressure probe insert were used to measure the cement pressure anterior, posterior and near the implant fin during implantation and polymerisation. A drilling and fixation jig was used for standardized positioning of the three temperature probes. The polymerization heat was measured 5 mm below the bone surface at the medial and lateral plateau as well as under the fin. The same cementing technique was performed for all knees using Refobacin^® Bone Cement R. One side of the paired knees was cleaned using jet lavage, contra lateral cleaning was done with conventional lavage. The lavage volume was equal for both

Methods: AP radiographs were taken and digitalized to quantify the cement penetration areas and depths, using a pixel-analysis-software. Group comparisons were done with the Wilcoxon-Test using SPSS (SPSS Inc., Chicago, Illinois).

Results: Average cement pressure under the tibial implant is significantly higher for conventional lavage (avg cement pressure 25.69 ± 17.85 kPa, p= 0.005) than for jet lavage (avg cement pressure 13.28 ± 12.82 kPa). Mean temperature increase measured 5 mm below the bone surface medial and lateral, as well as under the implant fin, were statistically significant higher for the cementing technique with jet lavage (lat. 14.10 ± 5.72°C, p= 0.018/med. 8.49 ± 4.20°C, p= 0.176/fin 5.95 ± 1.92°C, p= 0.063) than for the conventional lavage (lat. 9.42 ± 5.17°C/med. 6.42 ± 2.21°C/fin 3.96 ± 2.03°C). On AP radiographs, cement penetration areas under the tibial implant were significantly higher for jet lavage (penetration area: 122.15 ± 33.94 sq mm, p= 0.046) than for conventional lavage (penetration area: 89.82 ± 23.92 sq mm).

Discussion: The use of jet lavage showed clear advantages in our cadaver studies. Jet lavage resulted in higher cement penetration despite of lower cement pressures under the tibial implant. The higher cement penetration lead to higher interface temperatures but exposure to high temperatures over 50 °C with a risk for bone necrosis could not be measured.