Purpose of the study: Arthrodesis is the treatment of choice for advanced-stage infection involving the tibiotarsal joint. In aseptic conditions, clinical and biomechanical experiments have shown that internal fixation can lead to a better rate of bone fusion. In septic conditions, external fixation, or a hybrid system, is preferred by many authors. The purpose of this retrospective study was to report the outcomes obtained with tibiotarsal arthrodesis with exclusive internal fixation in a septic environment.

Material and methods: From March 1992 to October 2005, twenty patients underwent tibiotarsal arthrodesis for the treatment of septic arthritis, 18 in a one-phase procedure and two in a two-phase procedure with bone graft. The series included four women and 16 men, mean age 50±15 years. The joint lesions were posttraumatic in 15 cases, related to primary osteonecrosis of the talus in one and to primary arthritis in four. Mean duration of the infection was 2.5 years. Resection of infected bone and soft tissue, to a zone considered healthy, was systematic. Arthrodesis used the Méary technique (n=9) or the Crawford-Adams technique (n=11). Fixation was achieved with screws, staples or both. Mean duration of antibiotics was 97.5±37.5.

Results: The clinical and functional outcome was assessed with the Kitaoka score. The x-rays included an ap and lateral view of the ankle and Méary views. All patients were reviewed at mean 64±36 months; none of the patients were lost to follow-up. The patients were considered cured if clinical and radiographic signs of infection were absent; deep samples confirmed relapse (same germ) or reinfection (different germ).

Discussion: The healing rate for infection was 90% (91% for Crawford-Adams). Radiographic bone fusion was achieved in 90% (100% for Crawford-Adams) with a mean delay of 4.8 months (range 3–11). The mean Kitaoka was improved 45±18.

Conclusion: Tibiotarsal arthrodesis in a septic context can be achieved by internal fixation alone. This method allows good position for the bone fusion and cure of the infection in 90% of cases.

Purpose of the study: Plurimicrobial infections account for 4 to37% of all infections of total hip arthroplasties (THA). According to data in the literature, they are the source of failure, contraindicating one-phase replacement procedures. The purpose of our study was to evaluate the results of our management practices in this group of patients and also to identify factors of risk associated with multimicrobial infection.

Material and methods: A prospective study included 116 patients with an infected THA from November 2002 to December 2006. Sixteen patients (13.8%), mean age 68±12.7 years had a plurimicrobial infection defined by having at last two interoperative bacteriological samples positive for two or more germs. Surgical treatment consisted in a single-phase replacement in seven cases, a two-phase replacement in seven, resection of the head and neck in one, and wash-out resection in one. Mean duration of the antibiotic therapy ws 91±6 days, including 46±14 days intravenously. Anaerobic germs were isolated more commonly in plurimicrobial infections than monomicrobial infections (50% versus 11%). Patients were assessed with prospectively collected data. Mean follow-up was 34±13 months, with none lost to follow-up. The main outcome was apparent cure rate of the initial infection at minimum two years follow-up, defined by the absence of clinical, biological and radiographic signs of infection, and absence of death attributable to infection or its treatment. If infection was suspected, a hip puncture or intraoperative samples confirmed the relapse (same germs) or reinfection (different germs).

Results: The cure rate was 100% for plurimicrobial infections and 97% for monomicrobial infections. There were however four reinfections in the monomicrobial group. In this series, the risk factor statistically associated with plurimicrobial infections was the presence of a fistula with an odds ratio of 5.4.

Discussion: A larger number of patients would probably enable identification of other risk factors associated with plurimicrobial infections.

Conclusion: The cure rate of plurimicrobial infections was higher than reported in the literature but for a small group of patients. The presence of a fistula was strongly associated with these plurimicrobial infections.

Purpose of the study: The purpose of this work was to analyse the results of infection in patients with joint prostheses implanted after septic arthritis, distinguishing evolving versus cured arthritis.

