Treatment of proximal humerus fractures (PHF) is controversial in many respects, including the choice of surgical approach for fixation when using a locking plate. The classic deltopectoral (DP) approach is believed to increase the risk of avascular necrosis while making access to the greater tuberosity more difficult. The deltoid split (DS) approach was developed to respect minimally invasive surgery principles. The purpose of the present study (NCT-00612391) was to compare outcomes of PHF treated by DP and DS approaches in terms of function (Q-DASH, Constant score), quality of life (SF12), and complications in a prospective randomized multicenter study.

From 2007 to 2016, all patients meeting the inclusion/exclusion criteria in two University Trauma Centers were invited to participate in the study. Inclusion criteria were: PHF Neer II/III, isolated injury, skeletal maturity, speaking French or English, available for follow-up (FU), and ability to fill questionnaires. Exclusion criteria: Pre-existing pathology to the limb, patient-refusing or too ill to undergo surgery, patient needing another type of treatment (nail, arthroplasty), axillary nerve impairment, open fracture. After consent, patients were randomized to one of the two treatments using the dark envelope method. Pre-injury status was documented by questionnaires (SF12, Q-DASH, Constant score). Range of motion was assessed. Patients were followed at two weeks, six weeks, 3-6-12-18-24 months. Power calculation was done with primary outcome: Q-DASH.

A total of 92 patients were randomised in the study and 83 patients were followed for a minimum of 12 months. The mean age was 62 y.o. (+- 14 y.) and 77% were females. There was an equivalent number of Neer II and III, 53% and 47% respectively. Mean FU was of 26 months. Forty-four patients were randomized to the DS and 39 to the DP approach. Groups were equivalent in terms of age, gender, BMI, severity of fracture and pre-injury scores. All clinical outcome measures were in favor of the deltopectoral approach. Primary outcome measure, Q-DASH, was better statistically and clinically in the DP group (12 vs 26, p=0,003). Patients with DP had less pain and better quality of life scores than with DS (VAS 1/10 vs 2/10 p=0,019 and SF12M 56 vs 51, p=0,049, respectively). Constant-Murley score was higher in the DP group (73 vs 60, p=0,014). However, active external rotation was better with the DS approach (45° vs 35°). There were more complications in DS patients, with four screw cut-outs vs zero, four avascular necrosis vs one, and five reoperations vs two. Calcar screws were used for a majority of DP fixations (57%) vs a minority of DS (27%) (p=0,012).

The primary hypothesis on the superiority of the deltoid split incision was rebutted. Functional outcome, quality of life, pain, and risk of complication favoured the classic deltopectoral approach. Active external rotation was the only outcome better with DS. We believe that the difficulty of adding calcar screws and intramuscular dissection in the DS approach were partly responsible for this difference. The DP approach should be used during Neer II and III PHF fixation.

Treat to target is the use of a physiologic marker as a monitor of effectiveness or compliance to an intervention. A recent example has been the progressive use of CTX-1 (Marker of osteoclastic activity) as a surrogate of bone resorptive activity in osteoporosis treatment. CTX-1 levels were demonstrated to be inversely related to drug efficacy in the suppression of bone resorption. As far as fragility fractures are concerned, no reference value of CTX-1 for any index fracture sites was found in the literature. In order to prevent subsequent fractures, efforts to better manage this chronic disease are to be explored. The main objective of this study was to compare and validate the use of serum CTX-1 to the perceived compliance to treatment.

Five hundred and forty three patients (men and women) 40 years of age or older who had been treated for a fragility fracture were enrolled. The purpose of this study was to correlate the measurement of CTX-1 with the perceived compliance to treatment of patients at the time of fracture and at six, 12 and 18 months after initiation of treatment. Our secondary objectives were to evaluate two different CTX-1 suppression target levels (CTX-1< 0.3 ng/mL and CTX-1<0.2 ng/mL), to determine CTX-1 values according to fracture sites, and to explore the profile of patients with subsequent fractures.

Considering index fractures, compliant patients under treatment at baseline had lower CTX-1 levels than non-compliant patients (p=0.052). Patients who were compliant to treatment at six, 12 and 18 months also had lower CTX-1 levels than non-compliant patients (p=0.000). When index fractures were divided into fracture sites, regardless of CTX-1 suppression target level (i.e. CTX-1< 0.3 or 0.2 ng/mL), significant CTX-1 suppression was observed in non-hip and non-vertebral (NHNV) fractures at six, 12 and 18 months (p0.05). No clinically relevant difference was observed between the profile of patients with and without subsequent fractures.

