A multicentre trial of four Level One trauma centres retrospectively analysed complications and odds for complications in complex open and closed tibial fractures stabilised by unreamed, small diameter nails.

467 tibial fractures were included in the study. There were 52 proximal fractures (11.1%), 219 mid-shaft fractures (46.9%), and 196 distal fractures (42%). Breakdown into different AO/OTA groups revealed 135 type A fractures (28.9%), 216 type B fractures (46.3%), and 116 type C fractures (24.8%). 265 were closed fractures (56.7%) and 202 were open fractures (48 Gustilo grade I (10.3%), 80 grade II (17.1%), and 74 grade III (15.9%).

Analysis revealed five (1.1%) deep infections (with a 5.4% rate of deep infections in Gustilo grade III open fractures), 43 delayed unions (9.2%), and twelve (2.6%) non-unions. Compartment syndromes occurred in 62 cases (13.3%), screw fatigue in 47 cases (10%), and fatigue failure of the tibial nail in three cases (0.6%). Fracture distraction of more than 3 mm should not be tolerated when stabilizing tibial fractures with unreamed, small diameter nails as this increases the odds to acquire delayed union by twelve times (p < 0.001), and the odds to acquire non union by four times (p = 0.057).

There was a significant increase of complications in the group of grade III open fractures (p < 0.001), AO/OTA type C fractures (p = 0.002), and to a lesser extent in distal fractures. However, the rate of severe complications resulting in major morbidity was low compared to other methods of stabilisation in these severe fractures.