Material and methods: This was a retrospective series of 70 cases of septic arthritis (in 69 patients) including 7 patients with mycobacterial infections and 63 patients with ordinary germ infections. For the seven mycro-bacterial infections (five Mycobacterium tuberculosis and two Mycobacterium xenopi), the arthroplasty was implanted on evolving arthritis and in two on arthritis considered cured. For the 63 cases of common germs (70% staphylococcal infections), the septic arthritis was considered evolving in 36 and cured in 27. For half of the cases, the arthritis was blood-borne and localised in the knee. For cases considered evolving, the arthroplasty was generally a two-phase procedure (32/36 cases). Adapted antibiotics were associated for 93 days on average (45–180). For arthritis considered cured, the arthroplasty was implanted on average 53 months (range 6–700) after the infectious episode, generally in a one-phase procedure (22/27). Adapted antibiotics were associated for 80 days on average in seven patients because of positive intraoperative samples. One patient was lost to follow-up before two years and all others were reviewed with at least two years follow-up (mean 5 years, range 2–13 years).

Results: For the seven cases of mycobacterial arthritis, one patient was lost to follow-up, six had no signs of infection at mean 7 years follow-up. For the other cases, 89% of patients who had a prosthesis for evolving arthritis were considered as cured, 6% relapsed before 18 months and 6% presented a new infection with a different germ. For arthroplasty after assumed cured arthritis, 81% of patients were considered cured, 15% relapsed before 18 months and 4% presented a new infection with another germ.

Discussion: Arthroplasty is the treatment of choice for septic evolving septic arthritis, enabling cure in more than 80%, irrespective of the causal germ, and whether cure of the infection was apparently achieved or not.

Background: The treatment of deep infection following total hip arthroplasty (THA) is long and costly. However, there are few studies in the literature analysing the cost of total hip arthroplasty revision, especially for infection. The purpose of this study was to determine the cost of THA revision performed for infection and to compare it with the cost of revision for aseptic loosening on one hand, as well as the cost of primary THA, on the other hand.

Methods: From January to December 2006, we performed in our hospital 474 primary THA, 57 revisions for aseptic loosening and 40 revisions for infection. We identified for each procedure areas of cost: preoperative evaluation, surgical procedure, medical procedure including intravenous antimicrobial therapy during hospitalization, post-operative follow-up and physiotherapy. For the costs of preoperative evaluation, we used the refunding rate of the CNAM (the public health insurance company) applicable since September 2005. The total cost of the treatment includes direct and indirect costs, corresponding to the expenses of medical and surgical entities involved in the procedure, the operating charges of the hospital and the net expenses of general services. The cost of primary total hip arthroplasty was used as the reference cost.

Results: The average duration of hospital stay was 6 days for a primary THA, 8 days for a revision for aseptic loosening and 24 days for septic revision. The rate of transfer to a hospital for care-following and physiotherapy was 55% for a primary THA, 70% for aseptic revision and 65% for septic revision. Moreover, the rate of the hospitalization at home for the septic revision after the surgery was 30%. The cost of the revision of THA for aseptic loosening was 1.4 fold the cost of primary THA. In case of septic revision, the cost was 3.3 fold.

Discussion: The economic impact of the deep infection following THA is important. The additional cost is due to a longer duration of hospital stay and rehabilitation requiring more human and material resources.

Conclusions: The cost of revision THA for infection is high. The procedures of care must be optimized in order to increase the treatment success rate and minimise the total cost.

Introduction: The goal of the study was to evaluate our treatment protocols for peri-prosthetic infection after total hip replacement.

Méthode: A prospective study carried out between February 2003 and February 2005, included 100 patients treated for peri-prosthetic infection after total hip replacement. Debridement and prosthesis retention was performed in case of duration of symptoms of less than 14 days (11 cases), otherwise a one-stage (42 cases) or a two-stages (41 cases) prosthesis removal and re-implantation were carried out. A two-stage procedure was decided in case of important bone loss or undetermined germ. If general health state did not allow a re-implantation, an isolated prosthesis removal was performed (6 cases). Post-operatively, patients received intravenous antibiotics (6 weeks), then oral antibiotics (6 weeks). The mean follow-up was 2.2 years with no lost to follow-up. The main evaluation criteria was the rate of infection eradication with 2 years minimal follow -up. In case of a suspected new infection, a hip aspiration was performed to determine whether it was a non-eradication (same germ) or a new re-infection (other germ) which was not considered as a failure.