The correlation between serum CTX-1 at the time of fracture and at six, 12, 18 months and the perceived compliance to treatment was validated for NHNV fractures supporting the concept of the available treatments and their effects on bone remodeling for this type of fracture. The correlation was not validated for hip neither for vertebral fracture. There was no correlation between CTX-1 levels and subsequent fracture risk.

Summary

In a rabbit model of early osteoarthritis, structural changes in femoral condyle cartilage were severer in the lateral compartment and preceded alterations in the underlying bone. In the medial compartment, altered bone properties occurred together with structural changes in cartilage.

Purpose of the study: A medial incision for implantation of a total knee arthroplasty (TKA) offers an excellent surgical exposure while minimising the length of the skin opening. This incision however implies section of the proximal portion of the infrapatellar branch of the medial saphenous nerve, potentially associated with lateral hypoesthesia and formation of a neuroma (painful scar). We hypothesised that an anterolateral skin incision would produce less hypoesthesia and postoperative discomfort.

Material and methods: We conducted a prospective randomised study to compare the degree of hypoesthesia after a medial or lateral skin incision for the implantation of a TKA. Fifty-knees in 43 patients, mean age 65.9±8.4 years were included; 26 knees for the lateral incision and 24 for the medial. All patients had the same type of implant. Clinical results were assessed with WOMAC, KOOS and SF36. Semme-Weinstein monofilaments were applied to measure sensitivity at 13 characteristic points. Patients were assessed at six weeks and six months. The zone of hypoesthesia was delimited and photographed for measurement with Mesurim Pro9^®. Satisfaction with the surgery and the scar was noted. Data were processed with Statview^®; p< 0.05 was considered significant.

Results: The two groups were comparable preoperatively regarding age, gender, body weight, height, body mass index, body surface area, aetiology, and clinical score. Operative time, blood loss, and number of complications were comparable. The functional outcomes (WOMAC, KOOS, SF36) were comparable at six weeks and six months. Active flexion was significantly greater at six months in the lateral incision group (p=0.03). The zone of hypoesthesia was significantly smaller in the lateral incision group at six weeks (p< 0.01) and at six months (p< 0.01), as were the number of points not perceived on the filament test (p< 0.01 in both cases) while the length of the incision was comparable (p> 0.05). This was associated subjectively, with less loss of sensitivity and less anterior pain reported by the patient at six months.

Discussion: Lateral and medial incisions enable comparable functional outcomes. The lateral incision produces less hypoesthesia and less anterior pain. This improves the immediate postoperative period and facilitates rehabilitation as is shown by the gain in flexion at six months.

Purpose: Bone stress transmission by an implant has been demonstrated to be inversely proportional to its rigidity. Since trabecular metal has a high elasticity modulus, it is hypothesised that it should have a preservative impact on bone mineral density (BMD) loss. No current studies prospectively compare BMD variations using such implants.

Method: A randomized study recruiting 65 patients with osteoarthritis of the knee, were assigned to a cemented titanium or a non-cemented trabecular metal tibial base plate. Each patient had a DXA scan of the proximal tibia on the TKA side at two weeks, six months, one and two years follow-up. Analytic methods for DXA scans were standardized (Variation coefficient=0,59–0,84%), and BMD variation compared between groups using the Student t-Test.

Results: Versus early post operative evaluation, BMD loss was found in the two groups. Fixed effects on BMD, such as patient’s height (p< 0.001) and tibial implant size (p=0.04) were demonstrated. Patella resurfacing and polyethylene thickness had no effect on BMD. BMD loss was more important under titanium implants (−30.9%) than trabecular metal implants (−6.3%). The most affected area was the metaphysis (p=0.002) compared to the diaphysis (p=0.054).

Conclusion: Trabecular metal tibial base plate seems to diminish BMD loss under tibial implant compared to traditional titanium base plate. A long-term study will be necessary to determine the tibial trabecular metal component survival rate.

