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Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 113 - 113
1 Jul 2014
Laurent R Brennan M Renaud A D'arros C Obert L Layrolle P Gindraux F
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Summary

Properties of human amniotic membrane are particularly interesting. To use it as an Advanced Therapeutic Medicinal Product in bone surgery, we are evaluating its association with a potentially osteoinductive scaffold.

Introduction

The human Amniotic Membrane (hAM) is known to have a good potential to help the regeneration of tissues. It has been used for 100 years in many medical disciplines because of its properties: a membrane containing stem cells and growth factors, with low immunogenicity and anti-microbial, anti-inflammatory, anti-fibrotic and analgesic properties. Moreover, previous published data showed the possibility of in vitro osteodifferenciation of the whole tissue.

We aim to use hAM as an Advanced Therapeutic Medicinal Product for bone repair to treat large defects or pseudarthrosis. So we are studying the association of hAM with nanofiber jet sprayed polycaprolactone (PCL) scaffolds and the possibility to induce its osteodifferenciation.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_IV | Pages 559 - 559
1 Nov 2011
Ranger P Renaud A Dahan P Delisle J De Oliveira E Phan P
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Purpose: Knee dislocation, although very rare, remains a devastating injury with many complications because of the complex nature of this trauma. The best treatment for knee dislocation is yet to be determined. The purposes of the study were to describe our surgical method, to report our results and to compare them with those of other surgical reconstruction techniques for knee dislocation.

Method: Fifty-six (56) patients with knee dislocation underwent acute combined reparation and reconstruction using Ligament Advancement Reinforcement System (LARS) artificial ligament. Patients were divided in three different groups according to the follow-up period. Group 1 (G1) included patients with a follow-up between two and six months post-op, group 2 (G2) involved patients with a follow-up between six months and twenty-four (24) months and group 3 (G3) was composed of patients who had a follow-up between twenty-four (24) and ninety-one (91) months.

Results: There was a significant difference between G1 and G3 for the Lysholm score and for the posterior stability at 90o of flexion measured with the Telos.

Conclusion: The subjective and objective findings from our series are satisfactory and comparable to the results of other series of knee dislocations. Our findings suggest that with a follow-up at seven years, acute combined reparation and reconstruction with LARS ligaments is a valid alternative for the treatment of knee dislocation.