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Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 188 - 188
1 Mar 2006
Hulse N Narayan H Rajashekhar C Paul A Wylie J
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Background: Skin grafting is one of the simplest techniques of providing skin cover following enbloc resection of soft tissue sarcomas on extremities. But many authors have questioned the tolerance of skin graft to post operative radiotherapy.

Aim: To assess the integrity of skin grafts following post operative radiotherapy for soft tissue sarcomas on extremities.

Material and methods: During the period between 1997 and 2003, 10 patients received postoperative external beam radiotherapy following excision of soft tissue sarcomas on extremities and skin grafting at this regional soft tissue sarcoma unit. Age of these patients ranged from 26 years to 92 years. Malignant fibrous histiocytoma was the commonly encountered tumour. Commonest site of resection and skin grafting was lower leg. These patients were analysed for interval between skin grafting and radiotherapy, dose, type and fractions of radiation, break in radiotherapy, adjuvant chemotherapy and effect of radiation on skin graft.

Results: One patient developed moist desquamation and two developed dry desquamation during the course of treatment. All acute skin reactions were healed within 3 weeks of completion of radiotherapy. No patients required further soft tissue reconstruction.

Conclusion: Adjuvant external beam radiotherapy can be delivered to skin-grafted areas on extremities following enbloc excision of soft tissue sarcomas without any major complications. Our experience indicates that the radiation reaction can be minimised if the graft is allowed to heal adequately prior to the initiation of radiotherapy.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_I | Pages 75 - 75
1 Mar 2005
Hulse N Rajashekhar C Paul A Wylie J
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Background: Skin grafting is one of the simplest techniques of providing skin cover following enbloc resection of soft tissue sarcomas on extremities. But many authors have questioned the tolerance of skin graft to post operative radiotherapy.

Aim: To assess the integrity of skin grafts following post operative radiotherapy for soft tissue sarcomas on extremities.

Material and methods: During the period between 1997 and 2003, 10 patients received postoperative external beam radiotherapy following excision of soft tissue sarcomas on extremities and skin grafting at this regional soft tissue sarcoma unit. Age of these patients ranged from 26 years to 92 years. Malignant fibrous histiocytoma was the commonly encountered tumour. Commonest site of resection and skin grafting was lower leg. These patients were retrospectively analysed for interval between skin grafting and radiotherapy, dose, type and fractions of radiation, break in radiotherapy, adjuvant chemotherapy and effect of radiation on skin graft. Results: One patient developed moist desquamation and two developed dry desquamation during the course of treatment. All acute skin reactions were healed within 3 weeks of completion of radiotherapy. No patients required further soft tissue reconstruction.

Conclusion: Adjuvant external beam radiotherapy can be delivered to skin-grafted areas on extremities following enbloc excision of soft tissue sarcomas without any major complications. Our experience indicates that the radiation reaction can be minimised if the graft is allowed to heal adequately prior to the initiation of radiotherapy.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_I | Pages 78 - 78
1 Mar 2005
Hulse N Rajashekhar C Raja S Paul A
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Background: Extra skeletal osteosarcomas are rare malignancies that account for less than 1% of all soft tissue sarcomas. We describe this tumour arising in the belly of vastus medialis muscle in a 56-year-old woman.

Case report: A 56 year old, otherwise healthy teacher was referred to this regional soft tissue sarcoma unit regarding a progressively enlarging mass in her right thigh. She had noticed this swelling 12 months ago, which remained pain free. On examination there was a firm swelling on the medial side of the thigh measuring 6 cm in diameter. There was no regional lymphadinopathy. MRI scan was reported as a probable soft tissue sarcoma arising from vastus medialis. An open biopsy was reported as a sarcoma of chondroid differentiation but a specific diagnosis of extraskeletal osteosarcoma was reached only after definitive tumour resection. She was treated by wide resection, post operative radiotherapy and combined chemotherapy. At 24 months of follow up she remained tumour free.

Relevant literature is reviewed.