Purpose: Antero-medial parapatellar skin incision in total knee arthroplasty (TKA) provides excellent surgical exposure with minimal skin incision length. However, it is associated with the infrapatellar branch of the saphenous nerve section, leading to antero-lateral knee hypoesthesia and sometimes painful nevroma. We hypothesized that

antero-lateral skin incision in TKA produces a lower rate of hypoesthesia compared to the medial parapatellar cutaneous approach, and

Method: A total of 69 knees in 64 patients who underwent TKA were randomized for antero-medial (n=35) or antero-lateral (n=34) skin incision. Mean age was 66.4±8.2 years. Functional outcome was assessed by WOMAC, KOOS and SF-36 scores pre-operatively and at six weeks, six months and one year follow-up. Range of motion (active and passive flexion and extension) was measured. The area of hypoesthesia was analyzed in a standardized manner by an independent observer using a calibrated Semme-Weinstein monofilament applied on 13 reference points. A digital photograph was taken, and the area of hypoesthesia was then measured informatically (Mesurim Pro^® software). Patient satisfaction with their scar and their surgery was evaluated. Statistical analysis was carried out with p< 0.05 considered as significant.

Results: The two groups were comparable pre-operatively. There was no significant difference in functional outcome (WOMAC, KOOS, SF-36 scores) at six weeks, six months and one year between the two groups. Active and passive ranges of motion were comparable. The area of hypoesthesia and the number of non-perceived points in the monofilament test were significantly lower after antero-lateral incision at six weeks (p=0.007 and p=0.02, respectively) and 6 months (p=0.02 and p=0.005, respectively). At one year, the area of hypoesthesia was lower in the antero-lateral group, but was not significant (p=0.08). Antero-lateral incision patients reported a lower rate of subjective sensitivity loss and anterior knee pain at six weeks, six months and one year.

Conclusion: Antero-medial and antero-lateral parapatellar skin incisions in TKA have a similar functional outcome. However, antero-lateral cutaneous incision produces a lower rate of hypoaesthesia and less anterior knee pain in the early recovery period.

Hypothesis: 1. Increased wear results from modularity. 2. Modification of the patello-femoral articulation will decrease patellar fractures.

Materials & Methods: A prospective comparison of 100 consecutive Non-modular Insall Burstein Posterior Stabilized (IBPS) knee prostheses (1986–1989) with 100 consecutive modular IBPS II knee replacements (1989–1990). No patient was lost.

Results: IBI: Nine re-operations of which 6 were complete revisions: two for sepsis, one for tibial loosening, one for patellar wear and two for undiagnosed pain. Of seven patellar fractures, five required surgery. IBII: Nineteen re-operations of which six were complete revisions: two for sepsis, one for tibial loosening from catastrophic osteolysis, two for instability and one for stiffness. There were no revisions for patellar complications. Of 12 non-revision re-operations, two were for patellar fractures, three for dislocation of the posterior stabilized mechanism and one for failure of the modular locking mechanism. Six knees suffered patellar “clunks” treated arthroscopically.

Discussion: The femoral component patellar groove was smoothed and the posterior stabilized mechanism was relocated on the IB II. This increased motion and decreased patellar fractures but caused scar on the quadriceps tendon to “clunk” and lead to dislocations of the “spine and cam”. All failures occurred in the first five years.

Clinical Relevance: Specific patellar problems were improved with design modifications. New problems have been addressed and long-term survival has not been compromised by modularity

Introduction: The modular IBPSII prosthesis was introduced in 1989 with modifications to the patello-femoral articulation and the posterior stabilized mechanism.

Methods: 100 consecutive IBPSII knee arthroplasties were followed prospectively. Age, gender, deformity and diagnoses were comparable to previous groups.

Results: Fifty-one knees were evaluated at 10 or more years with the Knee Society scores and radiographs. 14 were evaluated by phone. An additional 6 knees required revision and 29 were in patients who died. None were lost. Revisions were performed for instability (2 knees), sepsis (2), loosening from osteolysis (1), and stiffness (1). In the 10-year group, 12 patients required reoperations: Patellar revision for loosening (1), patel-lectomy for fracture (1), polyethylene exchange for dislocation of the spine and cam mechanism (3) and for dissociation (1), and arthroscopic resection of scar from the quadriceps tendon (patellar clunk) in 6 knees.

Conclusion: The smoother patello-femoral groove was associated with fewer patellar fractures, but resulted in scar on the quadriceps catching on the femoral component. The tibial spine was moved posteriorly from previous models to increase rollback. This resulted in dislocation of the spine and cam mechanism. One case failed due to loosening and extensive osteolysis presumably associated with modularity. The last two complications were not observed with earlier versions of this prosthesis. All complications occurred within the first five years.