Functional outcome in Total Knee Arthroplasty (TKA), as measured by means of gait analysis for kinematics, kinetics, and muscular activity around the knee shows abnormalities even in patients with excellent clinical outcome. Knee flexion during loading response phase is reduced, accompanied by co-contraction of knee extensors and flexors. Such subtle failure in knee performance during loading absorption was claimed to depend on several factors: quadriceps weakness, prosthetic design, pre-surgical pattern, proprioception disruption. It was supposed to damage the implant in time. The lack of the anterior cruciate legament seems to play a major role in the loss of control of the roll back pattern of the condyles on the tibial plateau in TKA patients. Previous works on unicondylar knee artrhoplasty (UKA) demonstrated better gait performance when anterior cruciate ligament was preserved allowing the patients to maintain normal quadriceps mechanics. The aim of the present work is to evaluate UKA patients knee function during gait compared to TKA with the hypothesis that UKA ensures more physiological knee loading response pattern of movement and a more phasic muscular activation, thus reducing the risk of failure. Twenty patients with Oxford/Exactech UKA (mean age 70 (SD 7.9), mean follow-up 2 years) were evaluated by means of a Vicon 612-8 cameras system, two Kistler forceplates and Telemg respectively for knee 3D kinematics, kinetics and muscular activity. Data of UKA were compared to those of a control population of ten healthy subjects and ten patients with TKA matched for age and follow up. Mean UKA-IKS score at the time of gait analysis was 90. Time-distance parameters evidenced a slight slow gait with reduced stride length and cadence and a symmetric longer stance phase with respect to TKA and controls. Knee kinematics on the sagittal plane showed knee flex-ion during loading response very close to controls and a reduced but phasic pattern of joint moments on the sagittal plane. Adduction moment at the knee was normal. EMG showed controversy results as some patients had a regular pattern of activation of rectus femoris and hamstrings without co-contraction whereas other patients had co-contraction. These preliminary results indicate that UKA allows in most patients a quite normal knee kinematics and kinetics, although some abnormalities persist in quadriceps activation. Further research is required to understand these findings assessing other factors which could influence quadriceps activity such as age, proprioception, and muscular strength.