Data was collected on 139 eligible patients a minimum of 18 months post surgery who had had 2 or more ligaments reconstructed. 63 patients were available for clinical follow up. It is the largest single surgeon series studied.

27% of injuries were high energy traffic accidents. 73% were low energy, mainly sports related. 63% of patients were delayed referrals to our unit. Of these nearly 48% had already undergone knee surgery, often more than 6 months post injury. 17% of all cases presented with failed ligament reconstructions. Of those patients followed up 19% were operated upon within 3 weeks of injury, 56% were delayed reconstructions with a mean time to surgery of 21 months and 25% were revision reconstructions. Time to follow up ranged from 18 months to 10 years.

The median KOS ADL, KOS Sports Activity and Lysholm scores for uni-cruciate surgery were all better than those for bi-cruciate surgery. All results were better for acute rather than chronic cases, which in turn were better than those for revision cases. The Tegner score showed that only acute uni-cruciate reconstructions returned to their pre-injury level.

TELOS stress radiographs demonstrated a mean post drawer of 5.9 mm side-to-side difference after reconstructions involving the PCL. IKDC grades showed 6% of knees were normal and 57% were nearly normal.

37% required further surgery, mainly to increase movement or for hardware removal. There was 1 deep infection and 2 cases of thrombosis. There were no vascular complications but 2 had transient nerve injuries.

Multi-ligament surgery can produce good functional outcomes but the knee is never normal. There is an increased risk of PCL laxity post op. Early referral to a specialist unit is suggested as delayed referral to a specialist unit potentially subjects the patient to unnecessary surgery and may affect outcome.

The aim of this study was to compare accuracy of an image guided percutaneous core needle biopsy (PCNB), using ultrasound or computed tomography, to PCNB without image guidance in the diagnosis of palpable soft tissue tumors.

One hundred forty patients with a suspected soft tissue sarcoma underwent a percutaneous core needle biopsy with or without image guidance. One hundred eleven patients had subsequent surgical excision. The accuracy of guided PCNB and blind PCNB was calculated by comparing the histological results of the needle biopsy to the surgical specimen.

The diagnostic accuracy of blind percutaneous core needle biopsy was 78% (36 of 46 biopsies) and significantly lower (p ≤ 0.025) in comparison to image guided percutaneous core needle biopsy which was 95% (62 of 65 biopsies).

We suggest that image guidance improves the diagnostic accuracy of PCNB especially for small size deep sited suspected soft tissue tumours.

Current bone grafts include allograft and autografts, both of which have limitations. Tissue engineering biotechnology has shown considerable promise in improving grafts. A competent graft material should ideally have osteoconductive and osteoinductive properties and comprise of bone forming cells and osteoinductive growth factors. In this study, we have evaluated the in vitro formation of bone and have used human demineralised bone matrix [DBM] and human insoluble collagenous matric [ICM] as scaffolds for mesenchymal stem cells [MSCs] and osteogenic protein [OP-1]. The objective was to determine whether combined addition of OP-1 and MSCs resulted in a superior bone graft substitute by improving the inherent osteoinductive property.

DBM and ICM were prepared and combined with rhOP [1.4 mg/0.25 mg of bone] and MSCs [1 x 105/ ml]. Statistically significant differences in MSC proliferation were seen between materials with and without OP-1 [P< 0.05}, n=8] in DBM on day 1, and both DBM and ICM on day 7 and 14. Enhanced osteogenic differentiation was observed in the presence of OP-1 when compared to DBM alone and on DBM and ICM with OP-1. In conclusion MSCs and OP-1 can be seeded together on DBM and ICM and Von Kossa staining and X-ray analysis confirmed in vitro de novo bone formation, with DBM + MSCs + OP-1 being more successful in this regard.

Conclusion: To date, no other study, to the author’s knowledge, has used MSCs and OP-1 together on a graft material; this funding, therefore, has very important clinical implications.