Results: Infection eradication rate was 95% and 100% for the one-stage surgical procedure. 5 failures were recorded (2 deaths and 3 non-eradications). However, 3 patients were re-infected with different germs. The rate of non-infected patiens at the last follow-up was 92%.

Conclusion: Our protocols were validated with a high success rate of 95%. Peri-prosthetic infection of the hip is severe even if well treated with a mortality rate of 2%.

Purpose of the study: Dislocation of a total hip arthroplasty (THA) is a common complication, the third leading reason for revision. Anterolateral approaches produce the lowest rate of dislocation but have many drawbacks. Few studies have examined the rate of dislocation of THA implanted via an anterior approach such as described by Hueter which appears to be more anatomic and less damaging. The purpose of this study was to determine the rate of dislocation of THA implanted via this approach and to search for associated risk factors.

Material and methods: A prospective study included 1764 THA in 1374 patients, 891 females and 483 males, implanted between 1997 and 2003. Age ranged from 22 to 84 years (69±10.8). The right side was involved in 996 cases and the left in 768. Two senior surgeons performed the operations using the anterior approach described by Hueter. A cemented implant with a metal-backed polyethylene cup was used. The group of patients who presented at least one dislocation was compared with the group of patients free of dislocation. The effect of clinical, radiolgical, and prosthetic factors was studied: age, gender, body mass index, etioloy, intraoperative blood loss, head diameter, cup inclination and anteversion. Pearson’s chi-square test and Student’s t test were applied with a 5% level of significance.

Results: The rate of dislocation was 1.5% (27 patients). The rate of dislocation after discharge to home was 0.8%. All dislocations occurred early, from postoperative day 1 to 56, mean 13.8 days (SD 15.25). One patient underwent revision for reduction. Two underwent revision for recurrent instability (0.11%). Significant risk factors were male gender (p< 0.001), young age (p< 0.001), elevated body mass index (p< 0.001), osteonecrosis (p< 0.001), significant intraoperative blood loss (p< 0.001), head diameter 22.22 vs 28 (p< 0.001).

Discussion: The Hueter approach significantly reduces the risk of dislocation. This might be explained by the less invasive nature of the approach since it does not require any muscle section.

Conclusion: The risk of dislocation after implantation of a THA via the anterior Hueter approach is one of the lowest reported in the literature (0.8% after discharge to home). Subjects at risk are five years younger, overweight males operated on for osteonecrosis with significant intraoperative blood loss and a 22.22 diameter femoral head.

Purpose: We report results of management of infected total knee arthroplasty (TKA). Our aim was to analyse the different therapeutic options and identify factors predictive of cure.

Material and methods: This retrospective multicentric analysis included a consecutive series of 179 cases of infected TKA. Revision TKA was performed for 77 knees in two operative times, 30 in one operative time. Synovecetomy was performed for 26 knees, arthrodesis for 36 and amputation for nine. Minimum follow-up was two years. For each case, we assessed cure of infection and functional outcome. Non-parametric statistical tests were used to compare outcome.

Results: Mean follow-up was 41.2 months. There was a 17% death rate during the first two years after management of infected TKA. Cure was achieved in two-thirds of the revised cases (in one or two operative times) and in 54% of the synovectomy cases. Arthrodesis yielded cure in 50%. Staphylococci was identified in 65%. The functional outcomes of revised prostheses (two times) was less satisfactory if the anterior tibial tubercle was removed, if the extensor system was involved, or if a flap cover was necessary (p< 0.05). There was no significant difference in functional outcome for one-time and two-time operations. Cure was achieved in 95% of the synovectomies performed before 16 days. Relapse occurred in 95% of those performed after 56 days. Arthrodesis performed in patients with major bone loss failed. Among the arthrodesis failures, 50% were related to mechanical failure and the other 50% to recurrent infection.

Discussion: We discuss these results and indications for different treatments of infected total knee arthroplasty. For each therapeutic option, we analysed factors allowing hope for cure and good functional outcome.

Conclusion: The objective of treatment of an infected TKA is to achieve cure and maintain satisfactory function, often a difficult goal to reach. Major mutilating surgery can be avoided by early adapted care.