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Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXIV | Pages 12 - 12
1 May 2012
Aarvold A Smith J Edwards C Tayton E Gent E Oreffo RC
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Background

Unicameral bone cysts (UBCs) are difficult to treat and have a high recurrence rate. Their pathogenesis is unknown making targeted therapies difficult. Attributed causes include venous and interstitial fluid obstruction, oxygen free radicals, lysosomal enzymes, prostaglandins and genetic factors. Skeletal stem cells (SSCs) are osteoblast precursors critical to bone formation and cyst fluid may influence their growth, however the association between SSCs and cyst fluid has never been investigated.

Aim

To investigate the effect of UBC fluid on SSC growth.