Limitations of allografts and autografts for bone repair have increased the demand for a synthetic bone graft substitute for load-bearing and non-load bearing osseous defects. Tissue engineering of bone has thus been implicated to circumvent and eliminate the limitations of existing therapies, with living cell-scaffold constructs ultimately “integrating” with the patients own tissue. Bone engineering requires cells, growth inducing factors and a scaffold for delivery of cells to the anatomic site, creation of 3-D space for tissue formation and mechanical support. In this study, we investigated whether addition of osteogenic Protein-1 (OP-1) enhanced the osseoinductive properties of hydroxyapatite (HA) loaded with mesenchymal stem cells (MSCs). The study was conducted over a fourteen day period and the two groups HA/MSC and HA/MSC loaded with OP-1 were analysed qualitatively by SEM and quantitatively by assessment of proliferation (Alamar blue assay and total cellular DNA) and differentiation marker alkaline phosphatase activity (ALP). HA/MS/OP-1 showed a statistically significant (p< 0.05) increase in cell proliferation (286.52 ± 58.2) compared to the unloaded samples (175.62 ± 23.51). ALP activity (release) was also significantly enhanced (p < 0.05) in the loaded samples at day 14 (12.63 ± 1.58) compared to the control (2.73 ± 1.07).

Conclusion: the osseoinductive potential of HA was markedly improved by the incorporation of MSC’s and OP-1. This type of graft could provide improved mechanical stability at an earlier time point, and may influence future clinical application of HA for load bearing sites.

The aim of this study was to compare the accuracy of image guided (ultrasound or CT) percutaneous needle biopsy to percutaneous needle biopsy without image guidance in diagnosis of soft tissue tumours.

Eighty-eight consecutive patients with soft tissue lesion who were referred to the soft tissue tumour unit underwent percutaneous needle biopsies of their lesion either with image guidance or without. Sixty-one out of these 88 patients subsequently underwent excision of their lesion and the excised specimen was then subjected to histological examination. The accuracy of image guided percutaneous needle biopsy and percutaneous needle biopsy without image was then calculated by comparing the histological results of the needle biopsy to that of excision biopsy.

The diagnosis accuracy of image guided percutaneous needle biopsy was 92% (34 out 37) compared to 79% (22 out of 28) for percutaneous needle biopsy without image. In 3 out of the 28 patients who had percutaneous needle biopsy without image guidance, there was insufficient material obtained from the needle biopsy to allow a histological diagnosis. This was not the case with any of the patients who had image guided percutaneous needle biopsy.

Conclusion: Using image guidance, either USS or CT scan, improves the diagnostic accuracy of percutaneous needle biopsy and should be the gold standard technique in management of soft tissue tumours. However, if the lesion is palpable and not mobile, the accuracy of percutaneous needle biopsy without image guidance can be up to 79%.

To assess the outcome of periprosthetic femoral fractures (Vancouver B3 type) around loose stems treated by impaction grafting revision, 106 B3 fractures were reviewed. To assess the association between those who healed and those who did not for the factors of interest such as stem length, impaction grafting and the combination of the above, odd ratios along with their 95% CI and their p-values were reported. Logistic regression in STATA version 7.0 employed.

75 out of 89 fractures treated with long stem revision and 10 out of 17 with sort stem healed. 74 out of 89 fractures treated with impaction grafting and 11 out of 17 treated without impaction grafting healed.

66 out of 75 fractures treated with long stem and impaction grafting and 9 out of 14 treated with with long stem but no impaction grafting healed. 8 out of 14 fractures treated with short stem and impaction healed. Average healing 8.5 months.

Those treated with long stem are almost four times more likely to heal than those treated with short stem (odds ratio = 3.75 95%CI: 1.21–11.6 p=0.022) and those with impaction grafting are also more likely, but not statistically significant, to heal than those without impaction grafting (odds ratio = 2.69, 95%CI: 0.86– 8.45 p=0.090). Furthermore, those with long stem and impaction are significantly more likely to heal than those without impaction grafting and those with short stem and impaction grafting (odds ratios = 4.07, 95%CI: 1.10 – 15.0 p=0.035 and 5.5, 95%CI: 1.54 – 19.6 p=0.009 respectively).

Impaction grafting is an increasingly popular technique for the restoration of femoral bone stock. It can successfully be applied to periprosthetic femoral fractures but a long stem should be used to bypass the distal fracture line.

We compared the accuracy of image guided (ultrasound or CT) percutaneous core needle biopsy to percutaneous core needle biopsy without image guidance in diagnosis of soft tissue tumours. 140 patients with soft tissue lesion who were referred to a London bone and soft tissue tumour unit underwent percutaneous core needle biopsies of their lesion either with or without image guidance.111 of these 140 patients subsequently had surgical excision. The accuracy of image guided percutaneous biopsy and percutaneous biopsy without image was then calculated by comparing the histological results of the needle biopsy to that of the resection.

The diagnosis accuracy of unguided biopsy was 78% (36 out of 46) compared to 95% (62 out of 65) in image guided. In 6 out of the 46 patients who had unguided biopsy, there was insufficient material obtained from the needle biopsy to allow histological diagnosis. This was not the case with any of the patients who had image guided core needle biopsy.

Using image guidance, either USS or CT scan, improves the diagnostic accuracy of percutaneous core needle biopsy and must be considered in management of patients with soft tissue tumours.

Aims: Retrospective study of management and outcome of periprosthetic femoral fractures, in a lower limb reconstruction, reference centre. Methods: 144 fractures over a period of 20 years were reviewed. The Vancouver system was used to classify the fractures. The prosthesis length was measured pre and post operatively. The use of impaction grafting technique to compensate for inadequate bone quality of the surrounding bone was assessed (type B3 fractures). The use of Dall/Miles, DCP and Mennen plates also assessed. Healing was deþned using radiological and clinical criteria. Chi-square test with p< 0.05 was used for the analysis of the results. Results: When the Vancouver system was applied 2.85% of the fractures were classiþed as type A, 87.2% as type B and 10% as type C. Within type B group 13.2% were subtype B1, 12% subtype B2 and 62% subtype B3. Better healing achieved when the revision stem was bypassing the most distal fracture line (p=0.005). Better healing achieved when impaction grafting was used for B3 fractures (p=0,0001). 1 out of 6 Mennen, 4 out of 16 Dall/Miles and 2 out of 20 DCP plates used failed. Overall 68% healing, 5% non-union, 1% infection, 24% re-fracture rate at 12 months follow up. Conclusion: Impaction grafting could compensate for the inadequate bone in type B3 fractures. Revision stem should bypass the most distal fracture line to achieve healing. DCP plates do better than Dall/Miles. Mennen plates have got special indications.

Aims: MRI changes to the symptomatic intervertebral disc following Intradiscal Electrothermal Therapy (IDET), in particular those relating to the Ç High Intensity Zone È (HIZ) in the posterior annulus, were determined in this prospective study. Methods: MRI images before the IDET procedure were compared to those taken at six months post procedure in 10 patients. The presence and absence of an HIZ, the disc height and hydration, and Modic changes, were determined from the images. Two of the patients also had discography performed post-IDET to supplement the MRI. Results: In 6 out of the 10 patients, an HIZ was present on the MRI images of the disc before the IDET procedure. In all 6 patients, a HIZ was still present six months after the procedure. In all 10 patients, there were no changes to disc height and hydration signal on T2 weighted images. Modic changes were not present in any of the patients on pre or post IDET images. Two patients had signiþ-cant changes to the shape of the posterior annulus compared to the pre-treatment MRI scans. The two patients who had discography after IDET had persistent annular tears. Conclusion: Our þndings question the clinical relevance of the Ç High Intensity Zone È. They also suggest that the main mechanism of action of IDET, may be other than that of sealing the annular tear.

Aims: The aim of this study was to compare the results of Micro Endoscopic Discectomy (MED) toMicro Surgical Discectomy (MSD). Methods: 12 Patients were reviewed by an independent observer. This included the þrst 6 patients who underwent MED and 6 patients who underwent MSD selected randomly. There was no signiþcant difference between the two groups concerning age and sex distribution, occupation, preoper-ative time of work and clinical symptomatology. The disc herniations were located at L4-5 in 6 patients and L5-S1 in 6 patients. Patients were followed up for an average of 9 months (Range 2–22 months). They were assessed using the following questionnaires Oswestry low back pain and disability, Modiþed Gre-enough and Fraser and Mc Nab. Results: Both groups faired equally according to Mc Nab. The MED group appeared to require less postoperative analgesia especially opioid based preparations and were discharged earlier. The only complication was one patient in the MED requiring conversion to MSD. Conclusion: Our results indicate that MED is at least as effective as MSD, although it initially takes longer to perform due to the learning curve. However, the decrease in postoperative analgesia requirements and earlier discharge is beneþcial. In addition, we feel it has advantages over the percutaneous posterolateral discectomy for nerve root compression, which cannot treat sequestrated discs, or patients with disc herniations associated with recess stenosis.

Objectives: To describe a new method of catheter insertion in Intradiscal Electrothermal Therapy (IDET), when and adequate catheter position cannot be achieved with standard technique. Intradiscal Electrothermal Therapy is a new technique developed in 1998 for treatment of chronic low back pain. Adequate catheter position is of vital importance to the outcome of this procedure. If adequate position is not achieved with the standard technique, the recommendation is to reinsert a new cannula into the contralateral side. This requires more local anaesthesia, further discomfort for the patient and additional X-ray exposure. The “Pig Tail” Technique described here, eliminates the need for reinsertion of the cannula and catheter from the contralateral side in those patients in whom optimal positioning is not achieved with the standard technique. This new technique has not been described before.

Methods: In those patients in whom adequate catheter position cannot be achieved with the standard technique, instead of withdrawing the cannula after the initial treatment, we recommend rotating the cannula 180° through its long axis. This will allow the catheter to hit the anterior annulus and deflect backwards towards the cannula. It can then be negotiated across the midline to adequately thermally treat the whole posterior annulus.

Results: We have performed our technique in thirty two consecutive patients in whom initial navigation was difficult. This new method proved to be simple and did not cause patients additional discomfort.

Conclusion: “Pig Tail” Technique is safe and effective in IDET of those patients with difficult navigation. It avoids the need for second needle insertion therefore avoiding the use of more local anaesthsia, further discomfort for the patient and additional X-ray exposure.

Objective: MRI changes to the symptomatic intervertebral disc following Intradiscal Electrothermal Therapy (IDET), in particular those relating to the “High Intensity Zone” (HIZ) in the posterior annulus, were determined in this prospective study.

Material and Methods: MRI images before the IDET procedure were compared to those taken at six months post procedure in 10 patients. The presence and absence of an HIZ, the disc height and hydration, and Modic changes, were determined from the images. Two of the patients also had discography performed post-IDET to supplement the MRI.

Results: In 6 out of the 10 patients, an HIZ was present on the MRI images of the disc before the IDET procedure. In all 6 patients, a HIZ was still present six months after the procedure. In all 10 patients, there were no changes to disc height and hydration signal on T₂ weighted images. Modic changes were not present in any of the patients on pre or post IDET images. Two patients had significant changes to the shape of the posterior annulus compared to the pre-treatment MRI scans. The two patients who had discography after IDET had persistent annular tears.

Conclusion: Our findings question the clinical relevance of the “High Intensity Zone”. They also suggest that the main mechanism of action of IDET, may be other than that of sealing the annular tear.

Retrospective study of management and outcome of periprosthetic femoral fractures, in a lower limb reconstruction, reference centre.

144 fractures over a period of 20 years were reviewed. The Vancouver system was used to classify the fractures. The prosthesis length was measured pre and post operatively. The use of impaction grafting technique to compensate for inadequate bone quality of the surrounding bone was assessed (type B3 fractures). The use of Dall/ Miles, DCP and Mennen plates also assessed. Healing was defined using radiological and clinical criteria. Chi-square test with p< 0.05 was used for the analysis of the results.

When the Vancouver system was applied 2.85% of the fractures were classified as type A, 87.2% as type B and 10% as type C. Within type B group 13.2% were subtype B1, 12% subtype B2 and 62% subtype B3. Better healing achieved when the revision stem was bypassing the most distal fracture line (p=0.005). Better healing achieved when impaction grafting was used for B3 fractures (p=0,0001). 1 out of 6 Mennen, 4 out of 16 Dall/Miles and 2 out of 20 DCP plates used failed. Overall 68% healing, 5% non-union, 1% infection, 24% re-fracture rate at 12 months follow up.

Impaction grafting could compensate for the inadequate bone in type B3 fractures. Revision stem should bypass the most distal fracture line to achieve healing. DCP plates do better than Dall/Miles. Mennen plates have got special indications.

To the best of our knowledge, this prospective study is the first to investigate the prevalence of acetabular labrum tears in athletes presenting with groin pain.

Eighteen consecutive athletes who presented to our sports clinic with groin pain, underwent Magnetic Resonance Arthrography (MRA). Presence or absence of acetabular labrum tears, were reported on by a Consultant Radiologist, who has an interest in musculoskeletal radiology.

In 4 out of 18 athletes with groin pain (22.2%), the Magnetic Resonance Arthrography demonstrated the presence of acetabular labrum tear. Two underwent hip arthroscopy and treatment

Acetabular labrum tears can be a common cause of groin pain in athletes. Sports clinicians have to be well aware of the condition. Magnetic resonance arthrography of the hip can be a valuable tool in diagnosing this pathology.